• Title/Summary/Keyword: Genetic Architecture

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Analyzing the Negotiation Process for the Adoption of Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing Arising from their Utilization using the Conflict Management Process (갈등 관리 프로세스에 의한 ABS협상의 갈등 사례 분석)

  • Min, Seo-Jeong;Lee, Gwan-Gyu;Kim, Joon-Soon
    • Journal of Environmental Policy
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    • v.10 no.2
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    • pp.3-19
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    • 2011
  • Nagoya Protocol designed to establish criteria about material trade of biological genetic resources(ABS) was adopted in the 10th conference of the Parties to the Convention on Biological Diversity. In the course of the negotiation for adoption of the protocol, there was conflict between developed and developing countries, resource-rich and poor countries, and multinational corporations and environmentalists. This study investigates conflict process, subjects, issues and major factors in the negotiation case, and analyzes the negotiation by using the Conflict Management Process. To develope conflict management strategies for various conflict cases, we examine previous studies and analyze the intersectional conflict factors of this case and general cases, such as Fundamental side, Resource-allocation side, and Communication/Information-sharing side. These analyses of conflict prevention/resolution of the ABS negotiation show the importance of building mutual trust among stakeholders, enhancing mediator training, and constructing appropriate legislative/policy systems for successful conflict management.

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An efficient approach for model updating of a large-scale cable-stayed bridge using ambient vibration measurements combined with a hybrid metaheuristic search algorithm

  • Hoa, Tran N.;Khatir, S.;De Roeck, G.;Long, Nguyen N.;Thanh, Bui T.;Wahab, M. Abdel
    • Smart Structures and Systems
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    • v.25 no.4
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    • pp.487-499
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    • 2020
  • This paper proposes a novel approach to model updating for a large-scale cable-stayed bridge based on ambient vibration tests coupled with a hybrid metaheuristic search algorithm. Vibration measurements are carried out under excitation sources of passing vehicles and wind. Based on the measured structural dynamic characteristics, a finite element (FE) model is updated. For long-span bridges, ambient vibration test (AVT) is the most effective vibration testing technique because ambient excitation is freely available, whereas a forced vibration test (FVT) requires considerable efforts to install actuators such as shakers to produce measurable responses. Particle swarm optimization (PSO) is a famous metaheuristic algorithm applied successfully in numerous fields over the last decades. However, PSO has big drawbacks that may decrease its efficiency in tackling the optimization problems. A possible drawback of PSO is premature convergence leading to low convergence level, particularly in complicated multi-peak search issues. On the other hand, PSO not only depends crucially on the quality of initial populations, but also it is impossible to improve the quality of new generations. If the positions of initial particles are far from the global best, it may be difficult to seek the best solution. To overcome the drawbacks of PSO, we propose a hybrid algorithm combining GA with an improved PSO (HGAIPSO). Two striking characteristics of HGAIPSO are briefly described as follows: (1) because of possessing crossover and mutation operators, GA is applied to generate the initial elite populations and (2) those populations are then employed to seek the best solution based on the global search capacity of IPSO that can tackle the problem of premature convergence of PSO. The results show that HGAIPSO not only identifies uncertain parameters of the considered bridge accurately, but also outperforms than PSO, improved PSO (IPSO), and a combination of GA and PSO (HGAPSO) in terms of convergence level and accuracy.

Development of New Cultivars 'JangsungChorok' and 'JangsungSaetbyeol' in Zoysiagrass (한국잔디 신품종 '장성초록(JangsungChorok)'과 '장성샛별(JangsungSaetbyeol)' 개발)

