• 혜화의학회지
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• 제13권2호
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• pp.221-229
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• 2004

1.Purpose Stroke is the most frequent cause of mortality and morbidity rate in Korea with ischemic heart disease and cancer. Recent recurrence rate of stroke is high, but little attention had been given to the features of its' cause. The purpose of this studies is to examine the hematologic states in Korean normal adults through premature-examination of stroke(PES). 2.Method The study group consisted of 326 cases that they had no significant results by CT through premature examination of stroke(PES) in Cheonan oriental hospital of Daejeon university. We tested RBC, hemoglobin, hematocrit, WBC, PT, PTT, PLT, total protein, albumin, total bilirubin, direct bilirubin, GOT, GPT, $\gamma$-GTP, total cholesterol, triglyceride, HDL-C, glucose, BUN, creatinine, Na, K and evaluated by cross sectional study. 3.Result In the PES, there were many patients with low RBC(11%), shorten PT(26.7%), delayed PTT(19.3%), high TP, GPT, ${\gamma}$ -GTP(respective1y 16.9%, 14.4%, 13.5%), high cholesterol level and triglyceride level(respectively 18.7%, 28.2%). We didn't found significant cases in hemoglobin, hematocrit, WBC, PLT, albumin, total bilirubin, direct bilirubin, GOT, HDL-C, glucose, BUN, creatinine, Na, K. 4.Conclusion In this study, we demonstrated that short PT, high triglyceride level are special views in PES. Also prospective studies are needed continuously to search the preventing methods of the CVA.

• 인터넷정보학회논문지
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• 제21권1호
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• pp.179-190
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• 2020

유닉스 계열 시스템 환경에서 GOT 변조(GOT overwrite) 공격은 소프트웨어 권한 탈취를 위한 전통적인 제어흐름 탈취 기법 중 하나이다. 그 동안 GOT 변조를 방어하기 위한 몇 가지 기법들이 제안되었는데, 그 중 프로그램 로딩 단계에서 GOT 영역을 읽기전용 속성으로 메모리 배치하여 실행 시간에 GOT 변조를 원천적으로 차단하는 Full Relro(Relocation Read only) 기법이 가장 효과적인 방어기법으로 알려져 왔다. 하지만, Full Relro 기법은 로딩 시간의 지연을 가져와 시작 성능에 민감한 프로그램의 적용에는 제약이 있고, 라이브러리에 적용시 의존 라이브러리에 의한 연쇄적인 로딩 지연 문제 등으로 라이브러리에는 현재 적용되지 않고 있다. 또한, LLVM을 포함한 다수의 컴파일러들은 Full Relro 기법을 기본 적용하지 않아 실행환경의 프로그램은 GOT 공격에 여전히 취약하다. 이 논문에서는 현재 코드 재사용 공격 방어를 위해 가장 적합한 기법으로 인식되고 있는 CFI(Control Flow Integrity) 기법을 사용한 GOT 보호 장치를 제안한다. LLVM을 기반으로 본 기법을 구현하고 binutils-gdb 프로그램 그룹에 적용해 보안성, 성능, 호환성 등을 평가하였다. 본 CFI 기반 GOT 보호 장치는 우회하기 어렵고, 빠르며 기존 라이브러리 프로그램과도 호환되어 적용가능성이 높다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.755-758
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• 2016

본 논문에서는 바이너리 프로그램에서 함수가 호출될 시 바이너리 내에서 어떠한 방법으로 함수를 호출하는지 설명한다. 그리고 그 함수를 호출할시 필요한 요소들과 C언어 파일의 동적링크 컴파일 과정과 그 요소들을 이어주는 '링커'라는 개념을 설명하고, 정적링크와 동적링크를 차이점을 비교 분석한다. 또한 동적 링크를 활용하여 취약점을 공격하는 Return To Dynamic Linker에 대해 간략히 서술하며 테스트바이너리에 시험해본다.

