• The Journal of Korean Physical Therapy
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• 제15권2호
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• pp.52-66
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• 2003

The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body, It is believed to be important clinically because there is an association of disc degeneration with back pain. Degenerative changes in the intervertebral disc are thought to develop as aging, mechanical stress and metabolic factors. Genetic factors may also play a part in the onset or progress of the degenerative process. They, together with environmental factors, may act as determinants of the structural characteristics of the intervertebral disc and produce a tendency to generation, In this short review we outline the morphplogy and biochemistry of normal intervertebral disc and the changes that arise during degeneration. Therefore this study will review degeneration of intervertebral disc, so we will have knowledge about low back pain associated with degenerative change in the intervertebral disc.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2004년도 춘계학술대회 학술발표 논문집 제14권 제1호
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• pp.438-441
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• 2004

In this study, we introduce a noble neurogenetic approach to the design of fuzzy controller. The design procedure dwells on the use of Computational Intelligence (CI), namely genetic algorithms and Fuzzy-Set based Neural Networks (FSNN). The crux of the design methodology is based on the selection and determination of optimal values of the scaling factors of the fuzzy controllers, which are essential to the entire optimization process. First, the tuning of the scaling factors of the fuzzy controller is carried out by using GAs, and then the development of a nonlinear mapping for the scaling factors is realized by using GA based FSNN. The developed approach is applied to a nonlinear system such as an inverted pendulum where we show the results of comprehensive numerical studies and carry out a detailed comparative analysis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.44-54
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• 2008

Chronic functional constipation is a common problem in childhood, with soiling a significant issue. It presents a management problem for pediatrician, and parental concern is high. About 5% of pediatric patients is known to have constipation and/or encopresis which is the second most referred disease in pediatric gastroenterology clinic, accounting for up to 25% of all visits. The etiology of constipation was based on initiation factors including vicious cycle concept, genetic factors, psychological factors, dietary influences and histologic abnormalities of colon. Emphasis is placed on the evaluation and management options that are available to the treating pediatrician. Careful history taking is most important to diagnose functional constipation. In addition, diagnostic tests such as plain abdominal radiograph, colonic transit study, anorectal manometry, barium enema were helpful to diagnose the constipation. Childhood constipation can be very delicate to treat. It often requires prolonged supports by physicians and parents, demystification, medical treatment and especially with the child and parent's cooperation.

• 대한불안의학회지
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• 제5권1호
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• pp.3-7
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• 2009

In this article, we review research on how normal personality traits and personality disorder traits may relate to anxiety disorders ; as predisposing factors, 2) as complications, 3) as pathoplastic factors, and 4) as manifestations of common underlying etiologies. Based on current literatures, we draw a conclusion as follows : 1) Normal personality traits such as high neuroticism and low extraversion and personality disorder traits, especially cluster C traits, are at least risk factors for certain anxiety disorders ; 2) Anxiety disorders in early life might influence a later development of personality disorder ; 3) Personality disorder traits may have negative influence on the outcome of anxiety disorders ; 4) Personality and anxiety disorders may be manifestations of common genetic and environmental etiologies.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권1호
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• pp.13-18
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• 2012

The pathogenesis of inflammatory bowel diseases is not very well understood; it is currently thought to be caused by the interaction between genetic factors, environmental factors, intestinal microbes, and immune factors. Biological agents such as anti-tumor necrosis factor (anti-TNF) are widely being used as therapeutic agents. Infliximab, a chimeric monoclonal IgG1 antibody against tumor necrosis factor, has been demonstrated to have an effect in the induction and maintenance of remission in Crohn's disease in children. The effects of biological agents, typified by anti-TNFs, in inflammatory bowel disease in children; the recent concern on the administration of biological agents in combination with immunomodulators; and 'Top-down' therapy are some of the topics covered in this review.

• Environmental Analysis Health and Toxicology
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• 제25권4호
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• pp.259-262
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• 2010

In this review, we give an overview of psychiatric perspectives on environmental disease. The concept of genetic heritability and its meaning with regard to environmental risk factors will be discussed. Recent ideas of gene-environment interaction and neurodevelopmental disorder in psychiatry will also be introduced. This article discusses the environmental risk factors for attention deficit hyperactivity disorder (ADHD) and autism, the two major environmental diseases and neurodevelopmental disorders in psychiatry. Given that both ADHD and autism are complex conditions, the etiology is likely to involve multiple genes of moderate effect interacting with environmental factors. We will introduce recent environmental issues related to these two disorders.

