• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.3
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• pp.440-445
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• 1995

The antimutagenic effects of juices from green pepper(GP), red pepper leaf(RPL), red pepper(RP) and sweet pepper(SP) were examined by the Ames method using Salmonella typhimurium TA100. The juice supernatants of GP, RPL and RP showed antimutagenic activities against afltoxin B1(AFB1) in Salmonella typhimurium TA 100. The juice supermatants of GP and RPL also exhibited the inhibitory effects(p<0.05) to the mutagenicities induced by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and 4-nitro-quinoline-1-oxide(4-NQO). The juice of RP showed antimutagenic activities against indirect mutagen of AFB1, however, the activity was reduced at higher concentration(5.0%), furthermore, as the adding concentration of sample increased to 5.0%, it exhibited slight comutagenicith on direct mutagen of MNNG. Theantimutagenic activities of GP and RPL juices were reduced significantly after heating at 100℃ for 20min, supposing that the antimutagenic compound(s) in the juices were heat labile.

• YAKHAK HOEJI
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• v.55 no.4
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• pp.332-337
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• 2011

The purpose of this study was to investigate the effect of epigallocatechin gallate (EGCG) on the pharmacokinetics of nimodipine in rats. Pharmacokinetic parameters of nimodipine were determined in rats after oral and iv administration of nimodipine with or without EGCG and also the effect of EGCG on the cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) activity were evaluated. EGCG inhibited CYP3A4 and P-gp activity. EGCG significantly increased the area under the plasma concentration-time curve (AUC) and peak plasma concentration ($C_{max}$) of nimodipine. The absolute bioavailability (AB%) and relative bioavailability (RB%) of nimodipine by EGCG were increased by 16% and by 48%, respectively, compared to the control. In contrast, EGCG did not affect the intravenous pharmacokinetics of nimodipine. Based on these results, the increased bioavailability of nimodipine might be due to inhibition of CYP3A4 in the small intestine and/or in the liver and inhibition of P-gp in the small intestine by EGCG.

• Journal of Korean Academy of Nursing Administration
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• v.8 no.3
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• pp.381-392
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• 2002

Purpose : The purpose of this study was to examine the degrees of turnover intention among Korean staff nurses(N=175) and to identify discriminating factors of their turnover intention. Method : The data were driven from a larger study and staff nurses who had worked more than 1 year as nurses were included in the analyses. The original data were collected from May 1999 to March 2000. Descriptive and discriminant analyses were utilized. Results : 87% of the participants reported turnover intention. Nurses were grouped into three group(GP)s depending on the frequencies of turnover intention: Never GP(N=23), Sometimes GP(N=107), Frequent GP(N=43). With three GPs, two functions were produced and only function 1 was significant that significantly discriminated Never and Frequent GPs. Additional discriminant analysis with only Never and Frequent GPs produced function classified 93% of the participants correctly into two GPs. Sub-dimensions of work satisfaction were significant discriminating factors. Nurses who are satisfied with doctor and nurse relationship, pay, and hospital administration tend to report no intention in turnover. Conclusion : Based on the findings of this study, possible managemental intervention for increasing interpersonal skills and assertiveness of nurses, inviting medical residents in ward team meeting, increasing incentives or baseline adjustment of annual income for registered nurses were suggested.

• Journal of IKEEE
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• v.20 no.1
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• pp.75-81
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• 2016

This paper proposes a design of the tile based on graphic pipeline to improve the graphic application performance in SIMT based GP-GPU. The proposed Tile based on graphics pipeline avoids unnecessary graphic processing operation, and processes the rasterization step in parallel. The massive data processing in parallel through SIMT architecture improve the computational performance, thereby improving the 3D graphic pipeline performance. The more vertex data of 3D model, the higher performance. The proposed structure was confirmed to improve processing performance of up to 3 times from about 1.18 times as compared to 'RAMP' and previous studies.

• Biomolecules & Therapeutics
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• v.7 no.3
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• pp.216-220
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• 1999

A chemosensitivity assay with small replicate Mm5mt/cl C3H mammary tumor cell cultures was developed to determine whether changes in viral antigen expression and release into culture fluids could be utilized as an in vitro measure of modulating drug effect. The 52,000 MW viral envelope glycoprotein (gp52) of the mouse mammary tumor virus (MMTV) was measured in culture fluids of control and drug-treated cultures while cell density was simultaneously determined by cell staining and OD 664 nm determination. While extra-cellular gp52 levels and cell density progressively increased over 72 hours for control cultures, declines in both parameters provided dual measures of effect for combination [N(phophonacetyl-L-aspartic acid)+5-fluorouracil], combination 〔N(phophonacetyl-L-aspartic acid )+5-fluoro-5'-deoxyuridine〕and single component treatment of this combination. At each treated time point, thesecombinations begin to produce a greater decline in both cell density and gp52 levels as compared to single drug treatments. These results indicate that N(phopho-nacetyl-L-aspartic acid) in combination can enhance the effectiveness of single drug.

