• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.4
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• pp.74-91
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• 2015

Background and Objective : Asthma is a chronic inflammatory disease at the mucosa and is associated with excess production of Th2 cytokine and eosinophil accumulation in lung.Gamchomahwang-tangextract(GME) is one of the well known prescription used in oriental medicine for treating asthma. This study was designed to compare the anti-asthmatic effect of GME according to the ratio of 2 compounds.Methods : To examine the effects of GME on asthma, mice were sensitized with 100 ㎍ of OVA and 1 ㎎ of aluminum potassium sulfate(Alum; Sigma) intraperitoneally on day 1 and 15. From day 22, mice were challenged on 3 consecutive days with 5% OVA. The anti-asthmatic effects of GME were evaluated by enhanced pause(Penh), bronchoalveolar lavage fluids (BALF), inflammatory cytokine production and genes expression, serum IgE production. and histological change in lung tissue. GMEⅠ consists of ES and GU in the proportion 2:1(300 ㎎/㎏ group), GMEⅡ consist of ES and GU in the proprtion 4:1(300 ㎎/㎏ group).Results : GMEⅠ,Ⅱ generally inhibited lung inflammation, inflammatory cells infiltration and cytokine production and gene expression such as IL-4, IL-5 and IL-13 in BALF and serum IgE level. GMEⅡ significantly reduced the cytokine production and gene expression such as IL-4, IL-5 and IL-13 in BALF and GMEⅠ decreased cytokine production of IL-4, IL-13 in BALF and gene expression of IL-4, IL-5 in Lung. GMEⅡ potently inhibited the development of Penh and also reduced the number of eosinophil during OVA-induced AHR(airway hyper-reactivity). Overall the results show that GMEⅡ has more effect on inhibiting production, gene expression of cytokine, serum IgE level and development of Penh than GMEⅠ. Consequently, GMEⅡ might be more effective than GMEⅠ at inhibiting allergic asthma on the OVA-induced mice model.Conclusion : These results indicate that GME has a deep inhibitory effects on airway inflammation and hyperresponsiveness in mice model of asthma and that suppression of IL-4, IL-5, IL-13 expression and decrease of IL-4, IL-5, IL-13 production in BALF might contribute this effect. Hence, the results indicate that GME might be useful herbal medicine of allergic asthma. As a result, GMEⅡ mght be superior to GMEⅠ in the aspect of anti-asthmatic effect on the OVA-induced mice model.

• Journal of the Korean Society of Visualization
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• v.5 no.2
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• pp.9-13
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• 2007

Typhoon simulation based on dynamical forecasting results is demonstrated by utilizing geodesic model GME (operational global numerical weather prediction model of German Weather Service). It is based on uniform icosahedral-hexagonal grid. The GME gridpoint approach avoids the disadvantages of spectral technique as well as the pole problem in latitude-longitude grids and provides a data structure extremely well suited to high efficiency on distributed memory parallel computers. In this study we made an attempt to simulate typhoon 'NARI' that passed over the Korean Peninsula in 2007. GME has attributes of numerical weather prediction model and its high resolution can provide details on fine scale. High resolution of GME can play key role in the study of severe weather phenomenon such as typhoons. Simulation of future typhoon that is assumed to occur under the global warming situation shows that the life time of that typhoon will last for a longer time and the intensity will be extremely stronger.

• Archives of Plastic Surgery
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• v.50 no.6
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• pp.573-577
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• 2023