• 대한한의학회지
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• 제31권3호
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• pp.128-132
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• 2010

Objectives: This study aimed to review the general features of drug induced liver injury (DILI) and the important factors in consideration of herbal drugs and DILI. Methods: We reviewed general aspects of DILI such as classification, inducible factors, diagnosis methods, prevention, and the status of herbal drug-associated DILI via literature. Results: Besides the drug itself, genetic and environmental factors affect hepatic toxicity. There is a lack of definitive diagnoses of DILI by drugs, including herbal remedies. The possibility of herbal drug-associated DILI is exaggerated, and majority of herbal drug-derived hepatic injury could be easily prevented if Oriental doctors pay attention to this issue. Conclusion: This study can provide Oriental doctors an overview and be helpful in minimizing the episodes of hepatotoxicity in use of herbal drugs.

• Communications for Statistical Applications and Methods
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• 제26권2호
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• pp.103-129
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• 2019

The main goal of a case-control study is to learn the association between various risk factors and a primary outcome (e.g., disease status). Particularly recently, it is also quite common to perform secondary analyses of the case-control data in order to understand certain associations between the risk factors of the primary outcome. It has been repeatedly documented with case-control data, association studies of the risk factors that ignore the case-control sampling scheme can produce highly biased estimates of the population effects. In this article, we review the issues of the naive secondary analyses that do not account for the biased sampling scheme, and also the various methods that have been proposed to account for the case-control ascertainment. We additionally compare the results of many of the discussed methods in an example examining the association of a particular genetic variant with smoking behavior, where the data were obtained from a lung cancer case-control study.

• 한국산학기술학회논문지
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• 제11권12호
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• pp.4697-4706
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• 2010

본 연구에서는 시뮬레이션과 네트워크 분석법을 이용하여 다품종 소량생산 체제로 운영되는 자동차 부품 가공시스템의 최적 운영방안을 제시하였다. 이를 위해 먼저, 생산현장의 복잡하고 다양한 운영 요소들을 반영하여 시뮬레이션 모델링 한 후 반응표면법으로 메타모델을 설계하였다. 그 후 의사결정권자들로부터 주요 평가 요소들과 그 요소들 간의 중요도를 수집하여, 네트워크 분석법으로 그 가중치를 설계한 후 다목적 유전자알고리즘을 사용하여 그 최적운영방안을 제시하고 그 결과를 분석하였다. 그와 더불어 계층화분석법으로 설계한 가중치를 반영한 운영방안과의 비교를 통해, 본 연구에서 제시한 방법이 평가 요소간의 내 외부 종속성과 상호연관성을 반영하여 더 정밀하고 우수한 운영방안임을 입증하였다. 본 연구를 활용하면 자동차 부품산업과 같은 다품종 소량생산 시스템의 운영방안 설계시 의사결정권자에게 보다 효과적이고 정밀한 정보를 제공해 줄 수 있을 것이다.

• 한국수산과학회지
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• 제40권4호
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• pp.234-242
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• 2007

We examined the cause of albinism in a hatchery population of flounder in terms of environmental and nutritional factors, including the effects of light intensity (130-12,300 lux), photoperiod (12L/12D or 24L/0D), tank substrate (concrete or fiber-reinforced polymer), tank color (white or dark green) and supplement with enriched live food, and also compared the growth of normal and albino fry under both 12L/12D and 24L/0D. Further to, normalization of the skin pigmentation pattern on the ocular side has been juvestigated after rearing the albino fry for 2 years after their identification and classification and found that, light intensity did not play a critical role in the development of normal pigmentation or albinism in the flounder. By contrast, the photoperiod was a weak inducer of albinism in the flounder. Tank substrate and color also affected the hypomelanosis on the ocular side of the flounder fry. The choice and supplementation of enriched live foods could drastically reduce the incidence of albinos in hatcheries. On comparing the growth of normal and albino fry, while there was no difference between the groups under 24L/0D, the growth of the albino flounder was slower under 12L/12D. Although coloration resulting from xanthophore and melanophore, but not iridophores, occurred on the ocular side, evidence of albinism remained on the ocular side of flounders.