• Journal of Korean Academy of Nursing Administration
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• v.19 no.2
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• pp.304-314
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• 2013

Purpose: The purpose of this study was to analyze factors affecting burnout among clinical nurses according to Positive Psychological Capital. Methods: The study design was a descriptive survey and questionnaires were collected from 412 clinical nurses who worked in a general hospital in "J" city. Data were analyzed using frequency, percentage, mean, standard deviation, independent t-test, One-way ANOVA, Scheff$\acute{e}$ test, Pearson Correlation, and hierarchical multiple regression. Results: In Model individual characteristics accounted for 27.8% of the influence on burnout. In model II with the addition of the 4 factors; Self-efficacy, Hope, Resilience, Optimism, individual characteristics accounted for 48.5% of the influence on burnout. Optimism and Resilience of the Positive Psychological Capital sub-variables were statistically useful as factors influencing burnout. Conclusion: The results indicate that it is necessary to develop active human resource management and educational programs to decrease burnout and strengthen the Positive Psychological Capital of the nurses.

• The Korean Journal of Community Living Science
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• v.28 no.4
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• pp.561-579
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• 2017

The rural elderly population has social capital based on regionalism and kinship, which acts as a positive function in terms of their self-efficacy. Self-efficacy refers to the belief in one's own abilities. In general, elderly people with high self-efficacy maintain a healthy life and age successfully. This study examines how the rural elderly population perceive their self-efficacy and social capital and analyzes the role of social capital as a mediating variable. Social capital consists of 4 aspects; trust, norms, network and participation. For this study, data were gathered from 344 rural elderly people aged 60 years and over. The results of this study were as follows. According to the analysis of the structure equation modeling effect, the direct effect of subjective health status on self-efficacy, the indirect effect of the parameters of norms and the total effect were all statistically significant. Second, the direct effect of adult children's support on self-efficacy was significant, and the indirect effects of the parameters of trust, norms and total effect were all statistically significant. This study confirmed that social capital has a mediating effect on the relationship among the subjective health status of the rural elderly, adult children's support and self-efficacy. Furthermore, social capital had a positive impact on the self-efficacy of the rural elderly. Based on these results, a policy for making use of the social capital of the rural elderly should be developed.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.8
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• pp.3781-3789
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• 2012

Background: Pancreatic cancer is one of the most aggressive tumors with a dismal prognosis. The membrane cytoskeletal crosslinker Ezrin participates in several functions including cell proliferation, adhesion, motility and survival. There is increasing evidence that Ezrin is overexpressed in vast majority of malignant tumors and regulates tumor progression. However, its roles in pancreatic cancer remain elusive. Methods: Three pairs of specific Ezrin siRNAs were designed and synthetized and screened to determine the most efficient one for construction of a hairpin RNA plasmid targeting Ezrin. After transfection into the Panc-1 pancreatic cancer cell line, real-time quantitative PCR and Western blotting were performed to examine the expression of mRNA and protein. The MTT method was applied to examine the proliferation and the drug sensibility to Gemcitabine. Flow cytometry was used to assess the cycle and apoptosis, while capacity for invasion was determined with transwell chambers. Furthermore, we detected phosphorylated-Erk1/2 protein and phosphorylated-Akt protein by Western blotting. Results: Real-time quantitative PCR and Western blotting revealed that Ezrin expression was notably down-regulated at both mRNA and protein levels by RNA interference (P< 0.01). Proliferation was inhibited and drug resistance to gemcitabine was improved (P< 0.05). Flow cytometry showed that the proportion of cells in the G1/G0 phase increased (P< 0.01), and in G2/M and S phases decreased (P< 0.05), with no apparent differences in apoptosis (P> 0.05). The capacity for invasion was markedly reduced (P< 0.01). In addition, down-regulating Ezrin expression had no effect on phosphorylated-Akt protein (P>0.05), but could decrease the level of phosphorylated-Erk1/2 protein (P< 0.05). Conclusions: RNA interference of Ezrin could inhibit its expression in the pancreatic cancer cells line Panc-1, leading to a potent suppression of malignant behavior in vitro. Assessment of potential as a target for pancreatic cancer treatment is clearly warranted.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.273-286
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• 2021

