• 제목/요약/키워드: Geranyl phenyl ethers

검색결과 2건 처리시간 0.015초

Antitumor evaluation and antimicrobial activity of geranyl phenyl ethers

  • Oh Hyun-Ju;Shin Ji-Hee;Chung Woo-Young;Han Du-Seok;Baek Seung-Hwa
    • Advances in Traditional Medicine
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    • 제2권1호
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    • pp.52-57
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    • 2002
  • Geranyl phenyl ethers 1, 2, 3, 4 and 5, 5-fluorouracil 6 and adriamycin 7 as references were tested for their growth inhibitory effects against tumor cell lines and NIH 3T3 fibroblasts using two different assays, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays. These results suggest that methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate 1 showed growth inhibition activity against tumor cell lines. The maximum activity exhibited by methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate 3 against Staphylococcus epidermidis (MIC, $1,000{\mu}g/ml$).