• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.518-526
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• 2019

Purpose: Limited means exist to assess gastrointestinal activity in pediatric patients postoperatively. Recently, myoelectric gastrointestinal activity recorded by cutaneous patches has been shown in adult patients to be predictive of clinical return of gastrointestinal function postoperatively. The aim of this case series is to demonstrate the feasibility of this system in pediatric patients and to correlate myoelectric signals with return of bowel function clinically. Methods: Pediatric patients undergoing abdominal surgery were recruited to have wireless patches placed on the abdomen within two hours postoperatively. Myoelectric data were transmitted wirelessly to a mobile device with a user-interface and forwarded to a cloud server where processing algorithms identified episodes of motor activity, quantified their parameters and nominally assigned them to specific gastrointestinal organs based on their frequencies. Results: Three patients (ages 5 months, 4 year, 16 year) were recruited for this study. Multiple patches were placed on the older subjects, while the youngest had a single patch due to space limitations. Rhythmic signals of the stomach, small intestine, and colon could be identified in all three subjects. Patients showed gradual increase in myoelectric intestinal and colonic activity leading up to the first recorded bowel movement. Conclusion: Measuring myoelectric intestinal activity continuously using a wireless patch system is feasible in a wide age range of pediatric patients. The increase in activity over time correlated well with the patients' return of bowel function. More studies are planned to determine if this technology can predict return of bowel function or differentiate between physiologic ileus and pathologic conditions.

• 한국동물위생학회지
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• 제45권2호
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• pp.101-110
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• 2022

This study was performed to investigate infectious gastrointestinal diseases in 115 Korean cats (83 indoors and 32 outdoors) with digestive signs such as diarrhea, anorexia or abdominal distention. Detection of infectious pathogens was analyzed using real-time PCR. As a result, 85 of 115 Korean cats were detected with feline corona virus (FCoV), feline parvo virus, Group A rotavirus, Clostridium perfringens (C. perfringens), Campylobacter coli (C. coli), Campylobacter jejuni, enterotoxigenic Escherichia coli, enteropathogenic Escherichia coli, Salmonella spp., Tritrichomonas foetus, Cyclospora cayetanensis, and Giardia lamblia. The most frequently detected pathogen was C. perfringens (52 cats, 61.2%), followed by FCoV (43 cats, 50.6%) and C. coli (16 cats, 18.8%). Also, single infection was the most common (43 cats), followed by double infection in 31 cats, triple infection in 7 cats, and quadruple infection in 4 cats. There was no significant relationship between pathogen detection and age, gender, living environment, weather, and diarrhea. However, there was a significant difference between the age group under 1 year and the age group 1~7 (P value<0.05). In this study, cats with suspected gastrointestinal infection were randomly evaluated, and other factors that could affect pathogen detection were insufficiently considered. For this reason, additional epidemiological investigations with a larger number of cats and sufficient consideration of the causes that may affect the results are needed. Nevertheless, it is thought that this study can also provide valuable information on gastrointestinal pathogens in Korean cats.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제7권2호
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• pp.179-185
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• 2004

목적: 대구 부산 지역에서 신생아 시기에 수술이 시행된 소화기 질환의 최근 현황과 이와 관련된 임상적 소견들을 살펴보고 현재 소아 소화기 질환의 술 후 합병증과 사망률 등의 치료성과에 대해 살펴보았다. 방법: 1996년 1월부터 2003년 7월까지 부산대학교, 경북대학교, 영남대학교 및 대구가톨릭대학교 병원에서 생후 1개월 이내에 소화기 질환으로 수술을 시행받은 202명을 대상으로 하여 임상적 소견을 분석하였다. 결과: 1) 항문 직장 기형이 48명(23.8%), 선천성 중장 폐쇄가 27명(13.4%), 비후성 유문 협착증이 27명(13.4%), 선천성 거대 결장이 22명(10.9%), 십이지장 폐쇄가 15명(7.4%) 등의 빈도순을 보였다. 2) 남녀비는 2.8 : 1로 남아가 우세하였고, 비후성 유문 협착증과 장 회전 이상에서는 남아가 10배 이상 많았다. 3) 동반 기형의 빈도는 선천성 심장 기형, 잠복 고환, 수신증 등의 순서로 많았으며, 제대 기저부 탈장에서는 50%에서 동반 기형이 있었다. 4) 20명(9.9%)의 환아가 산전에 진단되었는데, 선천성 장폐쇄, 십이지장 폐쇄, 복벽 개열증, 제대 기저부 탈장과 같이 장 내 공기 패턴이 특이 소견을 보이는 경우였다. 5) 평균 입원 기간은 22.8일이었고, 신생아 괴사성 장염이 44.7일로 가장 길었다. 6) 술 후 합병증은 주로 창상 감염 또는 문합부 누출 등 사소한 합병증으로 18례(8.9%)에서 발생하였다. 7) 사망률은 횡격막 탈장증(37.5%), 식도 폐쇄(28.6%), 제대 기저부 탈장(20.0%) 순으로 많았으며, 12명이 사망하여 5.9%의 사망률을 보였다. 결론: 대구 부산 지역에서 신생아 시기에 소화기 질환으로 수술을 받았던 환자들의 질병 종류가 다양해졌고, 술 후 합병증과 사망률이 현저히 감소함을 알 수 있었으며, 이것은 관련 분야의 발전에 기인한 것으로 판단된다.

