• Clinical Endoscopy
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• 제56권4호
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• pp.531-533
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• 2023

• Clinical Endoscopy
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• 제56권4호
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• pp.534-536
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• 2023

• Clinical Endoscopy
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• 제56권4호
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• pp.527-530
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• 2023

• Clinical Endoscopy
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• 제56권6호
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• pp.738-740
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• 2023

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권4호
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• pp.291-292
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• 2016

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6849-6853
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• 2014

Multidrug resistance (MDR) is a major impediment to successful chemotherapy of gastric cancer. Our aim was to establish an epirubicin-resistant cell subline (AGS/EPI) and to elucidate the mechanisms involved in acquired EPI resistance. The AGS/EPI cell subline developed by exposing parental AGS cells to stepwise increasing concentrations of EPI demonstrated 2.52-fold resistance relative to the AGS cell line, and mRNA expression of the ATP-dependent drug-efflux pump P-glycoprotein (Pgp), more recently known as ABCB1 protein, was similarly upregulated. An AGS/EPI cell subline could thus be effectively established, and MDR mechanism of these cells was shown to be related to the overexpression of mRNA of the ABCB1 gene.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5509-5515
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• 2014

Gastric cancer (GC) remains a virtually incurable disease when metastatic and requires early screening tools for detection of early tumor stages. Therefore, finding effective strategies for prevention or recurrence of GC has become a major overall initiative. RNA-interference (RNAi) is an innovative technique that can significantly regulate the expression of oncogenes involved in gastric carcinogenesis, thus constituting a promising epigenetic approach to GC therapy. This review presents recent advances concerning the promising biomolecular mechanism of RNAi for GC treatment.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권2호
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• pp.119-126
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• 2021

The aim of our paper was to present current knowledge, review literature and available practice guidelines of international hepatological associations regarding the effect of severe acute respiratory syndrome coronavirus 2 coronavirus on the liver, patients with underline liver disease, awaiting on liver transplantation (LTx) or being after LTx in the pandemic coronavirus disease 2019 area.

• Clinical Endoscopy
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• 제56권1호
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• pp.125-128
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• 2023

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2173-2179
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• 2013

Ubiquitin carboxyl-terminal hydrolase 37 (UCH37, also called UCHL5), a member of the deubiquitinating enzymes, can suppress protein degradation through disassembling polyubiquitin from the distal subunit of the chain. It has been proved that UCH37 can be activated by proteasome ubiqutin chain receptor Rpn13 and incorporation into the 19S complex. UCH37, which has been reported to assist in the mental development of mice, may play an important role in oncogenesis, tumor invasion and migration. Further studies will allow a better understanding of roles in cell physiology and pathology, embryonic development and tumor formation, hopefully providing support for the idea that UCH37 may constitute a new interesting target for the development of anticancer drugs.