• 한국작물학회:학술대회논문집
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• 한국작물학회 2019년도 추계학술대회
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• pp.22-22
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• 2019

Green stem disorder (GSD) of soybean (Glycine max (L.) Merr.) is characterized by delayed senescence of stems with normal pod ripening and seed maturation (Hobbs, 2006). GSD complicates harvesting of soybeans by significantly increasing the difficulty in cutting the affected plants. There is also the potential for moisture in the stems to be scattered on the seed, reducing the grade and storability of the seed. Not only the cause of GSD is yet unknown, but also GSD cannot be evaluated until maturity, therefore the method to evaluate GSD in early growth stage with high sensitivity is necessary. In previous studies, it has been reported that vegetative storage protein (VSP) accumulates and the syndrome of GSD appears in soybean after depod treatment (Fischer, 1999). Soybean VSP is a storage protein which is abundant in young sink leaves and degraded during seed fill (Wittenbach, 1982). Hence, we have established a system to quantify VSP of high sensitivity by using standard protein made by genetically transformed E. coli and specific antibody against VSP, and studied the relationship between VSP and GSD, by depod experiment and drought/excess wet experiments. The result of depod experiment with the cultivar 'Yukihomare' was the same with the previous studies, VSP accumulated much more than control and the syndrome of GSD appeared in soybean in depod treatment. Drought and excess wet had different impact on GSD. Excess wet caused GSD of the cultivar 'Tachinagaha (GSD susceptible)', while drought caused a little syndrome of GSD in the cultivar 'Touhoku 129 (GSD resistant)'. The accumulation of VSP differed between the two cultivars over time. In conclusion, the accumulation of VSP came along with the emergence of GSD. Different cultivars showed different response to drought and excess wet. In the future, it is expected that the dynamics of VSP will be elucidated in detail, leading to the development of early diagnosis technology for green stem disorder and the elucidation of mechanism of soybean GSD.

• 대한본초학회지
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• 제29권6호
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• pp.55-62
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• 2014

Objectives : The objective of this study is to determine the best numbers of steaming-drying cycles of Gastrodiae Rhizoma for both efficacy and taste. We investigated various characteristics among Gastrodiae Rhizoma samples (GSD1, GSD3, GSD5 and GSD7) through the number of steaming-drying cycles increased. Methods : Gastrodiae Rhizoma were steamed and dried at different repeated numbers. They were divided into samples (GSD1; steamed and dried once, GSD3; steamed and dried three times, GSD5; steamed and dried five times, GSD7; steamed and dried seven times) for experiment. They were extracted using water, freeze dried and powdered to analyze proximate composition, free sugar amount, functional components, antioxidant activity and sensory evaluation. Results : Proximate composition and the amount of free sugars of Gastrodiae Rhizoma did not have meaningful differences among samples. Phenolic and flavonoid content of samples were increased by increasing steaming-drying numbers. Gastrodin content had different values and GSD7 was the highest in comparison with others. Increasing steaming-drying numbers led to a increasing in radical and nitrate scavenging activity in samples. Regarding to sensory evaluation, GSD5 was selected as the best sample according to its highest hedonic score mean (5.54/7) among all samples for appearance, color, taste and overall acceptability. Conclusions : The results indicated that 5th-cycling sample was effective in views of functional components, antioxidant activity and sensory characteristics. Moreover, it was suggested that steaming-drying process improved remarkably the effects of Gastrodiae Rhizoma.

• 인터넷정보학회논문지
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• 제8권5호
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• pp.45-58
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• 2007

