• Title/Summary/Keyword: GIST

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Characterization of gltA::luxCDABE Fusion in Escherichia coli as a Toxicity Biosensor

  • Ahn, Joo-Myung;Kim, Byoung-Chan;Gu, Man-Bock
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.11 no.6
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    • pp.516-521
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    • 2006
  • The use of gltA gene, as a new biomarker for environmental stress biomonitoring, was investigated because of its key position as the first enzyme of the tricarboxylic acid (TCA) cycle. A recombinant bioluminescent Escherichia coli strain, EBJM2, was constructed using a plasmid carrying the citrate synthase (gltA) promoter transcribing the Photorhabdus luminescens IuxCDABE genes (gltA::luxCDABE). The responses from this strain were studied with five different classes of toxicants: DNA damage chemicals, phenolics, oxidative-stress chemicals, PAHs, and organic solvents. EBJM2 responded strongly to DNA damage chemicals, such as mitomycin C (MMC) and methyl-nitro-nitrosoguanidine (MNNG) and nalidixic acid with the strongest responses. In contrast, tests with several compounds from the other four classes of toxicants gave no significant response. Therefore, EBJM2 was found to be sensitive to DNA damage chemicals.

Sparse Index Multiple Access for Multi-Carrier Systems with Precoding

  • Choi, Jinho
    • Journal of Communications and Networks
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    • v.18 no.3
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    • pp.439-445
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    • 2016
  • In this paper, we consider subcarrier-index modulation (SIM) for precoded orthogonal frequency division multiplexing (OFDM) with a few activated subcarriers per user and its generalization to multi-carrier multiple access systems. The resulting multiple access is called sparse index multiple access (SIMA). SIMA can be considered as a combination of multi-carrier code division multiple access (MC-CDMA) and SIM. Thus, SIMA is able to exploit a path diversity gain by (random) spreading over multiple carriers as MC-CDMA. To detect multiple users' signals, a low-complexity detection method is proposed by exploiting the notion of compressive sensing (CS). The derived low-complexity detection method is based on the orthogonal matching pursuit (OMP) algorithm, which is one of greedy algorithms used to estimate sparse signals in CS. From simulation results, we can observe that SIMA can perform better than MC-CDMA when the ratio of the number of users to the number of multi-carrier is low.

Development of Core Components of Projected Clustering for High-Dimensional Categorical Data (고차원 범주형 데이터를 위한 투영 군집화 기법의 핵심 요소 개발)

  • Kim Min-Ho;Ramakrishna R.S.
    • Proceedings of the Korean Information Science Society Conference
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    • 2006.06b
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    • pp.181-183
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    • 2006
  • 본 논문은 고차원의 범주형 데이터에 대한 군집화에 대해서 다룬다. 기존의 범주형 데이터 객체를 위한 유사성(상이성) 계측들의 기저에 깔려 있는 한계점은 수치형 데이터에서와 같은 순서화 (ordering)의 부재와 데이터의 고차원성과 희소성에 기인하는데, 이를 효과적으로 극복할 수 있는 기법이 투영 군집화이다. 본 논문에서는 고차원의 범주형 데이터를 효과적으로 처리할 수 있는 투영 군집화를 다루며 핵심 요소인 군집 차원의 정의와 군집 응집도를 제안한다.

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The Performance Advancement of Test Algorithm for Inner Defects In Semiconductor Packages (반도체 패키지의 내부 결함 검사용 알고리즘 성능 향상)

  • Kim J.Y.;Kim C.H.;Yoon S.U.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2005.10a
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    • pp.721-726
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    • 2005
  • In this study, researchers classifying the artificial flaws in semiconductor. packages are performed by pattern recognition technology. For this purposes, image pattern recognition package including the user made software was developed and total procedure including ultrasonic image acquisition, equalization filtration, binary process, edge detection and classifier design is treated by Backpropagation Neural Network. Specially, it is compared with various weights of Backpropagation Neural Network and it is compared with threshold level of edge detection in preprocessing method for entrance into Multi-Layer Perceptron(Backpropagation Neural network). Also, the pattern recognition techniques is applied to the classification problem of defects in semiconductor packages as normal, crack, delamination. According to this results, it is possible to acquire the recognition rate of 100% for Backpropagation Neural Network.

