• Journal of Ocean Engineering and Technology
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• v.21 no.1 s.74
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• pp.7-17
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• 2007

Based on the Boussinesq wave model, the wave distribution in the Chagui-Do sea area in Jeju was simulated by applying the directional irregular waves at an incident boundary. The time and spatial variations of monthly mean wave height and period were investigated, which aims to provide basic information on optimal sites for wave power generation. The grid size and time interval of the Boussinesq wave model were validated by examining wave distributions around a surface piercing wall, fixed at sea bottom with a constant slope. Except for the summer season, the significant wave height is dominated by wind waves and appears to be relatively high at the north sea of Chagui-Do, which is open to the ocean, while it is remarkably reduced at the rear sea of Chagui-Do because of its blocking effect on incident waves. In the summer, the significant wave height is higher at the south sea, and it is dominated by the swell waves, which is contributed by the strong south-west wind. The magnitude of significant wave height is the largest in the winter and the lowest in the spring. Annual average of the significant wave height is distinctively high at the west sea close to the Chagui-Do coast, due to a steep variation of water depth and corresponding wave focusing effect. The seasonal and spatial distribution of the wave period around Chagui-Do sea reveals very similar characteristics to the significant wave height. It is suggested that the west sea close to the Chagui-Do coast is the mast promising site for wave power generation.

• Journal of Genetic Medicine
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• v.20 no.1
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• pp.6-14
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• 2023

Fabry disease (FD), a rare X-linked lysosomal storage disorder, is caused by mutations in the α-galactosidase A gene gene encoding α-galactosidase A (α-Gal A). The functional deficiency of α-Gal A results in progressive accumulation of neutral glycosphingolipids, causing multi-organ damages including cardiac, renal, cerebrovascular systems. The current treatment is comprised of enzyme replacement therapy (ERT), oral pharmacological chaperone therapy and adjunctive supportive therapy. ERT has been introduced 20 years ago, changing the outcome of FD patients with proven effectiveness. However, FD patients have many unmet needs. ERT needs a life-long intravenous therapy, inefficient bio-distribution, and generation of anti-drug antibodies. Migalastat, a pharmacological chaperone, augmenting α-Gal A enzyme activity only in patients with mutations amenable to the therapy, is now available for clinical practice. Furthermore, these therapies should be initiated before the organ damage becomes irreversible. Development of novel drugs aim at improving the clinical effectiveness and convenience of therapy. Clinical trial of next generation ERT is underway. Polyethylene glycolylated enzyme has a longer half-life and potentially reduced antigenicity, compared with standard preparations with longer dosing interval. Moss-derived enzyme has a higher affinity for mannose receptors, and seems to have more efficient access to podocytes of kidney which is relatively resistant to reach by conventional ERT. Substrate reduction therapy is currently under clinical trial. Gene therapy has now been started in several clinical trials using in vivo and ex vivo technologies. Early results are emerging. Other strategic approaches at preclinical research level are stem cell-based therapy with genome editing and systemic mRNA therapy.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1249-1253
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• 2007

Experimental studies on the fabrication of sub-30 nm nanofibers using weakly two-photon induced photopolymerized region have been carried out. For the generation of nanofibers inside or outside microstructures, an over-polymerizing method involving a long exposure technique (LET) was proposed. Such nanofibers can find meaningful applications as bio-filters, mixers, and many other uses in diverse research field. A multitude of nanofibers with a notably high resolution (about 22 nm) in two-photon polymerization was achieved using the LET. Furthermore, it was demonstrated that the LET can be employed for the direct fabrication of various embossing patterns by controlling the exposure duration and the interval between voxels. Thin interconnecting networks are formed regularly in the boundary of the over-polymerized region, which allows for the creation of various pattern shapes. Overall of this work, some patterns including nanofibers are fabricated by the LET.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.5
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• pp.870-876
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• 2017

In this paper, we proposed the automatic vision inspection system using multi-layer perceptron to detect the defects occurred on rail surface. The proposed system consists of image acquisition part and analysis part. Rail surface image is acquired as equal interval using line scan camera and lighting. Mean filter and dynamic threshold is used to reduce noise and segment defect area. Various features to characterize the defects are extracted. And they are used to train and distinguish defects by MLP-classifier. The system is installed on HEMU-430X and applied to analyze the rail surface images acquired from Honam-line at high speed up to 300 km/h. Recognition rate is calculated through comparison with manual inspection results.

