• Title/Summary/Keyword: Gastrointestinal

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Oncologic Feasibility of Proximal Gastrectomy in Upper Third Advanced Gastric and Esophagogastric Junctional Cancer

  • Yun, Won-Gun;Lim, Myung-Hoon;Kim, Sarah;Kim, Sa-Hong;Park, Ji-Hyeon;Kong, Seong-Ho;Park, Do Joong;Lee, Hyuk-Joon;Yang, Han-Kwang
    • Journal of Gastric Cancer
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    • v.21 no.2
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    • pp.169-178
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    • 2021

  • Purpose: The aim of this study was to investigate the oncologic safety and identify potential candidates for proximal gastrectomy (PG) in upper third advanced gastric cancer (AGC) and esophagogastric junction (EGJ) cancers. Materials and Methods: Among 5,665 patients who underwent gastrectomy for gastric adenocarcinoma between January 2011 and December 2017, 327 patients who underwent total gastrectomy with standard lymph node (LN) dissection for upper third AGC and Siewert type II EGJ cancers were enrolled. We analyzed the correlation between the metastatic rates of distal LNs (No. 4d, 5, 6, and 12a) around the lower part of the stomach and the clinicopathological characteristics. We identified subgroups with no metastasis to the distal LNs. Results: The metastatic rate of distal LNs in proximal AGC and Siewert type II EGJ cancers was 7.0% (23 of 327 patients). On multivariate analysis, pathological T stage (P=0.001), tumor size (P=0.043), and middle third invasion (P=0.003) were significantly associated with distal LN metastases. Pathological 'T2 stage' (n=88), or 'T3 stage with ≤5 cm tumor size' (n=87) showed no metastasis in distal LNs, regardless of middle third invasion. Pathological T3 stage with tumor size > 5 cm (n=61) and T4 stage (n=91) had metastasis in the distal LNs. Conclusions: In the upper third AGC and Siewert type II EGJ cancer, pathological T2 and small-sized T3 stage groups are possible candidates for PG in cases without distal LN metastasis. Further validation studies are required for clinical application.

  • https://doi.org/10.5230/jgc.2021.21.e15 인용 PDF KSCI

Analysis of pharmacological studies on the purgation effect of Daeseunggi-tang (대승기탕의 사하작용(瀉下作用)에 대한 약리학적 연구 분석)

  • Byeon, Sung-Hee;Hur, Shin-Chul;Bye, Jeong-Hye;Jo, Gang-Mun;Lee, Soong-In
    • Herbal Formula Science
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    • v.26 no.1
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    • pp.27-41
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    • 2018

  • Objective : This study's purpose was to review the Daeseunggi-tang as the typical purgative. Method : We searched papers about Daeseunggi-tang about the gastrointestinal dysfunction caused by constipation, surgery and MODS. In total, 31 papers were analyzed in this study. Results : In matter of subject, researches on the gastrointestinal dysfunction caused by constipation were 16 cases, researches on the gastrointestinal dysfunction caused by surgery were 8 cases, researches on gastrointestinal dysfunction caused by MODS were 7 cases. Conclusion : In conclusion, the traditional use of Daeseunggi-tang on constipation, frequent flatus, and stomachache has proven to have sufficient evidences through the experimental and clinical evidences.

  • https://doi.org/10.14374/HFS.2018.26.1.27 인용 PDF KSCI