• The Korea Journal of Herbology
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• v.24 no.4
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• pp.215-224
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• 2009

Objectives : Atopic dermatitis is a chronic inflammatory disease characterized by typically distributed eczematous skin lesion with pruritus, lichenification and dry skin. In this study, we performed to assess the therapeutic effects of co-treatment of Chenilyeomgamibang (CGB) and Chenggihaedok-san (CHS, C&C) on the TNCB(trinitrochlorobenzene)-induced atopic dermatitis in NC/Nga mice, characterized by the onset of atopic dermatitis along with an increase the number of inflammatory cells and dysregulation of Th2 cytokines. Methods : Defined amount of CGB was sprayed on mice skin and CHS was simultaneously orally administrated to TNCB treated NC/Nga mice for 5 weeks. The immune cell types were caracterized by flow cytometry using each specific antibody. The amount of Th2 cytokines in serum and splenocytes culture supernatant were measured by ELISA. Results : Administration of C&C significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells were dramatically reduced. Flow cytometry analysis showed that infiltrated immune cell numbers of CCR3+, B220+/IgE+, Gr-1+/CD11b+, and CD117+ were significantly reduced in C&C-treated dorsal skin lesion. Furthermore, T cell composition rate in PBMC was also dramatically decreased by the treatment. C&C greatly down-regulated production of Th2 cytokines including IL-4, IL-5, IL-13 in the serum. The down- regulatory effects of C&C on these Th2 cytokines production were also detected in CD3/ CD28 activated splenocytes. Conclusions : These results indicated that C&C is a plausible therapeutic agent for treatment of atopic dermatitis through regulating the Th2 skewed immune system.

• Journal of agriculture & life science
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• v.50 no.3
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• pp.129-139
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• 2016

Curcumin plays a protective role in brain injury through its anti-oxidant and anti-inflammatory activities. Moreover, peroxiredoxin-5 exerts a protective effect against oxidative stress. The aim of this study was to investigate whether curcumin modulated the peroxiredoxin-5 expression in focal cerebral ischemic animal model. Middle cerebral artery occlusion(MCAO) was performed to induce cerebral ischemic injury in rats. Adult male rats were injected intraperitoneally with vehicle or curcumin(50mg/kg B.W.) 1 h after MCAO and cerebral cortex tissues were collected 24 h after MCAO. Photographs of hematoxylin and eosin staining showed that MCAO induced necrotic changes with scalloped shrunken form and apoptotic changes with nuclear chromatin condensations. However, curcumin treatment attenuated MCAO-induced histopathological changes. Moreover, this study clearly showed that peroxiredoxin-5 expression was decreased in MCAO operated animal with vehicle using a proteomics approach. However, this decrease in peroxiredoxin-5 expression was attenuated by curcumin treatment. Reverse-transcription PCR and Western blot analyses confirmed that curcumin treatment alleviated the MCAO injury-induced decrease in peroxiredoxin-5 expression(p<0.05). These results demonstrated that curcumin regulates peroxiredoxin-5 expression in MCAO animal model. In conclusion, our findings suggest that curcumin exerts a neuroprotective effect in cerebral ischemia by attenuating the MCAO-induced decrease in peroxiredoxin-5 expression.

• Korean Journal of Culture and Social Issue
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• v.20 no.2
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• pp.89-105
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• 2014

This study investigated the effects of a brief Loving-Kindness and Compassion Meditation(20 minutes) on compassionate love and altruism of undergraduate students. Among the 187 students who were completed the KIIP-SC, 35 of high scored students in Interpersonal Problem Scale were randomly assigned to one of two different groups: Loving-Kindness and Compassion Meditation group(LCM, n=19) and Imagery Trainning group(IT, n=16). During the 20 minutes of practice, LCM group was asked to practice loving-kindness and compassion meditation and IT group was asked to investigate personal characteristics of the imagined people who were same as LCM. Compassionate love, four immeasurebles, two kind of altruistic behaviors, and mood states were measured pre- and post-treatment. LCM group showed significantly higher incremental scores for compassionate love, donation for strange person, and helping behaviors for friends, for close person, and for stranger than IT group. Negative and positive mood states were improved for each of the groups, but there was no significant differences between groups. The results suggested that the comparatively short practice of loving-kindness and compassion meditation could increase altruistic attitudes and intentions toward other persons. And, these effects could not be attributed to mood effects. Limitations of this study and the directions of further research were discussed.

