• 대한한의학회지
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• 제31권3호
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• pp.128-132
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• 2010

Objectives: This study aimed to review the general features of drug induced liver injury (DILI) and the important factors in consideration of herbal drugs and DILI. Methods: We reviewed general aspects of DILI such as classification, inducible factors, diagnosis methods, prevention, and the status of herbal drug-associated DILI via literature. Results: Besides the drug itself, genetic and environmental factors affect hepatic toxicity. There is a lack of definitive diagnoses of DILI by drugs, including herbal remedies. The possibility of herbal drug-associated DILI is exaggerated, and majority of herbal drug-derived hepatic injury could be easily prevented if Oriental doctors pay attention to this issue. Conclusion: This study can provide Oriental doctors an overview and be helpful in minimizing the episodes of hepatotoxicity in use of herbal drugs.

• Communications for Statistical Applications and Methods
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• 제6권2호
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• pp.601-610
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• 1999

Crossover design is officially except for special occasions recommended by KFDA and FDA for assessing Bioequivalence between two drugs one for reference and the other for innovator. Such design is regarded as a special case of latin square split-polt or repeated measurement design and its main difference with other designing methods is that each subject in an experiment is exposed two drugs in sequence. Therefore general statistical analysis is not suitable since the model for this experiment includes carryover effect in addition to period and sequence effect. in this paper analysis for crossover model with two drugs and its interpretation are mainly discussed and an example is given for illustration.

• 약학회지
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• 제9권1_2호
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• pp.8-13
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• 1965

The sensitivity on microorganisms of ten sulfa-drugs and their Cu-complexes was observed. Ericsson's disc method and modified tube dilution method were applied. Dimethylformamide was used for solvent of sulfa drugs. In general, original sulfa-drugs showed more sensitive patterns than its Cu-complexes except sulfadimethoxine-Cu complex which showed more sensitive patterns than its original drug with disc method.

• 대한치과마취과학회지
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• 제8권1호
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• pp.35-39
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• 2008

Patients with seizures tend to demonstrate a poor oral condition and gingival hyperplasia due to some antiepileptic drugs. Although most patients attain good control of their seizures with anticonvulsant drugs, seizures can occur during dental treatment for various reasons. Sedation can be recommended for anxiety control, and general anesthesia should be considered for uncooperative patient such as patients with intellectual disability or autism. The purpose of this case report was to describe the dental treatment for a patient with seizure history and intellectual disability under general anesthesia.

• 셀메드
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• 제11권4호
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• pp.20.1-20.23
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• 2021

Background: The pandemic COVID-19 caused by a novel coronavirus SARS-COV-2 has spread like a forest fire. This disease may have serious consequences for pregnant women. Presently, no specific drugs or vaccines exist to battle this disease and researches are underway. Unani medicine has a unique role in prevention and management during epidemics. Here, we reviewed the overview of COVID-19 infection and pregnancy, concept and practices in Unani medicine for flu-like epidemics in general and pregnancy, and safety of Unani drugs for the prevention and treatment of mild symptomatic cases of COVID-19 during pregnancy. Methodology: Unani classical texts and pharmacopoeia were meticulously explored for concepts and practices for flu-like epidemic diseases. Further, we browsed scientific databases such as PubMed, Scopus and others for an overview, epidemics and Unani medicine, effectiveness and safety of Unani drugs in COVID-19 and pregnancy. Results: Unani medicine includes prevention and management of flu-like epidemic include quarantine and isolation, aromatic herbal drugs fumigation and spraying for environmental disinfection, ilaj bid tadbir for health promotion and use of health-protecting drugs and symptom-specific drugs in general and related to pregnancy. Lahsun, asalussus, behidana, banafsha, zanjabeel, unnab, etc are in use since antiquity for the prevention and treatment of asymptomatic and mildly symptomatic pregnant women during infectious and epidemic diseases. Conclusion: Currently, the aforementioned plants are proven for antiviral, antioxidant, immunomodulatory and anti-inflammatory activities, probably useful in the COVID-19 pandemic. Additionally, scientific studies have provided new insight into the mechanism underlying the therapeutic effect of Unani medicines that are safe in pregnancy.

• Journal of Yeungnam Medical Science
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• 제37권3호
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• pp.159-168
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• 2020

The demand for drug-induced sedation for magnetic resonance imaging (MRI) scans have substantially increased in response to increases in MRI utilization and growing interest in anxiety in children. Understanding the pharmacologic options for deep sedation and general anesthesia in an MRI environment is essential to achieve immobility for the successful completion of the procedure and ensure rapid and safe discharge of children undergoing ambulatory MRI. For painless diagnostic MRI, a single sedative/anesthetic agent without analgesia is safer than a combination of multiple sedatives. The traditional drugs, such as chloral hydrate, pentobarbital, midazolam, and ketamine, are still used due to the ease of administration despite low sedation success rate, prolonged recovery, and significant adverse events. Currently, dexmedetomidine, with respiratory drive preservation, and propofol, with high effectiveness and rapid recovery, are preferred for children undergoing ambulatory MRI. General anesthesia using propofol or sevoflurane can also provide predictable rapid time to readiness and scan times in infants or children with comorbidities. The selection of appropriate drugs as well as sufficient monitoring equipment are vital for effective and safe sedation and anesthesia for ambulatory pediatric MRI.

