• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.2
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• pp.83-99
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• 2020

Objectives : Atopic dermatitis is a chronic inflammatory skin disease with frequent relapses. This study was to investigate the effects of Gammakdaejo-tang(GMD) in DNCB induced atopic dermatitis mice. Methods : The study was divided into five comparion groups. 2,4-dinitrochlorobenzene(DNCB) solution was applied to Nc/Nga mice to induce atopic dermatitis, followed by normal group, negative control group with distilled water, positive control group with Dexamethasione and GMD 200mg/kg or 400mg/kg. The control group was orally administered 200㎕ once daily for 4 weeks. Visual skin condition, Immunoglobulin E, Histamine, Cytokine, Immune cells, Tissue biomarkers were observed. Results : As a result of the dermatitis score evaluation, it was confirmed that the GMD-administered group improved symptoms compared to the negative control group. As a result of measuring IgE, the GMD-administered group significantly decreased compared to the negative control group. As a result of measuring Histamine, GMD group except 200mg/kg of GMD significantly decreased compared to negative control group. As a result of measuring cytokine, GMD 200mg/kg significantly reduced IL-1β, IL-6 and TNF-α compared to the negative control. 400mg/kg significantly reduced IL-1β, IL-4, IL-5, IL-6, IL-10, TNF-α and significantly increased IL-2, IFNγ. As a result of confirming the immune cells, all experimental groups showed no difference in basophil, GMD group significantly reduced monocyte and eosinophil compared to negative control group, and GMD 400mg/kg group significantly reduced white blood cell and neutrophil. And significantly increased lymphocytes. As a result of measuring the gene expression level, all GMD group significantly increased TGF-β1 compared with the negative control group, and filaggrin, VEGF and EGF were significantly increased in GMD 400mg/kg group. Epidermis, dermis thickness, and eosinophil infiltration were found to be decreased in all GMD groups compared with the negative control group. Conclusions : GMD is effective in atopic dermatitis by reducing imbalance of immune response of T cells (Th1 / Th2) and reducing skin tissue damage and inflammatory response.

• Journal of Korean Library and Information Science Society
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• v.25
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• pp.377-404
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• 1996

The purpose of this study is to investigate material designation in library cataloging and to suggest General Material Designation (GMD) and Specific Material Designation(SMD) in Korean. A summary of the study follows. In library cataloging, methods of indicating the type of material are : (1) color-coding, (2) media code as part of the call number, (3) material designation in physical description area or note area, (4) GMD and SMD. GMD is a term indicating the broad class of material to which a bibliographic item belongs. SMD is a term indicating the special class of material to which a bibliographic item belongs. GMD was listed in parenthesis following the title proper before AACR1975 code, but currently it is listed in square brackets after the AACR1975 code. AACR2 was the standard cataloging rule in GMD and SMD terminology. It is suggested that GMD be used in Korean for graphic material, sound recordings, drawings, microform, multimedia, videorecordings, manuscripts, photographs, slides, printed music, motion pictures, printed texts, objects, braille, cartographic materials, computer files and transparenies.

• Archives of Pharmacal Research
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• v.24 no.1
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• pp.69-73
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• 2001

Biodegradable hydrogels based on glycidyl methacrylate dextran (CMD) and dimethacrylate poly(ethylene glycol) (DMP) were proposed for colon-specific drug delivery. GMD was synthesized by coupling of glycidyl methacylate with dextran in the presence of 4-(N, N-dimethylamino)pyridine (DMAP) using dimethylsulfoxide as a solvent. Methacrylate-terminated poly (ethylene glycol) (PEG) macromer was prepared by the reaction of PEG with methacryloyl chloride. CMD/DMP hydrogels were prepared by radical polymerization of phosphate buffer solution (0.1 M, pH 7.4) of GMD and DMP using ammonium peroxydisulfate (APS) and UV as initiating system. The synthetic GMD, DMP and GMD/DMP hydrogels were characterized by fourier transform infrared (FT-lR) spectroscopy. The FITC-albumin loaded hydrogels were prepared by adding FITC-albumin solution before UV irradiation. Swelling capacity of GMD/DMP hydrogels was controlled not only by molecular weight of dextran, but also by incorporation ratio of DMP Degradation of the hydrogels has been studied in vitro with dextranase. FITC-albumin release from the GMD/DMP hydrogels was affected by molecular weight of nextran and the presence of dextranase in the release medium.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.983-987
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• 2005

Hydrogels composed of glycidyl methacrylate dextran (GMD) and poly(acrylic acid, PM) were prepared by UV irradiation method for colon-specific drug delivery. GMD was synthesized by coupling of glycidyl methacrylate to dextran in the presence of 4-(N,N-dimethylamino)pyridine. GMD was photo-polymerized by ammonium peroxydisulfate as initiating system in phosphate­buffered solution (0.1 M, pH 7.4). And then, acrylic acid monomer was added and subsequently heat-polymerized by 2,2'-azobisisobutyronitrile as an initiator. The hydrogels exhibited high swelling ratio (about 20) at $37^{\circ}C$, and showed a pH-dependent swelling behavior. In addition, the swelling ratio of the hydrogel was remarkably enhanced to about 45 times in the presence of dextranase at pH 7.4. The swelling-deswelling behavior proceeded reversibly for the GMD/PM hydrogels between pH 2 and pH 7.4. Release of 5-aminosalicylic acid from the GMD/PAA hydrogels was evaluated in simulated gastrointestinal pH fluids in the absence or presence of dextranase. We concluded that the hydrogels prepared could be used as a dual-sensitive drug carrier for sequential release in gastrointestinal tract.