• Korean Journal of Culture and Social Issue
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• v.22 no.2
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• pp.263-283
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• 2016

The present study aimed at examining the factor structure, reliability and validity of the Korean version of the Continuing Bonds Scale (K-CBS). In study 1, exploratory factor analysis was administered to 293 bereaved adults who had experienced the death of a loved one, and it revealed a single factor structure with 10 items that explained 52.59% of the total variance. The K-CBS showed good internal consistency with Cronbach's alpha of .92. In study 2, confirmatory factor analysis in a different sample of 200 bereaved adults indicated satisfactory standardized regression weights of all items. However, one item had a squared multiple correlation less than .40, hence, this item was discarded, and 9 items remained for the final scale. The single factor model with 9 items displayed a good fit. The K-CBS had strong positive correlation with grief symptoms, and weak positive correlation with depression. After controlling for grief, however, the K-CBS was predictive of a decrease in depression. The K-CBS was positively associated with posttraumatic growth. In addition, significant differences in scores of the K-CBS were shown among groups based on the deceased's relation to the bereaved and expectedness of loss. These results suggest that the K-CBS is a reliable and valid instrument to measure continuing bonds. Finally, implications, limitations, and directions for future research were discussed.

• Korean Journal of Culture and Social Issue
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• v.13 no.4
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• pp.113-134
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• 2007

This study investigated body-related values, body-esteem, and the relationship between them based on the survey data drawn from female college students in three East Asian countries(Korea, Japan, and China). 168 Korean, 108 Chinese, and 152 Japanese female college students responded to questions designed to measure four sorts of body values (operability, inclination, locus of evaluation, and social utility) and four dimensions of body esteem (appearance, weight, health, overall). The results showed that body-related values and body-esteem differ among three countries. Japanese showed the highest acceptance level for the voluntary body alteration(operability), while chinese scored the lowest. Inclination to body appearance over health was higher in Korean than in Japanese and in Chinese. Korean also evaluated the importance of body appearance and its social utility the highest, followed by Japanese and Chinese. There were dramatic differences in body esteem between Korean and Japanese. Regarding body-esteem, Korean showed the highest appearance-esteem, but the health-esteem was the lowest. On the contrary, Japanese showed the highest health-esteem, but the appearance-esteem was lowest. Chinese showed the highest weight-esteem. Four sorts of body values showed significant correlations with appearance-esteem and weight-esteem, respectively but not with health-esteem. Overall, the result supported the prediction that different political, social, and economic backdrops in three countries would be related with different body-related values and body esteem in the female college students.

• Korean Journal of Culture and Social Issue
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• v.13 no.2
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• pp.55-76
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• 2007

This study investigated the relationship between emotional contagion and altruistic behaviors and also examined the moderating effect of self-construals(independent and interdependent self) in this relationship. It was hypothesized that the emotional expression of people in need would be caught by others through automatic mimicry, that emotional information would be internalized through the facial-feedback process and that the transferred emotion would eventually result in a motive to call for altruistic behaviors. In Study 1, participants watched a video clip about a disabled student reporting difficulties in school life but showing facial expression opposite to the contents of message to separate emotional contagion and empathy. Participants' decision to participate in voluntary works for the disabled student was measured. As a result, it was found that the more participants experienced emotional contagion, the more they participated in altruistic behaviors. Study 2 measured the vulnerability to emotional contagion, actual experiences of altruistic behaviors, and self-construals. The results of hierarchical regression showed that interdependent self moderated the influence of emotional contagion on altruistic behaviors whereas independent self moderated the relationship in an opposite direction. The implications of emotion and altruistic behaviors in human evolution process are discussed.

• Journal of the Korean Regional Science Association
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• v.40 no.1
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• pp.37-51
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• 2024

To respond to local extinction, South Korea, under the leadership of the Ministry of the Interior and Safety, identified depopulated areas in 2021 and launched the Local Extinction Response Fund in 2022. However, due to its early stage of implementation, analyzing the characteristics and changes of policy response to local extinction at the central government level remains a challenge. In contrast, Japan, facing similar issues of local extinction as South Korea, has established a robust central government-led response system based on the Regional Revitalization Act and the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. Hence, this study examines Japan's policy responses to local extinction by analyzing the first and second periods of the Comprehensive Strategy and Basic Policy on Community-Population-Job Creation. For the analysis, topic modeling was employed to enhance text analysis efficiency and accuracy, complemented by expert interviews for validation. The results revealed that the first-period strategy's topics encompassed economy and society, start-up, local government, living condition, service, and industry. Meanwhile, the second-period strategy's topics included resource, the New Normal, woman, digital transformation, industry, region, public-private partnership, and population. The analysis highlights that the policy target, policy direction, and environmental change significantly influenced these policy shifts.

