• 경영과정보연구
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• 제35권3호
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• pp.81-93
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• 2016

영국 FSMA 체계에서는 일반적 금지조항이 있음에도 불구하고, 변호사, 회계사 및 보험계리사 등 전문직 종사자들의 금융서비스 제공에 대한 면책조항을 제공하여 전문직종사자들이 적용면제규제대상업무를 수행할 수 있도록 한다. 특히 영국 재무부가 지정하는 전문직협회를 DPBs라고 칭하고 있으며, DPBs(designated professional bodies)는 반드시 규칙(rule)을 보유하여 해당 회원들의 적용면제규제대상업무를 감독하고 규제하는 역할을 수행한다. 또한 FSA는 DPBs의 역할에 대한 정보를 보지(保持)하고 있어야 하며, 다른 부류의 업자 또는 다른 종류의 규제대상업무와 형평성을 고려해서 전문직종사자의 면책조항에 대한 지침을 마련해야 할 의무도 있다. 한편, "자본시장법"에서는 국내 전문직종사자의 금융서비스 제공을 본연의 업무나 부수적 업무에 상관없이 투자자문업에서 명시적으로 적용을 제외시키고 있다. 영국 FSMA 체계에서는 전문직종사자의 금융서비스 제공이 본연의 업무로서 수행되려면 반드시 인가업자와 같이 인가를 받아야 하며, 부수적으로 행하더라도 일반적 금지에서의 적용면제 조항을 준수하도록 하고 있다. 따라서 투자자보호를 위해 입법론적으로 국내 전문직종사자의 금융서비스 제공에 관한 법적 제도를 마련할 필요성이 있다.

• 한국강구조학회 논문집
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• 제20권2호
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• pp.237-246
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• 2008

연속경간을 가지는 I형강 교량은 내부 지점근처에서 상대적으로 큰 부모멘트가 발생하게 되는데, 이에 경제적인 단면 활용을 위하여 내부 지점부위의 상부 및 하부플랜지에 플레이트를 보강한 변단면을 사용하고 있다. 본 연구에서는 기존 탄성 횡-비틀림 좌굴식에 관한 연구를 토대로 하여 비탄성 구간에 있는 계단식 I형보의 횡-비틀림 좌굴강도를 범용구조해석프로그램 ABAQUS(2006)를 이용하여 산정하고, 간편한 설계식을 제안하고 있다. 유한요소해석에는 4절점 쉘요소인 S4R이 사용되었고, 국내외에서 많이 사용되는 I형강 단면(${W36{\times}160}$)을 대상으로 하였다. 양단 및 한쪽 끝단에 계단식 단면을 가지는 보에 대해서 고려하였으며, 플랜지 길이방향 비, 너비방향 비, 두께의 비로 계단식 I형보를 나타내었다. 해석에 사용된 매개변수는 각각 27가지 및 36가지 조합이고, 하중조건으로 보의 순수굽힘이 발생하는 균일모멘트를 적용시켰으며, 비탄성 구간범위 내에 있는 비지지 길이에 대하여 구조해석을 수행하였다. 비탄성 횡-비틀림 거동을 보기 위하여 잔류응력 및 초기결함을 고려한 비선형해석을 실시하였는데, Pi(1995)등이 고려한 잔류응력의 형상과 국내 I형강 표준 치수 허용치에 근거하여 부재 길이의 0.1%를 초기제작오차로 고려하였다. 본 연구 결과는 다양한 형식의 I형보가 사용되는 빌딩 및 교량의 경제적이고 합리적인 설계의 근간을 제공해 줄 것이며, 향후 다양한 하중 조건을 가지는 양단 또는 일단 계단식 단면 변화보의 비탄성 횡-비틀림 좌굴강도를 계산할 수 있는 설계식 개발에 적극 활용 될 수 있을 것이다.

• Tuberculosis and Respiratory Diseases
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• 제65권3호
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• pp.230-234
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• 2008

본 증례에서 환자는 폐렴 치료 중 갑자기 발생한 복통을 주소로 급성 충수염을 진단받고 수술을 시행 받았다. 그 후 조직 검사 결과 소세포암으로 진단되었고 폐병변에 대해 추가적인 검사 결과 소세포폐암이 진단된 경우이다. 저자들은 소세포폐암의 충수 전이를 국내에서 처음으로 경험하여 문헌고찰과 함께 보고하는 바이다.

