• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.3
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• pp.672-676
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• 2003

To investigate the effect of acupuncture on Zusanli (ST 36) in this study, gastrin level of serum by radioimmunoassay was measured at 1, 3, 6 weeks in rats. In other groups, 1 mg/day omeprazole was administered for 1, 3, 6 weeks. Omeprazole increased significantly gastrin level of serum at 1, 3, 6 weeks in a time dependent manner. Acupuncture applied to the ST 36 acupoint decreased at 1, 3, 6 weeks. Furthermore, acupuncture applied to other acupoint, Yanglinquan (GB 34) did not produced significant effect. When the common peroneal nerve was dissected, acupuncture of ST 36 produced the change of gastrin level. These data suggest that acupuncture decreased gastrin level of serum in point specific way and that effect was not related with surrounding nerve.

• The Korean Journal of Nuclear Medicine
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• v.15 no.2
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• pp.67-74
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• 1981

The fasting serum gastrin levels were measured by radioimmunoassay in 32 normal healthy subjects without recognized gastrointestinal symptoms and 90 patients with various gastric diseases, who were visited or admitted to National Medical Center from February to June, 1981. The following results were obtained; 1) The fasting mean serum gastrin level in normal subjects was $55.9{\pm}26.3pg/ml$, and there was no difference between male and female. 2) The gastrin levels in gastric and duodenal ulcer were $85.0{\pm}28.4$ and $76.0{\pm}43.0pg/ml$ respectively, and it's values were elevated as compared with normal subjects. In gastric ulcer, the gastrin level was elevated than that of duodenal ulcer, but no significant difference in each other. 3) The gastrin level in stomach cancer was $89.5{\pm}42.2pg/ml$, and it's values were markedly elevated as compared with values in normal subjects. 4) The gastrin level in gastritis was $73.4{\pm}37.4pg/ml$, and it's values were elevated as compared with values in normal subjects. 5) The gastrin level in post-gastrectomy state was $50.3{\pm}16.3pg/ml$, and it's values were slightly decreased as compared with values in normal subjects.

• Journal of Acupuncture Research
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• v.21 no.3
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• pp.179-191
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• 2004

It is well known that acupuncture is effective for treatment of gastric disease in human. For years, we have been utilizing a electro-acupuncture(EA) in attempt to manage gastric symptoms. However, the data on clinical effectiveness is conflicting and the action of acupoints is unclear. The purpose of this study was to investigate the effects of manual and electro acupuncture(EA) at acupoints of ST 36 and GB 34 on the serum gastrin level by radioimmunoassay in rats. All of acupuncture treatment was applied to the acupoints for 30 min during 3 days. Manual acupuncture with both acupoints resulted in increased gastrin serum level when compare to control group treated with only anesthesia. Either high (100 Hz) and low (2 Hz) frequency EA at ST 36 decreased gastrin serum level compared with control group, but EA at GB 34 conversely increased. In EA with device was designed stimulating only acupoint(New EA), either low frequency on ST 36 and high frequency on GB 34 unusually increased gastrin serum level compared to control group. The results of this experiment suggest that many factors, such as the selection of acupoints, the manipulation and the specification of acupuncture device, are capable of affecting acupuncture effects.

• Journal of Acupuncture Research
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• v.21 no.3
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• pp.169-178
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• 2004

Objective : This study was designed to investigate the effects of acupuncture, moxibustion and electro-acupuncture at LI4 and LR3, BL18 and BL25 on serum gastin level in rats. Methods : LI4 and LR3 which belong to Large Intestine Meridian and liver Meridian are acupuncture points frequently used for healing gastrointestinal disease in oriental medicine. BL18 and BL25 which belong to Bladder Meridian are acupuncture points used for healing hepatic disease and intestinal disease in oriental medicine. Serum gastrin level by radioimmnunoassay was measured at 3 days after acupuncture, moxibustion and electro-acupuncture of those acupoints. Results & Conclusion : Moxibustion applied to the BL18 acupoint, BL25 acupoint decreased gastrin level of serum, but moxibustion applied to the BL18+BL25 acupoints did not produced significant effect. Acupuncture applied to the LI4 acupoint, LR4 acupoint did not produced significant effect, but acupuncture applied to the LI4+LR4 acupoints increased gastrin level of serum, Electro-acupuncture applied to the LI4 acupoint, LR4 acupoint increased gastrin level of serum, and electro-acupuncture applied to the LI4+LR4 acupoints also increased gastrin level of serum.

• Journal of Acupuncture Research
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• v.20 no.2
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• pp.135-144
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• 2003

Objective : The purpose of this study is To investigate the effects of acupuncture and moxibustion at Zusanli(ST36) and Weishu(BL21) Methods : serum gastrin level by radioimmunoassay was measured at 5 days after acupuncture and moxibustion of those acupoints. Gastric endocrine cell(G cell and Histamine immunoreactive density) by avidin-biotinylated complex(ABC) technique, histological examinations(Alcian Blue-PAS Stain; Alcian blue-Periodic Acid Schiff reagent) of the gastric mucosa were also performed. Acupuncture applied to the ST36 acupoint increased gastrin level of serum, but moxibustion did not produced significant effect. All of acupuncture and moxibustion at BL21 acupoint increased gastrin level of serum significantly. In moxibustion at ST36 and BL21, the number of gastrin secreting cells in gastric mucosa, the density of immunoreactive histamin secreting cells and the density of body mucosa stained by PAS were decreased compare to acupuncture at ST36 and BL21. In acupuncture and moxibustion at BL21, the density of pylorus mucosa stained by PAS were increased compare to the groups applied to ST36. In the density of body mucosa stained by AB, moxibustion at BL21 and ST36 were increased compare to the other groups. Results : These data suggest that acupuncture and moxibustion at BL21 increased gastrin level of serum and those effects were more potent than acupuncture at ST36.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.145-153
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• 2005

