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Clinical Manifestation of Extrapulmonary Tuberculosis in Children : A Single Center Experience (단일기관에서 경험한 소아 폐외결핵의 임상적 고찰)

  • Seung, So Jin;Kwak, Ga Young;Lee, Soo Young;Kang, Jin Han
    • Pediatric Infection and Vaccine
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    • v.15 no.2
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    • pp.167-173
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    • 2008
  • Purpose : We evaluated the prevalence and clinical, microbiological features of extrapulmonary tuberculosis (EPT) in pediatric patients. Methods : We retrospectively reviewed medical records of pediatric patients diagnosed with EPT at The Catholic University of Korea, Incheon St. Mary's Hospital between 2000 and 2007. Results : Of 109 patients diagnosed with tuberculosis (TB), 12 patients (11%) were admitted with EPT. At 2006-2007, the proportion of patients with EPT among patients with TB was the highest (20%) comparing with last 6 years. The ratio of male to female patients was 1.4:1 and the mean age was 9.2 years (range, 3 months-15 years). The involved sites were pleura in 5 (41.6%), central nervous system in 3 (25%), miliary TB in 2 (16.7%), gastrointestinal tract in 1 (8.3%) and bone and joint in 1 (8.3%). The most common symptom at admission was fever (91.6%) and mean duration of fever was 15.8 days (range, 0-47 days) in spite of the proper treatment. Confirmed rate for acid fast bacillus stain, culture, and polymerase chain reaction were 33.3%, 41.6% and 41.6%. Of 5 culture proven cases, 4 (80%) were resistant to more than one antituberculosis drugs. Eleven patients recovered without complication and 1 patient died. Conclusion : Total incidence of TB decreased steadily according to the nationwide survey. However, our results suggest that the proportion of diagnosis with EPT among diagnosis with TB in children has increased. Microbiological diagnosis of EPT in children was more difficult than that of pulmonary TB. And drug resistance rate has increased.

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The Effect of Smoking Status upon Occurrence of Impaired Fasting Glucose or Type 2 Diabetes in Korean Men (우리나라 성인 남성에서 흡연량과 공복혈당장애 또는 제2형 당뇨병 발생과의 연관성)

  • Park, Chang-Hae;Ga, Hyuk;Lee, Jong-Han;Kwak, Seung-Min;Kim, Hwan-Cheol;Choi, Ji-Ho
    • Journal of Preventive Medicine and Public Health
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    • v.41 no.4
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    • pp.249-254
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    • 2008
  • Objectives: To investigate whether smoking and the smoking status are predictors of the incident impaired fasting glucose (IFG) or type 2 diabetes in Korean men. Methods: A cohort of 1,717 Korean men without IFG or diabetes, who underwent annual periodic health examinations for 4 years (2002-2006), were retrospectively investigated. IFG and diabetes were defined as a serum fasting glucose concentration of 100-125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between smoking and development of IFG or type 2 diabetes. Results: A total of 558 cases (32.5%) of incident IFG and 50 cases (2.9%) of diabetes occurred. After controlling for the potential predictors of diabetes, the relative risk for IFG, compared with the never smokers, was 1.02 (95% CI=0.88 to 1.19) for the ever-smokers, 0.96 (95% CI=0.79-1.16) for those who smoked 1-9 cigarettes/d, 1.15 (95% CI=1.01 to 1.30) for those who smoked 10-19 cigarettes/d, and 1.31 (95% CI=1.10 to 1.57) for those who smoked 20 or more cigarettes/d (the P value for the current smokers was only p<0.002). The respective multivariate adjusted relative risks for type 2 diabetes, compared with the never-smokers, were 1.07 (95% CI=0.64 to 1.92), 1.47 (95% CI=0.71 to 3.04), 1.84 (95% CI=0.92-3.04), and 1.87 (95% CI=1.13-3.67), respectively (the P value for the current smokers was only p=0.004). Conclusions: The smoking status and the number of cigarettes smoked daily are associated with an increased risk for developing IFG or type 2 diabetes in Korean men.