• 한국과학교육학회지
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• 제40권4호
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• pp.415-427
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• 2020

본 연구는 북한에서 '2013 제1차 전반적 12년제 의무교육강령'이 시행된 이후에 출판된 소학교 1학년과 초급중학교 1학년 과학과 교사용 지도서에 나타난 PCK 요소를 분석함으로써 북한에서 진행되는 과학교육을 이해하는 데 목적이 있다. 분석 결과 두 지도서 모두 '과학 내용에 관한 지식'의 비율이 가장 높았고, '과학 교수전략에 관한 지식', '과학교육과정 관한 지식'이 뒤를 이었다. 반면에 '과학 평가에 관한 지식', '학생에 관한 지식'은 내용이 현저하게 부족하였다. '과학 내용에 관한 지식'에서는 소학교와 초급중학교 모두 '개념 및 이론'의 비중이 가장 높았으며 '실험 및 탐구'의 비중도 다른 PCK 요소에 비해서는 상당히 높았다. 북한의 과학과 지도서는 학생에게 과학 개념 및 이론을 전달하거나 탐구 수업을 진행할 때 '토론'을 활동으로 제시함으로써 구성주의 교수 흐름을 표방하고 있었다. '과학 교수 전략에 관한 지식'은 '주제-특이적 전략' 중 '활동 순서 및 방식'을 안내하는 부분이 주를 이루었으며 '교과-특이적 전략'은 극히 일부분만 제시되었다. 또한 북한의 과학과 지도서는 총론과 각론 모두에서 과학교육의 이론적 배경 요소가 거의 제시되지 않았다. '과학 교육과정에 관한 지식'은 '수업 목표'가 주를 이루었고, '수직 연계'와 '수평 연계'도 일부 제시되었다. '과학 평가에 관한 지식'과 '학생에 관한 지식'은 우리나라의 과학과 지도서와 비교했을 때 차지하는 비중이 작았다.

• 한국터널지하공간학회 논문집
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• 제22권4호
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• pp.451-468
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• 2020

단면이 작게 만들어진 노후화된 터널은 만성적인 교통정체를 유발한다. 이는 터널의 확폭을 통하여 해결할 수 있다. 일반적으로 터널을 확폭할 경우, 기계식 또는 발파식 굴착방법을 통하여 기존터널의 외곽부를 굴착하게 된다. 이러한 굴착은 주변 지반뿐만 아니라 기존터널에도 영향을 미치게 된다. Pre-cutting 공법의 적용은 이러한 문제를 효과적으로 해결할 수 있는 방법이 될 수 있다. 따라서 Pre-cutting을 적용하여 확폭을 수행할 경우, 이에 따른 영향분석은 필수적으로 수행되어야 한다. 본 연구에서는 터널 확폭에서 Pre-cutting을 적용할 경우, 이에 따른 영향을 분석하기 위하여 6가지의 지반등급에서 수치해석을 수행하였다. 해석에서는 확대차로와 Pre-cutting의 굴착길이를 변수로 하여 수행하였으며, 기존터널과 확폭터널의 천단침하에 주목하여 분석하였다. 그 결과, 확폭터널의 천단침하는 확폭이 완료가 되면, Pre-cutting의 굴착 길이와 상관 없이 동일한 값으로 수렴하는 것을 확인하였다. 기존터널의 경우, 굴진면의 전방 5 m 내에서 융기가 발생하였으며, Pre-cutting의 굴착 길이가 짧을수록 융기 발생 예방에 효과적인 것으로 나타났다.

• 대한불안의학회지
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• 제10권2호
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• pp.176-181
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• 2014

Objective : Despite high prevalence and effective treatments of panic disorder, lots of patients are not properly treated due to lack of awareness of the disorder. This study summarizes and presents the results from Public Awareness Survey of Panic Disorder during the Mental Health Exposition held in Seoul in April, 2014. Methods : A total of 401 participants who visited the booth of the Korean Academy of Anxiety Disorder agreed and completed the survey. The questionnaires comprised of three sections; first, after given a case of patient with panic disorder, participants were asked to choose a diagnosis and treatment options. Second, participants were asked to differentiate the symptoms of panic disorder from those of other mental disorders and answer where they acquired the knowledge of the disorder. Third, visual analogue scales were used to get more detailed information for several issues about panic disorder. The incidence and ratio for each question were provided and compared. Results : Among the participants, 78% reported a patient within the case need treatment, and 30% accurately recognized it was panic disorder. As for treatment needed, 40% selected psychotherapy by psychiatrists, 28% chose counseling by psychologist, 23% said that they can overcome it by self-care. Only 2% of participants selected the pharmacotherapy as treatment needed. Approximately 40% of participants have encountered information about the disorder from gossips of celebrities, 32% from mass-media, and merely 6% from medical professionals. About 80% of participants could discriminate the symptom of panic disorder from those of depression, schizophrenia, or generalized anxiety disorder. Conclusion : Our results suggest that substantial proportions of participants have the awareness of panic disorder, while as for treatment they were strongly biased against pharmacologic treatments. Most of their source of the awareness was not relied upon professional information. Efforts for giving correct information and increasing public awareness of panic disorder are needed to bridge a gap between professionals and general public.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8969-8974
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• 2014