• Journal of Korean Library and Information Science Society
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• v.42 no.2
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• pp.237-255
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• 2011

This study is to find new methods in describing material type as content type and carrier type for the improvement of OPAC retrieval and the embodiment of work and expression of FRBR. It is hard to describe type vocabulary in cataloging because division of content and carrier taxonomy in KCR4 and KORMARC is not distinct. This study is to review the characteristics of material type list in RDA and ISBD(2010), and to examine the various type vocabulary and description methods of videorecording, soundrecording, and cartographic by retrieving KERIS DB. As a result, there is no consistency in applying type vocabulary between KCR4 and KORMARC. Also, libraries use the mix of content and carrier or detailed carrier vocabulary for local use. Therefore, it is need to define the function of GMD as content type, to expand and correct content and carrier vocabulary, and to express both content and carrier type in citation and detailed display. This study will contribute to embody the expression of FRBR.

• The Transactions of the Korea Information Processing Society
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• v.3 no.1
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• pp.43-54
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• 1996

This paper presents new heuristic search algorithms for searching rectilinear r(L1), link metric, and combined shortest paths in the presence of orthogonal obstacles. The GMD(GuidedMinimum Detour) algorithm combines the best features of maze-running algorithms and line-search algorithms. The SGMD(Line-by-Line GuidedMinimum Detour)algorithm is a modiffication of the GMD algorithm that improves efficiency using line-by-line extensions. Our GMD and LGMD algorithms always find a rectilinear shortest path using the guided A search method without constructing a connection graph that contains a shortest path. The GMD and the LGMD algorithms can be implemented in O(m＋eloge＋NlogN) and O(eloge＋NlogN) time, respectively, and O(e＋N) space, where m is the total number of searched nodes, is the number of boundary sides of obstacles, and N is the total number of searched line segment. Based on the LGMD algorithm, we consider not only the problems of finding a link metric shortest path in terms of the number of bends, but also the combined L1 metric and Link Metric shortest path in terms of the length and the number of bands.

• Journal of the Korean Society for information Management
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• v.28 no.3
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• pp.103-121
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• 2011

This study is to seek to apply resource types of RDA to KCR4. It is difficult to choose appropriate term and to embody FRBR model because GMD of KCR4 is the mixture of content-based vocabularies and carrier-based vocabularies. SMD is to need to reflect the current technological terms. Resource type of RDA was already developed to overcome limitation of AACR2's GMD, and would affect the world cataloging environment, therefore it is need to apply resource type of RDA to Korean cataloging rule. For this study, case study and survey were used. In case study, it was to scan all GMD term for one university library to build by programming and to grape librarian and users' potential need. In the survey by cataloging librarian, it was to figure out the current description of resource type in university library and to test RDA resource type. As a result, it was needed to revise the vocabulary to the obvious and user-understandable list. Also it was different in correction rate in RDA testing by resource type. Based on the case study and the survey, RDA resource type was applied to KCR4 resource list by adding term such as computer game in content type, and by inserting terms such as DVD, CD-ROM, Blu-Ray, computer file in carrier type. It also applied RDA description method and display means to KCR4. This study would apply RDA resource type to KCR4 and contribute to revise KCR4 resource type.

• Journal of Korean Medicine for Obesity Research
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• v.17 no.2
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• pp.61-67
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• 2017

Objectives: The purpose of this study was to investigate the effects of Socheongryong-tang, a traditional herbal medicine, on gastrointestinal (GI) motility disorders (inflammatory and diabetic models) in mice. Methods: The in vivo effects of Socheongryong-tang on GI motility were investigated by calculating percent intestinal transit rates (ITR) and gastric emptying (GE) values using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). GMD models were induced by acetic acid and streptozotocin. Results: In normal ICR mice, ITR and GE values were significantly and dose-dependently increased by the intragastric administration of Socheongryong-tang (0.0025~0.25 g/kg). The ITR values (%) of GMD mice were significantly lower than those of normal mice, and these reductions were significantly and dose-dependently inhibited by Socheongryong-tang. Conclusions: These results suggest that Socheongryong-tang is a good candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.175-176
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• 2008

Exploiting block diagonal geometric mean decomposition (BD-GMD) for the multi-user MIMO broadcast channels, each user can achieve identical received SNRs for its subchannels. Thus, equal rate modulation can be applied to each user. Using BD-GMD, we can apply an adaptive modulation to each user with the required bit error rate (BER). In this paper, we propose an adaptive modulation algorithm for the multi-user MIMO broadcast channels with BD-GMD to maximize the system throughput satisfying the required BER performance.

• Journal of Life Science
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• v.29 no.12
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• pp.1345-1350
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• 2019

Our recent study has revealed that in vivo intestinal transit rate (ITR) in normal mice was significantly increased by the administration of an aqueous extract of dried Gentiana scabra rhizomes and roots (GS-W) in a dose-dependent manner. Following on from our previous study, the effect of GS-W on ITR was measured in mice with experimentally induced gastrointestinal motility dysfunctions (GMDs) in the present study. GS-W showed no significant acute toxicity even at an oral dose of 5 g/kg to mice. ITR was significantly retarded in the GMD mice compared with that in normal mice, and this retardation was significantly recovered by the oral administration of GS-W in a dose-dependent manner. Furthermore, the ITR value of GS-W at a dose of 1 g/kg appeared to be higher than that of cisapride, which was predominantly prescribed for human patients with various GMDs in the late 1900s but was withdrawn from the market in 2000 due to its fatal side effects. The current results suggest that GS-W is a potential substitute for cisapride to prevent or alleviate human GMDs.