• Archives of Pharmacal Research
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• 제16권1호
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• pp.71-74
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• 1993

The protective effect of adenosine triphosphate (ATP) on gastic ulcer induced in rats has been studied. Gastic ulceration was induced by hypothemic restraint stress or dicolofenac sodium. Gastic acid secretion and mucosal injury produced by the hypothemic restraint stress was greater as compared with those produced by diclofenac sodifum. ATP significantly reduced area of injury, however, increased cyclic adenosine monophosphate (cATP) content. Administration of dipyridamole along with ATP did not change the total lesion area in both models when compared to ATP alone. Aminophyline antagonized antagonized the protective effect of ATP on the injured area. Famotidine was found to be effective in reducing gastric acid output as well as the total injured area without any change in cAMP content when given along with ATP.

• Archives of Pharmacal Research
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• 제16권4호
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• pp.265-270
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• 1993

6, 10, 14, 18-Tetramethyl-5, 9, 131, 17(E, E, E)-nonadecatetraen-2-one was synthesized from geraniol or 6-methyl-5(E)-hepten-2-one in 6 steps, repectively. The key step in both syntheses, was the condensation of phenyl sulfone compound and allylic chloride.

• Biomolecules & Therapeutics
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• 제14권3호
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• pp.171-177
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• 2006

Gastritis and gastric ulcer were known to be induced by gastic acid, stress, ethanol, Helicobacter pylori and free radical, etc. This study was performed for the development of a new drug or nutraceutical from medicinal plants or natural products with anti-gastritis, anti-ulcerative and gastroprotective activities. The water extract of Scutellaria baicalensis was exhibited potent inhibition in HCl ethanol-induced gastric lesion, acetic acid-induced and Shay ulcers, indicating the effects on gastric lesion and ulcer in rats. The water extract of Scutellaria baicalensis significantly inhibited HCl ethanol-induced gastric lesions at the oral dose of 300, 500 mg/kg. In pylorus ligated rats, the treatments of the water extract from Scutellaria baicalensis showed decrease in the volume of gastric secretion and acid output and increase pH at oral dose of 300, 500 mg/kg. And significantly reduced acetic acid-induced ulcer at the oral dose of 500 mg/kg for 12 days. In this study, we have found that the water extract from Scutellaria baicalensis had significant improvement in acute gastritis and ulcer at the dose of 300, 500 mg/kg and in chronic gastritis and ulcer at the dose of 500 mg/kg. Also we evaluated the antibacterial activity against Helicobacter pylori treated with Scutellaria baicalensis. Scutellaria baicalensis had a equivalent antibacterial activity with ampicilin against H. pylori at the dose of $100\;{\mu}/ml$. In histological examination, the water extract of Scutellaria baicalensis drastically restored gastric damages induced by HCl ethanol solution, pylorus- ligature and acetic acid. Therefore, we may use the water extract from Scutellaria baicalensis as antigastritic and antiulcerative agent for the purpose of the improvement or treatment of gastritis and gastric ulcer.

• 한국식품위생안전성학회지
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• 제7권2호
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• pp.83-89
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• 1992

정향의 mathanol 추출물로 HCI-ethanol 위손상 실험을 하여 그 방어 효과를 확인하고 이를 계통 분획한 후 각 분획에 대한 HCI-ethanol 위손상실험, 기초위액 분비실험, indomethancin 위손상실험, acetic acid 궤양 실험을 하여 추출물에 대한 급성독성과 급.만성위염 및 위손상에 대한 실험한 바 다음과 같은 결과를 얻었다. (1) $LD_{50}$은 경구투여시 3000 mg/Kg 이사이었다. (2)HCL.ethanol 위손상실험에서 EtOAc fr. 165mg/Kg과 BuOH fr. 215mg/Kg에서 손상의 크기를 유의성있게 감소시켰다. (3) Acetic Acid 궤양 실험에서 위궤양의크기가 BuOH 분획 215mg/Kg으로 유의성 있게 감소되었다. 이상의 결과로서 생각은 급만성 위염 및 위손상에 대한 세포보호 작용이 있으며 그 작용기전은 위액분비의 억제작용에 인한 것이며 그 유효성분은 대부분 butanol 분획에 존재하는 것으로 생각된다.