• Journal of Dairy Science and Biotechnology
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• 제14권1호
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• pp.57-69
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• 1996

저자(著者)는 우리나라 국민(國民)들의 유산균 발효유(乳酸菌 醱酵乳)에 관한 보건학적 인식도(保健學的 認識度)를 파악(把握)하고, 유산균 발효유의 음용이 소화기질환으로 장티프스, 파라티프스 및 세균성이질 등의 예방에 미친 효과를 추구를 시도(試圖)하여, 우선 서울시내(市內) 거주(居住) 남녀청년(男女靑年) 987명(名)을 대상(對象)으로 심리측정통계법(心理測定統計法)에 의(依)한 설문지(設問紙)(question-narie)를 작성(作成) 무작위추출법(無作爲抽出法)에 따라 개별면접(個別面接)(face to face interview)에 의(依)하여 실시(實施)하고, 한편으로는 1975년도(年度)부터 1994년도(年度)에 이르는 20년간(年間)에 걸쳐서 국내(國內)에서 발생(發生)되고 있는 제1종(第1種) 법정(法定) 전염병중 소화기계 전염병(傳染病中 消化器系 傳染病)으로서 장티프스, 파라티프스 그리고 세균성이질(細菌性痢疾) 등의 발생율(發生率)과 국내(國內)에서 생산(生産)되는 유산균 발효유(乳酸菌 醱酵乳)의 생산소비량(生産消費量)과의 상관성(相關性)을 파악(把握)하여 식이개선(食餌改善)에 의(依)한 이들 급성소화기질환(急性消化器疾患)의 발생(發生)에 대한 예방효과(豫防效果)의 가능성(可能性)을 고찰(考察)한 바 이제까지 잘 알려지지 않은 결과(結果)를 얻어 그 성적(成績)를 다음과 같이 적요(摘要)한다. 유산균 발효유(乳酸菌 醱酵乳)의 건강보건효과(健康保健效果)에 대한 인식(認識)은 남녀(男女) 공(共)히 소화기관(消化器官)의 보건효과(保健效果)로서, ‘정장효과(整腸效果), 소화증진(消化增進) 그리고 변비예방효과(便秘豫防效果)’가 있는 것으로 인지(認知)하고 있어 이 부분(部分)의 설문항목(設問項目) 3가지의 합(合)이 각 각(各 各) 75.1%와 71.1%로 높은 반응(反應)을 보였으며, 항암효과(抗癌效果)와 미용효과(美容效果)에 대한 인식도(認識度)는 남성(男性)에 비(比)하여 여성측(女性側)의 응답(應答)이 유의(有意)하게 높았다(p<0.05), 1975년도(年度)부터 1994년도(年度)까지 사이에 우리나라에서 생산(生産)된 유산균발효유(乳酸菌醱酵乳)의 년도별(年度別) 소비량(消費量)이 증가(增加)함에 따라 동일기간내(同一期間內) 발생(發生)된 소화기전염병(消化器傳染病) (장(腸)티프스, 파라티프스 및 세균성이질(細菌性痢疾))의 년도별(年度別) 발생율간(發生率間)에는 통계학적(統計學的)으로 매우 유의(有意)한 상관관계(相關關係)가 성립(成立)되고 있었으며, 이를 기초로 서울시민(市民)과 강원도민간(江原道民間)에 이들 소화기전염병(消化器傳染病)의 발생율(發生率)을 상호비교(相互比較)한 바 유산균 발효유(乳酸菌 醱酵乳)의 소비량(消費量)이 많은 서울에서는 유산균(乳酸菌) 소비량(消費量)이 증가함에 따라 소화기질병(消化器疾病)의 발생율(發生率)이 감퇴(減退)되고 있음을 관찰(觀察)할 수 있었는 바, 이것은 유산균 발효유(乳酸菌 醱酵乳)의 음용효과(飮用效果)인 정장(整腸)과 면역증진효과(免疫增進效果)에 따라 소화기질환(消化器疾患)의 예방(豫防)이 가능했던 것으로 확인된다. 그리고 유산균 발효유(乳酸菌 醱酵乳)의 소비량(消費量)과 소화기질병(消化器疾病)의 발생율간(發生率間)에는 r = -0.704 (p<0.01) 과 같은 매우 유의(有意)한 상관계수(相關係數)가 성립(成立)되고 있었다.