Background: Prostate carcinoma is the second most common cancer among men worldwide. Developing new therapeutic approaches and diagnostic biomarkers for prostate cancer (PC) is a significant need. The Chinese herbal medicine Panax quinquefolius saponins (PQS) have been reported to show anti-tumor effects. We hypothesized that PQS exhibits anti-cancer activity in human PC cells and we aimed to search for novel biomarkers allowing early diagnosis of PC. Methods: We used the human PC cell line DU145 and the prostate epithelial cell line PNT2 to perform cell viability assays, flow cytometric analysis of the cell cycle, and FACS-based apoptosis assays. Microarray-based gene expression analysis was used to display specific gene expression patterns and to search for novel biomarkers. Western blot and quantitative real-time PCR were performed to demonstrate the expression levels of multiple cancer-related genes. Results: Our data showed that PQS inhibited the viability of DU145 cells and induced cell cycle arrest at the G1 phase. A significant decrease in DU145 cell invasion and migration were observed after 24 h treatment by PQS. PQS up-regulated the expression levels of p21, p53, TMEM79, ACOXL, ETV5, and SPINT1 while it down-regulated the expression levels of bcl2, STAT3, FANCD2, DRD2, and TMPRSS2. Conclusion: PQS promoted cells apoptosis and inhibited the proliferation of DU145 cells, which suggests that PQS may be effective for treating PC. TMEM79 and ACOXL were expressed significantly higher in PNT2 than in DU145 cells and could be novel biomarker candidates for PC diagnosis.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.2
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• pp.419-426
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• 2022

The digital economy is becoming an increasingly important source of regional competitiveness enhancement. The purpose of this research is to examine the spatial distribution characteristics of China's digital economy from 2016 to 2019. Moran's I analysis was performed to see if China's digital economy has spatial self-correlation. The Getis-Ord General G test was used to determine the clustering type of China's digital economy. In addition, we used OLS and GWR methodologies to figure out what drives China's digital economy level. The findings show that the digital economy is rapidly expanding throughout China; yet, there is a significant regional imbalance in the digital economy level in China, and the agglomeration of the digital economy is increasing over time. Furthermore, the findings reveal that human capital, information staff, telegram income, and Internet access are vital factors in the development of the digital economy. To close the digital economy gap, policymakers must invest in human capital and technology innovation. Simultaneously, the government must speed up the development and implementation of electronic information services.

• Journal of the Korean Geographical Society
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• v.31 no.2
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• pp.295-308
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• 1996

1. Retrospect of Political Geographic Studies since Liberation, 1945 : 1) Period from 1945 to mid 1960s : There was not political geography as a science in Korea at the time of liberation from Japan 1945. At that time were not pure political geographers in Korea. In 1947, Moon-Hwa Pyo, economics professor, published a book titled Outline of Korean Geopolitics. This book was a first one in the field of political geography and available at that time in the logical descriptions. Bok-Hyon Choi was a first political geographer who in 1959 wrote a book titled Political geography for the collegians of Seoul National University. Professor Choi introduced American-style political geography through the book above mentioned. In 1963, Kie-Joo Hyong published an article titled "Korean Unification: Possibility from the Geopolitical Viewpoint" which was a first article published by Korean young scholar who studied geography in this country. 2) Period from late 1960s to late 1980s : Both Yoon Cha and Duck-Soon Im published frequently several articles of political geography or geopolitics respectively in 1968-1969. And they issued geopolitical disputes on Korean geopolitical structure and an application of rimland theory to Korean peninsula in 1969 through a magazine named Joung-Kyong Younku (the political and economic researches). The disputes played an important role of showing political geography (or geopolitics) to political sciences especially international political Science. Active researches still continued in 1970s. In that atmosphere the first Korean book of political geography written by a post-liberation scholar (Duck-Soon Im) titled Principles of Political Geography was published in 1973. This book was influenced much by American political geography after Second World War. In 1980s, the researches continued more actively. Especially administrative districts, capital cities, and sub-capital cities were frequently studied during this period. 3) Period from late 1980s to Present: Recent Studies : 1985 was a year of much production of articles of political geography. The first Ph.D thesis of political geography published in the same year in our country. And since 1985 produced many M.A. articles. Several categories of esearches of political geography was made in the period from late 1980s to present. Capital cities, Korean unification, administrative districts, urban politics, elections, sub-capital cities, and defense walls were important research categories. Reviewing the researches from 1945 to present. I found eight categories of political geography in Korea: capital cities, administrative districts, geopolitical structure of Korean peninsula, division and unification of Korea, sub-capital cities, defense walls, elections, and urban politics. Each category includes several scholars respectiveiy. 2. Study Tasks and Prospects in Korean Political Geography: In relation to Korean circumstances there are three study-tasks. The first task of Korean people is unification of two Koreas. Political geographers of Korea must al survey titled Survey Methods of Human Geography for collegians. This book was first one on survey part in Korea. The book however, is insufficient in comprehensiveness in aspects too. I think that the important tasks of general-synoptic human geography in Korea are \circled1 publication of comprehensive books of human geography in the aspects and methodologies for collegians and \circled2 acceptance of academic world of human geography in Korea of variety in methodologies of human geography for future progress. progress.