  • Choi, Joon-Soo;Yang, Geun-Mo;Oh, Chan-Jin;Lee, Geung-Joo;Bae, Eun-Ji;Lee, Kwang-Soo
    • Weed & Turfgrass Science
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    • v.7 no.3
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    • pp.231-238
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    • 2018
  • This study was carried out to develope new zoysiagrass cultivars 'JangsungChorok' (Application No. :2013-3) and 'JangsungSaetbyeol' (Application No. :2013-4). One hundred and one genetic resources were collected at Jangsung Gun area from 2010 to 2011. Among the collected lines, CY6097 (JangsungChorok) and CY6069 (JangsungSaetbyeol) showed superior performance in spring green up and growth rate. 'JangsungChorok' showed genetically light green leaf color, with medium leaf width (4.4 mm), height from ground to first leaf blade of 3.2 cm and average plant height of 18 cm. Fast recovery rate and early spring green up rate will make this cultivar (JangsungChorok) for efficient sod producer. 'JangsungSaetbyeol' showed genetically dark green leaf color, with fine to medium leaf width of 3.5 mm, height from ground to first leaf blade of 4.3 cm and average plant height of 22.6 cm. Fast recovery rate and early spring green up rate with relatively narrow leaf will make this cultivar (JangsungSaetbyeol) for high sod quality.

The Vascular Plants in Mt. Geotdae, Cheongju-si, Chungcheongbuk-do (충청북도 청주시 것대산 일대에 분포하는 관속식물상)

  • Jeoung, Tae-Young;Park, Cheol-Ha;Yun, Hee-Bin;Lee, Gwi-Yong;Ahn, Chan-Ki;Lee, Kyung-Soo;Kim, Kyung-Tae;Lee, Woo-Sung;You, Ju-Han
    • Korean Journal of Plant Resources
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    • v.20 no.5
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    • pp.451-460
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    • 2007
  • This study was carried out to construct the data base for biodiversity conservation, and offer the raw data for obtaining the genetic resources. The vascular plants were summarized as 306 taxa; 79 families, 199 genera, 266 species, 35 varieties and 5 forma. The Korean endemic plants were 7 taxa; Salix caprea, S. purpurea var. japonica, Deuitzia coreana, Akebia quinata var. plyphylla, Spiraea prunifolia for. simpiciflora, Lonicera subsessilis and Weigela subsessilis. The naturalized plants were 16 taxa; Dactylis glomerata, Rumex acetocella, R. crispus, Phytolacca esculenta, Tlaspi arvense, Robinia pseudo-acacia, Trifolium repens, Ailanthus altissima, Oenothera lamarckiana, Veronica persica, Ambrosia artemisiifolia var. elatior, Erigeron annuus, Erigeron canadensis, Bidens frondosa, Taraxacum officinale and Sonchus asper. The specific plants by floristic region were 26 taxa; Chloranthus japonica, Populus davidiana, and so forth.

A Study on Genetically Optimized Fuzzy Set-based Polynomial Neural Networks (진화이론을 이용한 최적화 Fuzzy Set-based Polynomial Neural Networks에 관한 연구)

  • Rho, Seok-Beom;Oh, Sung-Kwun
    • Proceedings of the KIEE Conference
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    • 2004.11c
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    • pp.346-348
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    • 2004
  • In this rarer, we introduce a new Fuzzy Polynomial Neural Networks (FPNNs)-like structure whose neuron is based on the Fuzzy Set-based Fuzzy Inference System (FS-FIS) and is different from that of FPNNs based on the Fuzzy relation-based Fuzzy Inference System (FR-FIS) and discuss the ability of the new FPNNs-like structurenamed Fuzzy Set-based Polynomial Neural Networks (FSPNN). The premise parts of their fuzzy rules are not identical, while the consequent parts of the both Networks (such as FPNN and FSPNN) are identical. This difference results from the angle of a viewpoint of partition of input space of system. In other word, from a point of view of FS-FIS, the input variables are mutually independent under input space of system, while from a viewpoint of FR-FIS they are related each other. In considering the structures of FPNN-like networks such as FPNN and FSPNN, they are almost similar. Therefore they have the same shortcomings as well as the same virtues on structural side. The proposed design procedure for networks' architecture involves the selection of appropriate nodes with specific local characteristics such as the number of input variables, the order of the polynomial that is constant, linear, quadratic, or modified quadratic functions being viewed as the consequent part of fuzzy rules, and a collection of the specific subset of input variables. On the parameter optimization phase, we adopt Information Granulation (IG) based on HCM clustering algorithm and a standard least square method-based learning. Through the consecutive process of such structural and parametric optimization, an optimized and flexible fuzzy neural network is generated in a dynamic fashion. To evaluate the performance of the genetically optimized FSPNN (gFSPNN), the model is experimented with using gas furnace process dataset.