Pachyonychia congenita is a rare genetic disorder characterized by hypertrophic nail plates, hyperkeratotic nail beds, and thickened hyponychium of the fingers and toes, impairing manual dexterity and resulting in poor aesthetics. The current body of literature describes various treatment modalities, but no singular approach has been defined as the gold standard. In this case, the authors employed different surgical techniques for treating pachyonychia congenita to evaluate the most effective approach. A 3-year-old boy presented with hypertrophic nail growth involving all digits of both hands and feet. Three surgical procedures were performed on the patient's fingers and toes using germinal matrix excision (GME) alone, GME plus partial sterile matrix excision (pSME), or GME plus complete sterile matrix excision (cSME). The digits treated with GME + cSME exhibited no recurrence of nail growth. Those treated with GME alone exhibited recurrence of hypertrophic nail growth, although their growth slowed. Excision of GME + cSME prevented recurrence of hypertrophic nails, while GME alone or with pSME led to slower-growing hypertrophic nails. Complete excision of the germinal and sterile matrices with skin graft closure may be a definitive treatment for pachyonychia congenita, but further studies are needed to validate these findings.

• Korea Journal of Hospital Management
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• v.6 no.1
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• pp.120-146
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• 2001

This study was carried out to provide the essential information in improving the graduate medical education in Korea. For the study, a survey targeting the directors of GME of nationwide teaching hospitals was performed with a questionnaire asking the questions such as the director's perception on the quality of GME, trainees' salary level, trainees' specialty selection tendency, training system and its duration. The collected data were analyzed using t-test, ANOVA, and $x^2$-test. The results were as follows: 1. The survey were executed on 240 teaching hospitals in Korea and the response rate was 66.2% (159 hospitals replied). 2. The bigger a hospitals is the better in Quality of education. Larger hospitals tend to have better status in all items including medical specialists' experience, contents of medical curriculum, general environment for medical education and medical trainees's salary level. The result supported the general perception on the positive relationship between hospital size and Quality of GMA. 3. Providing convenience for medical trainees who prepares for the medical specialist Qualifying examination didn't affect the results of the examination. 4. The directions of GME have a perception that the trainees give positive impact on financial performance of their hospitals. This seems to be one of the reasons that hospitals try to retain as many trainees as possible. 5. The directors of GME considered medical trainees as an educate, and most of them responded positively on the need of governmental supports for the education cost and the trainee's salary. Considering above results, it seems that GME would get more social attention and the trainees' impact on hospitals operation would be increased more than before. In response to these trends, hospitals would find out the ways to lower dependency on trainees, and this change of attitude of hospitals on the GME would cause problems in operation of hospitals and GME itself. In order to prevent these problems the policy on GME should be directed in following ways. 1. The contents of Qualifying examination for specialist should be improved. 2. The curriculum of GME should be strictly followed. 3. The status of trainee in a hospital has to be defined as eductee. 4. Government has to support a half of the education cost and salary of trainee. 5. The distribution of the trainee among the hospital group have to be based on total available. 6. The financial support and welfare of trainee should be improved gradually and systematically.

• Communications for Statistical Applications and Methods
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• v.16 no.4
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• pp.659-667
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• 2009

Recently Song and Cheon (2006) and Cheon and Lim (2009) developed the generalized maximum entropy(GME) estimator to solve ill-posed problems for the regression coefficients in the simple panel model. The models discussed consider the individual and a spatial autoregressive disturbance effects. However, in many application in economics the data may contain nested groupings. This paper considers a two-way error component model with nested groupings for the ill-posed data and proposes the GME estimator of the unknown parameters. The performance of this estimator is compared with the existing methods on the simulated dataset. The results indicate that the GME method performs the best in estimating the unknown parameters in terms of its quality when the data are ill-posed.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.304-309
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• 2008

