• Title/Summary/Keyword: Gastropathy

Search Result 26, Processing Time 0.023 seconds

Unusual Ultrasonographic Features of Chronic Hypertrophic Pyloric Gastropathy in Two Dogs

  • Rhim, Haerin;Moon, Sohyeon;Lee, Gahyun;Park, Seungjo;Cho, Kyoung-Oh;Choi, Jihye
    • Journal of Veterinary Clinics
    • /
    • v.35 no.6
    • /
    • pp.302-307
    • /
    • 2018
  • This report describes the unusual ultrasonography features of chronic hypertrophic pyloric gastropathy in two dogs - a 12-year-old neutered male Pekingese (case 1) and an 11-year-old spayed female Shih Tzu (case 2) - with chronic vomiting and weight loss. Chronic hypertrophic pyloric gastropathy can be observed as the focal thickening of the pyloric wall with normal layers on ultrasonography images. However, in case 1, gastric neoplasia could not be ruled out because of the presence of regional lymph node enlargement; in case 2, an intussusception was tentatively diagnosed because of a mass within the pylorus, which appeared to be connected to the descending duodenum on the longitudinal image. In both cases, focally thickened pyloric walls were demonstrated through exploratory laparotomy, and the histopathological diagnosis of chronic hypertrophic pyloric gastropathy was made. Ultrasonography is useful for imaging the gastrointestinal tract, and the typical ultrasonographic features of chronic hypertrophic pyloric gastropathy have been reported. However, the possibility, that chronic hypertrophic pyloric gastropathy can present unusual ultrasonographic findings similar to those of tumors or intussusception, should also be considered.

Hypertrophic pyloric gastropathy with Helicobacter spp. in a dog

  • Jang, Hyunyoung;Lee, Seoung-Woo;Jang, Min;Yun, Sungho;Kwon, Young-Sam;Park, Jin-Kyu;Lee, Kija
    • Korean Journal of Veterinary Research
    • /
    • v.61 no.1
    • /
    • pp.3.1-3.5
    • /
    • 2021
  • A 12-year-old, castrated male, mixed dog presented with a history of gradual abdominal distention for a year and anorexia recently, with abdominal radiographs showing a gastric pylorus distention. A solitary, pedunculated, heterogeneous mass arising from the mucosal layer in the pylorus with intact wall layers was identified during ultrasound and computed tomography. The gastric muscular layer was evenly thick. After surgical excision of the mass, histological examination confirmed hypertrophic pyloric gastropathy with polypoid growth and Helicobacter spp. infiltrating the gastric mucosal epithelium. This is the first reported diagnostic imaging case of hypertrophic pyloric gastropathy with Helicobacter spp. in a dog.

Effects of Daegeum-eumja, Igwi-tang and Sihosogan-san on Gastric Mucosal Lesions Induced by Alcohol, Indomethacin and Burn-stress in Mice. (Alcohol, Indomethacin 및 Burn-stress로 유발된 생쥐의 위점막 손상에 대한 대금음자(對金飮子), 익위탕(益胃湯), 시호소간산(柴胡疎肝散)의 효과)

  • Kong, Kyung-Hwan
    • The Journal of Korean Medicine
    • /
    • v.28 no.2 s.70
    • /
    • pp.166-184
    • /
    • 2007
  • Objectives : This study was conducted to investigate the effects of Daegeum-eumja, Igwi-tang, and Sihosogan-san on gastric mucosal lesions induced by alcohol, indomethacin, and burn-stress in mice. Methods : Experimental mice were divided into six groups. The normal group (NOR) did not receive any treatment to elicit gastropathy. In the control group (GE), gastropathy was elicited by alcohol, indomethacin, and stress. In the misoprostol group (MS), misoprostol was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Daegeum-eumja group (DG), Daegeum-eumja was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Igwi-tang group (IW), Igwi-tang was administered after gastropathy was elicited by alcohol, indomethacin, and stress. In the Sihosogan-san group (SH), Sihosogan-san was administered after gastropathy waselicited by alcohol, indomethacin, and stress. The effects on gastric mucosal lesions were evaluated by the morphological change of gastric mucosa, the anti-oxidant effect, HSP 70, $NF-{\kappa}B$ p65, $I{\kappa}B$, COX-1, PNA, BrdU, and iNOS. Results : Hemorrhage erosion, HSP70, and $NF-{\kappa}B$ in the DG, IW and SH groups decreased more than that of the control. The $I{\kappa}B$, COX-1, PNA, BrdU, and iNOS in the DG, IW, and SH groups increased more than that of the control. DG showed the most effect against gastric mucosal lesions induced by alcohol; IW against gastric mucosal lesions induced by indomethacin; and SH against gastric mucosal lesions induced by burn-stress. Conclusions: Daegeum-eumja, Igwi-tang, and Sihosogan-san extracts have excellent effects on gastric mucosal lesions induced by alcohol, indomethacin, and burn-stress, respectively.