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Analysis of TIMP-2 and Vimentin Protein Expression and Epigenetic Reprogramming in Cloned Bovine Placentae

  • Kim, Hong-Rye;Han, Rong-Xun;Lee, Hye-Ran;Yoon, Jong-Taek;Cheong, Hee-Tae;Park, Chang-Sik;Jin, Dong-Il
    • Reproductive and Developmental Biology
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    • v.31 no.2
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    • pp.97-102
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    • 2007
  • The objective of this study was to analyzed pattern of proteins expression abnormally in cloned bovine placenta. TIMP-2 protein whose function is related to extracellular matrix degradation and tissue remodeling processes was one of differentially up-regulated proteins in SCNT placenta. And one of down-regulated protein in SCNT placenta was identified as vimentin protein that is presumed to stabilize the architecture of the cytoplasm. The expression patterns of these proteins were validated by Western blotting. To evaluate how regulatory loci. of TIMP-2 and vimentin genes was programmed reprogramming in cloned placenta. the status of DNA methylation in the promoter region of TIMP-2 and vimentin genes was analyzed by sodium Bisulfite mapping. The DNA methylation results showed that there was not difference in methylation pattern of TIMP-2 and vimentin loci between cloned and normal placenta. Histone H3 acetylation state of the nucleosome was analyzed in the cloned placental and normal placenta by Western blotting. A small portion of the protein lysates were subjected to Western blotting with the antibodies against anti acetyl-Histone H3. Overall histone H3 acetylation state of SCNT placenta was significantly higher than those of normal placenta cells. It is postulated that cloned placenta at the end of gestation seems to be unusual in function and morphology of placenta via improper expression of TIMP-2 and vimentin by abnormal acetylation states of cloned genome.

Genomic Analyses of Toll-like Receptor 4 and 7 Exons of Bos indicus from Temperate Sub-himalayan Region of India

  • Malik, Y.P.S.;Chakravarti, S.;Sharma, K.;Vaid, N.;Rajak, K.K.;Balamurugan, V.;Biswas, S.K.;Mondal, B.;Kataria, R.S.;Singh, R.K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.7
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    • pp.1019-1025
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    • 2011
  • Toll-like receptors (TLRs) play an important role in the recognition of invading pathogens and the modulation of innate immune responses in mammals. The TLR4 and TLR7 are well known to recognize the bacterial lipopolysaccharide (LPS) and single stranded (ssRNA) ligands, respectively and play important role in host defense against Gram-negative bacteria and ssRNA viruses. In the present study, coding exon fragments of these two TLRs were identified, cloned, sequenced and analyzed in terms of insertion-deletion polymorphism, within bovine TLRs 4 and 7, thereby facilitating future TLR signaling and association studies relevant to bovine innate immunity. Comparative sequence analysis of TLR 4 exons revealed that this gene is more variable, particularly the coding frame (E3P1), while other parts showed percent identity of 95.7% to 100% at nucleotide and amino acid level, respectivley with other Bos indicus and Bos taurus breeds from different parts of the world. In comparison to TLR4, sequence analysis of TLR7 showed more conservation among different B. indicus and B. taurus breeds, except single point mutation at 324 nucleotide position (AAA to AAM) altering a single amino acid at 108 position (K to X). Percent identity of TLR7 sequences (all 3 exons) was between 99.2% to 100% at nucleotide and amino acid level, when compared with available sequence database of B. indicus and B. taurus. Simple Modular Architecture Research Tool (SMART) analysis showed variations in the exon fragments located in the Leucine Rich Repeat (LRR) region, which is responsible for binding with the microbial associated molecular patterns and further, downstream signaling to initiate anti-microbial response. Considering importance of TLR polymorphism in terms of innate immunity, further research is warranted.