본 논문에서는 그리드 미들웨어인 글로버스 툴킷 4 상에서 그리드 서비스 개발자들이 효율적으로 서비스를 개발할 수 있는 사용자 인터페이스(UI4GSD, User Interface for Grid Service Development)를 제시하고자 한다. 일반적으로 그리드 서비스를 개발하기 위해서는 개발에 필요한 전문 지식이 요구되며, 서비스 개발 및 개발된 서비스를 글로버스 컨테이너에 배치하고 테스트하기 위해서는 많은 시간이 필요하기 때문에 서비스 개발의 효율성이 매우 떨어진다. 그러나 UI4GSD는 GUI를 통해 개발자로부터 서비스 개발에 필요한 정보를 입력 받아 처리함으로써 그리드 서비스 개발에 필요한 서비스 인터페이스 파일, 빌드 파일, 서비스 클래스들과 클라이언트 클래스를 자동으로 생성한다. UI4GSD에서는 정형화된 5단계의 개발 프로세스에 따라 그리드 서비스 개발이 이루어지고, 단계별로 입력된 데이터를 기반으로 쉽게 서비스를 개발할 수 있다. 결과적으로 UI4GSD는 그리드 서비스 개발을 위한 쉽고 편리한 작업 환경을 제공함으로써 서비스 개발의 편리성과 효율성을 증가시킬 수 있다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제4권2호
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• pp.213-217
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• 2001

목적: 당원병 Ia형(von Gierke disease)은 glucose 6-phosphatase (G6Pase)의 결함으로 인하여 출생 시부터 복부팽만과 간종대가 나타나고 저혈당, 락트 산혈증(lactic acidemia), 고지방혈증(hyperlipidemia), 고뇨산혈증(hyperuricemia) 등을 초래하며 점차 성장발육부전이 진행되는 상염색체 열성 유전성 질환이다. 본 연구에서는 한국인 GSD Ia 환자 9명을 대상으로 G6Pase 유전자의 돌연변이형에 관한 분석을 처음으로 시행하고자 하였다. 방법: 임상적인 증상과 G6Pase 효소 측정결과를 통하여 GSD Ia로 진단된 9명 환자의 혈액에서 genomic DNA를 분리하여 G6Pase 유전자의 5개 exon 부분이 포함되도록 polymerase chain reaction(PCR) 한 후 PCR 산물을 direct sequencing 하였다. 결과: 9명의 GSD Ia 환자 중 7명 환자에서 g727t homozygote 돌연변이를 발견하였고, 한 환자는 heterozygote로서 g727t 돌연변이와 c611g 돌연변이가 발견되었다. 나머지 한 명에서는 g727t 돌연변이 하나만 발견할 수 있었다. 한 개의 allele에서 발견된 c611g 돌연변이는 exon 4의 178번 아미노산 proline이 alanine으로 변경되는 것으로 지금까지 보고된 바 없는 새로운 돌연변이이다. 결론: 현재까지는 GSD Ia병의 정확한 진단을 위해서 환자의 간 생검 조직에서 G6Pase 효소의 활성도를 측정하는 것이 필요하였으나 한국인 GSD Ia 환자의 경우 g727t 돌연변이가 대부분을 차지하고 있기 때문에 앞으로는 상당수의 환자에서 혈액 채취만으로도 G6Pase 유전자 분석을 통한 GSD 진단이 손쉽게 이루어질 수 있으리라고 생각된다.

• Soft Computing and Machine Intelligence
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• 제1권1호
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• pp.36-52
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• 2021

Software development organizations are globalizing their development activities increasingly due to strategic and economic gains. Global software development (GSD) is an intricate concept, and various challenges are associated with it, specifically related to the software requirement change management Process (RCM). This research aims to identify humans' related success factors (HSFs) and human-related challenges (HCHs) that could influence the RCM process in GSD organizations and propose a theoretical framework of the identified factors concerning RCM process implementation. The Systematic Literature Review (SLR) method was adopted to investigate the HSFs and HCHs. Using the SLR approach, a total of 10 SFs and 10 CHs were identified. The study also reported the critical success factors (HCSFs) and critical challenges (HCCHs) for RCM process implementation following the factors having a frequency 50% as critical. Our results reveal that five out of ten HSFs and 4 out of ten HCHs are critical for RCM process implementation in GSD. Finally, we have developed a theoretical framework based on the identified factors that indicated a relationship among the identified factors and the implementation of the RCM process in the context of GSD. We believe that the results of this research can help tackle the complications associated with the RCM in GSD environment, which is vigorous to the success and progression of GSD organizations.