• Proceedings of the Korea Multimedia Society Conference
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• 2001.11a
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• pp.402-407
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• 2001

대용량의 데이터베이스로부터 연관규칙을 발견하고자 하는 연구가 활발하며, 수량 데이터의 항복에도 적용할 수 있도록 이들 방법을 확장하는 연구가 최근에 소개되고 있다. 본 논문에서는 수량 데이터 항목을 이진 항목으로 변환하기 위하여 빈발구간 항목집합을 생성할 때, 수량 데이터 항목의 정의 영역 내에서 특정 영역에 집중하여 발생하는 특성인 지역성을 이용하는 방법을 제안한다. 이 방법은 기존의 방법보다 많은 수의 세밀한 빈발구간 항목들을 생성할 수 있을 뿐만 아니라 세밀의 정도를 판단하여 활용할 수 있는 생성순서 정보도 포함하고 있어, 원 데이터가 가지고 있는 특성의 손실을 최소화한 수 있는 특징이 있다. 성능평가를 통하여 기존의 방법보다 우수함을 보였다.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2007.05a
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• pp.328-333
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• 2007

Traditional maintenance planning is based on a constant maintenance interval for equipment life. In order to consider economic aspect for tm based preventive maintenance, preventive maintenance is desirable to be scheduled by RCM(Reliability-Centered Maintenance) evaluation. The main objective of RCM is to reduce the maintenance cost, by focusing on the most important functions of the system and avoiding or removing maintenance actions that are not strictly necessary. So, Markov state model is utilized considering stochastic state in RCM In this paper, a Markov state model much can be used for scheduling and optimization of maintenance is presented. The deterioration process of system condition is modeled by the stepwise Markov model in detail. Also, because the system is not continuously monitored, the inspection is considered. In case study, simulation results about RCM will be shown using the real historical data of combustion turbine generating unit in Korean power systems.

• Proceedings of the KIEE Conference
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• 1988.11a
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• pp.92-94
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• 1988

One of the recurring problems facing energy control center dispatchers each day is how to operate the system during the periods of high load pick up and fluctuation. This method reduces the problem to a forward - revised by backward - sequence of dispatch problem, with the generator Limits being carefully adjusted between each time interval in the total intervals to be optimized. It is applied to system of 31 units. It is observed that the method presented here achieves that generation fellows the load changes without any mismatch.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.11a
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• pp.229-232
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• 2000

This research aims at developing a low-cost PC-NC system based on one-CPU and investigating the feasibility of its application to a simple-function lathe. Its hardware consists a two axes motion control board including a 24bit counter, 8253 timer, a 12bit DA converter, DIO board for PLC operation and a PC with Intel Pentium 466MHz. The fundamental real-time MC functions such as G-code interpretation, interpolation, position and velocity control of axes are performed. User programming interface with functions of icon manipulation, tool-path simulation and NC-code generation was implemented. In order to achieve real-time control and safety, axis control, NC interpretation, interpolation and user communication are completely executed during every interrupt interval of I msec.

• Journal of Communications and Networks
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• v.3 no.4
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• pp.374-382
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• 2001

Nowadays, the commonly used table lookup scheme for IP routing is based on the sc-called classless interdomain routing (CIDR). With CIDR, routers must find out the best matching prefix (BMP) for IP packets forwarding, this complicates the IP lookup. Currently, this process is mainly performed in software and several schemes hale been proposed for hardware implementation. Since the IP lookup performance is a major design issue for the new generation routers, in this article we investigate the properties of the routing table and present a new approach for IP lookups, our approach is not based Gn BMP and significantly reduces the complexity, thus the computation cast of existing schemes can be significantly reduced. We also propose an efficient IP lookup algorithm, with which we improve the binary search on prefixes to 30 millions of packets per second (MPPS) and 5,000 route updates/s under the same experiment setup with an even larger routing table.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.67-70
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• 1996

The values measured at different time and enumerated sequentially by homogenous interval is called time series. Its goal is to predict values in future by analysing the measured values in past. The stastical approach to time series prediction tend to be by a neural approach with difficulties in expressing the reationship among past data. In neural approach, the preblem is the acquisting of the enough training data in advance. The goal of this paper is that such problem is solved by generating another term as virtual term between terms in time series.