• Title/Summary/Keyword: GO modification

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Analysis of the Correlation Between Kidney Function Indicators and Kidney Size According Age Groups in Ultrasonography (신장 초음파 검사에서 연령대에 따른 신장 기능 지표와 신장 크기 간의 상관관계 분석)

  • Go, Ryo-won;Seoung, Youl-Hun
    • Journal of the Korean Society of Radiology
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    • v.14 no.7
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    • pp.871-879
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    • 2020
  • The purpose of this study was to analysis the correlation between kidneys function indicators and these size in ultrasonography. A total of 170 (male:86, female:84) patients of sex and age groups were examined by abdominal ultrasonography. The patients classified as those in their 20's, 30's, 40's, and over 50's. We measured the length, width, and cross-sectional height of the kidneys twice. At this time, the length of these were measured from the maximum upper to the maximum lower pole and the widest width in the same ultrasonography was measured to obtain the cross-sectional area. Other relevant indicators included body surface area, serum creatinine, glomerular filtration rate (GFR), MDRD (Modification of diet in renal disease) and C-G (Cockcroft-Gault). Significant comparisons of differences between relevant factors by age groups and sex were conducted with a one-way distribution analysis. Correlation analysis was also performed between relevant factors by using Pearson and Spearman correlation coefficient. It was defined as meaningful when the p-value was less than 0.05. As a result, the length, the width, and the cross-sectional area of kidneys were correlated with GFR, C-G, MDRD. Therefore, it is expected that the accuracy of diagnosis of kidneys disease will be increased if the relevant indicators are evaluated together rather than measuring only length of these in ultrasonography.

Identification of Differentially Expressed Genes in Ducks in Response to Avian Influenza A Virus Infections

  • Ndimukaga, Marc;Won, Kyunghye;Truong, Anh Duc;Song, Ki-Duk
    • Korean Journal of Poultry Science
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    • v.47 no.1
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    • pp.9-19
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    • 2020
  • Avian influenza (AI) viruses are highly contagious viruses that infect many bird species and are zoonotic. Ducks are resistant to the deadly and highly pathogenic avian influenza virus (HPAIV) and remain asymptomatic to the low pathogenic avian influenza virus (LPAIV). In this study, we identified common differentially expressed genes (DEGs) after a reanalysis of previous transcriptomic data for the HPAIV and LPAIV infected duck lung cells. Microarray datasets from a previous study were reanalyzed to identify common target genes from DEGs and their biological functions. A total of 731 and 439 DEGs were identified in HPAIV- and LPAIV-infected duck lung cells, respectively. Of these, 227 genes were common to cells infected with both viruses, in which 193 genes were upregulated and 34 genes were downregulated. Functional annotation of common DEGs revealed that translation related gene ontology (GO) terms were enriched, including ribosome, protein metabolism, and gene expression. REACTOME analyses also identified pathways for protein and RNA metabolism as well as for tissue repair, including collagen biosynthesis and modification, suggesting that AIVs may evade the host defense system by suppressing host translation machinery or may be suppressed before being exported to the cytosol for translation. AIV infection also increased collagen synthesis, showing that tissue lesions by virus infection may be mediated by this pathway. Further studies should focus on these genes to clarify their roles in AIV pathogenesis and their possible use in AIV therapeutics.

Comparison of sleep and related variables between young and old adults (일반성인과 노인의 수면양상과 수면방해요인의 비교연구)

  • 김신미;오진주;송미순;박연환
    • Journal of Korean Academy of Nursing
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    • v.27 no.4
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    • pp.820-830
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    • 1997
  • Sleep is an essential component for health and the quality of life of individuals, and is affected by multiple factors. Thereby, sleep impairment is known to be frequent even in healthy subjects. The purpose of the study is to compare sleep patterns and related factors between healthy young and old adults and to identify aging effects upon sleep in a cross-sectional way. The survey questionnaire was developed by translation and modification of two well-known sleep questionnaires which were originally developed by Monroe(1967) and Ellis, et al. (1982). Discussion with experts and pilot study were completed to finalize the contents of the questionnaire that was used in this study. Results are as follows : 1. Sleep complaints were lower in older adults. 2. The most frequent variables that explain sleep satisfaction were feeling rested in the morning in the older adults and feeling rested and failing asleep within five minutes in the young adults. 3. Regarding sleep-disturbing factors, physical factors were more frequently reported in the older adults and environmental factors are reported more frequently in the young adults, and there was no difference related to the emotional factors between the two groups. 4. Young adults were practiced strategies for better sleep more often than the older adults, and they were mainly in-home activities just before sleep. 5. Sleep patterns which change with aging were as follows : going to bed and waking up earlier : not staying in the bed long after waking up ; getting harder to fall asleep ; frequent arousal after sleep onset ; getting harder to go back to sleep after arousal during night sleep. From the results of this study, it can be concluded that sleep and related factors of the young and the older adults are different. Also, sleep patterns change with aging and those changes seem to be negative for sleep in the elderly. Repeated studies are needed to establish more concrete information regarding sleep patterns. In addition, further research is needed to develop more reliable, valid, and feasible sleep measure tools, and to develop and evaluate nursing interventions.

