• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.3
• /
• pp.1083-1088
• /
• 2016

Background: Cervical cancer is the second commonest cancer among Indian women and its association with human papilloma virus (HPV) is well established. This preventable cancer accounts for the maximum number of cancer related deaths among rural Indian women. Unlike in developed countries there are no organized cervical cancer screening programmes in India due to lack of resources and manpower. Objective: To detect genital HPV infection using urine samples among asymptomatic rural women in the age group of 18-65 years. Materials and Methods: The study area chosen was Perdoor village in Udupi Taluk, Karnataka State and all the women in the age group of 18-65 years formed the study cohort. A cross sectional study was conducted by house visits and 1,305 women were enrolled in the study. After taking written informed consent a data sheet was filled and early stream random urine samples were collected, transported to a laboratory at 4OC and aliquoted. Samples were tested using nested HPV PCR with PGMY09/11 and GP5+/6+ primers. Positive cases were genotyped by sequence analysis. Results: Study participants included 1,134 sexually active and 171 unmarried women with a mean age at marriage of 22.1 (SD=3.9) years. Study area showed high female literacy rate of 86.6%. Five urine samples tested positive for HPV DNA (0.4%). Conclusions: We found very low genital HPV infection rate among women from monogamous community. This is the first major population based study carried out among asymptomatic rural women to detect genital HPV infectio from Karnataka using urine samples.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.5 no.4
• /
• pp.75-85
• /
• 2002

The introduction of GPS technique in transportation study make real time tracking of driving vehicle's position possible. Position information data gauged with three dimension(X, Y, Z) can be achieved with time-continuity and from more than two driving vehicles. For this field of study, in past day, there were many difficulties in collecting real time data, but now, it becomes easy thanks to this. But for the resonable result analysis, fully understanding of GPS data-accuracy must be proceeded. Because accompanied magnitude of error depends on the study's accuracy. For this reason, this study surveyed the GPS data's error and suggest calibrate technique. This study's result will be helpful for following studies using DGPS data. For this, this study takes two types study in road, and set triangulation coordinates, and compare it with GPS data. DGPS data contains less than 0.6m's error.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.7
• /
• pp.3021-3027
• /
• 2014

Background: The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. This meta-analysis was performed to estimate the association between the MDR1 C3435T polymorphism and the risk of gastric cancer (GC) and peptic ulcer (PU). Materials and Methods: A literature search was conducted with PubMed, Embase and the Cochrane library up to November 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Data were analyzed using Review Manager (Version 5.2), and Stata package (version 12.0) for estimation of publication bias. Results: Six case-control studies were included, of which five were for GC and two for PU. Overall, no evidence was found for any association between the MDR1 C3435T polymorphism and the susceptibility to GC and PU. In the stratified analysis by H. pylori infection status, stage and histology classification of GC, and PU type, there was still no significant association between them. Conclusions: This meta-analysis suggested that the MDR1 C3435T polymorphism is not associated with susceptibility to GC and PU. Large and well-designed studies are warranted to validate our findings.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.8
• /
• pp.3447-3450
• /
• 2014

Objective: To observe the clinical efficacy of bevacizumab concomitant with pemetrexed in patients with advanced non-small cell lung cancer (NSCLC). Materials and Methods: A total of 72 patients were randomly divided into a combination group (pemetrexed+bevacizumab, n=36) and a pemetrexed group (n=36) and assessed for disease control (CR+PR+SD) after 4-cycles of first-line GP chemotherapy (gemcitabine+cisplatin). Clinical efficacy, progression-free survival time (PFS), overall survival time (OS), overall response rate (ORR), disease control rate (DCR) and rate of adverse responses between two groups were observed and compared. Results: ORR and DCR were 27.8% and 83.4% in combination group, and 16.7% and 69.5% in the pemetrexed group, respectively, but there were no significant differences (P>0.05). PFS in combination group and pemetrexed group were 4.6 months and 3.9 months respectively (P=0.09), whereas OS in the combination group was 14 months, evidently higher than in the pemetrexed group (11 months, P=0.004). Adverse responses in both groups included high blood pressure, bleeding, thrombocytopenia, anemia, elevated transaminase, diarrhea, vomiting and proteinuria, but there were no significant differences (P>0.05). Conclusions: Bevacizumab concomitant with pemetrexed has better clinical efficacy and safety, giving rise to prolonged survival time in patients with advanced NSCLC.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.4
• /
• pp.2083-2087
• /
• 2016

A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer.

• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.4
• /
• pp.670-677
• /
• 2020

Objective: Interleukin-6 (IL-6) is a T cell-derived B cell stimulating factor which plays an important role in inflammatory diseases. In this study, the pharmacokinetic properties of LMT-28 including physicochemical property, in vitro liver microsomal stability and an in vivo pharmacokinetic study using BALB/c mice were characterized. Methods: LMT-28 has been synthesized and is being developed as a novel therapeutic IL-6 inhibitor. The physicochemical properties and in vitro pharmacokinetic profiles such as liver microsomal stability and Madin-Darby canine kidney (MDCK) cell permeability assay were examined. For in vivo pharmacokinetic studies, pharmacokinetic parameters using BALB/c mice were calculated. Results: The logarithm of the partition coefficient value (LogP; 3.65) and the apparent permeability coefficient values (P_app; 9.7×10^-6 cm/s) showed that LMT-28 possesses a moderate-high cell permeability property across MDCK cell monolayers. The plasma protein binding rate of LMT-28 was 92.4% and mostly bound to serum albumin. The metabolic half-life (t_1/2) values of LMT-28 were 15.3 min for rat and 21.9 min for human at the concentration 1 μM. The area under the plasma drug concentration-time curve and C_max after oral administration (5 mg/kg) of LMT-28 were 302±209 h·ng/mL and 137±100 ng/mL, respectively. Conclusion: These data suggest that LMT-28 may have good physicochemical and pharmacokinetic properties and may be a novel oral drug candidate as the first synthetic IL-6 inhibitor to ameliorate mammalian inflammation.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2011.05a
• /
• pp.84-84
• /
• 2011