  • PDF

Prolapse Gastropathy Presenting with Hematemesis in a 3-year-old Child - A Case Report (3세 소아에서 토혈을 주소로 내원한 위식도 탈출증 1례)

  • Cho, Jin-Seong;Ryoo, Eell;Lee, Gun;Kim, Jae-Kwang
    • Pediatric Gastroenterology, Hepatology & Nutrition
    • /
    • v.6 no.2
    • /
    • pp.183-186
    • /
    • 2003
  • Prolapse gastropathy is not uncommon in adult, but is not reported yet in previously healthy children. A 3-year-old child came to our emergency room after a 1-day history of emesis episodes with coffee-ground hematemesis. During the endoscopic procedure, and the process of retching and vomiting was observed and a tense knuckle of gastric mucosa was seen to be forcefully and repeated prolapsed into the distal esophageal mucosa, and mucosal hematoma was found in the gastric fundus. Upper gastrointestinal study revealed no abnormality and 24 hour pH monitoring revealed no pathologic gastroesophageal reflux. Retching is thought to cause the forceful prolapse and induce subsequent trauma of gastric mucosa. This case illustrates that the episodes of vigorous retching and resultant gastric mucosa are now considered to be the cause of the hematemesis and epigastric pain in children.

  • PDF

Effect of the Rosa rugosa Extract on the Rat with the Alcohol-salicylate-induced Gastropathy (위액분비 및 실험적 위손상에 대한 해당근 엑기스의 효과)

  • Park, Hee-Juhn;Lim, Sang-Cheol;Kim, Dong-Hoon;Lee, Jeung-Hee;Kang, He-Ok;Choi, Jong-Won
    • Korean Journal of Pharmacognosy
    • /
    • v.36 no.1 s.140
    • /
    • pp.38-43
    • /
    • 2005
  • This study was undertaken to evaluate the gastrotherapeutic effects of the extract of Rosa rugosa. It can be regarded that the antigastric and anti-ulcerative effect of Rosa rugosa is originated from the reduction of total acid output identified by gastric secretion test. To clarify the protective mechanism of the Rosa rugosa extract, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. The acitivity of superoxide dismutase and glutathione peroxide were significantly increased and the total content of glutathione was recovered. We concluded that the protective effect of the extract of Rosa rugosa on gastropathy in rats is its ability increased the activities of the free radical scavenging enzymes.

DA-9601, a Phytomedicine Derived from Artemisia asiatica, Blocks the Increased Susceptibility of Portal Hypertensive Gastropathy to Ethanol Damage

  • Oh, Tae-Young;Ahn, Byoung-Ok;Ryu, Byung-Kweon;Kim, Soon-Hoe;Kim, Won-Bae;Lee, Eun-Bang
    • Proceedings of the Korean Society of Applied Pharmacology
    • /
    • 1998.11a
    • /
    • pp.124-124
    • /
    • 1998
  • Portal hypertensive gastropathy (PHG) is part of a complex syndrome which occurs as a complication of chronic liver disease and portal hypertension. The gastric mucosa in these patients shows typical congestion of ‘mosaic-like’ pattern and vulnerable to various noxious agents such as NSAIDs and ethanol. We previously reported that DA-9601, a quality-controlled extract from Artemisia asiatica, exhibits cytoprotection against various gastritis models. In the present study we investigated the effect of DA-9601 on ethanol-induced gastric damage in PHG rats. Experimental PHG was produced by CBD ligation in SD rats. DA-9601 was orally administered at a dose of 30 mg/kg or 100 mg/kg daily for 2 weeks.

