• The Journal of Internal Korean Medicine
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• v.42 no.5
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• pp.793-799
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• 2021

Objectives: This study examined the effects of Gamisachil-tang on an anorexic patient with depression. Methods: A patient suffering from anorexia and depression was treated with Korean herbal medicine (Gamisachil-tang) for 14 days. To evaluate the therapeutic effect, we measured the daily food intake of the patient and used the Visual Analogue Scale (VAS) for anorexia. Results: Following treatment, both the patient's daily food intake of the patient and VAS score for anorexia had improved. Conclusion: These results suggest that Gamisachil-tang has a beneficial effect on both anorexia and depression.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1352-1355
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• 2007

Dissociative disorder is a breakdown of one's perception of one's surroundings, memory, identity, or consciousness. Dissociative amnesia is too wide-ranged to define itself of simple amnesia or oblivion. In this case, a 62 years old female diagnosed as Geonmang due to Dameobijo. The patient was treated with mainly Gungsindodam-tang and Gamisachil-tang. Clinical symptoms and general conditions are improved after treatment and more extensive researches are needed.

• The Journal of Internal Korean Medicine
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• v.40 no.3
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• pp.541-550
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• 2019

Objective: The aim of this clinical study was to describe the case of a patient who experienced chronic diarrhea related to seasonal changes that improved with herbal medicine treatment. Methods: A patient with diarrhea and globus hystericus was treated following treatment with Hoehyangbanchong-san-hap-Ukgan-san and Gamisachil-tang. A defecation and urination diary, the Bristol Stool Form Scale, and the Visual Analog Scale (VAS) were used to evaluate the effectiveness of this treatment. Results: During treatment, the patient's Bristol Stool Form Scale score changed from Type 7 to Type 4, and the VAS score was significantly decreased. The symptoms of diarrhea and globus hystericus almost subsided. Conclusion: In this case, Korean traditional herbal medicine reduced the clinical symptoms of diarrhea and globus hystericus.

• Herbal Formula Science
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• v.19 no.1
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• pp.113-130
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• 2011

Objectives : This study was performed to investigate 93 prescriptions which are all affiliated Phlegm-Fluid Substances chapter depending on Symptoms in Dongeuibogam. Methods : The following conclusions are reached through investigations on the applications of prescriptions which are all affiliated Phlegm-Fluid Substances chapter Depending on Symptoms in Dongeuibogam. Results : 1. Fluid detention disease article represents that Byukeum(癖飮), Hyuneum(懸飮) and Yueum(流飮) have the same treat criteria, in effect, there is not any problem left in case it is reached fluid detention disease is not 8 but 6. 2. Strong water-utilization herbs can be mainly used in treating Fluid detention disease, eliminating phlegm warm herbs are almost used two times more than eliminating phlegm cold herbs in eliminating phlegm disease. 3. Arisamatis Rhizoma is only used by itself in Chongmongseok-hwan, the others are used at the same time with Pinelliae Rhizoma. As a result of this, Arisamatis Rhizoma has an effects on eliminating Wind relative dusease but eliminating phlegm disease which can cause upper body phlegm disease. 4. Fritillariae Cirrhosae Bulbus and Tricosanthis Radix are able to get rid of obstinate phlegm-Fluid disease in eliminating phlegm cold herbs. 5. Gamisachil-tang and Gamieejin-tang which are located in throat chapter are more proper prescriptions to treat phlegm at throat than Gwache-san or Jeoljehwadam-hwan which is located in Phlegm-Fluid Substances chapter in Dongeuibogam. 6. Glycyrrhizae Radix is used 46 times(49%) at total 93 prescriptions in eliminating phlegm disease herbs. It seems to be needed more study whether Glycyrrhizae Radix can control the Phlegm-Fluid disease or not. Conclusions : The 93 prescriptions for eliminating Phlegm-Fluid Substances in Dongeuibogam are mainly composed of Sobanha-tang, Eejin-tang and Baeksang-hwan, etc.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.539-542
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• 2007

After analyzing the cases of treating female patients troubled with morbid leukorrhea, the writer drew the conclusions as follows. The shapes of patients with morbid leukorrhea show a large number of shapes of Gi type, Sin type or being inclined to be vigorous Gi, to have depressive syndrome due to disorder of Gi, to be Fire's nature flared upward, to become retention of phlegm and fluid, to become retention of Gi or to become retention of heat, or San syndromes. Accompanied syndromes of morbid leukorrhea appear over the body of upper, middle or lowe portion. In lower cho, the symptoms are menopathy, menstrual irregularities, menstrual irregularities, oligomenorrhea, itching of external genitals, San syndromes, infertility, lumbago which are connected with uterus. And in the middle cho, those are indigestion, nausea, distress in the stomach, vomiting, swallowing acid connected with digestive organs. And also in the upper cho, globus hystericus, chest distress, headache, dizziness, neck stiffness, heat in the upper, pimples connected with upper cho are appeared. Among the prescriptions of treatment for morbid leukorrhea, Ijintang was applied with the widest range of all. Besides that there were mainly prescribed for symptoms such as Gamisachil-tang, Haenggihyangso-san, Gamigwibi-tang, hyangsapyeongwi-san, Onkyung-tang, Banchong-san, Yongdamsagan-tang, Sogampaedok-san, Ojeok-etc.

• Journal of Physiology & Pathology in Korean Medicine
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• v.37 no.2
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• pp.36-44
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• 2023

Essential oils and aromatherapy have traditionally been used for the treatment of anxiety and depression with few side effects. This study aimed to investigate the effects of essential oils from six herbal prescriptions known to be effective in treating anxiety and depression in Korean medicine. The neuroprotective and anti-neuroinflammatory effects of six essential oils, including Gamisachil-tang (GMSCT), Guibi-tang (GBT), Sihogayonggolmoryeo-tang (SYM), Danchisoyosan (DCSYS), Sihosogansan (SHSGS), and Soyosan (SYS), were examined in PC12 and BV2 cells. In corticosterone (CORT)-stimulated PC12 cells, all six essential oils ameliorated the CORT-induced decrease in cell viability at a concentration of 10 ㎍/ml. GMSCT, GBT, and SHSGS recovered CORT-induced cytotoxicity at concentrations of 1 ㎍/ml and 10 ㎍/ml. In lipopolysaccharide (LPS)-stimulated BV2 cells, GBT (10 ㎍/ml) decreased interleukin (IL)-1β production, whereas SHSGS (1 ㎍/ml) inhibited tumor necrosis factor (TNF)-α production. In the MK-801-induced anxiety in zebrafish, electroencephalogram (EEG) assessment indicated that GMSCT and SHSGS induced recovery in the delta and beta power densities and reduced theta/beta and delta/beta ratios. DCSYS and SYS decreased theta power density and theta/beta ratio, whereas GBT and SYM showed no effects on EEG signals. In the tail suspension test (TST) in mice, GBT, DCSYS, SHSGS, and SYS exhibited antidepressant-like effects by decreasing immobility time. These results suggest that the essential oils from the six herbal prescriptions, except SYM, may have beneficial effects on anxiety and/or depression. Further studies should be conducted to investigate the molecular signaling pathways that mediate the effects of these essential oils on anxiety and depression.