• 대한한의학회지
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• 제28권2호통권70호
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• pp.205-212
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• 2007

Objectives : Combined treatment (CT) of oriental herbal medicine and prescribed drugs is now being increasingly used among cancer patients around the world. However, in Korea, clinical information on the frequency, efficacy and safety of CT among cancer patients has not yet been thoroughly reported. This study aimed to identify the status and adverse effects of CT for the management of cancer patients. Methods : A questionnaire and medical record survey by oriental medical doctors or physicians were performed at two oriental medical hospitals and one general hospital. Of the initial 400 in-patients, 368 participated in this survey, representing a response rate of 92.0%. Results : Among cancer patients in oriental medical hospitals, the proportion of CT was 45.9%. In contrast, the proportion of CT in the general hospital was only 0.6%. The proportion of CT among breast cancer patients (20) and gastric cancer patients (35) were 85.0% and 51.4%, respectively. The proportion of CT among cancer patients was high in younger, female or married patients groups. 10 respondents (11.1%) among 90 cancer patients experienced several adverse effects including nausea, fatigue, etc. Conclusions : This study suggests that many more patients in oriental medical hospitals than general hospitals use combined treatment of oriental herbal medicine and prescribed drugs for management of cancer. Therefore, medical professionals should provide comprehensive and up-to-date clinical information about potential benefits and risks of CT to cancer patients in Korea.

• 한국가정과교육학회지
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• 제10권2호
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• pp.145-161
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• 1998

The purpose of this study was to survey the actual condition of the Middle School Students on a Drug. In this study, 500 middle school students in Seoul response to a questionnaire which is composed to analyse two categories, i.e. general facts, the actual condition of drug use (the frequency of drug use, the degree of perception on drugs, the people using a drug surrounding the degree of purchase on drugs). And the students are classified by satisfactory degree on their home backgrounds, satisfactory degree on their school life, and school record. The data is analysed by means of frequency, percentage, chi-square test and Pearson's correlation using the $SPSS-PC^+$ package program. The results of this study were as follow : The frequency of drug use except a alcohol and the degree of perception on a drug among female students are higher than among male. The female students are more permissive on the drug use and they are also tend to think more easily the purchase of a drug. The frequency of drug use and the degree of perception on drugs are higher in the group of the lower satisfactory degree on their home background. Especially, there are many people using drugs surrounding the students in the lower group. The frequency of drug use and the degree of perception on drugs are higher in the group that has the lower satisfactory degree on school life. The students in the group having low school record have more dangerous thought about the use of drugs than the students of high record. The degree of perception on a drug is higher in a higher group, and the students in a higher group also think more easily the purchase of drugs. The percentage of students using drugs are not high, but the high percentage of students are interested in the drugs and they have permissive attitudes on drugs. Thus, the preventive education for drug abuse must be done rapidly.

• 대한간호학회지
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• 제36권7호
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• pp.1215-1223
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• 2006

Purpose: This study was done to understand elderly women within a community who have used lots of drugs. Method: Data was collected through in-depth interviews with four elderly women from April 2001 to February 2002. Data was analyzed by Giorgi's phenomenological method(2000). Results: The components in common with drug usage of elderly women were as follows: 'Awareness of the limitation of physical strength and uncertainty of life', 'Dread of a crisis situation occurring', 'Attachment and dependency on drugs', 'Expectation of a comfortable life and death', 'Prevention of family burden', and 'Pursuit of psychological comfort'. The general structure of experiences was as follows: causal factors were 'Awareness of uncertainty and limitation', 'dread of a crisis situation occurring' the results factor was 'Attachment and dependency on drugs' and the facilitating factors were 'Expectation of a comfortable life and death', 'Prevention of family burden', and 'Pursuit of psychological comfort'. The causal relation was cyclic. This structure showed a realistic adaptation pattern. Conclusion: This study contributed to provide fundamental data for nursing interventions for health promotion and promoting quality of life in elderly women by increasing understanding of the experiences of drugs use.

• 생물정신의학
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• 제6권1호
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• pp.49-66
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• 1999

Polypharmacotherapy, both psychotropic and nonpsychotropic, is widespread in various situations including psychiatric hospitals and general hospitals. As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. The objective of this review is evaluation for drug-drug interactions often encountered in psychiatric consultation. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In psychiatric consultation, these two subdivisions of drug interactions between psychotropic drugs and other drugs are likely to happen. We gathered informations of the drugs used in physically ill patients who are consulted to psychiatric department in Korea University Hospital. And we reviewed the related literatures about the drug-drug interactions between psychotropic drugs and other drugs.