  • PDF

Surgical Correction of Chronic Hypertropic Pyloric Gastropathy in a Dog (개에서의 만성 비후성 유문 위장애에 대한 수술적 치료)

  • Kim Joon-young;Jeong Soon-wuk;Park Sang-heuk;Yoon Hun-young;Han Hyun-jung;Jang Ha-young;Lee Bo-ra;Kim Gu-yuong
    • Journal of Veterinary Clinics
    • /
    • v.21 no.4
    • /
    • pp.398-401
    • /
    • 2004
  • A ten-year-old, female Yorkshire terrier dog with intermittent vomiting, weight loss, polydipsia and depression was referred to the Veterinary Medical Teaching Hospital of Konkuk University. On the radiological survey, gas and fluid-filled gastric distention was detected. No contrast medium entraneed to the small bowel, in 60 minutes after contrast medium administration. And marked fluid accumulation in gastric body and thickening of the pyloric mucosa were found with ultrasonograph. So gastric obstruction by reason of pyloric stenosis was strongly suspected. At the surgery, hypertrophied mucosa was resected adequately, and Heineke-Mikulicz pyloroplasty was applied. Microscopically the symptom was characterized by gastric mucosa hyperplasia and mild diffuse Iymphoplasmocytic gastritis. So this condition was diagnosed as chronic hypertrophic pyloric gastropathy. Intermittent vomiting and mild depression were shown for 9 days after the operation. After that, the patient was recovered gradually. One month later, the patient had normal appetite and activity without complications.

Protective Effect of an Aged Garlic-bamboo Salt Mixture on the Rat with the Alcohol-salicylate Induced Gastropathy (마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향)

  • Huh, Keun;Kim, Young-Hee;Jin, Da-Qing
    • YAKHAK HOEJI
    • /
    • v.45 no.3
    • /
    • pp.258-268
    • /
    • 2001
  • Garlic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean, ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gas-tropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study, we found that the garlic-bamboo salt mixture reduced the severity of hemorrhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) were significnatly increased and the total content of GSH was recovered. From those results, we concluded that the protective effect of the garlic-bamboo salt mixture on gastropathy in rats is its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD, GPx, GR).

  • PDF

Gastric Emptying in Patients with Diabetes: Gastric Emptying Time, Retention Rate and Effect of Cisapride (당뇨병 환자의 위배출능 : 위배출시간, 위저류율 및 Cisapride의 영향)

  • Chung, Byung-Chun;Choi, Chung-Il;Gwak, Dong-Suck;Lee, Jae-Tae;Lee, Kyu-Bo;Kim, Bo-Wan;Chung, Jun-Mo
    • The Korean Journal of Nuclear Medicine
    • /
    • v.26 no.2
    • /
    • pp.299-306
    • /
    • 1992
  • Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symtoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using $^{99m}Tc-tin$ colloid labeled scramble egg in hamburger was performed in 10 healty male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was $75{\pm}13.6$ min and 2 hour gastric retension rate (GRR2) was $32{\pm}11.1%$. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was $58{\pm}23.1%$. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was $54{\pm}24.1%$ in no neuropathy group, $57{\pm}24.3%$ in peripheral neuropathy group and $69{\pm}24.6%$ in autonomic neuropathy group. According to degree of retinopathy, GET1/2 was $110{\pm}23.4$ min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was $45{\pm}21.6%$ in no retinopathy group, $71{\pm}19.7%$ in background retinopathy group and $73{\pm}21.5%$ in proliferative retinopathy group. 3) After cisapride medication for 2 weeks, GET1/2 and GRR2 were improved as $90{\pm}14.6$ min and $40{\pm}13.8%$ (initial GET1/2 and GRR2 were above 2 hours and $61{\pm}15.4%$). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder The degree of retinopathy and disease duration were correlated with severity of gastropathy in diabetics. From the results of gastric emptying scan, we can conclude that cisapride was useful drug for improving diabetic gastropathy and gastric emptying scan was valuable for assessing severity of diabetic gastropathy as non-invasive method.

  • PDF

Pharmacognostical Studies on the 'SanJagYag' (산작약의 생약학적 연구)

  • Bae, Ji-Yeong;Ahn, Mi-Jeong;Park, Jong-Hee
    • Korean Journal of Pharmacognosy
    • /
    • v.41 no.1
    • /
    • pp.6-8
    • /
    • 2010
  • Crude drug 'SanJagYag' has been used mainly as a pleurisy, abdominal pain, female disease and gastropathy. To clarify the botanical origin of SanJagYag from Korea, the anatomical characteristics of Paeonia japonica, Paeonia lactiflora and Paeonia obovata of Paeoniaceae were studied. As a result, it was clarified that SanJagYag was the root of Paeonia obovata.