• The Korean Journal of Financial Management
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• v.16 no.2
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• pp.365-381
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• 1999

본 연구는 국제 외환시장의 주요 통화들을 대상으로 조건부 이분산성을 고려한 GARCH-M 모형을 이용하여 불편기대가설과 시간변화 위험프리미엄의 존재를 규명하고 위험프리미엄 요인과 체계적 오차 요인간의 연계가능성 및 개별 외환시장의 특성과 시간변화 위험프리미엄의 변동성간의 관계를 규명하는데 목적을 두고 있다. 실증분석 결과, JPY를 제외한 DEM과 CHF, 그리고 GBP에서 불편기대가설을 지지하는 결과를 얻을 수 있었다. 또한 GBP의 경우에는 시장의 효율성과 위험프리미엄의 존재를 동시에 인정하는 일반효율성이 성립하는 것을 발견할 수 있었다. 한편 외환시장이 활성화될수록 시간변화 위험프리미엄의 변동성이 커지고 조정속도가 빨라진다는 사실도 발견할 수 있었다.

• The Korean Journal of Nuclear Medicine Technology
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• v.20 no.1
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• pp.13-19
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• 2016

Purpose In order to calculate the left ventricular ejection fraction (LVEF) accurately, it is important to acquire the best septal view of left ventricle in the multi-gated cardiac blood pool scan (GBP). This study aims to acquire the best septal view by measuring angle of ventricular septal wall (${\theta}$) using enhanced CT scan and compare with conventional method using left anterior oblique (LAO) 45 view. Materials and Methods From March to July in 2015, we analyzed the 253 patients who underwent both enhanced chest CT and GBP scan in the department of nuclear medicine at National Cancer Center. Angle (${\theta}$) between ventricular septum and imaginary midline was measured in transverse image of enhanced chest CT scan, and the patients whose difference between the angle of ${\theta}$ and 45 degree was more than 10 degrees were included. GBP scan was acquired using both LAO 45 and LAO ${\theta}$ views, and LVEFs measured by automated and manual region of interest (Auto-ROI and Manual-ROI) modes respectively were analyzed. Results $Mean{\pm}SD$ of ${\theta}$ on total 253 patients was $37.0{\pm}8.5^{\circ}$. Among them, the patients whose difference between 45 and ${\theta}$ degrees were more than ${\pm}10$ degrees were 88 patients ($29.3{\pm}6.1^{\circ}$). In Auto-ROI mode, there was statistically significant difference between LAO 45 and LAO ${\theta}$ (LVEF $45=62.0{\pm}6.6%$ vs. LVEF ${\theta}=64.0{\pm}5.6%$; P = 0.001). In Manual-ROI mode, there was also statistically significant difference between LAO 45 and LAO ${\theta}$ (LVEF $45=66.7{\pm}7.2%$ vs. LVEF ${\theta}=69.0{\pm}6.4%$; P < 0.001). Intraclass correlation coefficients of both methods were more than 95%. In case of comparison between Auto-ROI and Manual ROI of each LAO 45 and LAO ${\theta}$, there was no significant difference statistically. Conclusion We could measure the angle of ventricular septal wall accurately by using transverse image of enhanced chest CT and applied to LAO acquisition in the GBP scan. It might be the alternative method to acquire the best septal view of LAO effectively. We could notify significant difference between conventional LAO 45 and LAO ${\theta}$ view.

• The Korean Journal of Pain
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• v.33 no.1
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• pp.3-12
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• 2020

Neuropathic pain after spinal cord injury (SCI) has a significant negative impact on the patients' quality of life. The objective of this systematic review is to examine the safety and efficacy of pregabalin (PGB) and gabapentin (GBP) in the treatment of neuropathic pain due to SCI. PubMed, the Cochrane Library, Embase, Scopus, and the Web of Science were searched up to December 2018. The reference lists of key and review studies were reviewed for additional citations. The quality of the studies was evaluated using the Cochrane Collaboration's tools for assessing the risk of bias. A meta-analysis was performed for primary and secondary outcomes. Eight studies were eligible for inclusion. Meta-analysis of PGB vs. placebo showed that PGB was effective for neuropathic pain (standardized mean difference [SMD] = -0.40; 95% confidence interval [CI]: -0.78, -0.01), anxiety (MD = -0.68; 95% CI: -0.77, -0.59), depression (mean difference [MD] = -0.99; 95% CI: -1.08, -0.89), and sleep interference (MD = -1.08; 95% CI: -1.13, -1.02). Also, GBP was more effective than a placebo for reducing pain. No significant difference was observed between the efficacy of the two drugs (MD = -0.37; 95% CI: -1.67, 0.93). There was no significant difference between the two drugs for discontinuation due to adverse events (risk ratio = 3.00; 95% CI: 0.81, 11.15). PGB and GBP were effective vs. placebos in decreasing neuropathic pain after SCI. Also, there was no significant difference between the two drugs for decreasing pain and adverse events.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.10
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• pp.1860-1865
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• 2008

40Gbps WDMSystems have been studied by numerical simulation to optimize their performance. Standard single mode fiber is assumed, and the most popular modulation format, NRZ, is used for the study. These assumptions are valid when existing WDM systems are required to upgrade their performance to 40Gbps. It is shown that the standard single mode fiber can transmit optical signals over 4800 (BER < 10-15) by optimizing optical and electrical filter characteristics at the receiver and by compensation of dispersion. In addition, when the system performance is mainly limited by ASE noise of EDFAs, it is found that flattop-shaped optical filter at the receiver gives a better result than Gaussian-shaped filter unless the insertion loss of the optical filter is larger than 5dB.