• Journal of the Korean Regional Science Association
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• v.14 no.2
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• pp.65-75
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• 1998

Education is widely recognized one of main sources for growth. This paper attempts to incorporate the general recognition into formal regional growth model. The model structure is largely neoclassical. It produces a single good with the two factors, educated labor and non-educated labor, via a constant return production migrating to the region with the higher real wage. The educated labor in a region is accumulated by two sources, migration and physical education capital, while the non-educated labor is by only migration. The paper shows that regional growth equilibrium is characterized as a saddle point. This indicates the presence of the minimum threshold size that must be overcome before a region may grow. It contrasts sharply with results obtained in regional growth models. The paper suggests that regional growth is determined less by the technical characteristics of regional production function characteristics of regional production function but by the stock combination of educated function but by the stock combination of education labor and non-educated labor. Based on this result, the impact of agglomeration economies on regional growth is explored. It is by phase diagram demonstrated that the presence of agglomeration economies do not always lead a region to growth since there still exists the minimum threshold even in the presence of agglomeration economies.

• Korea Trade Review
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• v.43 no.2
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• pp.47-67
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• 2018

The purpose of this study is to determine factors of FDI inflows which positively influence economic development. While MNCs ultimately decide on which country to engage in FDI, it can be affected by the general investment environment of host countries. Thus, it may be closely linked to national macro socio-economic factors. In the fixed-effect panel regression analysis using 30 years of data of 13 developed countries and 15 developing countries, results indicate that labor redemption exerts the greatest influence on global FDI inflows; this implies that FDI decisions are based on locations featuring higher productivity by the reduction of labor costs. According to the level of economic development, the motive of FDI inflows differs. In developed countries, GDP, government expenditure and consumer expenditure exert the greatest influence on FDI inflows; which shows characteristics of market seeking and horizontal investment. However, in developing countries, labor redemption and human capital exert the greatest influence on FDI inflows; which shows characteristics of efficiency seeking and vertical investment.

• Journal of Labour Economics
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• v.35 no.2
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• pp.1-24
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• 2012

This paper analyzes the wage structure of college professors in private institutions in Korea. An analysis of earning functions reveals that the human capital of the professors is of more general type rather than firm-specific one. It is also found that the wage differential among colleges is far greater than that within colleges. Finally, the influence of research output or the fields of study on wage is found to be small. This shows that compensation for professors is set largely independent of individual performance or labor market conditions for professors.

• Structural Engineering and Mechanics
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• v.26 no.6
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• pp.617-634
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• 2007

Algeria is a country with a high seismic activity. During the last decade, many destructive earthquakes occurred, particularly in the northern part, causing enormous losses in human lives, buildings and equipments. In order to reduce this risk in the capital and avoid serious damages to the strategic existing buildings, the government decided to invest into seismic upgrade, strengthening and retrofitting of these buildings. In doing so, seismic vulnerability study of this category of buildings has been considered. Structural analysis is performed on the basis of site investigation (inspection of the building, collecting data, materials, general conditions of the building, etc), and existing drawings (architectural plans, structural design, etc). The aim of these seismic vulnerability studies is to develop guidelines and a methodology for rehabilitation of existing buildings. This paper will provide insight to the vulnerability assessment and strengthening of the telecommunication centre, according to the new code RPA 99/version 2003. Both, static equivalent method and non linear dynamic analysis are performed in this study.