• Textile Coloration and Finishing
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• v.7 no.4
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• pp.45-53
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• 1995

Natural rubber(NR)-polyacrylamide(PAAm) graft copolymers(GP)(toluene soluble GP : TSGP, water dispersible GP : WDGP) have been synthesized as coupling agents by pre-emulsification methods based on "inverse emulsion graft polymerization" technique. The polymerization was carried out at $65^{\circ}C$ using Azobisisobytyro nitrile(AIBN) as an initiator in the inverse emulsion system formed by inxing NR toluene solution with inverse emulsion of awueous AAm solution emulsified with $Tween^{\#}$ 80 in toluene. The mechanism of inverse emulsion graft copolymerization was studied on AAm conversion, % grafting, grafting efficiency, NR conversion, production ratio of TSGP and amount of GP(sum of TSGP and WDGP). The reaction has been confirmed through use of optical microscope to proceed via adsorption of emulsifier colloid particles onto the stretched NR molecule. From the analysis of the effects of various polymerization conditions on the grafting, it has also been found that the present rection system can easily yield high(over 90%) grafting efficiency and AAm conversion and relatively high(over 80%) NR conversion.onversion.

• Communications for Statistical Applications and Methods
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• v.29 no.1
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• pp.65-83
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• 2022

Although various statistical methods have been developed to map time-dependent genetic factors, most identified genetic variants can explain only a small portion of the estimated genetic variation in longitudinal traits. Gene-gene and gene-time/environment interactions are known to be important putative sources of the missing heritability. However, mapping epistatic gene-gene interactions is extremely difficult due to the very large parameter spaces for models containing such interactions. In this paper, we develop a Gaussian process (GP) based nonparametric Bayesian variable selection method for longitudinal data. It maps multiple genetic markers without restricting to pairwise interactions. Rather than modeling each main and interaction term explicitly, the GP model measures the importance of each marker, regardless of whether it is mostly due to a main effect or some interaction effect(s), via an unspecified function. To improve the flexibility of the GP model, we propose a novel grid-based method for the within-subject dependence structure. The proposed method can accurately approximate complex covariance structures. The dimension of the covariance matrix depends only on the number of fixed grid points although each subject may have different numbers of measurements at different time points. The deviance information criterion (DIC) and the Bayesian predictive information criterion (BPIC) are proposed for selecting an optimal number of grid points. To efficiently draw posterior samples, we combine a hybrid Monte Carlo method with a partially collapsed Gibbs (PCG) sampler. We apply the proposed GP model to a mouse dataset on age-related body weight.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.1788-1791
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• 2010

위치 측정 기술의 발달로 인해 다양한 서비스들이 개발 되어 현대 사회에 제공되고 있다. 이러한 서비스들 중 GPS는 현재 우리 사회에 깊숙이 녹아 들어와 핸드폰, 내비게이션, 배송처리, 차량 위치 파악, 긴급구조서비스, 항공 및 선박 항법장치, DSLR 등 다양한 분야에서 활용되고 있다. GPS는 위성신호를 수신하여 위치를 파악하기 때문에 위성신호를 수신할 때 공간상의 제약이 있고, 매우 민감하게 방해요소에 의해 간섭을 받을 수 있다. 차량이 충돌위험 발생시 GPS가 방해요소로 인해 수신되지 않으면 충돌회피를 위한 시스템이 제대로 작동하지 못할 우려가 있다. 본 논문에서는 GPS가 수신율이 떨어지는 터널, 고가도로, 지하주차장과 같은 장소에서의 WLAN을 기반으로 한 위치측정 기술을 이용하여 차량의 충돌회피를 방지하기 위한 프로토콜을 제안한다.

• Advances in concrete construction
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• v.17 no.3
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• pp.167-177
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• 2024

Disposal of waste glass derived from bottle or packaging glass, flat glass, domestic glass is one of the major environmental defies. Moreover, the remnants of bricks resulting from the remnants of buildings are also considered an important factor in polluting the environment due to the difficulty of filling or getting rid it. The aim of this study is to valorize these wastes through chemical activation to be an environmentally friendly material. The Microstructure, compressive strength, setting time, drying shrinkage, water absorption of different pastes produced by clear glass (CG), green glass (GG) and brick waste (BP) activated were tested and recorded after curing for 3, 7, 28 and 365 days. Five samples of pastes were mixed in proportions represented by: 100% GP (GP), 100% GGP (GGP), 100% BP (BP), 90% GP + 10% BP (GPB) and 90% GGP + 10% BP (GGPB). Various parameters considered in this study include sodium hydroxide concentrations (10 mol/l); 0.4 as alkaline liquid to binder ratio; 2.5 as sodium silicate to sodium hydroxide ratio and cured at 60℃ for 24 hours. Experimental results revealed that the addition of 10% of BP resulted in an increased strength performance of geopolymer paste especially with GGPB compared to GGP in 365 days. In addition, the 10% amount of BP increases the absorption and shrinkage rate of geopolymer pastes (GPB and GGPB) by reducing the setting time. SEM results revealed that the addition of BP and GP resulted in a dense structure.

• Tunnel and Underground Space
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• v.19 no.1
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• pp.31-42
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• 2009

One set of hardware system of guide point method (GP method), modified from the multistage convergent photographing technique, was developed to interpret the geometrical characteristics of Joints photogrammetrically on rock slope. Before the field application of the hardware system, the level of errors and constraints that ran be acceptable in the field measurement has been severely investigated in the laboratory and the optimum photographing scheme was analyzed. The range of the most suitable convergence angle between two cameras was $25^{\circ}{\sim}150^{\circ}$ and the photographing distance was about 5.5 m when using a 2 M pixel digital camera. An extended analyzing technique, which was newly developed in this study, was applied to the field measurement to magnify the benefits of GP method. This technique can be applied when survey for the wide range of rock surface is necessary. The global coordinates of ground control points for the neighbor photographing area ran be introduced without any preparation from the previous photographed area using this technique. It could reduce phographing time in the field.