• Journal of Preventive Medicine and Public Health
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• 제27권1호
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• pp.74-83
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• 1994

To investigate the sleeping patterns and gastrointestinal disorders of shift workers, the author studied 434 female workers who worked at textile industry ill Taejon city from September 1,1992 to September 31,1992. Shift pattern were divided into 3 categories ; 3 shift(shifts per 8 hours), 2 shift(day and night shift) and day work. The results obtained were as follows : 1 The average sleeping hours when adjusted for the education level of the total study subjects was 6.1 hours. That of 3 shift workers was 6.1 hours, 2 shift workers was 6.0 hours, but that of day workers was 6.5 hours. There were no significant difference among the shift workers. 2. For the 3 shift workers, the average physiologic adjusted duration in day shift (2.2 days) was shorter than that of night shift(2.7 days) and there were significant difference among the rotating shift works (p<0.001). The sleeping problems in day shift was less than those of night shift (p<0.001). 3. 44.9% of 3 shift workers, 39.3% of 2 shift workers and 33.1% of day workers complained gastrointestinal symptoms when adjusted for the age, education level, job tenure, work post. And the rates of gastrointestinal symptoms complained increase with job tenures (p<0.001). 4. The most frequent gastrointestinal diseases were gastitis and gastric ulcer with 14.2% , Irritable bowel syndrome with 3.1 %, duodenitis and duodenal ulcer with 2.1% and combined gastrointestinal disease with 2.1%. Age, eating habit, amount of coffee per day, job tenure, work post and shift pattern showed no significant difference with the gastrointestinal diseases when adjusted for the age. According to the above results, the author suggested that the shift pattern and job tenure can affect to the sleeping problem and gastrointestinal symptoms.

• 동의신경정신과학회지
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• 제33권1호
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• pp.21-31
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• 2022

Objectives: To perform correlation analysis between the Core Seven Emotions Inventory-Short Form (CSEI-s), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), upper gastrointestinal symptoms, and gastroscopic findings and to compare emotional characteristics with upper gastrointestinal endoscopic findings. Methods: In this study, medical records of 38 participants who visited the hospital for examination purposes or complained upper gastrointestinal symptoms and completed the CSEI-s, BAI, BDI, and Questionnaire for upper gastrointestinal symptoms were analyzed using SPSS (Statistical Package for the Social Sciences) version 25.0. Frequency Analysis, Descriptive Analysis, Independent t-test, Mann-Whitney's U-test, and Correlation analysis were performed. Results: The upper gastrointestinal symptom group showed higher levels of anger, sorrow, depression, and anxiety than the asymptomatic group. On gastroscopy, the normal group had higher levels of Joy than the abnormal group. The reflux esophagitis group showed higher levels of thought, depression, sorrow, and anxiety than the non-reflux esophagitis group. Joy showed a negative correlation with BDI score. However, anger, depression, sorrow, BAI, and BDI score showed positive correlations. Conclusions: Results of this study suggest that CSEI-s can be used to treat patients with upper gastrointestinal symptoms and reflux esophagitis.

• Journal of Korean Biological Nursing Science
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• 제18권4호
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• pp.288-295
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• 2016

Background: This study was conducted in order to survey the current state of cleaning, disinfection, rinsing, drying, and storage of gastrointestinal endoscopes. Methods: Eighty hospitals were selected through convenient sampling. Self-reported questionnaire was distributed from September 14 to October 10 in 2015. Results: The response rate was 67.5% (54/80). In 88.9% of the hospitals, reprocessing was performed in a cleaning space separated from the laboratory and 88.9% used an enzymatic cleaner. Disinfectants used were ortho-phthalaldehyde in 63.0%, and paracetic acid in 33.3%. Eighty seven percent of the hospitals used test strips in order to test the effective concentration of disinfectant and in 61.1%, drying was done through passing air and over 70% alcohol. Microbial culture for the quality control of gastrointestinal endoscopes was performed in 77.8%. In the comparison of the adequacy of gastrointestinal endoscope reprocessing, it was observed that gastrointestinal endoscopes were reprocessed more adequately in larger and tertiary care hospitals. Conclusion: Gastrointestinal endoscopes were reprocessed in similar manners, but there were differences in the detailed process. It is still necessary to segment reprocessing into stages, to prepare standardized guidelines, and to monitor compliance with the guidelines.

