• Journal of Environmental Health Sciences
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• v.19 no.2
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• pp.61-68
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• 1993

This study aimed at evaluating the preventive effect of Glycyrrhizae Radix and Glycine Semen Extract (GGE) against NAC intoxication. NAC is widely used pesticide in many countries and derivative of carbamats and GGE is well-known antidote to some kinds of toxicants which was referenced from oriental medicine text. The results obtained were as follows: 1) After injecting NAC (100,140 mg/kg), determined Ch.E activities decrease 44.77~50.86% for all experimental groups at one hour after exposure, and were gradually recovered in the course of time. 2) In toxicity test of GGE, there were no sign of death or poisoning up to 5000 mg/kg of GGE for p.o. in mice. From this, we suggest that the LD$_{50}$ of GGE would be above 5000 mg/kg. 3) The Ch.E activity in control group was 471.43 $\pm$ 4.85 luff, group I was 215.27 $\pm$ 23.13 IU/l, group II and group III were 304.03 $\pm$ 9.03 IU/l, 433.81 $\pm$ 21.73 IU/l, respectively. Compare to the control group with experimental group I, remarkable difference revealed (p< 0.01), but the Ch.E activities of group II and III were similar to those of control group. This is indicate that GGE possess a potent activity of recovering Ch.E. GGE had a very remarkable preventive effect on NAC toxicity, and it was able to know that Ch.E activity dramatically increased according to GGE dosage increasing. 4) When GGE and NAC were administered by p.o. simultaneously, LD$_{50}$ and confidence intervals of each group were as follows: the control group: 270 mg/kg, 234.99~310.23 mg/kg, group I and II (GGE 500 mg/kg, 1000 mg/kg by p.o.): 310 mg/kg, 271.69~353.71mg/kg, and 325 mg/kg, 285.09~370.50 mg/kg, respectively. In the comparison with the control group, the protective index was 1.1 and 1.2, respectively. From the above result, GGE has reactivation effect to decreasing Ch.E activity induced by exposure to NAC. Furthermore, GGE shows a preventive effect on NAC intoxication.

• Food Science and Preservation
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• v.9 no.2
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• pp.174-178
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• 2002

Changes in amino acids, organic acids and free sugars of soybean sprouts cultivated with extract of Glycyrrhiza glabra(GGE) during growth of 4 days were investigated. GGE was utilized as sprouting water of soybean and adjusted to 100 ppm, 200 ppm, 300 ppm and 400 ppm. Content of total amino acids of soybean sprouts cultivated with GGE was the most abundant, when soybean sprouts were cultivated for 3 days with 100 ppm of PGE. Content of aspartic acid was increased according to culturing days, but glutamic acid was shown to be a opposite trend. Content of total free sugar of soybean sprouts cultivated with GGE was lower than those of control group, and then increased by increasing of culturing days within GGE groups with same concentration. Sucrose of all groups during growth of soybean sprouts was decreased, but the other sugars were increased. Content of total organic acids was increased by increasing of culturing days and was the most abundant in soybean sprouts cultivated with 200 ppm of GGE among same groups. In conclusion, GGE as sprouting water of soybean was effective to increase of contents of amino acids and organic acids in soybean sprouts, indicating that GGE accelerated the quality of soybean sprouts.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1385-1391
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• 2009

The purpose of this research was to investigate the effects of the extracts of Glycyrrhiza uralensis (GE) and the combined extracts of Glycine max Merr. and Glycyrrhiza uralensis (GGE) on the activity of murine splenocytes and macrophages. GE and GGE were administered orally twice a day for 7 days at the dose of 500 mg/kg. GE decreased the viability of T- and B-lymphocytes in splenocytes, but GGE increased the viability of B-lymphocytes in splenocytes. GE increased the population of B-lymphocytes in splenocytes, but decreased the population of T-lymphocytes and splenic $CD4^+$ cells. Also, GGE decreased the population of B-lymphocytes in splenocytes, but increased the population of T-lymphocytes and splenic $CD4^+$ cells. Furthermore, GE and GGE enhanced the phagocytic activity of peritoneal macrophages and the production of nitric oxide. These results suggest that the regulative action of immune response of GGE is more potent than their of GE.