"The time vs. money effect" on undergraduate consumers' responses : Product type as a moderator (대학생 소비자에게 미치는 "시간 대 돈 효과" : 조절변인으로써의 제품유형)

  • Chung, Eun Kyoung;Kim, Hyun Jung;Lim, Ga Young;Sohn, Young Woo
    • Science of Emotion and Sensibility
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    • v.16 no.1
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    • pp.43-52
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    • 2013
  • "Time versus money effect" refers to a favorable shift in consumers' responses activated by time(vs. money). In general, how people spend their time or money could reflect one's personal identity. Previous research indicates that drawing individuals' attention to time makes more effective in product satisfaction rather than money. Also, whereas because time is experienced as an experience, time activates more positive product satisfaction for experiential product rather than materialistic product, money has the reverse effect because money relates with possessions. Present study examined the effect of time and money on consumers' attitudes and decisions and the role of product type including smartphone. In experiment 1, participants evaluated their experiences or their own products(family restaurant, smartphone, premium jean). They satisfied more with their smartphones when activated by time than by money. In experiment 2, 3 image ads, a promotion image ad for each product(family restaurant, smartphone, premium jean), were offered to find the effect of time and money in promotion ads. The interaction effects between activating condition and product type were revealed on the product attitudes, product satisfaction, purchase intent, and personal connection reflecting the consistent time effect on smartphone. In addition, the main effect of the activating condition was significant which meant time activating ads were more effective than money activating ads.

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Induction and RAPD Analysis of Mutant Plants by Chemical Mutagens in Gentiana axillariflora Leveille (큰용담 (Gentiana axillarifloa L,) 기내배양에서 화학돌연변이원 처리에 의한 돌연변이주 유기 및 RAPD 분석)

  • 임정대;김명조;유창연
    • Korean Journal of Plant Tissue Culture
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    • v.27 no.2
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    • pp.89-94
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    • 2000
  • In order to induce the mutants of Gentiana axillariflora Leveille, nodes were cultured on Schenk and Hilderbrandt (SH) medium containing TDZ 2 mg/L, BAP 2mg/L, GA3 0.5 mg/L and 0.1 mg/L NAA and each mutagen of ethylmethanesulfate (EMS), colchicine, N-methyl-N-nitrosourea (MNU), and sodium azide (NaN$_3$) through filtration. Comparision of morphological characteristics and survival rate in each mutant plants differed depending on mutagen sources and their concentrations. When EMS were treated on nodes, the regenerated plants was thin and albino, regenerated shoots appeared 'erectoides type' and get twisted. The case of colchicine were treated on nodes, the survival rate was from 84% to 97% at ail concentration after 30days but the rate of survival was decreased about 50% at 200 $\mu$M after 60days. The treatment of NaN$_3$200 $\mu$M was not survived. The survival rate was extremely decreased in MNU treatment at 500$\mu$M, according to concentrations two types of leaf characteristic were obtained. Type I of leaf characteristic was modified from oblanceolate to oboid at leaf shape and type II of leaf characteristic was modified from light green to dark violet at leaf color. RAPD analysis was carried out to check the genetic modification of regenerated plants by mutagen treatments. Three polymorphic DNA fragments out of thirty-seven obtained by RAPDs were observed in regenerated plants using 5 decamer primers.