• 대한수의학회지
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• 제40권1호
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• pp.173-186
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• 2000

This experiment was carried out to investigate the tendency of incident diseases in pre- and post- weaning piglets which ages were 1 to 7 weeks old by laboratory diagnosis and in order to minimize death in preweaning piglets and of stunted growth in postweaning piglets. The result of this experiment used as the basic data for the preventive programs in pre- and post- weaning piglets and were as follows: 23 different diseases diagnosed in 331 cases were studied in relation to age, season, and etiology. The most prevelent diseases of pre- and post- weaning piglet were Colibacillosis(79 case, 23.9%) and the major diseases were Salmonellosis(44 cases, 13.3%), Anemia(37 cases, 11.2%). Unknown viral disease(20 case, 6.1%), Rota viral infection(19 case, 5.8%), Porcine reproductive & respiratory syndrome(PRRS; 15 case 4.5%), Transmissible gastroenteritis(TGE; 12 case, 3.6%). The gastrointestinal disease, such as Colibacillosis, Salmonellosis, Swine dysentery, Clostridial infection, Rotaviral infection, TGE, Porcine epidemic diarrhea(PED) and Ballantidiosis occured pro- dominently in the period of pre- and post- weaning, which were 178 cases(53.8%) and not related to occurrence according to age and season. The respiratory diseases were Atrophic rhinitis(AR), Swine enzootic pneumonia, Pneumonic pasteurellosis, Pleuropneumonia, Branchopneumonia, PRRS and which were 48 cases(14.5%) and higher prevalent in spring and summer. The viral diseases was 73 cases(22.1%) that occurred in the period of 5 weeks piglet and prevalent mainly in spring. The bacterial diseases were 188 cases(56.8%) that were not related to occurrence according to age and season. Salmonellosis was prevalent in 3 to 5 weeks piglet and mainly occurred in summer. Viral septicemia and rotaviral infection occurred after 5 weeks piglets intensively and 3 to 5 weeks, respectively. And the both occurred without relation with season. PRRS occurred after 4 weeks piglet and prevalent in summer. TGE occurred 1 to 7 days old piglets and prevalent in spring and winter. Hematologic values of anemia was decrease in number of Red Blood Cell, concentration of Hemoglobin and Hematocrit. Amikacin, cephalothin, colistin, norfloxacin were effective to E coli, and amikacin, cephalothin, nortloxacin, neomycin were effective to Salmonellra spp. but clindamycin, erythromycin, penicillin, sulfonamides were resistant to E coli and Salmonella spp.

• 한국임상수의학회지
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• 제17권1호
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• pp.102-108
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• 2000