• Journal of Acupuncture Research
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• 제18권3호
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• pp.94-104
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• 2001

Objective : The objective of tihs study is to study the effects of anti-cancer, anti-metastasis and effects of immune-response of aqua-acupuncture with Cuscutae Semen infusion solution. Methods : We observed, in-vitro, the cytotoxicity and the effect on the expression of MMP-9 gene, and in-vivo, change of body weight, surviving number, MST, ILS, changes in amount of WBC, RBC, PLT, GOT, GPT, creatinine, glucose and LDH, number of Pulmonary colony. Results : 1. The effect on expression of MMP-9 gene was decreased in all the sample groups in B16-F10 cell line, and was decreased in Lane 1, 2, 3 in HT1080 cell, compared with control group. 2. BALB/c mice which was transpianted S-180 cancer cell line were inhibited significantly in weight increase, in all the sample groups, compared with control group. 3. The sample groups injected in vein with B16-F10 cancer cell line in C57BL/6 mice did'nt show significant change in the number of WBC, RBC, PLT. 4. In immune experiment, all the sample groups showed having more relevancy to the effect on splenic cell proliferation than normal groups. 5. $IFN-{\gamma}$ and $TNF-{\alpha}$ in cytokine-gene were increased in all the sample groups than control group. 6. In flow cytometry of spienic cell, the numbers of CD4+ cell, CD8+ cell and CD19+ cell in sample groups were increased than in control group. Conclusion : Above the results showed that aqua-acupuncture of Cuscutae Semen infusion solution has effects of anti-cancer, anti-metastasis and immune response improvement.

• 사상체질의학회지
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• 제17권3호
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• pp.91-102
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• 2005

1. Objectives The purpose of this study is to find out effects of Hyeongbangpaedok-san(HBPDS) and Dokhwaljihwang(DHJH) against decline of physical function as aging. 2. Methods Administrating HBPDS and DHJH to 40-week-old Wistar rat for 10 weeks so, I researched weight change, weight change of internal organs, and hematological and serological changes. 3. Results & Conclusions 1. Both examining groups, which were taken HBPDS and DHJH, got more weight than control group. But that was regardless. 2. Both examining groups got more weight on internal organs than control group. But that was regardless, too. 3. Both examining groups decreased in amount of MDA in serum, as contrasted with control group. But it was regardless. 4. Both examining groups improved on hematological condition. WBC, RBC, Hgb, monocytes and eosinophil rates were decreasing and HCT and PLT were increasing. Especially monocytes(p<0.001) and eosinophil(p<0.05) rate of DHJH taken group was decreased remarkably. 5-1. Both examining groups show decline in each item of functional examination of liver, such as ALT, AST, T-bilirubin, T-protein, ALB, A/G. T-chol, TG, etc. HBPDS taken group showed meaningful decline in Albumin(p<0.01) and A/G(p<0.01) and DHJH taken group showed meaningful decline in T-bilirubin(p<0.01). 5-2. Both examining groups showed decline in items of functional examination of kidneys. Specially HBPDS taken group showed meaningful decline in CRN rate(p<0.05) and DHJH taken group showed meaningful decline in BUN rate(p<0.05). As those results, HBPDS and DHJH are effective against decline of physical function as aging.

• 생약학회지
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• 제29권4호
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• pp.283-292
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• 1998

The hemopoietic effects of deer blood (whole blood, blood cell, plasma, respectively) were examined using in vivo rat model. Experimental animals (Sprague-Dawley rat, male, 200 g) were divided into negative control group (injection of saline), positive control group (injection of Sipjeondaebotang) experimental groups (injection of whole blood, blood cell, plasma) and healthy control group. Cyclophosphamide(150mg/kg) was injected into experimental groups, negative and positive control group to induce bone marrow supression. After 8 days, freez dried deer blood (whole blood, blood cell, plasma respectively) and Sipjeondaebotang of 200 mg/kg in dose was administered orally into experimental groups and positive control group, once a day for 3 days (A group) and once a day for 12 days (B group) respectively. And then body weight and organ weight, biochemical profile (ALB, GOT, GPT, PRO, CRE), hematological values (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, PLT) and CBC differentiation (Neutro, Lymph, Mono, Reticulo) were carried out. Finally, platelets were specially increased in the plasma treated A group and reticulocytes were specially increased in the plasma treated B group.

