• Toxicological Research
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• v.27 no.3
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• pp.167-172
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• 2011

We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) activates macrophage function. Analysis of the infiltration of macrophages into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages into the peritoneal cavity. In order to further confirm and investigate the mechanism of GDB on macrophage activation, we analyzed the effects of GDB on the cytokine expression including IL-$1{\beta}$, TNF-${\alpha}$, and IL-6 in mouse peritoneal macrophages. GDB increased the expression of IL-$1{\beta}$, TNF-${\alpha}$, and IL-6. Cytokine induction by GDB was further confirmed by RT-PCR and ELISA in mouse macrophage cell line, RAW264.7 cells. Treatment of RAW264.7 cells with GDB produced strong induction of NF-${\kappa}B$ DNA binding and MAPK phosphorylation, markers for macrophage activation and important factors for cytokine gene expression. Collectively, this series of experiments indicates that GDB stimulates macrophage activation.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.6
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• pp.431-436
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• 2012

Dioscorea species continue to be used in traditional Chinese medicine, and represent a major source of steroid precursors for conventional medicine. In the previous study, We isolated glycoprotein (GDB) from Dioscorea batatas, characterized, and demonstrated immunostimulating activity in C57BL/6 mice. The aim of this study was to investigate the mechanism whereby GDB activates macrophages. Macrophages activation by GDB was investigated by analyzing the effects of GDB on nitric oxide (NO) production, iNOS expression, mitogen activated protein kinase (MAPK) phosphorylation, and transcription factor activation. In the presence of IFN-${\gamma}$, GDB strongly stimulated macrophages to express iNOS and produce NO. Furthermore, the activation of p38 was synergistically induced by GDB plus IFN-${\gamma}$, but SB203580 (a p38 inhibitor) inhibited GDB plus IFN-${\gamma}$-induced p38 activation. This study indicates that GDB is an important activator of macrophages. Furthermore, due to the critical role that macrophage activation plays in innate immune response, the activation effects of GDB on macrophages suggest that GDB may be a useful immunopotentiating agent.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1861_1862
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• 2009

Linux 시스템에서 gdb와 gdbserver를 이용하여 원격지의 대상 프로세스에 대해 호스트 컴퓨터에서 디버깅이 가능하다. 이는 상대적으로 적은 리소스를 가진 원격지 컴퓨터나 임베디드 시스템에서 프로세스를 원격지의 시스템보다 풍부한 리소스를 지닌 호스트 컴퓨터를 통해서 디버깅을 수행함으로써 직접 디버깅을 수행할 때 원격지 시스템에 오는 부하를 줄일 수 있다는 장점이 있다[1]. 하지만 gdb와 gdbserver를 이용한 원격지 디버깅은 gdb가 동작하는 호스트 컴퓨터가 반드시 gdb가 운용 가능한 환경이어야 한다는 점과 디버깅을 수행하기 전 호스트 컴퓨터에 대한 환경 설정에 많은 시간과 노력이 필요하다는 점을 생각했을 때 효율적이지 못하다. 또한 gdb에서 기본적으로 제공하는 사용자 인터페이스가 CLI(Comman Line Interface) 라는 점은 익숙하지 않은 사용자에게 불편함을 안겨줄 수 있다. 본 논문에서는 gdb와 gdbserver의 기본 동작을 웹 인터페이스와 연동함으로써 이러한 문제점에 대한 해결 방안을 제시하고자 한다.

• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.2
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• pp.57-70
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• 2010

Purpose: In this study, we investigated the effects of GDB(Gidaebang) on the immune response to establish the treatment mechanism of vaginitis. Methods: We examined the effects of GDB on the DCs(Dendritic cells) phenotypic and functional maturation. iDCs were cultured in the presence of GM-CSF and the generated iDCs were respectively stimulated by GDB or LPS as the control group for 24 hours. To evaluate the DCs phenotypic and functional maturation, we used flow cytometric analysis, RT-PCR and ELISA. Results: 1. GDB upregulated the expression of class II MHC and CD40 on DCs. 2. GDB upregulated the expression of CD80 and CD86 on DCs. 3. GDB induced cytokine IL-12 production and mRNA expression in DCs. Conclusion: These results suggest that GDB is able to improve the antigen-presenting capacity of DCs through the upregulation of their maturation, and might induce proliferation of T cells. In conclusion, this immunomodulatory properties of GDB may be useful in the treatment of vaginitis.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.2
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• pp.101-106
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• 2011