Background: The aim of this study was to determine the predictors of health promoting lifestyle behaviour among medical students attending seven of the medical schools in Turkey. Materials and Methods: This crosssectional descriptive study was performed during the second semester of the first and last (sixth) years of study from March to May 2011. A questionnaire with two sections was specifically designed. The first section contained questions on demographic characteristics; the second consisted of the Health Promoting Lifestyle Profile II (HPLP) Scale. From a total of 2,309 medical students, 2,118 (response rate 91.7%) completed the questionnaire. Data were analyzed using descriptive statistics, t, Anova, Tukey test and binary logistic regression analysis. The research was approved by the Ethics Committee of Erciyes University. Results: The mean age was $20.7{\pm}2.9$ years and it was found that 55.1% were men, 62.3% were in the first year. The overall prevalence of smoking was 19.1%, and for drinking alcohol was 19.4%. HPLP point averages of the first year students were $129.2{\pm}17.7$, and for last year $125.5{\pm}19.0$. The overall mean score for the HPLP II was $2.5{\pm}0.4$. They scored highest on the spiritual growth subscale ($2.9{\pm}0.5$), interpersonal relations ($2.8{\pm}0.5$), health responsibility subscale ($2.3{\pm}0.5$), nutrition subscale ($2.3{\pm}0.5$), stress management subscale ($2.3{\pm}0.4$), and the lowest subscale physical activity ($2.0{\pm}0.5$). It is established that student's grade, educational level of parents, economic status of family, marital status, smoking and general health perception of the students resulted in a significant difference in HPLP Scale total score average and the mean score of majority of subscales. There was no statistically significant difference between the total HPLP when evaluated for gender, chronic disease, alcohol drinking status and BMI. Conclusions: Based on these results, particularly in the curriculum of medical students in order to increase positive health behaviours including physical activity, health promotion issues, and giving more space to aim at behaviour change in these matters is recommended.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1809-1817
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• 2012

Background: Gastric cancer is frequently lethal despite aggressive multimodal therapies, and new treatment approaches are therefore needed. Retinoids are potential candidate drugs: they prevent cell differentiation, proliferation and malignant transformation in gastric cancer cell lines. They interact with nuclear retinoid receptors (the retinoic acid receptors [RARs] and retinoid X receptors [RXRs]), which function as transcription factors, each with three subclasses, ${\alpha}$, ${\beta}$ and ${\gamma}$. At present, little is known about retinoid expression and influence on prognosis in gastric cancers. Patients and Methods: We retrospectively analyzed the expression of the subtypes RARa, $RAR{\beta}$, $RAR{\gamma}$, RXRa, $RXR{\beta}$, $RXR{\gamma}$ by immunohistochemistry in 147 gastric cancers and 51 normal gastric epithelium tissues for whom clinical follow-up data were available and correlated the results with clinical characteristics. In addition, we quantified the expression of retinoid receptor mRNA using real-time PCR (RT-PCR) in another 6 gastric adenocarcinoma and 3 normal gastric tissues. From 2008 to 2010, 80 patients with gastric cancers were enrolled onto therapy with all-trans-retinoic acid (ATRA). Results: RARa, $RAR{\beta}$, $RAR{\gamma}$ and $RXR{\gamma}$ positively correlated with each other (p < 0.001) and demonstrated significantly lower levels in the carcinoma tissue sections (p < 0.01), with lower $RAR{\beta}$, $RAR{\gamma}$ and RXRa expression significantly related to advanced stages (p < =0.01). Tumors with poor histopathologic grade had lower levels of RARa and $RAR{\beta}$ in different histological types of gastric carcinoma (p < 0.01). Patients whose tumors exhibited low levels of RARa expression had significantly lower overall survival compared with patients who had higher expression levels of this receptor (p < 0.001, HR=0.42, 95.0% CI 0.24-0.73), and patients undergoing ATRA treatment had significantly longer median survival times (p = 0.007, HR=0.41, 95.0% CI 0.21-0.80). Conclusions: Retinoic acid receptors are frequently expressed in epithelial gastric cancer with a decreased tendency of expression and RARa may be an indicator of a positive prognosis. This study provides a molecular basis for the therapeutic use of retinoids against gastric cancer.

