• Journal of Microbiology and Biotechnology
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• v.15 no.1
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• pp.59-65
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• 2005

Poly-${\gamma}$-glutamic acid (PGA) is an unusual anionic polypeptide and has great potential as an environmentally and industrially significant biodegradable material. A new ${\gamma}$-PGA producer, Bacillus mesentericus MJM1, with high production capacity was isolated from Korean domestic Chungkuckjang bean paste. It produced ${\gamma}$-PGA at the level of 10 g/l in suitable media. The viscosities of 5% initially extracted mucin and purified ${\gamma}$-PGA solutions were 660 cps and 600 cps, respectively. The produced ${\gamma}$-PGA polymer consisted of 2,000 glutamic acid residues with even proportion of L and D types with molecular mass of about 200- 300 kDa. Bacillus mesentericus MJM1 displayed ${\gamma}$-glutamyltranspeptidase (${\gamma}$-GTP) activity that is known to play a key role in ${\gamma}$-PGA biosynthesis. The ${\gamma}$-GTP coding region was located on the plasmid of 5.8 kb. The plasmid, named pMMH1, is a rolling-circle replication (RCR) plasmid and additionally contained a replication origin and type I signal peptidase (sipP) coding region.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.12
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• pp.4567-4583
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• 2021

This study proposes an analytical approximation algorithm based on extreme value theory (EVT) for the inverse of the power of the incomplete Gamma function. First, the Gumbel function is used to approximate the power of the incomplete Gamma function, and the corresponding inverse problem is transformed into the inversion of an exponential function. Then, using the tail equivalence theorem, the normalized coefficient of the general Weibull distribution function is employed to replace the normalized coefficient of the random variable following a Gamma distribution, and the approximate closed form solution is obtained. The effects of equation parameters on the algorithm performance are evaluated through simulation analysis under various conditions, and the performance of this algorithm is compared to those of the Newton iterative algorithm and other existing approximate analytical algorithms. The proposed algorithm exhibits good approximation performance under appropriate parameter settings. Finally, the performance of this method is evaluated by calculating the thresholds of space-time block coding and space-frequency block coding pattern recognition in multiple-input and multiple-output orthogonal frequency division multiplexing. The analytical approximation method can be applied to other related situations involving the maximum statistics of independent and identically distributed random variables following Gamma distributions.

• Journal of the Korea Society of Computer and Information
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• v.19 no.2
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• pp.133-142
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• 2014

According to the development of medical information systems, shortened examination time per patient could increase the number of treatments, resulting in the rapid growth of the amount of medical data. Studies on how to efficiently compress and store medical text data of increasing patients are in progress. However, previous methods have the shortcoming of compressing medical text data as it is, resulting in low compression rate. This research tries to overcome the problem by using the gamma coding method which enables compression in bit unit. We propose a new compression scheme which encodes the deviations between measured values and normal range values. Furthermore, we suggest to use the previous value with the least deviation from the measurement as the standard value to encode that deviation. Even though the suggested methods are simple, they have high compression rates. Through performance evaluation, we show that the suggested methods are more efficient than the previous methods.

• Tuberculosis and Respiratory Diseases
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• v.52 no.5
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• pp.497-505
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• 2002

Background : INF-${\gamma}$ plays an important role in the host response to a mycobacterial infection. A complete IFN-${\gamma}$ receptor 1 deficiency is a life threatening condition because it renders patients highly susceptible to a mycobacterial infection. Several mutations in the IFN-${\gamma}$ receptor and STAT1 gene have been identified in the rare mycobacterial infections. These mutations have partial function of the IFN-${\gamma}$ receptor and similar pathologic features to clinical tuberculosis. Materials and Methods : The function of the IFN-${\gamma}$ receptor was evaluated in the patients with clinical tuberculosis. In addition, the DNA coding sequence of the IFNgR1 and STAT1 gene was also analyzed in disseminated tuberculosis patients who might have a defective IFN-${\gamma}$ receptor. Results : The cell surface expression levels of HLA-DR and CD64 in the PMBC after being stimulation with IFN-${\gamma}$ (100IU/ml, 1000IU/ml) were increased in both controls and patients. However, the rate of increase in both groups was similar. The production of TNF-${\alpha}$ in the response to stimulation with LPS was higher in the both groups ($850.7{\pm}687.8$ vs. $836.7{\pm}564.3$ pg/ml). Pretreatment with IFN-${\gamma}$ prior to LPS stimulation resulted in further increase in TNF-${\alpha}$ production between both groups ($2203.5{\pm}242.5$ vs. $2227.5{\pm}560.4$ pg/ml). However, the rate of the increase in TNF-${\alpha}$ production in the both groups was similar. The known mutations in the IFNgR1 and STAT1 coding sequences were not found in the genomic DNA of patients with disseminated tuberculosis. Conclusion : The functional and genetic defects of the IFN-${\gamma}$ receptor were not identified in clinical tuberculosis. This suggests the defective IFN-${\gamma}$ receptor that predispoe patients to a BCG or NTM infection can not alone account for the cases of clinical tuberculosis.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.7
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• pp.1118-1130
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• 1999

In this paper, error performance of DS/FH CDMA system has been analyzed in a radio channel which is characterized by near-far problem and multi-path fading. The DS/FH CDMA system adopts Maximum Ratio Combining(MRC) diversity and BCH(Bose-Chau dhuri-Hocquenghem) coding techniques to enhance system performance. Using the derived error probability equation, the error performance of DS/FH CDMA system has been evaluated and shown in figures to discuss as a function of PN code length(N), hopping rate(q), number of diversity branch(M), coding rate($\gamma$) and bit energy per noise power ratio ${E_b/N_o}$. The results show that DS/FH system is more effective to restrain the affection of near-far problem and multi-path fading than DS system. And there is a substantial enhancement in performance by employing an MRC diversity or BCH coding techniques. Consequently, we expected that proposed system structure is reliable to the voice communication system in near-far problem and multi-path fading channel.

