• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.675-687
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• 2010

Objective : Interaction of warfarin with herbal medicines still remains controversial. The aim of this study was to examine the effect of herbal medicines which contain ginseng on PT INR in patients being treated with warfarin. Method : We studied patients who take herbal medicines which contain ginseng with warfarin during their hospitalization. We retrospectively investigated the effect of herbal medicines which contain ginseng. 10 patients were assigned to receive one of the following adjuncts: Group A (n=4) that received Bojungikkitang-gagam, Group B (n=2) that received Ukgunjatang-gagam, and Group C (n=4) that received Shihogyeji-tang, Gamiondam-tang, Gwininaanshim-tang, and Saengpe-san together. We then investigated changes of PT INR in each group. Result : In group A, there were diminutions of PT INR in 3 cases, and increment in 1 case. In group B, there were increments of PT INR in both cases. In group C, there were increments of PT INR in 3 cases and there was no big change in 1 case. Conclusion : In this study, we found that the interaction of combined herbal medicine is very complicated. So, we must study further more study about interactions of combined herbal medicine on PT INR.

• The Journal of Internal Korean Medicine
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• v.37 no.5
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• pp.776-785
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• 2016

The purpose of this study is to report and demonstrate the effect of Korean medical treatment on a wedge resection of a lung patient with mucinous adenocarcinoma. The patient was an 84-year-old female who was diagnosed with mucinous adenocarcinoma and underwent wedge resection. The patient was treated with acupuncture and herbal medicine (Banhahubak-tang and Gamiondam-tang). The EORTC Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30), EORTC Quality of Life Questionnaire, Lung Cancer 13 (EORTC QLQ-LC13), numeric rating scale (NRS), and the Global Assessment (G/A) were used to assess the changes in symptoms, including operation site pain and dyspnea. After treatment, the patient showed improvement in operation site pain and dyspnea, based on the NRS and G/A. However, dyspnea and pain were aggravated based on the EORTC QLQ-C30 and EORTC QLQ-LC13. Therefore, Korean medicine may have a substantial benefit for patients with mucinous adenocarcinoma after wedge resection of the lung.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.313-353
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• 2023

Objectives: Heart failure is a chronic disease with increasing prevalence rates despite advancements in medical technology. Korean medicine utilizes herbal prescriptions to treat heart failure, but little is known about the specific herbal medicines comprising the network of herbal prescriptions for heart failure. This study proposes a novel methodology that can efficiently develop prescriptions and facilitate experimental research on heart failure by utilizing existing databases. Methods: Herbal medicine prescriptions for heart failure were identified through a PubMed search and compiled into a Google Sheet database. NetMiner 4 was used for network analysis, and the individual networks were classified according to the herbal medicine classification system to identify trends. K-HERB NETWORK was utilized to derive related prescriptions. Results: Network analysis of heart failure prescriptions and herbal medicines using NetMiner 4 produced 16 individual networks. Uhwangcheongsim-won (牛黃淸心元), Gamiondam-tang (加味溫膽湯), Bangpungtongseong-san (防風通聖散), and Bunsimgi-eum (分心氣飮) were identified as prescriptions with high similarity in the entire network. A total of 16 individual networks utilized K-HERB NETWORK to present prescriptions that were most similar to existing prescriptions. The results provide 1) an indication of existing prescriptions with potential for use to treat heart failure and 2) a basis for developing new prescriptions for heart failure treatment. Conclusion: The proposed methodology presents an efficient approach to developing new heart failure prescriptions and facilitating experimental research. This study highlights the potential of network pharmacology methodology and its possible applications in other diseases. Further studies on network pharmacology methodology are recommended.