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High Conversion Gain and Isolation Characteristic V-band Quadruple Sub-harmonic Mixer (고 변환이득 및 격리 특성의 V-band용 4체배 Sub-harmonic Mixer)

  • Uhm, Won-Young;Sul, Woo-Suk;Han, Hyo-Jong;Kim, Sung-Chan;Lee, Han-Shin;An, Dan;Kim, Sam-Dong;Park, Hyung-Moo;Rhee, Jin-Koo
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.40 no.7
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    • pp.293-299
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    • 2003
  • In this paper, we have proposed a high conversion and isolation characteristic V-band quadruple sub-harmonic mixer monolithic circuit which is designed and fabricated for the millimeter wave down converter applications. While most of the sub-harmonic mixers use a half of fundamental frequency, we adopt a quarter of the fundamental frequency. The proposed circuit is based on a sub-harmonic mixer with APDP(anti-parallel diode pair) and the 0.1 ${\mu}{\textrm}{m}$ PHEMT's (pseudomorphic high electron mobility transistors). Lumped elements at IF port provide better selectivity of IF frequency and increase isolation. Maximum conversion gain of 0.8 ㏈ at a LO frequency of 14.5㎓ and at a RF frequency of 60.4 ㎓ is measured. Both LO-to-RF and LO-to-IF isolations are higher than 50 ㏈. The conversion gain and isolation characteristic are the best performances among the reported quadruple sub-harmonic mixer operating in the V-band millimeter wave frequency thus far.

A study on the hand washing practice of a clinical nurse in a hospital based on health belief model (건강신념모형을 적용한 일개 병원 임상간호사의 손씻기 수행도에 대한 연구)

  • Kim, Ga-Hyun;Kwon, Yong-Sun
    • Journal of the Korean Applied Science and Technology
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    • v.35 no.2
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    • pp.532-539
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    • 2018
  • This study is a descriptive study to analyze the hand washing practice of nurses working in clinic applying health belief model. This research involved 162 clinical nurse at G city. The data were collected from Sep 1, 2017 to Oct 31, 2017. The collected data were analyzed using an independent t-test, 1-way ANOVA, pearson's correlation coefficient and multiple regression analysis, where p-values of <0.05 were considered statistically significant by using SPSS 20.0. The overall practice of hand washing by general subjects were high 3.1 in all subjects, but there was no statistically significant difference. Health beliefs about hand washing practice according to general characteristics showed significant difference in perceived benefits (p<0.05), and there was a significant difference in perceived benefits and perceived barriers in age(p<0.05). In regard to the correlation among the subfactor of health beliefs, benefits had a statistically significant negative correlation to barriers and, positively correlated to cues to action. The results of this study suggest that continuing education of infection management in hospitals considering health beliefs about proper hand washing training will enhance hand washing practice.