저수지에서 수체의 거동정보는 저수지관리를 위해 매우 중요하며, 이를 수리 및 수질모형에 적용하여 다양한 예측에 활용할 수 있는 기본적인 정보이다. 그러나 저수지 수체의 흐름은 매우 느리고 조사시기에 따라 혹은 수심에 따라 영향을 받으며, 바람 등 외부요인에도 영향을 받게 됨으로 정확한 측정에 많은 어려운 문제가 있다. 따라서 보다 정확한 측정을 위해서는 최신의 기술이 적용되어야 한다. 현장조사에 적용한 저수지 수체거동조사장비(drifter)는 수체의 유동을 관측하는 장치로 GPS 및 Drogue를 장착한 장치가 저수지 수체의 흐름에 따라 이동하면서 위치정보를 무선통신으로 실시간 전송할 수 있도록 만들어진 장치이다. 수체흐름 측정장치는 크게 수체거동정보 생산부이 시스템과 수집서버 및 데이터베이스 서버로 구성되어 있다. 현장 조사시에는 부이에 장착되어 있는 GPS를 통해 현재의 위치가 매번 정해진 시간 간격마다 본체 내부의 메모리에 저장되며, 측정자가 설정한 시간간격으로 위치정보를 수신국으로 전송하도록 구성되어 있다. 수체이동부이의 데이터 수신은 CDMA를 통해 송신된 메일 데이터를 자체적으로 수집하여 데이터형태로 변환한 뒤 실시간으로 표출하고 저장되며, 최대 10개의 부이를 동시에 추적 및 모니터링할 수 있게 구성되어 있다. 본 연구는 용담댐저수지에서 평갈수기 및 풍수기로 구분하여 수체거동을 조사하였다. 평갈수기 조사는 2010년 4월부터 6월까지 총 3차례에 걸쳐 실시하였으며, 풍수기 조사는 8월에 3차례에 걸쳐 실시하였다. 수집된 자료에 의하면 평갈수기 drifter의 평균 속도는 2.25 cm/sec, 최고 속도는 3.46 cm/sec, 최저 속도는 1.15 cm/sec로 나타났으며, 풍수기 조사에서는 평균 속도 2.0 cm/sec, 최고 속도는 2.5 cm/sec, 최저 속도는 1.29 cm/sec로 조사되어 평갈수기와 풍수기간 저수지 수체의 이동속도는 유사한 것으로 평가되었다. 그러나 수기별 조사는 보다 더 많은 정보가 필요하며, 수심에 따른 차이도 있을 것으로 판단되어 좀더 다양한 조사가 수행되어야 보다 정확한 결과를 도출할수 있을 것으로 판단된다.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.35 no.11A
• /
• pp.1078-1084
• /
• 2010

The tracking performance of a big parabola tracking antenna system for tracking and receiving of the signal from the vehicle is impacted by many factors of the internal and the external of the system. In this paper, we analyze the tracking error due to the radio refraction in the application of the tracking and positioning of the vehicle by using radio frequency. The real measurement data are used for the analysis which had been acquired by using GPS and the tracking systems of C- and S-band frequencies in NARO Space centre. To verify the correlation between the tracking errors measured and the radio refraction, we review the error factors and the accuracies of the tracking systems, and the characteristics of the refractivity. The analysis shows that there are angular errors which are due to the radio refraction and not to be neglected, compared to the accuracies of the tracking systems, in case of low elevation angle less than 10 degrees. Also, the tracking errors depend on the target altitude as well as the elevation angle for the case of the target in the troposphere. It is recommended to correct the tracking angle considering the target altitude and elevation angle for the precise target positioning.

• Smart Media Journal
• /
• v.5 no.4
• /
• pp.90-95
• /
• 2016

Recently, the quality of cultural experience can be improved through a stereoscopic information service provided by the latest mobile-based Information Telecommunication technology without the human cultural commentators, which was used in order to enhance the understanding of our cultural heritage. The purpose of this paper is to produce contents that introduce cultural heritage using the Android-based GPS and augmented reality. In this paper we propose a culture content creation method that is based on location information such as user/cultural anomalies using GPS and augmented reality based on Markerless Tracking. Marker Detection Technology and Markerless Tracking Technology are used for smart phone's rapid recognition of augmented real world and accurate recognition according to the state of the cultural heritage. Also, the Google Map of Android is used to locate the user. The strength of this method lies in that it can be used for a variety of subjects while the existing methods are limited to certain kinds of augmented reality contents.

• Journal of Korean Society for Geospatial Information Science
• /
• v.4 no.2 s.8
• /
• pp.15-22
• /
• 1996

As the exact geographical information has been nowadays required for effective developing and using of national land, in the country, there has been interested in using of GPS, and its practical use is expected. Various kinds of fundamental research for practical use of GPS is being accomplished. In this study, a test was carried out over 9 stations with baseline of the range of 1.5 to 210km, and the accuracy of baseline length by GPS relative positioning was variously considered. As result of this study, using a GPS receiving L1 frequency only, baseline accuracy for 2 hour observation was of the order of 0.3ppm for the 10km, and for I hour was below 1ppm. Using a GPS receiving dual frequency(L1/L2), baseline accuracy was of the order of 0.3ppm for the 100km to 200km as 3 hour observation using double difference methods by carrier phase. With basic on the result of this study, when observation and baseline processing are proceeded by the selected optimum observation time and using of baseline processing method, we can expect that geographical information will be acquired effectively.