• Clinical and Experimental Pediatrics
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• v.63 no.7
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• pp.265-271
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• 2020

Background: Pneumococcal diseases among children aged <5 years worldwide are associated with high annual mortality rates. Purpose: This study aimed to evaluate the immunogenicity and safety of GBP411, a 12-valent pneumococcal conjugant vaccine, with a dosing schedule of 2 primary doses plus 1 booster dose (2p+1) in healthy infants. Methods: This randomized active-controlled (Prevnar 13) double-blind phase 2 trial enrolled healthy subjects aged 6-10 weeks. Three serum concentrations of pneumococcal serotype-specific immunoglobulin G (IgG) were evaluated using the pneumococcal serotype-specific pneumonia polysaccharide enzyme-linked immunosorbent assay at 1 month after the primary doses and before and 1 month after the booster dose. The pneumococcal serotype-specific IgG titer was evaluated using a multiplex opsonophagocytic assay in a subset of 15 subjects per group. Results: After administration of the primary doses, the proportion of subjects who achieved pneumococcal serotype-specific IgG concentrations of >0.35 ㎍/mL was lower for some serotypes in the GBP411 group than in the comparator group (6B: 20.83% vs. 39.22%, P=0.047 and 19A: 58.33% vs. 90.20%, P<0.001). However, after administration of the booster dose, >97% of the subjects in each group achieved IgG concentrations of ≥0.35 ㎍/mL for all 12 serotypes. Increased immunogenicity was observed for some serotypes that showed significant intergroup differences after administration of the primary doses but not after the booster dose. We also found no significant intergroup difference in the overall incidence of solicited local adverse events. Furthermore, the overall incidence of solicited systemic adverse events was significantly lower in the GBP411 group than in the comparator vaccine group (79.59% vs. 98.04%; P=0.003). Conclusion: The GBP411 vaccine with a dosing schedule of 2p+1 may be immunogenic and safe for healthy infants.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.741-741
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• 2005

• Photonics industry news
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• s.33
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• pp.34-41
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• 2006

광통신은 인터넷 이용자의 증가와 디지털기술 발전에 의한 화상정보 활용의 보편화, 전자 상거래, 양방향 TV등 전송 데이터가 폭증하는 정보화 사회의 필수적인 기술이다. 이는 광섬유 한 가닥의 정보전달 능력이 수십 Gbps이며 전자파 장애에 의한 누화나 잡음이 없고 수명이 길다는 장점이 있기 때문이다.

• The Magazine of the IEIE
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• v.31 no.8
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• pp.44-51
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• 2004

최근 SoC (System on Chip) 기술의 발전으로 최대 10 Gbps의 처리율을 갖는 네트워크 프로세서가 개발되고 있다. 네트워크 프로세서는 기존의 ASIC (Application Specific Integrated circuit)또는 FPGA (Field Programmable Gate Array) 등 하드웨어가 수행하던 고속의 패킷 처리 기능을 소프트웨어 기반으로 처리하도록 함으로써 다양한 기능의 패킷 처리를 저비용으로 단시간 내에 개발 할 수 있는 장점을 갖고 있다.(중략)

• Venture DIGEST
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• no.1 s.126
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• pp.16-18
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• 2009

구리는 가라. 빛을 통한 신호 전송이 PCB에서도 구현된다.' 구리가 아닌 광 회로를 통해 신호를 전달할 수 있는 광PCB 기술이 한창 개발되고 있다. 광PCB의 전송속도인 2.5Gbps보다 수십 배 빠른 속도를 구현함으로써 고속 데이터 전송 및 처리를 필요로 하는 컴퓨터, 휴대폰, 게임기 등 각종 첨단 분야에 폭넓게 응용되고 있다. 초고속 스피드 시대를 열어 갈 전기-광PCB 기술을 소개한다.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.3
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• pp.43-49
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• 2014

This paper presents a theoretical study of transmission performance for an optical duobinary transmitter employed a Mach-Zehnder modulator and a electrical low pass filter at 40Gbps optical communication links. It depends on the bandwidth of the low pass filter in the transmitter, the optical filter and the filter in the receiver. Also, each filter affected to the various parts of the optical power spectrum. By optimizing the bandwidth of each filter, we could control the side robes and the ripples and improve the dispersion tolerance of the transmission system.