• 사상체질의학회지
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• 제19권3호
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• pp.227-241
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• 2007

1. Objectives The purpose of this study is to investigate the anti-oxidative and immune regulatory effect of oral administration of Chungsimyeonja-tang decoction in aged rats. 2. Methods The rats in the normal group were 14 weeks old, and those in the control and Chungsimyeonja-tang groups were 40 weeks old. The rats in Chungsimyeonja-tang group were orally treated with chungsimyeonjatang decoction daily for 2 months. To observe the anti-oxidative effect and immune regulatory effect of Chungsimyeonja-tang, we performed blood chemistry analysis, histological analysis. 3. Results and Conclusions 1) The number of WBC in blood was significantly increased and the number of PLT in blood was significantly decreased by oral administration of Chungsimyeonja-tang decoction. 2) The levels of albumin, LDL cholesterol, ALP and GOT in serum were significantly decreased, and the level of glucose in serum was significantly increased by oral administration of Chungsimyeonja-tang decoction. 3) The concentrations of glutathione and catalase were significantly increased and the concentrations of NO and MDA were significantly decreased in the liver of early aged rats by oral administration of Chungsimyeonja-tang decoction. 4) The concentrations of SOD and catalase were significantly increased and the concentration of MDA was significantly decreased in the lung of aged rats by oral administration of Chungsimyeonja-tang decoction. 5) The levels of IL-4 and IL-6 were significantly decreased while the levels of IFN-${\gamma}$ were significantly increased in the spleen of early aged rats by oral administration of Chungsimyeonja-tang decoction.

• 대한수의학회지
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• 제47권2호
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• pp.233-239
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• 2007

This study was carried out to evaluate the effects of Dochetang for the treatment of chronic diarrhea in a 4 months-old-female Korean native calf. The calf was presented to the Wow Animal Clinic, Iksan with the history of chronic diarrhea for several weeks. The feces test did not reveal the presence of the parasites or microbes causing diarrhea in calf. The blood test was also negative to the virus that causes of diarrhea in calf. Adminstration of parenteral antibiotics resulted in improvement of the condition temporarily but diarrhea was recurred again after 2-3 weeks. Then the calf was treated with Dochetang administered orally once a day in an empty stomach for 15 days. Feces was significantly reduced in moisture on 7 days after initial treatment. On 9 days after initial treatment, the calf had normal appetite and defecation in physiological conditions. Blood samples were collected before administration and on 1, 2 and 3 weeks after initial administration of Dochetang for hematology and biochemistry. A significantly differences were observed in the white blood cell (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), albumin (ALB), glutamic pyrubic transaminase (GPT), inorganic phosphorus (IP) and magnesium (Mg), while no significant differences were seen in the red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), platelet (PLT), glucose (Glu), total protein (T-pro), glutamic oxaloacetic transaminase (GOT), blood urea nitrogen (BUN) and creatine (CRE). This study suggests that Dochetang administration can be a successful alternative therapeutic agent in instead of antibiotics for the treatment of chronic diarrhea in calves.

• 혜화의학회지
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• 제13권2호
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• pp.317-326
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• 2004

Administrating PalMoolGoonJaTang and SipIMiGwanJungTang to 40-weeks-(old Wistar rat for 10 weeks so, I researched into weight change, weight change of internal organ, and hemtological and serological changews. Then I got these conclusions. 1. Observed gain in weight than control group form of SipIMiGwanJungTang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of SipIMiGwan JungTang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocytes, eosinophil etc. increase, and HCT, PLT etc. showed tendency that decrease according to old-week, and observed improvement that is hematological value than control group form of SipIMiGwanJungTang 5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol., TG, TP, ALB, A/G, P etc. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of SipIMiGwanJungTang As those results, PalmoolGoonJaTang and SipIMiGwanJungTang are effective against dacline of physical function as aging. Moreover, considered to the serogical results, SipIMiGwanJungTang is much more effective than the other.