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A study on hull form design for small fishing vessels (소형어선의 선형설계에 관한 연구)

  • Kim, In-Seob;Go, Dae-Gyu;Park, Dong-Woo
    • Journal of Advanced Marine Engineering and Technology
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    • v.41 no.4
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    • pp.316-322
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    • 2017
  • The primary objective of the current study is to develop outstanding hull form on resistance performance by using numerical analysis code. Model tests were conducted to assess the resistance performance of the developed hull form. The investigation of an existing vessel was performed for validating the actual ship design based on the drawing. The operating displacement and speed were mainly confirmed through investigation of the existing vessel. The resistance performance of the existing vessel was analyzed using numerical code. The developed vessel was derived through studies on wave improvement of the bow shoulder, the balance of displacement distribution, the modification of the frame shape, and the size and shape change of the center skeg. Based on the results of a computational fluid dynamics analysis, the resistance performance of the developed vessel showed an improvement of 15% over the existing vessel at a speed of 11 knots. Resistance tests were conducted to evaluate the performance of the existing vessel and the developed vessel in the towing tank. Finally, the effective horsepower of the developed vessel showed an improvement of 17% over the existing vessel.

A Study on TCP-friendly Congestion Control Scheme using Hybrid Approach for Multimedia Streaming in the Internet (인터넷에서 멀티미디어 스트리밍을 위한 하이브리드형 TCP-friendly 혼잡제어기법에 관한 연구)

  • 조정현;나인호
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2003.10a
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    • pp.837-840
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    • 2003
  • Recently the multimedia streaming traffic such as digital audio and video in the Internet has increased tremendously. Unlike TCP, the UDP protocol, which has been used to transmit streaming traffic through the Internet, does not apply any congestion control mechanism to regulate the data flow through the shared network. If this trend is let go unchecked, these traffic will effect the performance of TCP, which is used to transport data traffic, and may lead to congestion collapse of the Internet. To avoid any adverse effort on the current Internet functionality, A study on a new protocol of modification or addition of some functionality to existing transport protocol for transmitting streaming traffic in the Internet is needed. TCP-frienly congestion control mechanism is classified with window-based congestion control scheme and rate-based congestion control scheme. In this paper, we propose an algorithm for improving the transmitting rate on a hybrid TCP-friendly congestion control scheme combined with widow-based and rate-based congestion control for multimedia streaming in the internet.

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A Study on the Types of "Gogyeong-Jeongripyo" and Its Genealogy ("거경정리표(距京程里表)"의 내용유형과 계통에 관한 연구)

  • Todoroki, Hiroshi
    • Journal of the Korean Geographical Society
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    • v.45 no.5
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    • pp.647-668
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    • 2010
  • As well as "Sangyeongpyo," "Gogyeong-Jeongripyo," table of national road transportation system is important to comprehend identity of national geography in Joseon era even if it had not been researched yet. The aim of this study is to divide type of these tables and find its genealogy through mainly analyzing the road network and land names. As the result of this research, "Yeojigo," topographical researches of Korea, edited by Shin Gyeong-Jun as a palt of "Dongguk-Munheonbigo" official book in natural history of the Joseon Dynasty published in 1770, might be identified as the origin for all copy of "Gogyeong-Jeongripyo." Then "Gogyeong-Jeongripyo," can be divided into at least three major types; almost direct descent of "Yeoji go" as 'type1', minor modification as 'type2', and hybrid edition(type3) with second type that quoted many land names as route information from "Dorogo," another topography specialized for road transportation. Since "Dorogo" was also composed by Shin, after all, all genealogy of "Gogyeong-Jeongripyo" came from him.