• 생명과학회지
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• 제30권8호
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• pp.672-679
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• 2020

원위 근병증은 원위 근육의 퇴행성 질환이며 임상적, 유전적으로 이질적인 그룹이다. 당원 축적병 9D (GSD9D)는 원위 근병증 중 하나이며, 근육의 포스포릴라아제키나아제(phosphorylase kinase) 결핍을 특징으로 하는 대사 근병증이다. GSD9D 환자는 운동 후 근육 약화, 근육 변성, 경련과 비정상적인 근육통 및 근육 경직이 발생될 수 있다. GSD9D는 글리코겐 대사의 주요 조절 효소 인 근육 포스포릴라아제키나아제의 알파 소단위를 암호화하는 PHKA1 유전자의 돌연변이로 유발된다. 이 연구에서 우리는 한국인 GSD9D 가족에 대해 PHKA1 유전자에서 c.3314T> C (p.I1105T) 돌연변이를 동정하였다. 이 돌연변이는 이전에 어떠한 돌연변이 데이터베이스에서도 보고되지 않았으며 500명의 건강한 대조군에서도 발견되지 않았다. 이 돌연변이 영역은 다양한 다른 종 내에서 잘 보존되었으며 in silico 분석에서 돌연변이가 병원성일 가능성이 있다고 예측했다. 현재까지 PHKA1 유전자에는 보고된 병원성 돌연변이가 7개뿐이며 한국에서는 보고된 사례가 없다. 따라서 이 연구는 한국 GSD9D 환자의 첫번째 사례이다. 또한 이 연구는 이전에 보고된 환자와 한국 환자의 임상 증상과 병리 상태를 비교하고 설명하고자 하였다. 아울러 우리는 본 연구가 GSD9D의 분자 진단에 유용하게 활용될 것으로 기대한다.

• 대한공간정보학회지
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• 제18권1호
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• pp.135-143
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• 2010

국가기본도는 국가공간정보의 기준이 되는 공간정보로서 그 가치와 역할이 매우 중요하다. 그러나 현행 국가기본도인 1/5,000 수치지도는 품질 및 정확도의 한계로 인하여 기초 공간정보로서의 역할을 충분히 수행하지 못하고 있는 실정으로 이에 대한 보완 방안이 필요한 시기이다. 이에 본 연구에서는 현 1/5,000 국가기본도의 고도화 방안을 제시하고자 GSD 0.25m 디지털 항공사진으로 제작 가능한 수치지도 지형 지물 항목을 선정하고, GSD 0.25m 디지털 항공사진을 이용한 최적 수치지도 제작 실험을 통해 수치지도 제작 최적 방법을 정립하였다. 또한 GSD 0.25m 디지털 항공사진으로 제작된 수치지도의 정확도 및 활용성 분석을 수행하였다. GSD 0.25m 디지털 항공사진을 이용한 수치지도 제작 기준을 정립하기 위하여 판독력 분석을 수행하여 대분류 9 개, 중분류 31개, 소분류 509개의 지형 지물 항목을 선정하였으며, 수치지도 제작 방법에 따른 수치지도 제작 실험을 수행하여 입체도화 방법을 수치지도 제작 최적 방법으로 선정하고, 최적 공정을 정립하였다. 본 연구 성과를 이용하여 GSD 0.25m 디지털 항공사진을 이용한 수치지도 시범 제작을 수행한 결과 기존 1/5,000 수치지도에 비해 약 2배의 수평 및 수직위치 정확도를 확보할 수 있었으며, 지형 지물의 상세한 묘사가 가능하여, GSD 0.25m 디지털 항공사진을 이용하여 국가기본도를 제작할 경우 신뢰성 있는 공간정보를 제공으로 대국민 서비스 만족도 향상과 국가기본도 고도화를 추진할 수 있을 것으로 판단된다.