전기로 셀렌화 공정에 의한 CuInSe2 박막 연구

  • Go, Hang-Ju;Lee, Gyeong-Hun;Kim, Jin-Hyeok;Kim, Hyo-Jin;Han, Myeong-Su
    • Proceedings of the Korean Vacuum Society Conference
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    • 2010.08a
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    • pp.318-318
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    • 2010
  • 전기로를 이용하여 셀렌화한 $CuInSe_2$ (CIS)박막에 대해 연구한 결과를 발표하고자 한다. 화석연료의 과도한 사용으로 지구온난화의 환경문제가 대두되면서 영구적이고 무상의 태양에너지 이용에 대한 필요성이 점차 높아지고 있다. 빛에너지를 전기에너지로 변화시키기 위한 태양전지는 재료에 따라 다양하게 개발되고 있으며 그 중 가장 주목을 받고 있는 것 중의 하나가 $CuInSe_2$을 흡수층으로 하는 CIS 박막 태양전지이다. CIS 박막은 태양전지의 흡수층으로 사용되는데 직접천이형 밴드구조를 가지고 있고, 약 $10^5\;cm^{-1}$의 높은 광흡수계수를 가지고 있어 태양전지의 흡수층으로 적합한 물질로 각광받고 있다. 에너지 밴드갭이 1eV로 실리콘과 유사한 밴드갬을 가지고 있으나 이는 Ga, Al을 In 대신 치환함으로 조절할 할 수 있다. 무엇보다도 유리와 같은 저가의 기판위에 스퍼터와 같은 장치로 대면적 CIS 태양전지를 만들수 있다는 것이 산업적인면에서의 장점으로 알려져 있다. 본 연구에서는 $50mm{\times}50mm$ 넓이의 sodalime 유리판을 기판으로 하여 CIS 박막을 제조하고 연구하였다. 스퍼터를 이용하여 유리기판 위에 Mo (Molybdenum) 을 증착하고 그 위에 Cu-In막을 증착하였다. Cu-In/Mo/유리기판 시료는 전기로에 도입되어 셀렌화 처리 하였다. 전기로는 $10^{-1}$ Torr 정도의 진공을 수분간 유지하여 반응할 수 있는 공기(산소)를 제거하였다. 진공 혹은 5N의 고순도 질소를 흘려주며 열을 가하여 셀렌화를 하였다. 전기로에는 1g의 셀레늄(Se)이 Cu-In/Mo/유리기판 시료와 함께 도입되었다. Se이 Cu-In 막과 높은 반응성을 갖도록 Se과 Cu-In 시료는 그라파이드 상자에 함께 넣었고, 그라파이트 상자는 전기로에 넣어 셀렌화하였다. 셀렌화 온도는 $400^{\circ}C{\sim}500^{\circ}C$까지 변화시켜 가며 CIS 박막을 제조하였으며 그 물성도 조사하였다. 물성 조사는 사진, 현미경, SEM, EDX, XRD, Hall effects를 이용하였다. 셀렌화 온도가 $450^{\circ}C$ 이상에서는 CIS 박막의 흡착성이 낮아 CIS 박막이 Mo 표면에서 떨어짐을 알 수 있었다. 셀렌화 후 박막에 함유된 Se은 48%~49% 정도있었다. 제조된 CIS 박막시료를 SEM으로 확인한 결과 생성된 CIS/Mo 사이에 계면층이 생겼있음 알 수 있었다. 이러한 계면층은 $MoSe^2$층으로 사료되고, 셀렌화 온도가 높으면 계면층의 두께도 증가되는 경향을 보였다. 셀렌화 온도가 높아질수록 많은 양의 산소가 CIS 박막에 들어가는 것도 알 수 있었다. 학술회의에서 보다 깊은 조사결과를 발표하고자 한다.

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Cytotoxicity of Hyaluronic Acid Membrane Cross-linked with Lactide (락타이드로 가교시킨 히아루론산 막의 세포독성)

  • Kim, Won-Jung;Kwon, Ji-Young;Cheong, Seong-Ihl;Kim, In-Seop
    • KSBB Journal
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    • v.21 no.4
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    • pp.255-259
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    • 2006
  • The biodegradable hyaluronic acid(HA) membranes cross-linked with lactide using the crosslinking agent, 1-ethyl-3(3-dimethyl aminopropyl) carbodiimide(EDC) were prepared as a potential biocompatible material for tissue engineering. HA membranes having different mechanical properties were synthesised by varying degree of the mole ratio of lactide to HA, EDC concentration, and crosslinking temperature. HA membranes were degradable in water solution and the degradation became slower with the increasing mole ratio of lactide to HA. HA membranes were sterilized using ethylene oxide gas and extracted with cell culture medium for 24 h at $37^{\circ}C$ and 200 rpm. Cytotoxicity of the extract was tested using NIH/3T3 mouse embryo fibroblast as a model cell. Growth inhibition was not observed in the extracts of HA membranes with the mole ratios of lactide to HA, 5 or 10, and 10% EDC concentration, however 11% of growth inhibition was observed in the extract with the mole ratio of 13. Growth inhibition was not observed in the extracts of HA membranes prepared with 5% EDC or 10% EDC and the mole ratio of lactide to HA, 10, however 12% of growth inhibition was observed in the extract with 20% EDC. Cytotoxicity was not observed in the extracts of HA membranes prepared at varying crosslinking temperatures, $15^{\circ}C,\;25^{\circ}C,\;and\;28^{\circ}C$ with the mole ratio of lactide to HA, 10 and 10% EDC.

