• 대한한의학회지
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• 제39권4호
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• pp.126-135
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• 2018

Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and irreversible airflow. This study aimed to evaluate the effects of GHX02 in a COPD-induced mouse model. Methods: The COPD mouse model was established by exposure to cigarette smoke extract and lipopolysaccharide which were administered by intratracheal injection three times with a 7 day interval. GHX02 (100, 200, 400 mg/kg) and all other drugs were orally administrated for 14 days from Day 7 to Day 21. Results: GHX02 significantly decreased the neutrophil counts in bronchoalveolar lavage fluid (BALF) and the number of $CD4^+$, $CD8^+$, $CD69^+$, and $CD11b^+/GR1^+$ cells in BALF and lung cells. GHX02 also suppressed the secretion of tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C-X-C motif) ligand 1 (CXCL-1) in BALF and ameliorated the lung pathological changes. Conclusions: Thus, GHX02 effectively inhibited airway inflammation by inhibiting migration of inflammatory cells and expression of pro-inflammatory cytokines. Therefore, GHX02 may be a promising therapeutic agent for COPD.

• 설비공학논문집
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• 제26권10호
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• pp.453-459
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• 2014

This paper presents an analysis on the initial ignoring time of SCW type GHX using Mean Square Error method. Line source method is a useful method for estimating the ground thermal conductivity for the vertical type and SCW type GHX in Korea. The line source method for ground thermal conductivity of geothermal in-site test is the basis of linear approximation between the temperature of a borehole and logarithmic time in a GHX. To apply the line source method to the estimation of SCW type GHX, it is necessary to ignore the initial time of data at the stage of a linear approximation. This paper proposed a new initial ignoring time of SCW type GHX among various initial ignoring time at the time for reaching MSE of $0.02^{\circ}C^2$.