• Natural Product Sciences
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• v.20 no.3
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• pp.170-175
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• 2014

Twenty five methanolic plant extracts were investigated to determine the anticancer activity against sonic hedgehog (shh)/Gli signaling pathway dependent cancer, PANC-1 human pancreatic cancer cells, through three screening programs. All extracts were inspected their inhibitory properties on sonic hedgehog-conditioned medium (shh-CM) induced alkaline phosphatase (ALP) activity in C3H10T1/2 mouse mesenchymal stem cells to examine whether the plant extracts affect the shh/Gli signaling pathway. Next, plant extracts were screened the ability to suppress the cell proliferation of PANC-1 human pancreatic cancer cells. Finally, active plant extracts from the two screening systems were evaluated for the suppressive effect on Gli-mediated transcriptional activity in PANC-1 cells. Among active plants, Cinnamomum cassia suppressed Gli-mediated transcriptional activity leading to the down-regulated expression of Gli-target genes such as Gli-1 and Patched-1 (Ptch-1). This study provides the consideration for the important role of natural products in drug discovery process as well as the basis for the further analysis of active plant and potential identification of novel bioactive compounds as inhibitors of Gli and therapeutic candidates against shh/Gli signaling pathway dependent cancers.

• BMB Reports
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• v.49 no.7
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• pp.394-399
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• 2016

Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulated in glioma tissues, as in comparison to in normal tissues. These up-regulation phenomena were also observed in glioma U251 and U87 cells. It was demonstrated that Gli1 positively regulated the AQP1 expression. By luciferase reporter gene and ChIP assay, we observed that this modulation process was realized by combination of Gli1 with AQP1 promotor. In addition, knock down of Gli1 by siRNA interference reduced the viability of glioma cells as well as suppressed cell metastasis. Also, the inhibitory effects of cell survival by silenced Gli1 were abrogated by AQP1 overexpression. In summary, glioma cell survival is a regulatory process and can be mediated by Gli1-AQP1 pathway.

• Proceedings of the KSRS Conference
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• 2003.11a
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• pp.482-484
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• 2003

GLI on boarded ADEOS-II satellite allows us to observe vegetation status in the two different resolutions simultaneously, because of thirty 1km resolution channels and six 250m resolution channels. There are four GLI land higher level products from these channels ; those are PGCP (Precise Geometric Correction Parameter), L2A_LC (TOA reflectance), ACLC (atmospheric corrected reflectance), and VGI (NDVI and EVI). This paper shows ADEOS-II GLI land data processing, and some of the latest results.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.29-36
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• 2023

This study proposes a spirometry reference equation suitable for Asian migrant workers undergoing special health examinations. The study participants were divided according to their region: Central Asia, Northeast Asia, and South Asia Pacific. We confirmed results of the spirometry analysis of migrant workers and the interpretation consistency between the prediction equations. Based on this data, we propose a reference equation suitable for domestic migrant workers and suggest a scaling factor applicable to the spirometer wherein the reference equation is not easily applicable. The kappa-values obtained for men and women, respectively, between the global lung function initiative 2012 (GLI2012)-Southeast Asian and the Southeast Asian equations were 0.819 and 0.770, between the GLI2012-Southeast Asian and the South Asian equations were 0.881 and 0.866, and between the GLI2012-Northeast Asian and the Central Asian equations were 0.831 and 0.833. We propose applying the GLI2012-Northeast Asian equation for Northeast Asian and Central Asian countries, whereas the GLI2012-Southeast Asian equation was found to be more suitable for predicting Southeast Asian and South Asian populations. For spirometry, we recommend applying a scaling factor of 0.87 to the Dr. Choi equation, wherein the GLI2012-Southeast Asian equation is not applicable.