• Biomedical Science Letters
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• v.29 no.4
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• pp.242-248
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• 2023

Platelets are activated at the sites of vascular injury by a number of molecules, including adenosine diphosphate, collagen and thrombin. The full platelet aggregation is absolutely essential for the normal hemostasis. Glycyrrhiza glabra is a well-known medicinal herb that grows in various parts of the world and is known to have various effects such as antioxidant, anti-inflammatory, anti-atherogenic, anti-osteoporotic and skin-whitening. However, the platelet inhibitory effect of Glycyrrhiza glabra extract (GGE) has not been identified. In this study, we investigated if GGE inhibited platelet aggregation. We observed that GGE inhibited collagen-induced platelet aggregation, Ca²⁺ mobilization, and thromboxane A2 generation. In addition, GGE suppressed phosphorylation of phosphatidylinositol-3 kinase (PI3K), Akt and elevated phosphorylation of inositol 1,4,5-trisphosphate receptor (IP3R), vasodilator stimulated phosphoprotein (VASP). Taken together, GGE showed strong antiplatelet effects and may be used to block platelet-mediated cardiovascular diseases.

• Annals of Clinical Neurophysiology
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• v.22 no.2
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• pp.92-103
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• 2020

Background: The purpose of this study was to identify the top-100 cited articles on genetic generalized epilepsy (GGE) published in journals that have made key contributions to the field of epilepsy. Methods: We searched the Web of Science website produced by Clarivate Analytics for articles on GGE, and sorted them according to the number of citations to identify the top-100 cited articles. We then manually reviewed the contents of the top-100 cited articles, which were designated as "citation classics". Results: The top-100 cited articles were published in 27 journals, with the largest proportion appearing in Epilepsia (19 articles). The articles originated from institutions in 17 countries, with 31 articles from the USA. The institution associated with the largest numbers of articles in the field of GGE was the University of Melbourne, Australia (9 articles). Panayiotopoulos C. P. was the first author of three articles, and was listed most frequently in the GGE citation classics. The publication years were concentrated in the 2000s, when 56 articles were published. The most-common study topics were genetics (35 articles) and neuroimaging (17 articles). Conclusions: This study has identified the top-100 cited articles on GGE. These citation classics represent the landmark articles on GGE, and they provide useful insights into international research leaders and the research trends in the field.

• Convergence Security Journal
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• v.13 no.6
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• pp.51-59
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• 2013

Cyberspace, based on the dramatic development of information and communications technology, has brought enormous benefits to mankind. However, concerns over cyber terrorism and cyber attack are becoming serious. It is time to expand the global dialogue on international security issues in cyberspace. It is imperative to have a common understanding that cyberspace, the infrastructure for prosperity, should not be utilized as a space to create conflicts among states, and that all states agree to build confidence and peace in cyberspace. For this purpose, there are 3 tracks of international cooperations: 1)international cooperation such as UN and Conference on Cyberspace, 2)regional cooperations such as ARF and OSCE. 3)bilateral cooperations such US-Russia Cybersecurity Agreement, US-China presidential level dialogue. This paper will analyze the 1st track of international cooperations of UN and Conference on Cyberspace. With this, Korean government can prepare the forthcoming GGE activities and make our own strategy to deal with the global norms of good behaviour in cyberspace.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.60 no.3
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• pp.349-354
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• 2015

The AMMI (additive main effects and multiplicative interaction) and GGE (genotype main effect and genotype by environment interaction) biplot which were accounted for a substantial part of total sum of square in the analysis of variance suggested to be more appropriate models for explaining G $\times$ E interaction. The grain yield of total ten sesame genotypes was significantly affected by environment which explained 61% of total variation, whereas genotype and genotype x environment interaction (G $\times$ E) were explained 16%, 24% respectively. From the results of experiment, three genotypes Miryang49, Koppoom and Ansan were unstable, whereas other three genotypes Kyeongbuk18, Miryang50 and Kanghuk which were shorter projections to AEA ordinate were relatively stable over the environments. Yangbak which was closeness to the mean yield and short projection of the genotype marker lines was regarded as genotype indicating good performance with stability. Ansan, Miryang48 and Yangbaek showed the best performance in the environments of Naju, Suwon, Iksan and Andong. Similarly, genotype Miyrang47 exhibited the best performance in the environments of Chuncheon and Miryang. Andong is the closest to the ideal environment, and therefore, is the most desirable among eight environments.

• Geophysics and Geophysical Exploration
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• v.14 no.1
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• pp.123-126
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• 2011

• Geophysics and Geophysical Exploration
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• v.19 no.4
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• pp.249-249
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• 2016

• Geophysics and Geophysical Exploration
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• v.23 no.4
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• pp.267-267
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• 2020