• 한국전자통신학회논문지
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• 제3권1호
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• pp.26-30
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• 2008

CDMA 이동망 환경에서는 한정된 자원을 효율적으로 사용하여 멀티미디어 서비스 요구에 따른 무선 트래픽 채널을 할당하는 기법은 무선이라는 특수 환경으로 인해 제약을 받을 수밖에 없다. 이동망의 기지국의 경우 여러 무선 가입자 보드로부터 요구되는 서비스별 트래픽 요구에 대한 채널 할당과 이에 대한 메인보드에서 처리해야 하는 작업 스케줄링은 무선과 CPU라는 서로 다른 환경을 잘 매핑하는 과제를 안고 있다. 본 논문에서는 음성과 데이터 호를 동시에 서비스하는 셀룰러 시스템에서 멀티미디어 서비스 트래픽 특성을 고려한 주파수할당과 작업 스케줄링이라는 두 가지 요소를 접목할 때 적합한 작업 스케줄링 방식을 제안한다.

• 동의생리병리학회지
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• 제22권6호
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• pp.1482-1486
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• 2008

The antihypertensive effects of the Wild Mountain Ginseng Cultured Root Extract (WMGCE) were investigated in spontaneously hypertensive rats (SHR). Daily oral administration of the WMGCE (100 and 200 mg/kg) exhibited a significant decrease in blood pressure in SHR rats during for 8 weeks. The systolic blood pressure was dose- and time-dependently decreased significantly from the second weeks (p < 0.05) to the end of WMGCE treatment in SHR. The WMGCE decreased the plasma levels of sodium, potassium, chlorides, urea and osmolarity in SHR rats but no statistically significant change was observed. Furthermore, no significant changes were noted on heart weight, heart rate and diameter of aorta after WMGCE treatment in SHR. Our results suggest that daily oral administration of WMGCE at the dose of 100 and 200 mg/kg for 8 weeks exhibited antihypertensive activities.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 ISIS 2003
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• pp.187-190
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• 2003

Many manufacturing companies consider the integrated and concurrent scheduling because they need the global optimization technology that could manufacture various products more responsive to customer needs. In this paper, we propose an advanced scheduling model to generate the schedules considering resource constraints and precedence constraints in make-to-order (MTO) manufacturing environments. Precedence of work- in-process(WIP) and resources constraints have recently emerged as one of the main constraints in advanced scheduling problems. The advanced scheduling problems is formulated as a multiobjective mathematical model for generating operation schedules which are obeyed resources constraints, alternative workstations of operations and the precedence constraints of WIP in MTO manufacturing. For effectively solving the advanced scheduling problem, the multi-objective hybrid genetic algorithm (m-hGA) is proposed in this paper. The m-hGA is to minimize the makespan, total flow time of order, and maximum tardiness for each order, simultaneously. The m-hGA approach with local search-based mutation through swap mutation is developed to solve the advanced scheduling problem. Numerical example is tested and presented for advanced scheduling problems with various orders to describe the performance of the proposed m-hGA.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 추계학술대회 논문집
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• pp.163-166
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• 2003

Hull form designers have to design a ship with satisfying an economical, technical and environmental demand. When it is concerned by a technical and environmental demand, there will be a economical demand left to criticize optimization. In this case, there were used to be requirements which needs to meet only a best performance not concerning about input of Human resource. Life cycle's cost contains building cost and operation cost so that now we need to check Man Hour cost in building a ship. This research shows a correlation between hull form information, i.e. curvature, length, breadth and thickness of surface and Man Hour of the Shell plating manufacture with using Artificial Neural Network and Gentic Programming. This study will support to classify initial work, to have a high assumption possible through predicting a Man Hour and to provide a guide book to infer a building cost and a economical optimization hull form.