• 한국산업보건학회지
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• 제4권2호
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• pp.224-239
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• 1994

본 연구는 1993년 10월부터 1994년 3월 사이에 PCE를 세정제로 사용하는 세탁소중 충청권에 있는 23개소의 세탁소 작업자 30명을 폭로군으로, 모대학교 사무직원 42명을 비폭로군으로 하여 자각증상을 조사하였고, 세탁소 작업자의 PCE 폭로농도 및 작업장 기중농도를 측정하였다. 혈액과 뇨를 채취하여 혈액학적, 임상화학적 검사 및 뇨단백, 뇨당을 검사함으로써 PCE 폭로정도에 따른 관련성을 분석하여 다음과 같이 결과를 요약하고, 세탁소의 작업장 환경을 양호하게 관리하기 위한 몇가지 방안을 제안하고자 한다. 1. 폭로군이 비폭로군에 비해 조사항목 대부분에서 높은 자각증상 호소율을 나타냈으며, 특히 호흡기계, 심혈관계, 소화기계, 신경정신계에서 높은 자각증상을 호소했다. 개인폭로농도와 자각증상 호소율은 상호 관련성이 없었다. 2. 1일 8시간 작업시 PCE의 허용농도는 우리나라의 경우 50.0ppm, ACGIH에서는 25.0ppm으로 권장하고 있다. 조사대상 세탁소 형태별로 작업자의 PCE폭로농도는 체인본부가 16.85ppm, 일반 세탁소가 8.83ppm, 셀프-서비스점이 3.07ppm으로 나타났다. 전체적으로 세탁소 작업자의 PCE 폭로농도는 25.0ppm 이하가 19개소(82.6%)였으며, 25.0ppm 이상 측정된 세탁소는 4개소(17.4%)였고, 50.0ppm을 넘는 세탁소는 한 곳도 없었다. 이상의 결과에서 측정대상 세탁소의 작업환경 관리가 비교적 양호함을 알 수 있다. 3. PCE 기기의 가동횟수가 증가할수록 또한 작업량(세탁량)이 많아질수록 PCE 폭로정도는 증가하였다. 또 개방형 PCE 기기를 사용하는 작업자의 폭로농도는 6.18ppm, 밀폐형은 11.48ppm으로 나타났으나, 밀폐형을 사용하는 세탁소의 경우 개방형보다 작업량이 2-3배 정도 많았으며, 이 결과는 기기의 형태보다 작업량과 관계가 있는 것으로 나타났다. 4. 혈액학적 검사에서는 WBC, RBC, Hgb, Hct, MCV, MCH, MCHC, PLT 모두 정상으로 나타났으며, 혈액의 임상화학적 검사에서도 간기능, 신장기능 진단에 이용되는 GOT, GPT, ALP, U-A 및 LDH가 정상으로 나타났다. 5. 뇨단백 및 뇨당 검사에서는 대부분 정상이었고, 3명의 뇨단백이 30mg/dl 이하로 약간 배출되었으며, 뇨당은 3명이 100mg/dl 이하, 2명이 100-250mg/dl로 약간 높게 배출하였다. 이상의 결과에서 PCE 폭로군은 비폭로군보다 신체의 여러부분에 대해 높은 자각증상 호소율을 나타냈다. 조사대상 세탁소의 작업환경은 비교적 양호하게 관리되고 있었으며, 혈액학적 및 임상화학적 검사는 직업성으로 인해 이상이 유발되었다고 평가할만한 사실은 관찰되지 않았다. 그러나 세탁소에서는 PCE뿐만 아니라 얼룩을 제거하기 위하여 여러 종류의 유기용제를 사용하기 때문에 작업자들은 항상 위해한 환경 인자에 노출되고 있다고 사료되므로, 작업장 환경을 보다 쾌적하게 관리하기 위해서는 PCE의 기계적 누출을 조사하고, 의류의 충분한 건조, 적절하고 합리적인 환풍기의 가동 및 개인보호구 착용 등에 관심을 기울여야 할 것이다.