• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1781-1787
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• 2015

Background: miRNAs are relatively recently discovered cancer biomarkers which have important implications for cancer early diagnosis, treatment and estimation of prognosis. Here we focussed on expression of mir-196a-5p in gastric cancer tissues and cell lines so as to analyse its significance for clinicopathologic characteristics and generate enriched KEGG pathways clustered by target genes for exploring its potential roles as a biomarker in gastric cancer. Materials and Methods: The expression of mir-196a-5p in poorly, moderate and well differentiated gastric cancer cell lines compared with GES-1 was detected by RT-qPCR, and the expression of mir-196a-5p in gastric cancer tissues comparing with adjacent non cancer tissues of 58 cases were also assessed by RT-qPCR. Subsequently, an analysis of clinical significance of mir-196a-5p in gastric cancer and enriched KEGG pathways was executed based on the miRWalk prediction database combined with bioinformatics tools DAVID 6.7 and Mirfocus 3.0. Results: RT-qPCR showed that mir-196a-5p was up-regulated in 6 poorly and moderate differentiated gastric cancer cell lines SGC-7901, MKN-45, MKN-28, MGC-803, BGC-823, HGC-27 compared with GES-1, but down-regulated in the highly differentiated gastric cancer cell line AGS. Clinical data indicated mir-196a-5p to beup-regulated in gastric cancer tissues (47/58). Overexpression of mir-196a-5p was associated with more extensive degree of lymph node metastasis and clinical stage (P < 0.05; x2 test). Enriched KEGG pathway analyses of predicted and validated targets in miRWalk combined with DAVID 6.7 and Mirfocus 3.0 showed that the targeted genes regulated by mir-196a-5p were involved in malignancy associated biology. Conclusions: Overexpression of mir-196a-5p is associated with lymph node metastasis and clinical stage, and enriched KEGG pathway analyses showed that targeted genes regulated by mir-196a-5p may contribute to tumorgenesis, suggesting roles as an oncogenic miRNA biomarker in gastric cancer.

• The Journal of the Korea Contents Association
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• v.15 no.7
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• pp.43-56
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• 2015

Amidst various efforts which have been made to revive a city, the potential discovery related to the development of public design based on copious cultural heritages is extremely significant. Therefore, in this study, qualitative researches were conducted based on bibliographic data and image materials centered on public design of Theme Park in Daechon-dong, Gwangju Metropolitan City. The case studies verifying the identity of Korean public design through countless numbers of research materials. However, it's necessary to pay attention to a common fact because it's essential to find the national legitimacy and regional identity by tiding over problems in standardized urban development through well-designed development plan for history, living and economy bloc among the regional traditional cultural assets while rejecting the meaning in an excessively broad sense. The spaces assigned with significance are cultural contents embedded with cultural original form of the region and there is room for creative development in order to generate city brand value and to activate the space. This study is significant in that the spatial interpretation of Daechon-dong's Theme Park and the methodology of semiotic spatial planning can not only be applied but also in that this study has demonstrated positive effects on space.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.13 no.6
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• pp.25-33
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• 2014

This study investigates the reliability of DSRC-based traffic information system on the typical urban arterial with the minimum sample size method. VISSIM has been employed to calculate the required sample size. After comparing the number of hi-pass vehicles recorded from DSRC and the required sample size, this study found that the interrupted traffic state tends to generate more outliers than the uninterrupted one, the lack of the number of vehicles completely passing links with multiple driveways makes it difficult to estimate the reliable traffic information, the traffic information during peak hour is relatively more reliable than that during off-peak hour, and the reliability of DSRC-based traffic information system depends on the significance level in calculating the sample size. The driveway density and traffic signal operation due to the individual link length significantly affects the required sample size, resulting in determining the reliability of the DSRC-based traffic information system.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.5
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• pp.1043-1057
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• 2015

In order to recognize intelligent threats quickly and detect and respond to them actively, major public bodies and private institutions operate and administer an Intrusion Detection Systems (IDS), which plays a very important role in finding and detecting attacks. However, most IDS alerts have a problem that they generate false positives. In addition, in order to detect unknown malicious codes and recognize and respond to their threats in advance, APT response solutions or actions based systems are introduced and operated. These execute malicious codes directly using virtual technology and detect abnormal activities in virtual environments or unknown attacks with other methods. However, these, too, have weaknesses such as the avoidance of the virtual environments, the problem of performance about total inspection of traffic and errors in policy. Accordingly, for the effective detection of intrusion, it is very important to enhance security monitoring, consequentially. This study discusses a plan for the reduction of false positives as a plan for the enhancement of security monitoring. As a result of an experiment based on the empirical data of G, rules were drawn in three types and 11 kinds. As a result of a test following these rules, it was verified that the overall detection rate decreased by 30% to 50%, and the performance was improved by over 30%.