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Equitable Peer Assessment Method in Collaboration Project Using Statistical Technique (통계적 기법을 이용한 집단 협업 프로젝트에서의 공정한 동료 평가 방법론에 대한 연구)

  • Cho, Miyeon;Ko, Sung-Seok
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.36 no.1
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    • pp.44-52
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    • 2013
  • For evaluating participation in collaboration project, the peer assement method is mostly used and various scoring methods have been proposed. But, the reliability and validity of the peer assessment method are still doubted for all most method. In order to overcome these weaknesss, some guidelines and training methods have been recommended. In this article, however, statistical technique is proposed for measuring individual contributions to collaboration projects considering each assessor's reliability. The gist of our proposed algorithm is that an assessor's reliability depends on the evaluation policy, and this reliability is evaluated by an analysis of variance of the scores assigned by the assessor. We also show that the proposed method is very efficient by case study in university class.

Visualization of Social Networks Service based on Virtualization (가상화 기반의 SNS 시각화)

  • Park, Sun;Kim, Chul Won
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2014.05a
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    • pp.637-638
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    • 2014
  • This paper proposes a new visualization method based on Vitualization technique which uses internal relationship of user correlation and external information of social network to visualize user relationship hierarchy. The proposed method use hadoop on virtual machine of OpenStack for distribution and parallel processing which the result of calculation visualizes hierarchy graph to analyze link nodes of Social Network Services for users.

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Spatio-Temporal Visualization of Cultural Heritage Collections (문화유산 데이터의 시공간상 시각화 연구)

  • Park, Narae;Jeon, Moongu
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2020.07a
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    • pp.55-57
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    • 2020
  • 본 연구는 문화유산 데이터의 효과적 정보 시각화 방안을 탐색한다. 문화유산 데이터는 역사적 사회적 맥락 속에서 충실히 이해될 수 있기에, 지리적 평면과 시간 축으로 이루어지는 3차원 시공간 큐브상에 문화유산 데이터들을 배치하는 것은 문화유산의 특성을 반영하면서도 통시적·공시적 조망을 동시에 제공하는 유익한 시각화 방안이 될 수 있다. 이를 확인하기 위해 문화유산 컬렉션 데이터를 지도 평면과 시간 축으로 구성된 시공간 큐브 상에서 탐색·체험할 수 있는 웹 어플리케이션과 AR 어플리케이션을 구현하고, 이에 대한 사용자 평가를 실시했다. 평가 분석 결과 문화유산 데이터의 3차원 시각화는 데이터에 대한 총체적 시야를 제공하고 새로운 체험에 대한 관심과 호기심을 유발하는 한편, 낯선 형식으로 인한 인지적 피로가 뒤따를 수 있어 대상 데이터의 특성, 매체 형식의 특성, 사용자의 경험적 이해, 인간의 지각방식을 고려한 다각적 정보 체험 설계가 필요할 것으로 파악되었다.

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Korean Dependency Parsing as Machine Reading Comprehension (기계독해 기반 한국어 의존 파싱)

  • Min, Jinwoo;Na, Seung-Hoon;Shin, Jong-Hoon;Kim, Young-Kil;Kim, Kangil
    • Annual Conference on Human and Language Technology
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    • 2021.10a
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    • pp.270-273
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    • 2021
  • 한국어 의존 파싱은 전이 기반 방식과 그래프 기반 방식의 두 갈래로 연구되어 왔고 그 중 그래프 기반 의존 파싱 방법은 문장 내의 모든 단어에 대해 인코딩한 후 지배소, 의존소에 대한 MLP를 적용하여 각각 표상을 얻고 Biaffine 어텐션을 통해 모든 단어 쌍에 대한 그래프 점수를 얻고 트리를 생성하는 방법이 대표적이다. Biaffine 어텐션 모델에서 문장 내의 각 단어들은 구문 트리 내의 서브트리의 역할을 하지만 두 단어간의 의존성만을 판단하기 때문에 서브 트리의 정보를 이용할 수 없다는 단점이 존재한다. 본 연구에서는 이러한 단점을 해결하기 위해 제안된 Span-Span(서브트리-서브트리)로의 서브트리 정보를 이용할 수 있도록 하는 기계 독해 기반 의존 파싱 모델을 한국어 구문 분석 데이터 셋에 적용하여 소폭의 성능향상을 얻었다.