기존의 태풍예측과 관련된 연구들은 전 지구적인 흐름이 직접적으로 계산되지 않은 중규모 기상모형이나 태풍모형들을 이용하여왔다. 하지만 최근 전 세계적으로 전구 규모의 모형들이 40km 이하의 고해상도 모형들이 개발되어 20km이하의 초고해상도 시물레이션이 가능해짐에 따라 지역적인 기상현상들을 전구모형을 통해서 재현해 내고 있다. 따라서 본 연구에서는 고해상도 전구모형을 이용하여 태풍 실험을 하고자 하며, 독일기상청에서 개발된 Icosahedral-hexagonal 격자체계의 GME전구 모형을 이용한 태풍모의 결과를 기상청 태풍 best track과 비교 분석 하였다. 실험에 사용된 모형 분해능은 연직 47layer (7 soil layer 포함), 수평 약 40km와 20km으로 구성되었다. 최근 3년($2005{\sim}2007$)간의 동아시아지역을 지나간 태풍을 대상으로 하였다. 태풍모의 시작시간은 각 TD(Tropical Depression)발생 24시간 전 자료를 이용하였으며, 각 태풍의 소멸 24시간 후까지 모의하였다. GME 모형을 이용한 태풍모의 결과에서 best track의 경우 모의 시작 후 약 168시간 forcast 결과가 매우 유사한 경로를 따라 진행해 가고 있으며, 태풍의 전향이 이루어지는 시각은 ${\pm}3$시간 내외의 오차를 보이고 있다. 태풍경로의 경우 40km 결과에 비해 20km 모의 결과가 best track에 더 가까운 결과를 보이고 있다. 중심기압변화의 경우 40km의 결과가 20km 결과에 비해 변화경향이 유사한 형태를 보이고 있으며, 20km 결과의 경우 중심기압의 변화가 다소 급하게 나타나는 경향을 보이는 특성을 가지고 있지만 40km결과에 비해 최저 중심기압이 더욱 뚜렷하게 나타나고 있으며 특히, MANYI case의 경우 관측값 930hPa보다 더 낮은 911.4hPa의 결과를 보이고 있다. 풍속의 경우도 중심기압변화와 유사한 결과를 보이고 있으나, 최대 풍속의 경우 40km 결과에 비해 20km결과가 관측과의 오차범위가 $2{\sim}3\;m/s$ 내외로 나타나고 있다. 그리고 GME모형의 경우 태풍(TD) 발생 약168시간 이전에 예측이 가능한 결과를 보인다. 이 연구의 결과는 다른 기상모형에서 태풍 강도가 약하게 모의되던 현상이 상당히 개선된 것을 알 수 있으며, 이는 20km 고해상도 GME 모형이 태풍예측모형으로 활용이 간능 할 것으로 사료 된다.

• Korean Journal of Veterinary Research
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• v.54 no.3
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• pp.171-177
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• 2014

Garlic and mugwort have long been used in traditional medicine to prevent various diseases. Several in vitro studies have reported protective efficacies of garlic and mugwort in cases of gastric cancer. In the present study, we investigated the cancer preventive effects of garlic and mugwort mixture extract (GME) in a Helicobacter (H.) pylori-associated gastric carcinogenesis mouse model. To induce gastric cancer, C57BL/6 mice were treated with N-methyl-N-nitrosourea and H. pylori. Various concentrations of GME (0, 100, 500, and 1,000 ppm) were then fed to the mice for 38 weeks, after which the tumor tissues were examined for histopathology, mucin histochemistry and ${\beta}$-catenin. The incidence of gastric tumors was significantly lower in the highest dose GME-treated mice (46.7%) than control mice (85.7%) (p < 0.05). The multiplicity and size of tumors were also significantly reduced by GME feeding in a dose-dependent manner (p < 0.01). Furthermore, GME suppressed the H. pylori-associated chronic inflammation measured by histologic grading of H. pylori density, chronic gastritis, glandular atrophy and intestinal metaplasia in non-tumorous gastric mucosae. Our data suggest that GME suppresses gastric tumorigenesis via suppression of H. pylori-associated chronic inflammation.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.10a
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• pp.230-232
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• 2015

이번 발표는 혀 인천해사고의 해사영어 교육과정, 수업이 이루어지는 환경, 학습자의 수준과 수업에서 이루어지는 교수기법, 교사가 느끼는 한계점을 비교하면 살펴보고, 경쟁력있는 해기사 배출을 위해 우리 학교가 보완하여 나아갈 방향을 검토하는데 목적이 있다.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.2207-2211
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• 2008

