• Title/Summary/Keyword: Gastroenterology

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Establishment and Partial Characterization of an Epirubicin-Resistant Gastric Cancer Cell Line with Upregulated ABCB1

  • Felipe, Aledson Vitor;Moraes, Andrea Aparecida;de Oliveira, Juliana;da Silva, Tiago Donizetti;Forones, Nora Manoukian
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6849-6853
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    • 2014

  • Multidrug resistance (MDR) is a major impediment to successful chemotherapy of gastric cancer. Our aim was to establish an epirubicin-resistant cell subline (AGS/EPI) and to elucidate the mechanisms involved in acquired EPI resistance. The AGS/EPI cell subline developed by exposing parental AGS cells to stepwise increasing concentrations of EPI demonstrated 2.52-fold resistance relative to the AGS cell line, and mRNA expression of the ATP-dependent drug-efflux pump P-glycoprotein (Pgp), more recently known as ABCB1 protein, was similarly upregulated. An AGS/EPI cell subline could thus be effectively established, and MDR mechanism of these cells was shown to be related to the overexpression of mRNA of the ABCB1 gene.

  • https://doi.org/10.7314/APJCP.2014.15.16.6849 인용 PDF KSCI

RNA Interference: a Promising Therapy for Gastric Cancer

  • Felipe, Aledson Vitor;Oliveira, Juliana de;Chang, Paula Yun Joo;Moraes, Andrea Aparecida de Fatima Souza;Silva, Tiago Donizetti da;Tucci-Viegas, Vanina Monique;Forones, Nora Manoukian
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.14
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    • pp.5509-5515
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    • 2014

  • Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.

  • https://doi.org/10.7314/APJCP.2014.15.14.5509 인용 PDF KSCI

Coronavirus Disease 2019-Liver Injury-Literature Review and Guidelines Based on the Recommendations of Hepatological Societies

  • Pawlowska, Joanna;Lebensztejn, Dariusz M.;Jankowska, Irena
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.24 no.2
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    • pp.119-126
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    • 2021

  • The aim of our paper was to present current knowledge, review literature and available practice guidelines of international hepatological associations regarding the effect of severe acute respiratory syndrome coronavirus 2 coronavirus on the liver, patients with underline liver disease, awaiting on liver transplantation (LTx) or being after LTx in the pandemic coronavirus disease 2019 area.

  • https://doi.org/10.5223/pghn.2021.24.2.119 인용 PDF KSCI