• Journal of Life Science
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• v.25 no.8
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• pp.861-869
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• 2015

One of the domesticated species; the dog has been selectively bred for various aims by human. The dog has many breeds, which are artificially selected for specific behaviors and morphologies. Dogs contribute their life to human as working dogs for guide, rescue, detection or etc. Working dogs requires good personality, such as gentleness, robustness and patience for performing their special duty. Many studies have concentrated on finding genetic marker for selecting the high-quality working dog. In this study, we confirmed quantitative expression patterns of eight genes (ABAT; 4-Aminobutyrate Aminotransferase, PLCB1; Phospholipase C, Beta 1, SLC10A4; Solute Carrier Family 10, Member 4, WNT1; Wingless-Type MMTV Integration Site Family, Member 1, BARX2; BarH-Like Homeobox 2, NEUROD6; Neuronal Differentiation 6, SEPT9; Septin 9 and TBR1; T-Box, Brain, 1) among brains tissues from four dog breeds (Beagle, Sapsaree, Shepherd and Jindo), because these genes were expressed and have functions in brain mostly. Specially, BARX2, SEPT9, SLC10A4, TBR1 and WNT1 genes were highly expressed in Beagle and Jindo, and Sapsaree and German Shepherd were vice versa. The biological significance of total genes was estimated by database for annotation, visualization and integrated discovery (DAVID) to determine a different gene ontology (GO) class. In these analyses, we suppose to these eight genes could provide influential information for brain development, and intelligence of organisms. Taken together, these results could provide clues to discover biomarker related to functional traits in brain, and beneficial for selecting superior working dogs.

• Journal of Korea Port Economic Association
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• v.24 no.4
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• pp.363-384
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• 2008

This study aims at improving Korea's competitiveness in port logistics through marketing strategy with integrating the conceptual approach into the empirical one and combining both the oldest military treatise and the newest evaluating model in social science that was applied by the HFP(hierarchical fuzzy process) model enhanced by the KJ method. The empirical results of this study show Busan in the middle among subject ports. At present, Korea plays a reciprocal role in the port market in East Asia, but in the medium- and long-term, Korea's ports will vie together with most major ports in the East Asian region. A descriptive investigation shows that Korea's developing tasks in port logistics must be considered in the context of the direction for developing port policies, the necessity of expanding port facilities in the capital region, securing the sufficient traffic volume through the establishment of the hinterland linking system and its positive utilization, and reforming the direction for developing the global logistics through increased port competitiveness. In the short- and medium-term, Korea must use the opportunity factor of 'Growth and open door policy of China' as a geoeconomic advantage and to utilize Korea's ports as a gate to Chinese foreign trade. With the rise of China's economy, China also plays a significant role in both port and airport markets. Hence, the linking system between the two must be established to meet the expanding traffic volume, especially in the capital area. Moreover, it is necessary for Korea to secure port logistics through the establishment of the hinterland linking system and its positive utilization. The great accomplishment of this paper is to present strategies to increase Korea's port competitiveness in the rapidly changing environments of world logistics with the focus on both the oldest military strategic treatise and the newest empirical method in social science. In order to reinforce this study, it needs further compensative research because the evaluation structure could be subdivided with more extensive and precise criteria.

• Korean Journal of Poultry Science
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• v.10 no.2
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• pp.123-128
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• 1983

Fifty of one day-old chicks of silky fowl were hatched at Dept. of Animal Science, Gyeongsang National University and fifty of one day-old chicks of quails were hatched at Gim Hae, Gyung Nam. This experiment was investigated at 24 hours after incubation. Twee items investigated in this experiment were the live weights, the weights of head, eye-ball, brain, heart, liver, lung, kidney, stomach, small intestine, large intestine, and yolk sac. The results obtained are summarized as follows; 1, Average weights of body, head, eye-ball brain, heart, liver, lung, kidney, stomach, small intestine, large intesine and yolk sac of the quail chicks and standard errors were 6.54${\pm}$0.02g, 1.38${\pm}$0.l3g, 0.29${\pm}$0.004g, 0.24${\pm}$0.006g, 0.08${\pm}$0.002g, 0.21${\pm}$0.005g, 0.06${\pm}$0.002g, 0.05${\pm}$0. 002g, 0.46${\pm}$0.010g, 0.24${\pm}$0.008g, 0.10${\pm}$0.004g, and 0.28${\pm}$0.0l6g, respectively. 2. Average weights of body, head, eye-ball, brain, heart, liver, lung, kidney, stomach, small intestine, large intestine, and yolk sac of the silky fowl chicks and standard errors were 26.60${\pm}$0.491g, 4.28${\pm}$0.071g, 0.64${\pm}$0.039g, 0.55${\pm}$0.025g, 0.21${\pm}$0.0l2g, 0.77${\pm}$0.030g, 0.13${\pm}$0.006g, 0.08${\pm}$0.006g, 1,53${\pm}$0.076g 0.73${\pm}$0.036g, 0.42${\pm}$0.031g, and 2.65${\pm}$0.297g, respectively. 3. The relative ratios of the organ weight versus body weight in guails were compared with those of the commercial chicks (Hibro, Hubbard, and Hisex) and silky fowls. It was noted that the relative weights of the brain and eye ball with respect to body weight were larger in case of quails (Table 3). The weights of heart, liver, lung, kidney, stomach and small intestine in silky fowl were smaller than those of commercial chicks and quail chicks. Other items were similar in weight to commercial chicks ana quail chicks.