• Journal of Distribution Science
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• v.14 no.1
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• pp.85-91
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• 2016

Purpose - Recently, the importance of rapid change in business models is more and more increasing as the change of information technology environment. Therefore, a variety of business models have emerged. On the other hand, there is no company that can generate revenue. Many enterprises are still maintained while they are changing only their appearance of the business model. Business model is important in e-commerce. However, a lot of researches are targeted only in Web sites. Thus, e-commerce companies do not have the infrastructure for measuring and business models. The purpose of paper is to evaluate factors which are related with the structuring of the e-commerce success. And it proposed a financial items and non-financial items. From the perspectives of administrators and managers, the paper researches the possibility for E-Commerce Evaluation Model as a valuable criteria in measuring business model. Research design, data and methodology - The methods are taken by the classification for the type of business-to-business transactions, transactions subject, and the degree of integration and innovation capabilities. Financial and Non-financial value is used to build E-Commerce Evaluation Model. Evaluation items in Administration's perspective are composed with enhance the effectiveness of the mission, improving efficiency of the administration, and control of costs. Evaluation items in the customer's perspective were measured by customer participation and cooperation with customer Satisfaction. In the case of researching the information system's perspective, three criteria are used such as adequacy of the development process, improvement of the quality of service, and maintenance of standardized information technology. In researching for the ICT competence's perspective, evaluation items were composed of enhanced user capabilities, utilizing new technologies, and empowerment of information workers. Results - In this paper, E-Commerce Evaluation Model with financial and non-financial perspectives shows the possibility to be criteria in the case of measuring business model. Moreover, it gives the positive expectation to be successful criteria. But the research may have ambiguity in its essential concept because it cannot avoid the limitation in selecting evaluation tools from merely the model. It is impossible to exclude the possibility in omitting specific properties which may take place in actual case study. Therefore, In hereafter research, it is necessary to include actual case study research in selecting evaluation tools in order to improve the limit point. Actual measurement items which are derived from actual case study should be subdivided, and it would be more effective to complete the research. Conclusions - In rapid change in business models, there are various kinds of business models. But it is general situation that companies which adopted business models have not brought in revenue. For this reason, E-Commerce Evaluation Model is needed as an important factor for the structuring of the e-commerce success. Although it has the limitation in selecting evaluation tools from model, E-Commerce Evaluation Model proposes the implication for measuring business models as a valuable criteria.

• Journal of the Korea Computer Graphics Society
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• v.17 no.1
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• pp.9-16
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• 2011

In this paper, we describe the development of a system for generating a 3-dimensional human face and predicting it's appearance as it ages over subsequent years using 3D scanned facial data and photo images. It is composed of 3-dimensional texture mapping functions, a facial definition parameter input tool, and 3-dimensional facial prediction algorithms. With the texture mapping functions, we can generate a new model of a given face at a specified age using a scanned facial model and photo images. The texture mapping is done using three photo images - a front and two side images of a face. The facial definition parameter input tool is a user interface necessary for texture mapping and used for matching facial feature points between photo images and a 3D scanned facial model in order to obtain material values in high resolution. We have calculated material values for future facial models and predicted future facial models in high resolution with a statistical analysis using 100 scanned facial models.