A STUDY OF THE EFFECTS OF THE LOW POWER DENSITY LASER ON THE MECHANICALLY EXPOSED PULP (저출력 레이저가 기계적 노출치수에 미치는 영향에 관한 연구)

  • Park, Dong-Sung;Lim, Sung-Sam
    • Restorative Dentistry and Endodontics
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    • v.14 no.1
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    • pp.109-118
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    • 1989
  • The purpose of this study was to investigate the bio-stimulating effect of low power density laser radiation on the mechanically exposed pulp. Class V cavities on dog's teeth were prepared and the pulps were mechanically exposed with a round bur. In control group, the exposed pulps were capped with $Ca(OH)_2$ powder and the cavities were sealed with Z.O.E.. In experimental group A, the pulps were irradiated with GaA1As laser for 5 minutes and then they were treated the same as control group. In experimental group B, the exposed pulps were covered by aluminum foil and sealed with Z.O.E. after they were irradiated with the laser as the experimental group A. In the all groups, the pulps were histopathologically observed at the time intervals of 1, 2 and 3 week after experiment and the results were statistically evaluated. The results were as follows: 1) In control and experimental groups, mild vascular congestion and bleeding was found in most of the specimens and for the new formation of dentin bridge, experimental group A had the most cases. The dentin bridge had discontinuous osteodentin like appearance without any dentinal tubules. Inflammatory cell infiltration consisted of acute and chronic inflammatory cell, and the formation of microabscess was also observed. 2) The degree of inflammatory cell infiltration was not significantly different among control group and experimental groups at 1 week, 2 week and 3 week. 3) The formation of new dentin bridge was not significantly different between control group and experimental group A at 1 week, but at 2 week and 3 week, experimental group A showed significantly more cases of new dentin formation than control groups. (P < 0.05). 4) Between control group and experimental group B, there was no significant difference in formation of the new dentin bridge at 1, 2 and 3 week. (P> 0.05). 5) There was no significant difference in formation of the new dentin bridge at 1 and 2 week between experimental group A and experimental group B, but at 3 week, the former significantly had more cases of new dentin bridge formation than the latter.(P < 0.05).

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A Valuation for Gas Hydrate R&D Project Using Fuzzy Real Options Model (퍼지실물옵션모형을 이용한 가스하이드레이트 R&D 사업의 가치평가)

  • Yun, Ga-Hye;Heo, Eunnyeong
    • Environmental and Resource Economics Review
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    • v.18 no.2
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    • pp.217-239
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    • 2009
  • As gas hydrate is recently emerging as a new energy source to solve environmental and exhaustion problems caused by fossil energy, Korea is working on a gas hydrate development project under a 10-year plan from 2005 to 2014. Gas hydrate is expected to have a big effect on the economy and society of Korea, which is largely depending on energy imports besides water energy and atomic energy. However, it is uncertain whether the project will produce successful results. Thus, it is very important to improve its validity and to propose effective execution strategies by evaluating the value of the project in advance. Thus, this study intended to include new information, which had not been evaluated in existing methods, and to reduce biases or errors in value evaluation results by applying a fuzzy risk analysis to the real option model in order to evaluate the value of a gas hydrate development project. It is advantageous that the real option model based on the fuzzy risk analysis modelizes the vagueness and inexactness of intangible element judgment into an appropriate language scale so as to evaluate these elements clearly and integrate them with estimated financial performance results. The application of the fuzzy risk analysis makes it possible to conduct an analysis by dissolving a decision-making issue with complicated and various attributes into several simplified problems. With the continuing high oil prices and today's demand of clean energy, the necessity of energy resources and technology development projects keeps growing. Amid this situation, it is expected that these study results will contribute to proposing a guideline not only for gas hydrate projects but also for policy decision-making related to future energy industries.

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