We demonstrate that glycoprotein isolated from Dioscorea batatas (GDB) has immunostimulatory effects including macrophage activation. Analysis of infiltration of inflammatory cells into peritoneal cavity showed GDB treatment significantly increased the recruitment of macrophages, lymphocytes, neutrophils, and monocytes into the peritoneal cavity. Treatment of spleen cells isolated from C57BL/6 mice with GDB significantly increased the proliferation of B cells and T cells induced by LPS and ConA, respectively. Treatment with GDB significantly increased the cytolytic capacity of NK cells and macrophages against YAC-1 and B16 cells, respectively. In order to further confirm and investigate the mechanism of GDB on macrophage activation, we analyzed the effects of GDB on the cytokine expression including iNOS, IL-1${\beta}$, and TNF-${\alpha}$ in mouse macrophage cell line, RAW 264.7 cells. RT-PCR and ELISA showed that GDB increased the expression of IL-1${\beta}$, and TNF-${\alpha}$, whereas iNOS was not induced by GDB. Collectively, this series of experiments indicates that GDB stimulates immune system including macrophage activation.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.6
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• pp.630-638
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• 2002

Debugging for application Programs running in embedded Linux systems has mostly been done remotely due to the limited resources of the target systems. The gdb, which is one of the most famous debugger in Linux systems, does not support the debugging of the child processes which is created by the fork system call in local and remote environments. Therefore, by using gdb, developers can debug the application programs that have single-process structure in local and remote environments, but they cannot debug the application programs that have multi-process structures by using gdb in remote environments. Also, although developers can debug the application programs that have multi-process structures by using gdb in local environments, it needs additional and unnecessary codings. In this paper, we presents the remote debugging scheme that can be used for debugging multi-process structured applications. The proposed scheme is implemented by using the library wrapping scheme, and also uses the conventional system components such as gdb and gdbserver.

• The KIPS Transactions:PartA
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• v.17A no.3
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• pp.153-158
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• 2010

Most of software developers use the GNU Debugger (GDB) in order to debug code execution. The GDB supports a remote debugging environment through serial communication. However, in embedded systems, the speed is limited in the serial communication. Due to this reason, the serial communication is rarely used for the debugging purpose. To solve this problem, many embedded systems adapt the JTAG and the USB interface. This paper proposes debugging environment via USB-JTAG interface to debug the EISC processor, and introduces how the USB interface works on the GDB and how the JTAG module handles debugging packets.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.1579-1581
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• 2010

GDB 는 프로그램의 버그를 찾고 수정할 수 있는 기능을 포함하고 있는 디버거로써 소프트웨어 개발자가 효과적인 프로그램 개발과 유지를 위해 꼭 필요하다. 그러나, PICO 프로세서와 같이 새로 개발된 프로세서는 그 위에서 동작하는 프로그램을 디버깅 하기 위한 환경을 갖추고 있지 않다. 이 논문은 PICO 프로세서를 위한 GNU 디버거인 GDB 와 그래픽 유저인터페이스를 제공하는 DDD 를 포팅하는 방법에 대해 소개하고 설명한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2022.05a
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• pp.22-24
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• 2022

Recently, Graph Database (GDB) is being used in wide range of industrial fields. GDB is a database system which adopts graph structure for storing the information. GDB handles the information in the form of a graph which consists of vertices and edges. In contrast to the relational database system which requires pre-defined table schema, GDB doesn't need a pre-defined structure for storing data, allowing a very flexible way of thinking about and using the data. With GDB, we can handle a large volume of heavily interconnected data. A network service provider provides its services based on the heavily interconnected communication network facilities. In many cases, their information is hosted in relational database, where it is not easy to process a query that requires recursive graph traversal operation. In this study, we suggest a way to store an example set of interconnected network facilities in GDB, then show how to graph-query them efficiently.

• Journal of Convergence for Information Technology
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• v.10 no.7
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• pp.41-48
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• 2020

Recently, the spreading business of AMI (Advanced Metering Infrastructure) remote metering systems in various regions of the country has been activated, and it provides various metering functions such as two-way communication and security plan functions for power demand management. Current AMI system is difficult to analyze based on the existing RDB(Relational Database) due to the increase in the size of new internal IoT devices and networks. This study proposes a new GDB(Graph Database) based failure analysis method that utilizes existing RDB data. It analyzes the correlation of new failure patterns through accumulated data such as internal thresholds and status values. As a result of GDB-based simulation, it was confirmed that RDB can predict to a new obstacle pattern that was difficult to analyze.