A study on the change of material width by forging processing in fine pitch connector of C5210-H(HP) and NKT322-EH materials (C5210-H(HP)와 NKT322-EH 소재의 협피치 커텍터에서 단조 가공에 의한 소재 폭 변화에 관한 연구)

  • Shin, Mi-Kyung;Lee, Chun-Kyu
    • Design & Manufacturing
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    • v.14 no.3
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    • pp.17-22
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    • 2020
  • As devices such as smartphones, tablet PC, and wearable devices have been miniaturized, the connectors that go into the devices are also designed to be very small. The connector combines the plug and the receptacle to transfer electricity. As devices are miniaturized, the contact shape is formed by partially thinning the thickness of the raw material of the terminal in order to lower the coupling height of the plug and receptacle. The product used in this study is a receptacle terminal used for 0.4mm pitch board to board connector among fine pitch connectors. When the material thickness is reduced by forging the receptacle terminal, the width change of the pin is checked. To reduce the thickness of the material by forging, pre-notching is applied in the first step, forging in the second step, and notching in the third step. After forming the width dimension of the pin to 0.28 mm in the pre-notching process, in the forging process, the material thickness 0.08 mm and 0.02 mm (25%) were forged and the thickness was changed to 0.06 mm and the width change amount of the pin was measured. The facility produced 10,000 pieces at 400 SPM using a Yamada Dobby (MXM-40L) press, and thirty pins were measured and the average value was shown. After forging by using C5210-H (HP) and NKT322-EH, which are frequently used in connectors, analyze the amount of change in each material. The effect of punching oil on forging is investigated by appling FM-200M, which is highly viscous, and FL-212, fast drying oil. This study aims to minimize mold modification by predicting the amount of material change after forging.

Development of Small Area Health Promotion Indicator for Community Health Initiative (지역보건 관련 소지역간 건강증진지표 개발에 관한 연구)

  • Kim, Chun-Bae;Go, Kawung-Uk;Park, Jae-Sung;Choe, Heon
    • Korean Journal of Health Education and Promotion
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    • v.20 no.1
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    • pp.19-39
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    • 2003
  • Purpose: Although there is a lot of secondary data available for comparing community health status and planning health policies in terms of large area such as metropolitan cities or provinces, there is restricted data for establishing community health policies of the small areas such as towns, Gun(i.e., districts), and Gu. Specifically, the problems of producing a valuable index for health promotion in small areas are three fold: First, there is not an appropriate index model for measuring a small community health status. Second, a large part of secondary data in the small areas has been produced in an irregular time interval. In addition, all valuable data can not be integrated without time consuming work. Thus this study tries to establish a health promotion index model for assisting community health promotion initiatives of local governments. Methods and materials: Literature review, community health specialist consultation and a questionnaire survey was performed. Results: Based on Dever's model, a prototype of health promotion indicators was proposed and modified by the community health specialists. 15 classification scheme of statistical yearbook reorganized into the six areas. Those six areas were comprised in 24 indicator class with 96 specific indicators. Through further modification processes by a questionnaire survey, we developed a health promotion indicator model that contains six areas with 23 indicator class encompassed by 87 specific indicators. Conclusions: This study proposed a model of health promotion indicator comprised in the six areas with 23 indicator classes for measuring small area health promotion status. However, more specific or additional data in human biology, environment, and socioeconomic data is essential for producing a stronger model for health promotion measurement.

Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel

  • Choi, Seungkyu;Go, Jai Hyang;Kim, Eun Kyung;Lee, Hojung;Lee, Won Mi;Cho, Chun-Sung;Han, Kyudong
    • Genomics & Informatics
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    • v.14 no.3
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    • pp.78-84
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    • 2016
  • Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis. Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. Using the Ion Proton Comprehensive Cancer Panel, we sequenced 409 cancer-related genes to identify somatic mutations in five NKTCL tissue samples. The sequencing analysis detected 25 mutations in 21 genes. Among them, KMT2D, a histone modification-related gene, was the most frequently mutated gene (four of the five cases). This result was consistent with recent NGS studies that have suggested KMT2D as a novel driver gene in NKTCL. Mutations were also found in ARID1A, a chromatin remodeling gene, and TP53, which also recurred in recent NGS studies. We also found mutations in 18 novel candidate genes, with molecular functions that were potentially implicated in cancer development. We suggest that these genes may result in multiple oncogenic events and may be used as potential bio-markers of NKTCL in the future.

Implementation of an Expert System for COTS Fault Diagnosis (COTS 고장진단을 위한 전문가 시스템 구현)

  • Kim, A-Ram;Roh, Jin-Song;Rhee, Sang-Yong
    • Journal of Digital Convergence
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    • v.11 no.1
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    • pp.275-281
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    • 2013
  • This space is for the of your study in English. If simple menu item changes or the addition of check items are necessary on GUI menu of existing test equipments for military facilities that are programmed by using RAD tools such as Visual C++, they should go through complex steps, such as numerous conducting steps, coding, flash design modification, recompiling and distribution. It is cumbersome process and waste much time. Also, on implementing them, it was worried about leaking secrets because a number of military security considerations were included. To solve such as the above problem, we proposed commercial RIA technologies and a COTS fault diagnostic knowledge-based system that implemented by the XML data design technique in this research. The proposed approach solves the problem of existing methods, reduced inspection time, and improved performance, usability, and maintainability.