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Retrieval of Pollen Optical Depth in the Local Atmosphere by Lidar Observations (라이다를 이용한 지역 대기중 꽃가루의 광학적 두께 산출)

  • Noh, Young-Min;Lee, Han-Lim;Mueller, Detlef;Lee, Kwon-Ho;Choi, Young-Jean;Kim, Kyu-Rang;Choi, Tae-Jin
    • Korean Journal of Remote Sensing
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    • v.28 no.1
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    • pp.11-19
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    • 2012
  • Air-borne pollen, biogenically created aerosol particle, influences Earth's radiative balance, visibility impairment, and human health. The importance of pollens has resulted in numerous experimental studies aimed at characterizing their dispersion and transport, as well as health effects. There is, however, limited scientific information concerning the optical properties of airborne pollen particles contributing to total ambient aerosols. In this study, for the first time, optical characteristics of pollen such as aerosol backscattering coefficient, aerosol extinction coefficient, and depolarization ratio at 532 nm and their effect to the atmospheric aerosol were studied by lidar remotes sensing technique. Dual-Lidar observations were carried out at the Gwangju Institute of Science & Technology (GIST) located in Gwagnju, Korea ($35.15^{\circ}E$, $126.53^{\circ}N$) for a spring pollen event from 5 to 7 May 2009. The pollen concentration was measured at the rooftop of Gwangju Bohoon hospital where the building is located 1.0 km apart from lidar site by using Burkard trap sampler. During intensive observation period, high pollen concentration was detected as 1360, 2696, and $1952m^{-3}$ in 5, 6, and 7 May, and increased lidar return signal below 1.5km altitude. Pollen optical depth retrieved from depolarization ratio was 0.036, 0.021, and 0.019 in 5, 6, and 7 May, respectively. Pollen particles mainly detected in daytime resulting increased aerosol optical depth and decrease of Angstrom exponent.

Gastrointestinal Stromal Tumor (GIST) of the Stomach: Clinicopathologic Analysis and Outcome (위에 발생한 위장관 간질성 종양의 임상병리학적 특성과 치료성적)

  • Ryu Je-Seock;Lee Sung-Ryul;Choi Sae-Byeol;Park Sung-Soo;Lee Ju-Han;Kim Seung-Joo;Kim Chong-Suk;Chae Yang-Seok;Mok Young-Jae
    • Journal of Gastric Cancer
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    • v.5 no.1
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    • pp.40-46
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    • 2005
  • Purpose: Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms of the gastrointestinal tract. GISTs are positive for the expression of c-Kit protein at immunohistochemistry, and their clinical presentations vary. This retrospective study was performed to evaluate the clincopathologic characteristics of GISTs and to define the prognostic factors. Materials and Methods: 40 patients who underwent a complete resection of a GIST during the period $1996\~2003$ at the Department of Surgery, Korea University College of Medicine, were studied. We divided them into low- and high-risk. groups by using tumor size and mitotic count: 23 cases were low risk, and 17 were high risk. Clinicopathologic features, immunohistochemical findings, and prognoses were compared between the low- and the high-risk groups. Results: The mean age of the 40 patients was $61.3\pm11.1$years, and the male-to-female ratio was 1:1.1. There was no significant difference in age and sex between the groups. A comparative analysis revealed tumor size, mitotic count, clinical symptoms, preoperative pathologic diagnosis, ulceration, and necrosis to be variables that had statistically significant differences between the high- and the low-risk groups. In the univariate analysis, tumor size, mitotic count, ulceration, necrosis, and abnormal endoscopic ultrasound findings were associated with disease-free survival, but in the multivariate analysis, mitotic activity was the only independent factor associated with disease-free survival. 8 patients had recurrences during the follow-up period, and four of them were treated with STI-571 (imatinib mesylate, $Gleevec^{(R)}$). The treated patients have survived until now; however, two of non-treated patients died from disease progression. Conclusion: Based on this study, tumor size, ulceration, and necrosis are significant factors affecting survival, and mitotic activity may be a useful prognostic marker. STI-571 may be used in an adjuvant setting because the drug has shown anticancer activity in patients with recurrence or metastasis.

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