한반도 및 동아시아의 여름철은 장마와 태풍으로 인한 집중호우의 발생으로 많은 피해를 입는다. 따라서 여름철에 나타나는 이러한 집중호우가 나타나는 지역, 시기, 기간, 그리고 강수량 등을 예측하는 것은 매우 중요하다. 특히, 효율적인 수자원 관리를 위하여 이러한 예측은 매우 중요한데, 단기적으로 정확하고 신속하게 강수를 예측하는 것도 중요하지만, 장기적으로 계절 강수, 특히 여름철의 장마 또는 우기의 시기와 강수량과 태풍 발생의 시기 등을 미리 예측하여 이에 따른 집중 호우의 발생 지역, 기간, 강수량을 예측하여 사전에 대비하는 것도 매우 중요하다. 특히, 최근에는 6,7월 장마에 의한 집중 호우의 영향보다도 8월에 강수량이 높아지고 있는 경향을 보이므로 강수량의 장기적 경향의 파악이 매우 중요하다. 장기 기후를 예측하는 데는 과거 자료를 이용한 통계 방법도 유용하지만 최근에는 AOGCM (Atmospheric Oceanic General Circulation Model)을 이용한 연구가 활발하게 이루어지고 있다. 하지만 강수와 같이 지역적으로 나타나는 현상은 저해상도의 AOGCM으로는 유용한 정보를 제공하기가 어려움이 따른다. 따라서 본 연구에서는 전구를 삼각형으로 된 20면체로 격자화 시켜 모든 격자의 크기가 거의 동일하고, 해상도 조절이 가능한 Geodesic 격자를 활용한 GME 모델을 사용하였다. GME 모델은 icosahedral-hexagonal grid 격자 체계를 가진 독일 기상청(Deutscher Wetterdient)에서 현업으로 사용 중인 모델이다. 본 연구에서는 수직/수평 해상도를 40km/40layers로 하여 GME 모델을 수행하였으며, 일간격의 장기 기후 자료를 생산하였다. 사용된 초기자료로는 ECMWF (European Centre for Medium Range Weather Forecasts) 자료이며, 경계 자료로는 ERA Climatology의 최근 30년간의 SST (Sea Surface Temperature) 평균 자료를 이용하여 규준 실험(Control Run), 즉, climatology 자료를 생산하였으며, persistent SST 아노말리와 ERA Climatology의 최근 30년간의 SST 자료를 이용하여 내삽 과정을 거친 SST forcing을 주어서 예측 실험(Prediction Run)을 통하여 모의 자료를 생산하였다. 특히, 규준 실험에서는 수치 모델이 가지는 불확실성을 줄이고 예보 정확도를 향상시키기 위하여 각각의 실험은 초기자료를 달리한 앙상블 모의실험을 수행하였다. 장기 모의 3개월을 위하여 모의 기간 1달 전부터 모의를 수행하여, 첫 1달은 모델의 spin-up 시간으로 분석에서 제외 하였다. 생산된 Climatology 자료와 Prediction 자료를 비교하여 아노말리와 Category 분석을 실시하여 한반도 및 동아시아 지역의 강수(Precipitation)를 중심으로 기압장(Pressure), 온도(2m Temperature) 위주로 분석하였다. 이러한 예측된 매 계절의 전망 자료 중에서도 수자원 분야에서 관심이 집중되는 여름철에 초점을 맞추어 실제 관측 자료와 비교하여 GME 모델의 계절 모의 예측성 성능을 분석하여 평가하고 다가올 여름철의 강수량의 장기 변화를 모의하고자 하였다.

• The Korean Journal of Applied Statistics
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• v.19 no.3
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• pp.521-534
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• 2006

This paper considers a panel regression model with ill-posed data and proposes the generalized maximum entropy(GME) estimator of the unknown parameters. These are natural extensions from the biometries, statistics and econometrics literature. The performance of this estimator is investigated by using of Monte Carlo experiments. The results indicate that the GME method performs the best in estimating the unknown parameters.