• 한국실내디자인학회논문집
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• 제13권2호
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• pp.192-199
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• 2004

This study is to understand the emotional tendency through out the history of architecture and interior design. In this process, a broad range of analysis of the period between Romanticism and Post Modernism will be done to collect historical data and the influence of the social situation. A thorough review and close examination of the 90's architectural trend will reveal the foundation of the concept behind GSD not just as the post-structuralism as a value system of digitalism but also makes easy to understand GSD in space design. In particular, the study will reveal how the ideas of post-structural philosophy has effected the formation of its movement as well as its influence to become the theoretical nutrition for digital architecture. The result of the study will be used as the valuable reference to define 'Emotional Design'(So call 'Gam-Sung Design = GSD) and become the foundation for further investigation on GSD space design in the near future.

• Molecules and Cells
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• 제28권3호
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• pp.139-148
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• 2009

Cell death has been traditionally classified in apoptosis and necrosis. Apoptosis, known as programmed cell death, is an active form of cell death mechanism that is tightly regulated by multiple cellular signaling pathways and requires ATP for its appropriate process. Apoptotic death plays essential roles for successful development and maintenance of normal cellular homeostasis in mammalian. In contrast to apoptosis, necrosis is classically considered as a passive cell death process that occurs rather by accident in disastrous conditions, is not required for energy and eventually induces inflammation. Regardless of different characteristics between apoptosis and necrosis, it has been well defined that both are responsible for a wide range of human diseases. Glycogen storage disease type I (GSD-I) is a kind of human genetic disorders and is caused by the deficiency of a microsomal protein, glucose-6-phosphatase-${\alpha}$ ($G6Pase-{\alpha}$) or glucose-6-phosphate transporter (G6PT) responsible for glucose homeostasis, leading to GSD-Ia or GSD-Ib, respectively. This review summarizes cell deaths in GSD-I and mostly focuses on current knowledge of the neutrophil apoptosis in GSD-Ib based upon ER stress and redox signaling.

• 한국산업보건학회지
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• 제6권1호
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• pp.67-76
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• 1996

This study was performed to estimate total dust concentrations and particle size distribution of wood dust in the furniture and sawmill industries. To compare total wood dust concentrations, two samplers recommended by the American Conference of Governmental Industrial Hygienists and by the National Institute for Occupational Safety and Health were used. Concentration data were analyzed by paired-t tests using the SAS program and two parameters of the particle size distributions were determined by histogram. The results were as follows: 1. Particle size distributions showed a unimodal pattern in cutting and a bimodal in sanding operations. Mass median aerodynamic diameters(MMAD) were $17.35{\mu}m$ in cutting, and $1.39{\mu}m$ for small mode and $18.89{\mu}m$ for large mode in sanding operations. The proportions of particle size larger than $9.8{\mu}m$ estimated by the impactor were 61.16 % in cutting and 62.33 % in sanding operations, respectively. 2. The average personal total dust concentrations measured by IPM sampler were $17.12mg/m^3$ (GSD=1.45) from indoor samples, $2.97mg/m^3$(GSD=1.90) from outdoor samples in cutting, and $8.01mg/m^3$(GSD=1.58) from sanding operation. And those of by 37 mm closed-face cassette were $9.12mg/m^3$(GSD=1.46), $1.06mg/m^3$(GSD=1.99) from cutting, and $3.32mg/m^3$(GSD=2.16) from sanding operations. 3. The average area total dust concentrations measured by IPM sampler were $1.88mg/m^3$(GSD=2.04) from indoor cutting, $4.76mg/m^3$(GSD=2.83) from indoor sanding operations. And those of by 37mm closed-face cassette were $0.49mg/m^3$(GSD=2.34) from cutting, and $1.32mg/m^3$(GSD=3.03) from sanding operations. 4. The ratio of personal total dust concentrations measured by 37 mm closed-face cassette to those by IPM sampler were 35.7 %, 53.3 % from cutting, and 41.4 % from sanding operations. 5. The ratio of area total dust concentrations measured by 37 mm closed-face cassette to those by IPM sampler were 26.1 % from cutting, and 27.7 % from sanding operations. 6. A statistically significant difference of total dust concentrations between the 37 mm closed-face cassette and the IPM sampler was found.