• The Journal of Natural Sciences
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• v.8 no.2
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• pp.35-41
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• 1996

To find the substrate interacting site of the MCAT1, charged amino acid residues in the transmembrane domain were changed to opposite charged amino acids and studied the arginine uptake, gp70 binding, efflux and protein expression using the Xenopus oocyte expression method. Among the five mutants of MCAT1, the D403K showed the most interesting characteristics, which had normal gp70 binding but low arginine uptake function, that means the normal expression on the membrane but decreased transport function. All mutants except K211E showed decreased arginine efflux, and kinetic study showed decreased Vmax. Together, Clu(403) residue of MCAT1 may show the possible substrate interacting site in the transmembrane domain of MCAT1.

• Journal of the Korean Institute of Intelligent Systems
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• v.20 no.6
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• pp.780-785
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• 2010

This paper introduces GP(Genetic Programming) based color detection model for an object detection and tracking. Existing color detection methods have used linear/nonlinear transformatin of RGB color-model and improved color model for illumination variation by optimization or learning techniques. However, most of cases have difficulties to classify various of colors because of interference of among color channels and are not robust for illumination variation. To solve these problems, we propose illumination robust and non-parametric multi-colors detection model using evolution of GP. The proposed method is compared to the existing color-models for various colors and images with different lighting conditions.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.3
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• pp.146-152
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• 2009

Traditional surgical method or injection using filler is performed for soft tissue augmentation. Surgical methods have disadvantage of surgical morbidity. Commercially available injectable materials have the disadvantages such as resorption, short-term effect. repeated application and hypersensitivity. Significant shortcoming of cell therapy using autologous fibroblasts is delay of treatment effect. Chitosan/${\beta}$-glycerol phosphate (GP) solution has thermosensitive property and allows sol-gel transition at physiologic pH and temperature. These properties may resolve the delay of treatment effect. The purposes of this study are to evaluate the viscosity and pH changes of chitosan/${\beta}$-GP solutions and to evaluate the effect of chitosan/${\beta}$-GP solution on fibroblast proliferation and production of collagen. We measured the viscosity and pH as function of temperature, of the solution containing 1:0.7, 1:0.75, 1:0.8 chitosan (1, 10, 100, 700 kDa) /${\beta}$-GP. Fibroblasts from ears of 5 rats were cultured in chitosan/${\beta}$-GP solutions for 3 weeks. Cell proliferation and collagen contents were measured every week with WST (water-soluble tetrazolium salt) assay and Collagen assay respectively. The Results are 1) Chitosan(100 kDa<)/${\beta}$-GP solution (1:0.75) showed sol-gel transition at physiologic pH and body temperature and injectable properties. It will enable to resolve the delay in treatment effect 2) Cell proliferation and total collagen contents of the control group were increased with time. However, these decreased after the 1st week in experimental group 3) Collagen contents in the experimental group are higher than that of control group. Chitosan/${\beta}$-GP solution may provide favorable conditions for cell function

• The KIPS Transactions:PartA
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• v.14A no.1 s.105
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• pp.1-14
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• 2007

MPICH-G2 is an MPI implementation to solve complex computational problems by utilizing geographically dispersed computing resources in grid environments. However, the computation nodes in MPICH-G2 are exposed to the external network due to the lack of supporting the private IP clusters, which raises the possibility of malicious security attacks. In order to address this problem, we propose MPICH-GP with a new relay scheme combining NAT(Network Address Translation) service and an user-level proxy. The proxy running on the front-end system of private IP clusters forwards the incoming connection requests to the systems inside the clusters. The outgoing connection requests out of the cluster are forwarded through the NAT service on the front-end system. Through the connection path between the pair of processes, the requested MPI jobs can be successfully executed in grid environments with various clusters including private IP clusters. By simulations, we show that the performance of MPICH-GP reaches over 80% of the performance of MPICH-G2, and over 95% in ease of using RANK management method.

• Journal of Advanced Navigation Technology
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• v.20 no.1
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• pp.29-36
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• 2016

Accuracy of GPS (global positioning system) deteriorates dramatically or positioning is impossible in urban area occasionally since high-rise buildings and elevated roads make the reception of navigation signal very difficult so that number of visible satellites decreases. In these cases, vertical error usually becomes much larger than the horizontal error due to the intrinsic geometry of GPS satellites. To obtain more accurate and reliable height information, this paper proposes a hybrid method that combines GPS and a low-cost barometric altimeter. In the proposed method, the sea-level pressure and the sea-surface temperature are applied to the output of the altimeter. Next, the difference between the ellipsoid and the geoid is compensated. Finally, a simple Kalman filter combines the compensated barometric altitude and the GPS height. By static and car experiments, performance of the proposed method is evaluated. By the experiment results, it can be seen that the proposed method improves the altitude accuracy considerably.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.176-183
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• 2019

