• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.4
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• pp.846-855
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• 1994

An effective stiffness, analogous to that of a wound spring, can be created by antagonistic redundant actuation of general closed-chain mechanisms. The qualitative and quantitative characteristics of the effective stiffness are investigated through a Four-bar mechanism, and a load distribution method is introduced which simultaneously guarantees the required system motion and the effective stiffness of the Four-bar mechanism. Furthermore, a simulation is performed to understand the inter-relationship among the effective stiffness, the Four-bar geometry, and the actuation effort. Based on this analysis, the Four-bar synthesis problem for effective stiffness generation is discussed.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.266-271
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• 2008

Generation mechanisms of pressure waves from the H-IIA launch vehicle are analyzed numerically. The Mach wave radiated downstream from wavy shearlayer of supersonic exhaust plume is revealed to be the dominant noise source. Reflecting from the constructions of the launch-pad, the Mach wave turns to propagate to the vehicles. It was also found that the fluctuating supersonic plume entering into the flame duct is the dominant noise source that appears in the flame duct. Then, the pressure wave propagates through the flame duct and is ejected outside to the vehicle.

• Genomics & Informatics
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• v.21 no.1
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• pp.11.1-11.5
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• 2023

Breast cancer is the most common cancer worldwide, and advanced breast cancer with metastases is incurable mainly with currently available therapies. Therefore, it is essential to understand molecular characteristics during the progression of breast carcinogenesis. Here, we report a dataset of whole genomes from the human mammary epithelial cell system derived from a reduction mammoplasty specimen. This system comprises pre-stasis 184D cells, considered normal, and seven cell lines along cancer progression series that are immortalized or additionally acquired anchorage-independent growth. Our analysis of the whole-genome sequencing (WGS) data indicates that those seven cancer progression series cells have somatic mutations whose number ranges from 8,393 to 39,564 (with an average of 30,591) compared to 184D cells. These WGS data and our mutation analysis will provide helpful information to identify driver mutations and elucidate molecular mechanisms for breast carcinogenesis.

• Communications for Statistical Applications and Methods
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• v.30 no.4
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• pp.355-368
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• 2023

This article introduces the R package ELCIC (https://cran.r-project.org/web/packages/ELCIC/index.html), which provides an empirical likelihood-based information criterion (ELCIC) for model selection that includes, but is not limited to, variable selection. The empirical likelihood is a semi-parametric approach to draw statistical inference that does not require distribution assumptions for data generation. Therefore, ELCIC is more robust and versatile in the context of model selection compared to the currently existing information criteria. This paper illustrates several applications of ELCIC, including its use in generalized linear models, generalized estimating equations (GEE) for longitudinal data, and weighted GEE (WGEE) for missing longitudinal data under the mechanisms of missing at random and dropout.

• Molecules and Cells
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• v.38 no.3
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• pp.195-201
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• 2015

Antibodies are powerful defense tools against pathogens but may cause autoimmune diseases when erroneously directed toward self-antigens. Thus, antibody producing cells are carefully selected, refined, and expanded in a highly regulated microenvironment (germinal center) in the peripheral lymphoid organs. A subset of T cells termed T follicular helper cells (Tfh) play a central role in instructing B cells to form a repertoire of antibody producing cells that provide life-long supply of high affinity, pathogenspecific antibodies. Therefore, understanding how Tfh cells arise and how they facilitate B cell selection and differentiation during germinal center reaction is critical to improve vaccines and better treat autoimmune diseases. In this review, I will summarise recent findings on molecular and cellular mechanisms underlying Tfh generation and function with an emphasis on T cell costimulation.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.6
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• pp.100-107
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• 1999

This paper describes a probabilistic remaining life assessment program for the creep crack growth. The probabilistic life assessment program is developed to increase the reliability of life assessment. The probabilistic life assessment involves some uncertainties, such as, initial crack size, material properties, and loading condition, and a triangle distribution function is used for random variable generation. The resulting information provides the engineer with an assessment of the probability of structural failure as a function of operating time given the uncertainties in the input data. This study forms basis of the probabilistic life assessment technique and will be extended to other damage mechanisms.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1996.11a
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• pp.702-706
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• 1996

The King Sejong's Striking water-clock was named for its distictive day and night time announcing system. Its time announcing system generates acoustic and visual signals for the twelve double hour, and combinations of two different acoustic signals for the five night watches, The mechanism of this signal generation system is triggered by a copper ball which is mechanically digitized time keeping signal, and is generated from the water clock. The time announcing system consisted four parts: 1) the mechanical amplifier which changes small copper to heavy steel ball, 2) day time announcing system, 3) night time announcing system, 4) sounding mechanism. The time announcing system of King Seong's Striking Clepsidra is remotely related to the Arabic clock system, however, it does have world-widely distictive mechanisms of its era, such as mechanical amplifier, self-weight rachet mechanism, and resetable mechanical computer etc.

• Journal of Convergence Society for SMB
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• v.4 no.4
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• pp.19-23
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• 2014

Group communication is becoming increasingly popular in Internet applications such as videoconferences, online chatting programs, games, and gambling. For secure communications, the integrity of messages, member authentication, and confidentiality must be provided among group members. To maintain message integrity, all group members use the Group Key (GK) for encrypting and decrypting messages while providing enough security to protect against passive attacks. Tree-based Group Diffie-Hellman (TGDH) is an efficient group key agreement protocol to generate the GK. TGDH assumes all members have an equal computing power. One of the characteristics of distributed computing and grid environments is heterogeneity; the member can be at a workstation, a laptop or even a mobile computer. Member reordering in the TDGH protocol could potentially lead to an improved protocol; such reordering should capture the heterogeneity of the network as well as latency. This research investigates dynamic reordering mechanisms to consider not only the overhead involved but also the scalability of the proposed protocol.

• Korean Journal of Audiology
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• v.24 no.3
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• pp.113-118
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• 2020

Tinnitus is a prevalent disorder that has no cure currently. Within the last two decades, neuroscientific research has facilitated a better understanding of the pathophysiological mechanisms that underlie the generation and maintenance of tinnitus, and the brain and nerves have been identified as potential targets for its treatment using non-invasive brain stimulation methods. This article reviews studies on tinnitus patients using transcranial magnetic stimulation, transcranial electrical stimulation, such as transcranial direct current stimulation, alternating current stimulation, transcranial random noise stimulation as well as transcutaneous vagus nerve stimulation and bimodal combined auditory and somatosensory stimulation. Although none of these approaches has demonstrated effects that would justify its use in routine treatment, the studies have provided important insights into tinnitus pathophysiology. Moreover bimodal stimulation, which has only been developed recently, has shown promising results in pilot trials and is a candidate for further development into a valuable treatment procedure.

• Journal of Audiology & Otology
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• v.24 no.3
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• pp.113-118
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• 2020

Tinnitus is a prevalent disorder that has no cure currently. Within the last two decades, neuroscientific research has facilitated a better understanding of the pathophysiological mechanisms that underlie the generation and maintenance of tinnitus, and the brain and nerves have been identified as potential targets for its treatment using non-invasive brain stimulation methods. This article reviews studies on tinnitus patients using transcranial magnetic stimulation, transcranial electrical stimulation, such as transcranial direct current stimulation, alternating current stimulation, transcranial random noise stimulation as well as transcutaneous vagus nerve stimulation and bimodal combined auditory and somatosensory stimulation. Although none of these approaches has demonstrated effects that would justify its use in routine treatment, the studies have provided important insights into tinnitus pathophysiology. Moreover bimodal stimulation, which has only been developed recently, has shown promising results in pilot trials and is a candidate for further development into a valuable treatment procedure.