• Journal of KIISE:Information Networking
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• v.36 no.1
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• pp.12-23
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• 2009

Sensor networks deployed in battlefields to support military operations or deployed in natural habitats to monitor the rare wildlifes must take account of protection of the location of valuable assets(i.e., soldiers or wildlifes) from an adversary or malicious tracing as well as the security of messages in transit. In this paper we propose a routing protocol GSLP(GPSR-based Source-Location Privacy) that is capable of enhancing the location privacy of an active source node(i.e., message-originating node) in the presence of multiple dormant sources(i.e., nodes lying nearby an asset whose location needs to be secured). Extended is a simple, yet scalable, routing scheme GPSR(greedy perimeter stateless routing) to select randomly a next-hop node with a certain probability for randomizing paths and to perform perimeter routing for detouring dormant sources so that the privacy strength of the active source, defined as safety period, keeps enhanced. The simulation results obtained by increasing the number of dormant sources up to 1.0% of the total number of nodes show that GSLP yields increased and nearly invariant safety periods, while those of PR-SP(Phantom Routing, Single Path), a notable existing protocol for source-location privacy, rapidly drop off as the number of dormant sources increases. It turns out that delivery latencies of GSLP are roughly less than two-fold of the shortest path length between the active source and the destination.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2008.04a
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• pp.5-20
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• 2008

GLP-1-based drugs (GLP-1 analogues and DPP IV inhibitors) and incretin mimetics are currently one of the most exciting classes of agents for type II diabetes. GLP-1, a gut peptide, is an incretin that potentiates glucose-dependent insulin release from the pancreas, slows GI-transit and stimulates the proliferation of beta-cells. DPP IV inhibitors act like incretins by inhibiting DPP IV which inactivates GLP-1. LC15-0133 is a competitive, reversible DPP IV inhibitor ($IC_{50}$ = 24 nM, Ki=0.247 nM) with excellent selectivity over other critical human proteases such as DPP II, DPP 8, elastase, trypsin. and urokinase. LC15-0133 showed long half-life and good bioavailability in rats and dogs. Inhibition of plasma DPP IV activity by LC15-0133 was kept more than 50% 24 hours after oral dosing in rats and dogs at 0.1 mg/kg and 0.02 mg/kg, respectively. The Minimum effective doses of LC15-0133 were 0.01 mg/kg for lowering blood glucose excursion during oral glucose tolerance test and 0.1 mg/kg for increasing glucose-induced GLP-1 response in C57BL/6 mice. Repeat oral administration of LC15-0133 for 1 month delayed the progression to diabetes and reduced HbA1c levels in a dose-dependent manner in Zucker Diabetic Fatty rats. In conclusion, LC15-0133 is a novel, potent, selective and orally active DPP IV inhibitor and showed an excellent blood glucose lowering effects in various animal models.

• Journal of Korean Tunnelling and Underground Space Association
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• v.25 no.2
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• pp.157-173
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• 2023

Although this site is designed with a non-vibration excavation method for a section of 265 m, there are concerns about decline of constructability and economic feasibility. For this reason, the low-vibration electronic detonator blasting method was suggested. To evaluate the applicability of the low-vibration electronic detonator blasting method, the damage range of blasting vibration of low-vibration electronic detonator blasting applied just before the site (suggestion I) and low-vibration electronic detonator blasting constructed close range the subway like this site (suggestion II) was analyzed. As a result of comparing the blasting vibration damage ranges of the two suggestions, the damage range of suggestion II was calculated more conservatively. Considering the specificity of the close range of this site, suggestion II was selected for design change for safer construction. As a result, it is predicted that there will be no damage to the structure even if the 72 m section out of the non-vibration excavation 265 m section is changed to the Low-vibration electronic detonator blasting. And it is evaluated that high economic benefits can be obtained because the total expected excavation period can be reduced by 144 days from 662.5 days.