• Applied Biological Chemistry
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• v.45 no.4
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• pp.203-206
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• 2002

${\gamma}-Tocopherol$ methyltransferase (TMT) is an enzyme catalyzing ${\gamma}-tocopherol$ into ${\alpha}-tocopherol$ at the final step of ${\alpha}-tocopherol$ synthesis pathway. Putative TMT cDNA clone specific to Perilla frutescens immature seeds was isolated from cDNA library. The cDNA clone consisted of 1369 bp open reading frame encoding 369 amino acids with a relative Mw of 42 kDa. Results revealed the CDNA has 60% homology to Arabidopsis thaliana TMT, and possesses methyltransferase and S-adenosyl methionine-binding domains, suggesting that cDNA encodes a ${\gamma}-tocopherol$ methyltransferase To characterize the properties of the TMT gene, the cDNA sequences coding for mature TMT were expressed in E. coli and assayed to determine the enzyme activity in vitro.

• Biomolecules & Therapeutics
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• v.18 no.4
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• pp.411-419
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• 2010

Korean mistletoe has a variety of biological effects, such as immunoadjuvant activities. This study investigates the effects of Korean mistletoe lectin (Viscum album L. var. coloratum agglutinin, VCA) on human T lymphocytes to determine whether VCA acts as an immunomodulator. Purified human T-lymphocytes were cultured with VCA and RNA from each point was analyzed using Affymetrix human genome chips containing 22,500 probe sets which represents more than 18,000 transcripts derived from 14,500 human genes. As a result, there was a striking upregulation of genes coding for chemokines. Seventeen genes out of 50 coding for proteins with chemokine activity were upregulated including CXCL9 and IL-8 which are related to the treatment of cancer. In addition, 28 cytokine genes were upregulated including IL-1, IL-6, IL-8, IFN-$\gamma$, and TNF-$\alpha$. Taken together, the data suggest that Korean mistletoe lectin, in parallel with European mistletoe, has an ability to modulate human T cell function.

• Journal of the Korean Institute of Telematics and Electronics
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• v.23 no.5
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• pp.597-604
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• 1986

This paper describes various mismatch phenomena in differential pulse code modulation (DPCM) coding, such as the mismatch effects of probability density functin(pdf), signal variance, and correlation. At a high transmission rate(i.e., above 32 kbits/s), the performance of DPCM can be improved by matching the pdf shape between the input signal and the quantizer. However, the same gain cannot be obtained at a lower transmission rate. Also, it is shown that the gamma quantizer is realtively robust to the variation of pdf shaper and signal variance. Moreover, as the transmission rate increases, the performance of DPCM for the input signal with large variance is worse than that of DPCM for the signal with small variance due to the increase of overload noise. According to our simuladiton results, the mismatch effects of pdf shape and variance appear to yield more degradatin than that of correlation in a DPCM system.

• KIISE Transactions on Computing Practices
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• v.23 no.10
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• pp.594-598
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• 2017

Tremendous quantities of numerical data are generated every day from various sources, including the stock market. Universal codes such as Elias gamma coding, Elias delta coding and Fibonacci coding are generally used to store arrays of integers. Studies have been conducted to support fast access to specific elements in an integer array, while occupying less space. We suggest an improved code system that utilizes the concepts of succinct data structures. This system is based on a data structure that allows compressing a delimiter bit array while supporting queries in constant time. The results of an experiment show that the encoded array uses lower space, while not sacrificing time efficiency.

• Horticultural Science & Technology
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• v.28 no.5
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• pp.818-827
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• 2010

A full-length cDNA and genomic DNA of a $leucoanthocyanidin$ $dioxygenase$ ($DgLDOX$) gene was isolated from the petals of chrysanthemum 'Argus', and comparative features of the gene among three flower color mutants derived from a gamma-ray mutagenesis were characterized. The cDNA coding region of the gene was 1068 bp and was translated into 356 amino acids accordingly. The genomic DNA size was 1346 bp for 'Argus', while three mutants revealed ranges of 1363 to 1374 bp. A single intron between two coding exons for the $DgLDOX$ gene was found, of which size was 112 bp for 'Argus', but 128 or 137 bp for three flower color mutants, indicating that a genomic insertion in the intron occurred during the gamma-ray mutagenesis. DNA blot analysis revealed the $DgLDOX$ gene presenting as a single copy in the chrysanthemum genome. The $DgLDOX$ gene was expressed in both 'Argus' of light-pink color and two purple color mutants (AM1 and AM3) but had very weak expression in only white color mutant (AM2). The results demonstrated that variations in the flower color of the mutants might be associated with changes in the amino acid moieties in the coding exons or fragment insertions in the intron of the $DgLDOX$ gene, which potentially resulted in less expression of the gene in the white colored mutant.