• 대한한의학회지
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• 제23권4호
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• pp.161-168
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• 2002

Objectives: Hwangryunhaedok-tang (Huang-lian-jie-du-tang, HRHDT, 黃連解毒湯) is a traditional Korean herbal medicine that is formulated with Coptidis Rhizoma, Phellodendri Cortex, Scutellariae Radix and Gardeniae Fructus. HRHDT is cold (寒) and bitter (苦) in nature and has general properties of clearing heat and detoxifying (淸熱解毒), strengthening the stomach and settling the liver (健胃平肝), and reducing inflammation, fever and swelling. This formula can prevent and treat artherosclerosis, hyperplasia of the endothelium, cerebral fluid circulation, cerebral vascular deterioration through aging, impairment of neurotransmitters, or disruption of the functioning of the cerebral cortex following infection or trauma. The purpose of the study reported here was to determine the neuroprotective effect of HRHDT on global ischemia induced by 4-vessel occlusion in Wistar rats. Methods: HRHDT extract was lyophilized after extraction with 85% methanol and 100% water. Rats were induced to 10 minutes of forebrain ischemia by 4-vessel occlusion (4-VO) and reperfused again. HRHDT was administered with a dose of 100 mg/kg, and 500 mg/kg of 85% methanol extracts and 100 mg/kg of 100% water extracts, respectively, at 0 min and 90 min after 4-VO. Rats were killed at 7 days after ischemia and the number of CA1 pyramidal neurons was counted in hippocampal sections stained with cresyl violet. Results: Body temperature of animals showed no significant difference between saline-treated groups and HRHDT extracts-treated groups until 5 hours of reperfusion. This result indicated that neuroprotective effects of HRHDT extracts were not due to hypothermic effects. The administration of HRHDT showed a significant neuroprotective effect on hippocampal CA1 neurons at 7 days after ischemia compared to the saline-treated group (P<0.001). HRHDT methanol extracts of 100 mg/kg, 500 mg/kg and HRHDT water extracts of 100 mg/kg showed 88.5%, 98.3% and 95.1 % neuroprotection, respectively. Conclusions: The results of this study demonstrate that administration of HRHDT is highly effective in reducing neuronal damage in response to transient global cerebral ischemia. HRHDT may involve many mechanisms that might account for its high degree of efficacy. A number of factors including free radicals, glutamate, calcium overload, NO, and various cytokines have been proposed to have an important role in causing neuronal death after short periods of global ischemia. Further studies are needed to know the neuroprotective mechanisms of HRHDT.

• 대한약침학회지
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• 제17권1호
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• pp.27-34
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• 2014

Objectives: This experiment was conducted to examine the toxicity of Water soluble Carthmi-Flos herbal acupuncture (WCF) by administering a single intramuscular dose of WCF in 6-week-old, male and female Sprague-Dawley rats and to find the lethality dose for WCF. Methods: The experiment was conducted at Biotoxtech according to Good Laboratory Practices under a request by the Korean Pharmacopuncture Institute. This experiment was performed based on the testing standards of "Toxicity Test Standards for Drugs" by the Ministry of Food and Drug Safety. Subjects were divided into 4 groups: 1 control group in which normal saline was administered and 3 test groups in which 0.1, 0.5 or 1.0 mL of WCF was administered; a single intramuscular dose was injected into 5 males and 5 females in each group. General symptoms and body weights were observed/measured for 14 days after injection. At the end of the observation period, hematological and clinical chemistry tests were performed, followed by necropsy and histopathological examinations of the injected sections. Results: No mortalities were observed in any group. Also, symptoms, body weight, hematology, clinical chemistry and necropsy were not affected. However, histopathological examination of the injected part in one female in the 1.0-mL group showed infiltration of mononuclear cells and a multi-nucleated giant cell around eosinophilic material. Conclusion: Administration of single intramuscular doses of WCF in 3 groups of rats showed that the approximate lethal dose of WCF for all rats was in excess of 1.0 mL, as no mortalities were observed for injections up to and including 1.0 mL.