Characteristics of Developmental Stages in Bacterial Biofilm Formation (세균 생물막 형성의 단계별 특징)

  • Kim Chang-Beom;Rho Jong-Bok;Lee Hyun-Kyung;Choi Sang Ho;Lee Dong-Hun;Park Soon-Jung;Lee Kyu-Ho
    • Microbiology and Biotechnology Letters
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    • v.33 no.1
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    • pp.1-8
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    • 2005
  • Since Anton van Leeuwen­hoek first observed a surface-associated multicellular structure of bacterial cells in the 17th century, it has been shown to exhibit an ability to form a biofilm by numerous bacterial species. The biofilm formation is composed of distinct developmental stages, which include an attachment/adhesion of a single cell, a proliferation toward monolayered coverage, a propagation to aggregated microcolony, a maturation to 3-dimensional structure, and subsequently a local degradation. Investigation to identify the essential factors for bacterial biofilm formation has been performed via classical genetic approaches as well as recently developed technologies. The initial stage requires bacterial motility provided by a flagellum, and outermembrane components for surface signal interaction. Type IV-pilus and autoaggregation factors, e.g., type I-fimbriae or Ag43, are necessary to reach the stages of monolayer and micro colony. The mature biofilm is equipped with extracellular polymeric matrix and internal water-filled channels. This complex architecture can be achieved by differential expressions of several hundred genes, among which the most studied are the genes encoding exopolysaccharide biosyntheses and quorum-sensing regulatory components. The status of our knowledge for the biofilms found in humans and natural ecosystems is discussed in this minireview.

A Whole Genome Association Study on Meat Palatability in Hanwoo

  • Hyeong, K.E.;Lee, Y.M.;Kim, Y.S.;Nam, K.C.;Jo, C.;Lee, K.H.;Lee, J.E.;Kim, J.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.27 no.9
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    • pp.1219-1227
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    • 2014
  • A whole genome association (WGA) study was carried out to find quantitative trait loci (QTL) for sensory evaluation traits in Hanwoo. Carcass samples of 250 Hanwoo steers were collected from National Agricultural Cooperative Livestock Research Institute, Ansung, Gyeonggi province, Korea, between 2011 and 2012 and genotyped with the Affymetrix Bovine Axiom Array 640K single nucleotide polymorphism (SNP) chip. Among the SNPs in the chip, a total of 322,160 SNPs were chosen after quality control tests. After adjusting for the effects of age, slaughter-year-season, and polygenic effects using genome relationship matrix, the corrected phenotypes for the sensory evaluation measurements were regressed on each SNP using a simple linear regression additive based model. A total of 1,631 SNPs were detected for color, aroma, tenderness, juiciness and palatability at 0.1% comparison-wise level. Among the significant SNPs, the best set of 52 SNP markers were chosen using a forward regression procedure at 0.05 level, among which the sets of 8, 14, 11, 10, and 9 SNPs were determined for the respectively sensory evaluation traits. The sets of significant SNPs explained 18% to 31% of phenotypic variance. Three SNPs were pleiotropic, i.e. AX-26703353 and AX-26742891 that were located at 101 and 110 Mb of BTA6, respectively, influencing tenderness, juiciness and palatability, while AX-18624743 at 3 Mb of BTA10 affected tenderness and palatability. Our results suggest that some QTL for sensory measures are segregating in a Hanwoo steer population. Additional WGA studies on fatty acid and nutritional components as well as the sensory panels are in process to characterize genetic architecture of meat quality and palatability in Hanwoo.

Performance assessment of multi-hazard resistance of Smart Outrigger Damper System (스마트 아웃리거 댐퍼시스템의 멀티해저드 저항성능평가)

  • Kim, Hyun-Su
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.5
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    • pp.139-145
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    • 2018
  • An outrigger system is used widely to increase the lateral stiffness of high-rise buildings, resulting in reduced dynamic responses to seismic or wind loads. Because the dynamic characteristics of earthquake or wind loads are quite different, a smart vibration control system associated with an outrigger system can be used effectively for both seismic and wind excitation. In this study, an adaptive smart structural control system based on an outrigger damper system was investigated for the response reduction of multi-hazards, including seismic and wind loads. A MR damper was employed to develop the smart outrigger damper system. Three cities in the U.S., L.A., Charleston, and Anchorage, were used to generate multi-hazard earthquake and wind loads. Parametric studies on the MR damper capacity were performed to investigate the optimal design of the smart outrigger damper system. A smart control algorithm was developed using a fuzzy controller optimized by a genetic algorithm. The analytical results showed that an adaptive smart structural control system based on an outrigger damper system can provide good control performance for multi-hazards of earthquake and wind loads.