• 한방안이비인후피부과학회지
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• 제29권3호
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• pp.208-216
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• 2016

Objectives : The purpose of this study is to report the effectiveness of Soshiho-tang on the patients who suffered from atopic dermatitis with gastrointestinal disorders.Methods : We diagnosed the symptoms and the signs of the patients who suffered from atopic dermatitis with gastrointestinal disorders as Soshiho-tang syndrome(嘔而發熱) according to 'Treatise on Cold Damage Disease(傷寒論)'. Patients are treated only with Soshiho-tang. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Gastrointestinal disorders(mainly food allergy, indigestion) were evaluated by patients' subjective complaint.Results : After the treatment, not only the severity of atopic dermatitis but gastrointestinal disorders were also improved.Conclusions : Soshiho-tang has improved the symptoms of Atopic dermatitis with gastrointestinal disorders in this study.

• 동의신경정신과학회지
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• 제20권2호
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• pp.187-196
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• 2009

Objectives : This study was performed to report the effect of oriental treatments for panic disorder with functional gastrointestinal disturbance. Methods : In this case, a 30 year-old female patient has been suffered by panic disorder with functional gastrointestinal disturbance for 10 years. This case can be caused by KanKiUlKyul(肝氣鬱結), KanKiBeomYi(肝氣犯胃) and KanKiSeungBi(肝氣乘脾). We treated the patient with Herbal medication, Cognitive-behavioral therapy and Relaxation therapy. The effects of treatment were measured by GSRS(Gastrointestinal Symptom Rating Scale), BPI(Brief Pain Inventory) and VAS(Visual Analog Scale) Results : As a result of oriental treatments, the symptoms of Panic Disorder with Functional Gastrointestinal Disturbance was improved. Conclusions : These results suggest that oriental treatments have an effect on Panic Disorder with Functional Gastrointestinal Disturbance.

• 약학회지
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• 제40권1호
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• pp.1-9
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• 1996

The purpose of this investigation was to determine pharmacokinetic parameters of gentamicin using nonlinear least square regression(NLSR) and Bayesian analysis in Korean normal volunteers and gastrointestinal surgical patients. Nonparametric expected maximum(NPEM) method for population pharmacokinetic parameters was used. Gentamicin was administered every 8 hours for 3 days by infusion over 30 minutes. The volume of distribution(V) and elimination rate constant(K) of gentamicin were $0.226{\pm}0.032,\;0.231{\pm}0.063L/Kg\;and\;0.357{\pm}0.024,\;0.337{\pm}0.041hr^{-1}$ for normal volunteers and gastrointestinal surgical patients using NLSR analysis. Population pharmacokinetic parameters, KS and VS were $0.00344{\pm}0.00049(hr{\cdot}ml/min/1.73m^2)^{-1}\;and\;0.214{\pm}0.0502L/Kg$ for gastrointestinal surgical patients using NPEM method. The V and K were $0.216{\pm}0.048L/Kg\;and\;0.336{\pm}0.043hr^{-1}$ for gastrointestinal surgical patients using Bayesian analysis. There were no differences in gentamicin pharmacokinetics between NLSR and Bayesian analysis in gastrointestinal surgical patient.