• Nuclear industry
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• v.28 no.5
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• pp.34-35
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• 2008

• Tunnel and Underground Space
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• v.20 no.1
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• pp.58-64
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• 2010

GLI model was verified to consider the interaction between a ground and a tunnel lining and to rationally reduce the ground load acting on the secondary lining(concrete lining) of a tunnel. In this study, the economy and the construction condition of tunnel concrete linings designed by a conventional frame model at Lot O of OO line were highly enhanced through a field design change using GLI model. For a few safe considerations, not only about 50% saving of reinforcing steel could reduce the material cost but also the wide space between bars could make it easy to pour concrete mix without voids. There was large saving effect of reinforcing steel for poor ground conditions because Terzaghi's load used in the conventional frame model produces too much high loads for those conditions.

• Journal of Korean Tunnelling and Underground Space Association
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• v.17 no.6
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• pp.575-586
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• 2015

In NATM tunnel, the Ground-Lining Interaction model(GLI model) had been proposed a one of the numerical analysis as the ground load estimation method of the concrete lining. But this model was not applied with the interface mechanism between the ground and the support member or concrete lining. Therefor in this study, it is implemented as a model for closer than actual states that the interface element applied to the existing GLI model. And the modified GLI formula is proposed with the ground load estimation that is from the numerical results for each ground and rock cover conditions. Based on the numerical results, the ground load acting on concrete lining is reduced to ave. 88~106% in case of IV ground condition and ave. 47~57% in case of weathered soil condition comparing with the existing GLI model. It can be anticipated that the results obtained from this study can be applied to an estimation of the ground load on the concrete lining modeled like as real states, consistent and economical design.

• The Journal of Engineering Geology
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• v.16 no.4 s.50
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• pp.327-335
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• 2006

Three processing strategies of seismic refraction data are tested in terms of velocity and depth profiles or structures for mapping of geological discontinuities: GRM(generalized reciprocal method), GLI(generalized linear inversion), Tomography. The test data used in this study are the shot gathers reconstructed by numerical modeling for the structures of 3 planar layers(horizontal, inclined), the buried vertical fracture zones, and vertical fault zones. Tomography is shown to be very efficient for mapping of more complicated tone such as vertical fault and buried fracture zones, whereas GRM and GLI can be useful for horizontal and/or inclined layers, probably on their bases of analysis of first arrivals in travel time curves.

• Proceedings of the KSRS Conference
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• 2005.10a
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• pp.381-384
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• 2005

We have applied the TOMS aerosols retrieval algorithm to GLI measurements. TOMS has utilized the aerosol index, which is a measure of the change in spectral contrast due to the wavelength-dependent effects of aerosols. We have retrieved the GLI aerosol index, which is made by the pair of 380/400nm, 380/412nm, 380/460nm, and 412/460nm. We have found that the biomass burning aerosols represent the absorbing aerosols. In addition, the pair of 380/460nm has shown the best signal for detecting aerosols in Principal Component Analysis(PCA) and comparison of aerosol optical thickness from AERONET data. The theoretical aerosol index is also shown the best signal in the pair of 380/460nm.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.4
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• pp.365-375
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• 2006

The structural analysis for the secondary lining of tunnels is generally performed by a frame analysis model. This model requires a ground loosening load estimated by some empirical methods, but the load is likely to be subjective and too large. The ground load acting on the secondary lining is due to the loss of the supporting function of the first support members such as shotcrete and rockbolts. Therefore, the equilibrium condition of the ground and the first support members should be considered to estimate the ground load acting on the secondary lining. Ground-lining interaction model, shortly GLI model, is developed on the basis of the concept that the secondary lining supports the ground deformation triggered by the loss of the support capacity of the first support members. Accordingly, the GLI model can take into account the ground load reflecting effectively not only the complex ground conditions but the installed conditions of the first support members. The load acting on the secondary lining besides the ground load includes the groundwater pressure and earthquake load. For the structural reinforcement of the secondary lining based on the ultimate strength design method, the factored load and various load combination should be considered. Since the GLI model has difficulty in dealing with the factored load, introduced in this study is the superposition principle in which the section moment and force of the secondary lining estimated for individual loads are multiplied by the load factors. Finally, the design method of the secondary lining using the GLI model is applied to the case of a shallow subway tunnel.