This study was carried out to investigate the epidemiological prevalence of diseases from birth to weaning in 66 dairy calves which were delivered from three stock farm in Chonbuk area. We examined body weight gain, incidence rate of diseases and population mortality rate in relation to age, season, environmental temperature and rearing management conditions for one year. The results of this experiment were as follows: Birth weight of dairy calves born of primiparae was lower than those of multiparae. But no significant difference in body weight gain was observable between dairy calves born of primiparae and those of multiparae. Body weight gain of diseased calves was lower than normal calves. Of 66 delivered calves, 34 calves(51.5%) were affected with gastronitestinal and/or respiratory diseases. The prevalence of the diseases were gastrointestinal disease(28.7%), respiratory disease(18.2%), and gastronitestinal and respiratory disease(4.6%). The gastronitestinal disease was occurred contrinually regardless of the season. Whereas all of the respiratory disease were occurred in winter and a change of season(December to April). 68.4% of the gastronitestinal disease, and all of the respiratory disease were occurred at atmospheric temperatures below 1$0^{\circ}C$. 89.5% of the gastronitestinal disease were occurred within 3 weeks old, whereas 50% of the respiratory disease were occurred intensively between 3 weeks and 4 weeks old. Of 66 delivered dairy claves, 2 calves were died(3%) with respriratory disease.

• 대한예방한의학회지
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• 제19권2호
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• pp.113-121
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• 2015

Objective : This study was aimed to classify diseases that Traditional Chinese Medicine(TCM) is better at treating. Method : Literature was searched on China National Knowledge Infrastructure(CNKI) and categorized according to literature type, published date and research method. Studied six types of research papers and four types of published books. Results : Experts were surveyed and interviewed, medical records were studied retrospectively, and doubleblind method was used in selecting diseases that TCM was better at treating. There were a total of 372 diseases that TCM was better at treating. By the KCD classification, 45 were in gastrointestinal (12.1%), 39 in urogenital (10.5%), 36 in circulatory (9.7%), 35 in musculoskeletal or connective tissues (9.4%). Conclusion : Total of 372 diseases were classified as diseases that TCM was better at treating, and if the results are used adequately, the values of western and TCM can be maximized and benefit the government, patients and the medical practitioners.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.582-595
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• 2021

Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune system in the host gastrointestinal tract is believed to be the major causative factor. Omics is a powerful methodological tool that can reveal biochemical information stored in clinical samples. Lipidomics is a subset of omics that explores the lipid classes associated with inflammation. One objective of the present systematic review was to facilitate the identification of biochemical targets for use in future lipidomic studies on inflammatory bowel diseases. The use of high-resolution mass spectrometry to observe alterations in global lipidomics might help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases and discover novel biomarkers for them. Assessment of the characteristics of previous clinical trials on inflammatory bowel diseases could help researchers design and establish patient selection and analytical method criteria for future studies on these conditions. In this study, we curated literature exclusively from four databases and extracted lipidomics-related data from literature, considering criteria. This paper suggests that the lipidomics approach toward research in inflammatory bowel diseases can clarify their pathogenesis and identify clinically valuable biomarkers to predict and monitor their progression.

• 동의생리병리학회지
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• 제32권1호
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• pp.1-12
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• 2018

This article is for understanding characteristics of febrile disease through analysing usage of representative prescriptions in "Wenbingtiaobian", composition of their related prescriptions and their coverage of modern diseases. Analysis of prescriptions was based on "Translation of Wenbingtiaobian", "Modern Shanhanlun" and "Herbal Formula Science" and clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI). Conclusions are as follows. First, principles of modifying or formulating prescriptions for febrile diseases are clearing heat, nourishing yin or dispelling dampness. Second, Zengyechengqitang, Xinjiahuanglongtang and Huweichengqitang are applied to pattern of bowel excess such as constipation or ileus. Third, Jiajianfumaitang is applied to heart diseases, Sanjiafumaitang to liver and heart, Dadingfengzhu to liver diseases. Fourth, Jiajianzhengqisan related prescriptions are applied to spleen diseases like conspitation, diarrhea or gastritis. Fifth, Baihujiarenshentang is applied to diabetes or fever and Baihujiaguizhitang to gout or arthritis. Sixth, Xuanbaichengqitang is applied to lung diseases and Taorenchengqitang to gynecology diseases. Seventh, Sanrentang is applied lung diseases like cough or pneumonia, spleen diseases like diarrhea or enteritis and kidney diseases like edema, arthritis or leucorrhea. Eighth, Yinqiaosan and Sangjuyin tend to be applied to exogenous diseases and diseases of five organs of sense, Jiajianfumaitang and Sanjiafumaitang to heart diseases, Angongniuhuangwan to encephalopathy, Qingyingtang and Huabantang to skin diseases, Zengyetang to gastrointestinal disorders, Shashenmaidongtang to lung or spleen diseases.

• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.405-418
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• 2022

Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.