• Asian Pacific Journal of Cancer Prevention
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• v.15 no.10
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• pp.4203-4206
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• 2014

Purpose: The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD). Materials and Methods: A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients with invasive GTD (Group 1; n=8) were compared with patients who showed no invasion (Group 2; n=119). All underwent a prior uterine evacuation and followed up by regular assessment of ${\beta}$-hCG titers. Results: Demographic and obstetric history and pre-evacuation hCG levels of the patients showed no statistically significantly difference between the groups (p>0.05). The mean gestational weeks (GW), size of the GTD and NLR levels were statistically significantly higher in the invasive GTD group (p<0.05). Correlations between invasion and gestational weeks, size of GTD, post-evacuation chemotherapy and NLR were evident. ROC curve analysis demonstrated that GW, size of GTD and NLR may be discriminative parameters in predicting invasion of GTD. Conclusions: To the best of our knowledge, this is the first study evaluating the predictive role of NLR in invasion of GTD. In conclusion, we think that pretreatment NLR can be used as a biomarker of invasion in GTD.

• Journal of Yeungnam Medical Science
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• v.14 no.2
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• pp.383-392
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• 1997

To study the differences of bone mineral density according to the gestational ages and the birth weight and get a reference data for the diagnosis of metabolic bone diseases in the newborn infants, bone mineral densities of the lumbar vertebrae were measured in fifty-three newborn infants born at Yeungnam University Hospital from March 1, 1995 to February 28, 1997, whore gestational ages were between $28^{+3}$ and $41^{+3}$ weeks and who had no intrauterine growth retardation, using dual energy X-ray absorptiometry (X-R 26, Norland, USA) within seven days of life. 1. There was no sexual difference in bone mineral density. The bone density increased significantly as gestational age increased from $0.149{\pm}0.009g/cm^2$ at 28-30wks to $0.229{\pm}0.034g/cm^2$ at 39-41wks of gestational age (p<0.05), but there was no significant difference between bone mineral densities at 33-34 wks and 35-36wks. There was positive linear correlation between gestational age and bone mineral density ($Y=7.5{\times}10^{-3}X-0.082$, r=0.7018, p<0.001). 2. The bone mineral density increased significantly as the birth weight increased from $0.158{\pm}0.020g/cm^2$ in 1,000-1,499 g to $0.251{\pm}0.021g/cm^2$ in 3,500-4,000 g of the birth weight (p<0.05), but there was no significant difference between bone mineral densities in 1,000-1,499 g and 1,500-1,999 g of the birth weight. There was positive linear correlation between the birth weight and the bone mineral density ($Y=3.9{\times}10^{-5}X+0.093$, r=0.7296, p<0.001). There were positive correlations between the bone mineral density and gestational age, and between the bone mineral density and the birth weight. It can be used as a reference data for the further study on the bone mineral metabolism in the newborn infants including preterm babies.

• Proceedings of the Korean Environmental Health Society Conference
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• 2003.06a
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• pp.27-31
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• 2003

• Clinical and Experimental Pediatrics
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• v.49 no.7
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• pp.703-709
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• 2006

Since the advent of growth hormone(GH), children with a wide variety of growth disorders have received GH treatment. In GH deficiency(GHD), Turner syndrome, chronic renal failure, children born small for gestational age, Prader-Willi syndrome, and idiopathic short stature, the therapeutic effects and safety profile of GH are reviewed. GH therapy has been clearly shown to improve height velocity and final adult height in a variety of pediatric conditions in which growth is compromised irrespective of GHD. Early initiation and individualization of GH treatment has the potential to normalize childhood growth. The supra-physiological doses of GH have been shown to increase height velocity during childhood and final height in non-GHD conditions. Adverse events during GH therapy are uncommon and often not drug related. However continued surveillance into adult life is crucial, especially in children receiving supra-physiological doses or whose underlying condition increases their risk of adverse effects.

• Clinical and Experimental Pediatrics
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• v.58 no.3
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• pp.77-83
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• 2015

Relative to a fetus of the same gestational age, very low birth weight (VLBW) infants are more likely to be underfed and to undergo growth restriction during their early hospital stay. The current trend towards "early and aggressive" nutritional strategies in VLBW infants aims to overcome the early nutritional deficiency and thereby boost postnatal catch-up growth, simultaneously improving long-term neurodevelopmental outcomes. Although the minimum starting amino acid (AA) dose to prevent negative nitrogen balance is well established, the upper limit and the rate of increase of early AA doses are controversial. Most randomized controlled trials show that early and high-dose (target, 3.5 to 4.9 g/kg/day) AA regimens, with or without high nonprotein calories, do not improve long-term growth and neurodevelopment. High-dose AA supplementation may lead to early metabolic disturbances and excessive or disproportionate plasma AA levels, particularly in infants of very low gestational age. Further large studies are needed to clarify the optimal strategy for early administration of parenteral AA doses in VLBW infants.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2000.09a
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• pp.20-20
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• 2000

The objective of this investigation was to evaluate of influence of gestational age at exposure on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed to single dose of 2.0 Gy gamma-radiation at gestation days from 2.5 to 15.5 days post-coitus. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. The only demonstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. (omitted)

• Korean System Dynamics Review
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• v.11 no.3
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• pp.5-31
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• 2010

The purpose of this study is to develop a system dynamics model for growth prediction of low birth weight infants(LBWIs) based on nutrition. This growth prediction model consists of 9 modules; body weight, height, carbohydrate, protein, lipid, micronutrient, water, activity and energy module. The results of the model simulation match well with the percentiles of weights and heights of the Korean infants, also with the growth records of 55 LBWIs, under 37 weeks of gestational age, whose weights are appropriate for their gestational age. This model can be used to understand the current growth mode of LBWIs, predict the future growth of LBWIs, and be utilized as a tool for controlling the nutrient intake for the optimal growth of LBWIs in actual practice.

• Korean Journal of Veterinary Research
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• v.23 no.1
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• pp.1-8
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• 1983

The purpose of the present study is to determine variations in synthesis of DNA in the nuclei of various elements of the golden hamster (Mesocricetus auratus) placenta with increasing gestational age from the eighth day post coitus to parturition. The method employed for such determination was autoradiography following injection of pregnant animals with tritiated thymidine. From the results reported, the following points are concluded. The mitotic activities of the endodermal cells of the visceral yolk sac and of the parietal yolk sac, the trophoblastic cells of the labyrinth and the trophospongium and the giant cells were decreased with increasing gestational age, The placentation was nearly completed by day 13 of pregnancy and the increase in size of labyrinth was by appositional growth from the trophospongial cells. It was considered that the inner trophoblastic cells in the vicinity of the fetal blood vessels were originated from the pure chorion. The interrelation among the various cells and the polyploidal giant cells in the placenta were discussed.

• Proceedings of the Korean Society of Toxicology Conference
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• 2003.10b
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• pp.190-191
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• 2003

We investigated the effects of gestational and lactational exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differential induction of CYP1A1 in the levels of protein and gene expression in the liver and brain regions of offspring rats. For this study, pregnant Sprague Dawley rats were orally exposed to TCDD (1 or 10 ng/kg body weight/day) starting at Day 1 of gestation up to Day 20 of postpartum. (omitted)

• 대한세포병리학회:학술대회논문집
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• 1992.11a
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• pp.6.2-7
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• 1992