• Journal of the Korean GEO-environmental Society
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• v.8 no.3
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• pp.27-33
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• 2007

The vertical drain method recently being used in Korea is one of the popular soft ground improvement methods, and it is divided into the sand drain method, the pack drain method, the paper drain method, and the PBD method according to the drainage. However, these methods generate the disturbed zone called the smear zone when the drainage is penetrated into the in-situ ground. The characteristics of the smear zone generated cause the problems that the coefficient of permeability decreases, and then the consolidation time in the design becomes longer than expected. Even though the coefficient of horizontal consolidation and the coefficient of permeability in the smear zone are very important design factors directly influencing the degree of consolidation, in the existing studies, these coefficients have been empirically derived by the coefficient of vertical consolidation and used for the design. However, in case that these coefficients derived by the coefficient of vertical consolidation are applied to the actual design, a loss of the duration of construction and a loss of economical efficiency can be happened because of the inaccuracy of the coefficient of horizontal consolidation and the coefficient of permeability. Hence, in this study, in order to understand such influence, the laboratory test was carried out so as to reasonably determine the coefficient of permeability and the coefficient of consolidation in diverse ground conditions. Then, the range of smear effect on clay and silt was estimated with monitoring data through the laboratory test.

• Journal of the Korean Geographical Society
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• v.43 no.2
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• pp.235-252
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• 2008

Many cartographers have for many years searched for a way to construct cartograms in which the sizes of geographic areas such as states, counties or census tracts are reseated in proportion to their population or some other socio-economic properties. While many techniques and algorithms for creating cartograms have been proposed, some of them are still extremely complex to generate in a proper manner, and many of them suffer either from this lack of readability or from seamless integration with GIS software. This paper, therefore, presents a simple population cartogam technique based on the Circular Cartogram Algorithm(CCA) by Dorling(1996) to tackle these drawbacks by drawing the areas as simple circles for use as a base map and linking the construction with GIS mapping processes. For an automated approach in the cartogram generation, this paper proposes a close coupling method of ArcView GIS 3.3. package in order for users to access to the cartopam algorithm. Then, they will be available through an interface that the ArcView GIS system allows user-written routines to be accessed easily. The CCA and its coupling architecture ensure to improve the potential applicability of the use of cartograms to census mapping at practical levels. As the cartogram examples, cartograms of population and property types in 2005 Korea census data sets are illustrated in the end, by which viewers can easily identify the residential concentration and their relative ratio in Seoul metropolitan area.

• Journal of Korean Society of Forest Science
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• v.102 no.4
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• pp.601-607
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• 2013

The purpose of this study was to identify the effects of ozone pollution on the one woody species and two indoor plants in controlled environment. Pinus densiflora, Spathiphyllum patinii and Epipremnum aureum seedlings were exposed in both control and ozone chambers to investigate photosynthetic rate, water use efficiency, antioxidative enzyme activities such as GR(Glutathione reductase) and APX(Ascorbate peroxidase) activity and leaf anatomical response. Ozone was fumigated 8 hours for a day with 30 ppb concentration for 50 days. Pinus densiflora seedlings showed no significant difference on photosynthetic rate, water use efficiency, antioxidant enzyme activity during ozone exposure. Ozone concentration (30 ppb in this study) is not high enough to generate ozone damage on Pinus densiflora species. In contrast, ozone generally altered photosynthetic rate, antioxidant enzyme (especially GR) activity and leaf anatomy in two indoor species (Spathiphyllum patinii and Epipremnum aureum) exposed in ozone chamber were significantly differ from those of control in every measurement. These data suggest that two indoor species(Spathiphyllum patinii and Epipremnum aureum) are more sensitive to ozone than Pinus densiflora.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.40 no.5
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• pp.535-546
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• 2020

Land cover maps are derived from satellite and aerial images by the Ministry of Environment for the entire Korea since 1998. Even with their wide application in many sectors, their usage in research community is limited. The main reason for this is the map compilation cycle varies too much over the different regions. The situation requires us a new and quicker methodology for generating land cover maps. This study was conducted to automatically generate land cover map using aerial ortho-images and Landsat 8 satellite images. The input aerial and Landsat 8 image data were trained by Residual U-Net, one of the deep learning-based segmentation techniques. Study was carried out by dividing three groups. First and second group include part of level-II (medium) categories and third uses group level-III (large) classification category defined in land cover map. In the first group, the results using all 7 classes showed 86.6 % of classification accuracy The other two groups, which include level-II class, showed 71 % of classification accuracy. Based on the results of the study, the deep learning-based research for generating automatic level-III classification was presented.