• Genomics & Informatics
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• 제12권3호
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• pp.121-126
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• 2014

Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide polymorphism was rs6978712 (chromosome 7, $p=4.87{\times}10^{-7}$), which is located proximal to the GCC1 gene, which was previously implicated in decision-making capability in drug abusers. Two suggestive single nucleotide polymorphisms were in strong linkage disequilibrium ($r^2$ > 0.8) with rs6978712. Thus, in the aspect of decision-making in adherence behavior, the association between medication adherence and three loci proximal to the GCC1 gene seems worthy of further research. However, to overcome a few limitations in this study, defining the standardized phenotype criteria for self-reported adherence should be performed before replicating association studies.

• Genomics & Informatics
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• 제14권4호
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• pp.160-165
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• 2016

Over the past decade, the detection of gene-gene interactions has become more and more popular in the field of genome-wide association studies (GWASs). The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. However, such tests are computationally demanding and methodologically challenging. Recently, a simple but powerful method, named "BOolean Operation-based Screening and Testing" (BOOST), was proposed for genome-wide gene-gene interaction analyses. BOOST was designed with a Boolean representation of genotype data and is approximately equivalent to the log-linear model. It is extremely fast, and genome-wide gene-gene interaction analyses can be completed within a few hours. However, BOOST can not adjust for covariate effects, and its type-1 error control is not correct. Thus, we considered two-step approaches for gene-gene interaction analyses. First, we selected gene-gene interactions with BOOST and applied logistic regression with covariate adjustments to select gene-gene interactions. We applied the two-step approach to type 2 diabetes (T2D) in the Korea Association Resource (KARE) cohort and identified some promising pairs of single-nucleotide polymorphisms associated with T2D.

• Genomics & Informatics
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• 제14권4호
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• pp.138-148
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• 2016

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.

• 한국전산유체공학회지
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• 제19권4호
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• pp.14-19
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• 2014

This study conducts shape optimization of rib turbulator on the internal cooling passage that has triangular cross-section of high pressure turbine nozzle. During optimization, various types of rib turbulator including angled, V-shaped, A-shaped and angled rib with intersecting rib are considered. Each type of rib turbulator is parameterized with attack angle(s), rib height, spacing ratio and bending/intersecting location. For optimization, Design of Experiment (DOE) and Kriging surrogate model are used to utilize computational resource more efficiently and Genetic Algorithm (GA) is used to search the optimum points. As a result, Pareto front of each type of rib turbulator with friction factor that relates to pressure drop in cooling passage and spatially averaged Nusselt number that relates to heat transfer on the wall is drawn and optimum points on the Pareto front are suggested.

• Plant Biotechnology Reports
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• 제3권1호
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• pp.103-109
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• 2009

In this study we established reliable methods for conservation of seeds of Phaius tankervilleae as an orchid genetic resource. The seeds, which were dehydrated to 5% water content and preserved at $4^{\circ}C$, showed no decrease in viability and germinability after three months. After storage for six months, however, the seeds showed a drastic decrease in germinability, even though survival rate was high. For long-term preservation of seeds of P. tankervilleae, cryopreservation is applied to the freshly harvested seeds. When the seeds were cryopreserved by the vitrification method for up to 12 months there was no apparent deterioration effect of storage time. These results indicate that cryopreservation by the vitrification method is useful for long-term conservation of P. tankervilleae seeds, which are difficult to preserve for more than three months under dry and low-temperature conditions.

• Journal of Crop Science and Biotechnology
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• 제11권1호
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• pp.13-16
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• 2008

Pepper fruit anthracnose caused by Colletotrichum species is an economically important disease that causes serious yield loss and quality deterioration in many Asian countries including South Korea and Taiwan. Recently, Capsicum baccatum PI594137 was found to exhibit broad-spectrum resistance to Colletotrichum acutatum. The inheritance of anthracnose resistance to C. acutatum was analyzed in an intraspecific population derived from a cross between C. baccatum Golden-aji and PI594137. Detached mature green fruits were inoculated using the microinjection method. The disease response was evaluated as the disease incidence and the overall lesion diameter at 7 days after inoculation(DAI). The segregation ratios of resistance and susceptibility to C. acutatum in the $F_2$ and $BC_s$ populations significantly fit a 3:1 Mendelian model. This result indicates that the resistance of PI594137 to C. acutatum is controlled by a single dominant gene.