Objective: In the current work, we investigated the cytotoxic and apoptotic effects of Thymoquinone (TQ), an active compound of Nigella sativa (N. sativa) and Cis-platinum, on normal renal epithelial (GP-293) and human renal adenocarcinoma cell lines (ACHN). Methods: GP-293 and ACHN cell lines were cultured in Dulbecco's modified Eagle's medium (DMEM) with 10% Fetal bovine serum (FBS) and 1% penicillin plus streptomycin antibiotic. The MTT assay was used for cellular viability assessment. Viability of cells was observed using inverted light microscope 24, 48 and 72 h after exposure of the cells to various concentrations of TQ (1, 2.5, 5, 10, 50 and $100{\mu}g/ml$) and Cis-platinum (0.5, 1, 1.5, 2, 3, 6 and $12.5{\mu}g/ml$). Moreover, apoptosis was analyzed with a flow-cytometry method. The untreated cells were considered as control group. Results: Morphological changes such as reduced cell number and increased intercellular distance and reduced cell viability in ACHN and GP-293cell lines were observed in both TQ and Cis- platinum groups; however, Cis-platinum had greater effect on ACHN cell line than GP-293 cell line. In addition, GP-293 cell line was more sensitive to TQ compared to ACHN cell line. Furthermore, TQ and Cis-platinum had apoptotic effects on both ACHN and GP-293 cell lines. Conclusion: Our findings demonstrated that TQ and Cis-platinum had cytotoxic and apoptotic effects on both cell lines, However, GP-293 cell line was more sensitive to TQ. Additionally, Cis-platinum was more effective on ACHN cell line than on GP-293 cell line.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.643-644
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• 2018

Recently indoor and outdoor location tracking systems are operated in different ways. The indoor positioning method uses WiFi and BLE beacon positioning, and the outdoor positioning uses GPS and PDR. In this paper, it is a device to measure position by using it. It is used to check whether it is indoors or outdoors when measuring based on a smart phone, A automatic conversion method is needed. When using GPS in the room, it is difficult to distinguish the floor or space. We propose a method to solve this problem.

• Restorative Dentistry and Endodontics
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• v.42 no.4
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• pp.264-272
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• 2017

Objectives: Literature has shown that micro-organisms contaminate gutta percha (GP) during storage and manipulation. Till date herbal extracts are not explored as an alternative medicament for pre-operative chairside disinfection of GP cones. The purpose of our study was to evaluate the antimicrobial activity and efficacy of lemon grass oil (LG), basil oil (BO), and obicure tea extract (OT) in disinfecting GP cones before obturation. Materials and Methods: Agar diffusion method was used to evaluate the antimicrobial efficacy of LG, BO, OT, and sodium hypochlorite (control) against common contaminants, namely, Enterococcus faecalis, Staphylococcus aureus, and Candida albicans. One hundred and twenty GP cones were contaminated and cut into 2. First half was placed in the broth and incubated; whereas the second was treated with herbal extracts for 1 minute and then incubated for 24 hours in the broth. Any inhibition in bacterial growth was noted with presence/absence of turbidity. Two-way analysis of variance and ${\chi}^2$ test were used to assess the effectiveness of herbal extracts to decontaminate GP. Results: LG showed the highest inhibition zones ($29.9{\pm}6.9mm$) for all tested organisms, followed by OT extract ($16.3{\pm}1.8mm$), sodium hypochlorite ($16.0{\pm}1.6mm$), and BO ($14.5{\pm}5.3mm$). Statistically significant difference was observed between LG and other herbal extracts (p < 0.05). Conclusions: All extracts proved to be potential rapid chairside disinfectants of GP cones with LG showing the highest antimicrobial activity.

• Journal of Korean Society of Transportation
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• v.18 no.5
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• pp.99-107
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• 2000

Path-based assignment(PBA) is valuable to dynamic traffic control and routing in integrated ITS framework. As one of widely studied PBA a1gorithms, Gradient Projection(GP) a1gorithm typically fields rapid convergence to a neighborhood of an optimal solution. But once it comes near a solution, it tends to slow down. To overcome this problem, we develop more efficient path-based assignment algorithm by combining Conjugate Gradient method with GP algorithm. It determines more accurate moving direction near a solution in order to gain a significant advantage in speed of convergence. Also this algorithm is applied to the Sioux-Falls network and verified its efficiency. Then we demonstrate that this type of method is very useful in improving speed of convergence in the case of user equilibrium problem.

• Journal of IKEEE
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• v.19 no.3
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• pp.455-459
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• 2015

This paper proposes a dispatch unit of GP-GPU with SIMT architecture to support the acceleration of general-purpose operation as well as graphics processing. If all the information of an operand used instructions issued from the warp scheduler is decoded, an unnecessary operand load occurs, resulting in register loads. To resolve this problem, this paper proposes a method that can reduce the operand load and the load on the resister by decoding only the information of the operand using a pre-decoding method. The operand information from the dispatch unit is passed to the operand selection unit with preventing register bank collisions. Thus the overall performance are improved. In the simulation test, the total clock cycles required by processing 10,000 arbitrary instructions issued from the wrap scheduler using ModelSim SE 10.0b are measured. It shows that the application of the dispatch unit equipped with the pre-decoding function proposed in this paper can make an improvement of about 12% in processing performance compared to the conventional method.