• Clinical and Experimental Pediatrics
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• 제49권2호
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• pp.203-207
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• 2006

위장관계의 신경섬유종의 발생빈도는 드물다고 알려져 있다. 저자들은 제1형 신경섬유종증의 15세 남자 환아에서 상부위장관 출혈로 발현한 위에 생기는 신경섬유종을 내시경 및 상부위장관 조영술을 통해 진단을 내리고, 수술적 제거를 시행하였던 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제9권3호
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• pp.101-108
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• 2020

최근의 영상 처리 분야는 딥러닝 기법들의 성능이 입증됨에 따라 다양한 분야에서 이와 같은 기법들을 활용해 영상에 대한 분류, 분석, 검출 등을 수행하려는 시도가 활발하다. 그중에서도 의료 진단 보조 역할을 할 수 있는 의료 영상 분석 소프트웨어에 대한 기대가 증가하고 있는데, 본 연구에서는 데이터 셋이 방대하고 판단에 시간이 오래 걸리는 캡슐내시경 영상에 주목하였다. 본 논문의 목적은 캡슐내시경 영상의 판독에서 모든 환자에 대해 공통으로 수행되고, 판독하는 데 많은 시간을 차지하는 위장관 랜드마크를 구별하고 위장관 교차점을 추정하는 것이다. 이를 위해, 위장관 랜드마크를 식별할 수 있는 CNN 학습 모델을 설계하였으며, 이를 이용하여 결괏값을 필터링해 위장관 교차점을 추정하였다. 무작위로 환자 데이터를 샘플링한 모델을 이용해서 나온 결과를 필터링 후에 위장관 교차점을 추정하였을 때, 88% 환자는 위장에서 소장으로 변화하는 위장관 교차점(유문판) 의심 구역 안에 들어왔으며, 소장에서 대장으로 변화하는 위장관 교차점(회맹판)의 경우 100% 환자가 위장관 교차점 의심 구역 안에 들어온 것을 확인할 수 있었다. 100프레임 범위로 위장관 교차점 의심 구역을 찾을 수 있었으며, 판독자가 초당 10프레임의 속도로 판독을 진행한다면 10초안에 위장관 교차점을 찾아낼 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.539-543
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• 2016

Background: It is well known that peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is associated with a poor prognosis. However, data on the prognostic significance of modern chemotherapy containing bevacizumab, cetuximab or panitumumab are not available. Materials and Methods: This retrospective review concerned 526 patients with metastatic CRC who were classified into two groups according to the presence or absence of PC, and were treated with systemic chemotherapy, with or without bevacizumab or anti-EGFR antibodies. The genetic background, in particular KRAS, BRAF, and PIK3CA gene mutations, and overall survival (OS) were compared between the two groups. Results: The median OS values were 23.3 and 29.1 months for PC and non-PC patients, respectively (hazard ratio [HR]=1.20; p=0.17). Among all patients, tumor location, number of metastatic sites and BRAF mutation status were significant prognostic factors, whereas the presence of PC was not. In the PC group, chemotherapy with bevacizumab resulted in a significantly longer OS than forchemotherapy without bevacizumab (HR=0.38, p<0.01), but this was not the case in the non-PC group (HR=0.80, p=0.10). Furthermore, the incidence of the BRAF V600E mutation was significantly higher in PC than in non-PC patients (27.7% versus 7.3%, p<0.01). BRAF mutations displayed a strong correlation with shorter OS in non-PC (HR=2.26), but not PC patients (HR=1.04). Conclusions: Systemic chemotherapy, especially when combined with bevacizumab, improved survival in patients with PC from CRC as well as non-PC patients. While BRAF mutation demonstrated a high frequency in PC patients, but it was not associated with prognosis.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.136-142
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• 2008

In patients with functional gastrointestinal disorders, dietary factors have an important effect on the development or worsening of gastrointestinal symptoms. Therefore, nutritional advice is often needed for the treatment of these patients. Although no firm conclusions can be drawn from current studies, the use of low-fat diets can be recommended in patients with functional dyspepsia. Constipation can be treated with a high-fiber diet. There are few studies in irritable bowel syndrome patients with diarrhea. The diet recommendations must be applied to each patient depending on symptoms.