Objective : It was well knownth at electro-acupuncture(EA) of ST36 in the hindimb affected a gastrointestinal disease. This study was designed to compare the factors affected EA`s effect such as stimulation duration, operating time and inserted needle`s length. Meyhods and Results : The lightly anaesthetized rat was used and serum gastrin level was observed in this study. Standard stimulation of ST36 consisted of a 5 mA at 2 Hz for a duration of 30 min, applied at 5 times the threshold to evoke muscle twitch. In the study of comparing stimulation duration, 60 min of EA produced no effect, whereas both of 10 and 30 min of EA increased gastrin level. When operating time was altered, both of 5 and 10 days only produced effects of increasing gastrin level. When comparing the depth of inserting needle, stimulation of the outer layer increased gastrin serum level as well as stimulation of full length. Conclusion : These data suggest that the difference of factors affected EA`s effect such as stimulation duration, operating time and inserted needle`s length produced difference effects.

• Journal of Acupuncture Research
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• v.21 no.6
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• pp.167-176
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• 2004

Objective : This study was designed to investigate the effects of electro-acupuncture(EA) and moxibustion at CV13, CV12, CV10 and ST36 serum gastin level in rats. Methods : The present study was conducted to see the effects produced by combined electro-acupuncture(EA) and moxibustion using four different acupoints on serum gastrin level in rats. Electro-acupuncture (2 Hz, intensity ; 10 times muscle twitch threshold) was applied for 30 minutes to ST36 under halothane anesthesia. Moxibustion ($1.6{\pm}0.3mg$, 5 times of a day) was applied during 3 days to CV13, CV12, CV10 under halothane anesthesia. Results : Both of EA applied to the ST 36 and Moxibustion applied to the CV10, CV12 decreased serum gastrin level significantly. And the effect of combined EA at ST36 and moxibustion at CV10 was shown stronger effect than each singular stimulus of EA at ST36 and moxibustion at CV10. These data suggest that both of EA and moxibustion at specific acupoints produce change of serum gastrin level in rats and combined EA and moxibustion was shown quite effect than each singular stimulus.

• Journal of International Academy of Physical Therapy Research
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• v.4 no.1
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• pp.499-504
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• 2013

This study aims to address the effect of interferential current therapy and thereby to provide basic resources to physical therapies for internal medicine by identifying symptoms for functional dyspepsia and serum gastrin level that shows gastric motility. Following results were obtained by performing interferential current therapy to 16 subjects composed of 8 for functional dyspepsia group and 8 for control group for 20 minutes a day, 3 days a week, for 6 weeks. In control group, serum gastrin level was significantly( p<.01), lowered after the therapy whereas there was no significant difference observed in all questions from questionnaire for symptoms of functional dyspepsia between before and after the therapy. In functional dyspepsia group, serum gastrin level was significantly(p<.01), lowered after the therapy and there was also significant(p<.01) reduction in every question from questionnaire for symptoms of functional dyspepsia between before and after the therapy. There was more significant decrease in serum gastrin level and reduction in questionnaire for symptoms of functional dyspepsia in the functional dyspepsia group compared to the control group(p<.01). This study confirms the interferential current therapy as an effective therapeutic method for internal diseases including functional dyspepsia since it not only improves the symptoms of functional dyspepsia but also allows the gastric motility close to normal.

• The Journal of Internal Korean Medicine
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• v.22 no.4
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• pp.703-707
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• 2001

Each decoction of Coptidis Rhizoma, Scutellariae Radix and Phellodendri Cortex was orally administrated to the rates. And the effects on the Gastrin and Uropepsin secretions were observed. The results were as follows: 1. The effects on the secretio of Gastrin in the experimental groups administrered each with Coptidis Rhizoma and Scutellariae Radix comparing with the normal group, showed signficant values P<0.05, P<0.02, P<0.01 and P<0.001 separately. However the group medicated with Phellodendri Cortex showed significant values only 30 minutes after the administration. 2. Uropepsion level in the experimental group administered each with Coptidis Rhizoma and Phellodendri Cortex, comparing with the normal group, showed highly significant statistic values (P<0.001). Another experimental group medicated with Scutellariae Radix showed significantly statistical values (P<0.001) 240 minutes after the administration. 3. According to the above mentioned results it was onculuded tat the secretion of Gastrin in plasma and Uropepsin content of urine in albino rats treated with Coptiodis Rhizoma decoction were remarkaby increased as comparing with Scutellariae Radix and Phellodendri Cortex decoction.

• Journal of Veterinary Clinics
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• v.23 no.2
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• pp.119-122
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• 2006

This study was performed to clarify the effect of oculo-acupuncture (OA) on change of serum gastrin concentration. Twenty-three clinically healthy mongrel dogs were used in this study. This study was comprised of two experiments. In experiment 1, the effect of OA (stomach/spleen region) with comparison of non-a cup oint was examined. On the other hand, the effect of OA (stomach/spleen region) with comparison by body acupuncture (BL-21) was also examined in experiment 2. Serum gastrin levels were measured on before, 0, 30, 60 and 120 minutes after treatment in both non-acupoint and stomach/spleen region groups, and BL-21 The results showed that significant decreases in serum gastrin level was detected on 30 mins(p<0.05) after OA when compared with that of non-acupoint group. Serum gastrin concentrations with OA at stomach/spleen region group were significantly decreased on 60 mins (p<0.05) and 120 mins (p<0.01) compared with those of the AP at BL21 group. In conclusion, it was demonstrated that OA at stomach/spleen region had significantly decreased serum gastrin levels in dogs and OA at stomach/spleen region decreased serum gastrin concentration more than that body acupuncture at BL-21.