• Journal of Industrial and Engineering Chemistry
• /
• v.67
• /
• pp.316-325
• /
• 2018

Aluminum based metal-organic framework using a di-carboxylate linker succinic acid (Al-SA MOF), are synthesized in water with minimal generation of secondary pollutants. The physicochemical properties of Al-SA MOF were examined, followed by its utility for the adsorption of Acid Black 1 (AB1) in aqueous media. Influences of key parameters such as pH, contact time, initial AB1 concentration,temperature, and selectivity on the adsorption process were assessed. A series of adsorption mechanisms are proposed, which involve electrostatic, hydrogen bonding, and hydrophobic interactions. These findings suggest that Al-SA MOF is a potent candidate in removing complex azo dyes molecules from aqueous media.

• Biomolecules & Therapeutics
• /
• v.32 no.1
• /
• pp.25-37
• /
• 2024

Atopic dermatitis (AD) is an allergic disorder characterized by skin inflammation. It is well known that the activation of various inflammatory cells and the generation of inflammatory molecules are closely linked to the development of AD. There is accumulating evidence demonstrating the beneficial effects of herbal extracts (HEs) on the regulation of inflammatory response in both in vitro and in vivo studies of AD. This review summarizes the anti-atopic effects of HEs and its associated underlying mechanisms, with a brief introduction of in vitro and in vivo experiment models of AD based on previous and recent studies. Thus, this review confirms the utility of HEs for AD therapy.

• Earthquakes and Structures
• /
• v.6 no.1
• /
• pp.111-125
• /
• 2014

Multiple level performance of seismically isolated elevated storage tank isolated with multi-phase friction pendulum bearing is investigated under totally 60 records developed for multiple level seismic hazard analysis (SLE, DBE and MCE). Mathematical formulations involving complex time history analysis have been proposed for analysis of typical storage tank by multi-phase friction pendulum bearing. Multi-phase friction pendulum bearing represent a new generation of adaptive friction isolation system to control super-structure demand in different hazard levels. This isolator incorporates four concave surfaces and three independent pendulum mechanisms. Pendulum stages can be set to address specific response criteria for moderate, severe and very severe events. The advantages of a Triple Pendulum Bearing for seismic isolation of elevated storage tanks are explored. To study seismic performance of isolated elevated storage tank with multi-phase friction pendulum, analytical simulations were performed with different friction coefficients, pendulum radii and slider displacement capacities.

• Journal of Pharmacopuncture
• /
• v.20 no.4
• /
• pp.243-256
• /
• 2017

Doxorubicin as a chemotherapeutic drug is widely used for the treatment of patients with cancer. However, clinical use of this drug is hampered by its cardiotoxicity, which is manifested as electrocardiographic abnormalities, arrhythmias, irreversible degenerative cardiomyopathy and congestive heart failure. The precise mechanisms underlying the cardiotoxicity of doxorubicin are not clear, but impairment of calcium homeostasis, generation of iron complexes, production of oxygen radicals, mitochondrial dysfunction and cell membrane damage have been suggested as potential etiologic factors. Compounds that can neutralize the toxic effect of doxorubicin on cardiac cells without reducing the drug's antitumor activity are needed. In recent years, numerous studies have shown that herbal medicines and bioactive phytochemicals can serve as effective add-on therapies to reduce the cardiotoxic effects of doxorubicin. This review describes different phytochemicals and herbal products that have been shown to counterbalance doxorubicin-induced cardiotoxicity.

• Journal of Microbiology and Biotechnology
• /
• v.33 no.5
• /
• pp.680-686
• /
• 2023

Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using Drosophila as an in vivo model system, we identified Crataegus pinnatifida extract (CPE) as a novel anti-aging substance. Regardless of sex, Drosophila treated with CPE showed a significantly increased lifespan compared to those without CPE. In this study, we also evaluated the involvement of CPE in aging-related biochemical pathways, including TOR, stem cell generation, and antioxidative effects, and found that the representative genes of each pathway were induced by CPE administration. CPE administration did not result in significant differences in fecundity, locomotion, feeding amount, or TAG level. These conclusions suggest that CPE is a good candidate as an anti-aging food substance capable of promoting a healthy lifespan.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2002.10b
• /
• pp.383-384
• /
• 2002

Frictional sound is observed in great many practical systems, but its generation mechanism is still unknown Model systems are best suited for research on the fundamental mechanisms, but results cannot be easily applied to real systems, because each system has different sound radiation properties. At present, there is no easy method for evaluation of these properties. We propose to describe the sound radiation property of a tribo-system by the relationship between friction-induced sound power and the friction-induced vibration velocity of the contact element. It was found that the sound power of a tribo-system is linearly proportional to the mean-square velocity of the sliding element by a constant coefficient having the dimension of mass flow rate (kg/s).

• Structural Engineering and Mechanics
• /
• v.32 no.5
• /
• pp.685-699
• /
• 2009

Current research and development of high performance concrete, together with study of phenomena that are pertinent to impact resistance, have lead to a new generation of barriers with improved properties to resist impact loads. The paper reviews major properties and mechanisms that affect impact resistance of concrete barriers as per criteria that characterize the resistance. These criteria are the perforation limit, penetration depth and the amount of front and rear face damage. From the long-known, single strength parameter that used to represent the barriers' impact resistance, more of the concrete mix ingredients are now considered to be effective in determining it. It is shown that the size and hardness of the aggregates, use of steel fibers and micro-silica have different effects on performance under impact and on the resistance. Additional pertinent phenomena, such as the rate and size effects, confinement and local versus global response, are pointed out with their reference to possible future developments in the design of impact resisting concrete barriers.

• BMB Reports
• /
• v.39 no.2
• /
• pp.113-131
• /
• 2006

Sphingolipids have emerged as molecules whose metabolism is regulated leading to generation of bioactive products including ceramide, sphingosine, and sphingosine-1-phosphate. The balance between cellular levels of these bioactive products is increasingly recognized to be critical to cell regulation; whereby, ceramide and sphingosine cause apoptosis and growth arrest phenotypes, and sphingosine-1-phosphate mediates proliferative and angiogenic responses. Sphingosine kinase is a key enzyme in modulating the levels of these lipids and is emerging as an important and regulated enzyme. This review is geared at mechanisms of regulation of sphingosine kinase and the coming to light of its role in disease.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 1992.11a
• /
• pp.11-13
• /
• 1992

The dielectric reliability of the Thin $SiO_2$ films of wet oxidation on n-type Si substrates has been studied by using self-healing method of breakdown and according to injection time high frequence C-V tests. These experiments have been performed to investigate the dielectric breakdown mechanism of a thin film in which positive charge generation during high-field Fowler-Nordheim tunneling are considered. In addition, The weak spots and robust areas are distinguished so that the localized dielectric breakdown could be described.

• Journal of Mechanical Science and Technology
• /
• v.15 no.9
• /
• pp.1274-1280
• /
• 2001

The fretting wear behavior of the contact between Zircaloy-4 tube and Inconel 600, which are used as the fuel rod cladding and grid, respectively, in PWR nuclear power plants was investigated in air. In the study, number of cycles, slip amplitude and normal load were selected as the main factors of fretting wear. The results indicated that wear increased with load, slip amplitude and number of cycles but was affected mainly by the slip amplitude. SEM micrographs revealed the characteristics of fretting wear features on the surface of the specimens such as stick, partial slip and gross slip which depended on the slip amplitude. It was found that fretting wear was caused by the crack generation along the stick-slip boundaries due to the accumulation of plastic flow at small slip amplitudes and by abrasive wear in the entire contact area at high slip amplitudes.