• 전기전자학회논문지
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• 제19권3호
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• pp.282-287
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• 2015

본 연구에서는 연구에서는 Ce:GAGG 섬광체, 광섬유 그리고 광전자증배관을 이용하여 광섬유 검출기를 제작하였다. 섬광체의 단결정 크기는 MCNPX 코드를 이용하여 섬광체 깊이에 따른 감마선 계수효율을 전산모사하여 $3{\times}3{\times}20mm^3$로 설정하였다. 제작된 검출기는 표준 감마선원인 $^{137}Cs$과 $^{133}Ba$을 이용하여 세기의 따른 선형성 평가와 거리 변화에 따른 계수량 변화 측정을 하였다. 그 결과 추세선식 R-square 값이 0.99741로 매우 좋은 응답선형성을 보였고, 거리에 따른 검출 특성 또한 MCNPX값과 비교하였을 때 2% 이하로 좋은 검출특성을 보였다. 또한 단일선원과 혼합선원에서의 감마선 에너지 분광 결과 $^{137}Cs$은 662keV에서 그리고 $^{133}Ba$은 356keV에서 감마선 에너지 피크를 확인하였다. 광섬유 검출기를 사용한다면 작업자의 작업시간과 피폭을 줄여줄 것으로 보인다.

• 환경생물
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• 제21권1호
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• pp.56-59
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• 2003

The Salmonella typhimurium cdd gene encoding cytidine deaminase (cyti-dine/2'-deoxycytidine aminohydrolase; EC 3.5.4.5.) was isolated through shotgun clon-ing by complementation of the E. coli odd mutation. By subsequent deletion and sub-cloning from the original 3.7 Kb of EcoRI insert (pSAMI), the precise region of the cdd structural gene is located around the BglII site in the middle part of 1.7 Kb of NruI/PvuI segment. The 1.7 Kb containing odd gene wag subcloned to the pUC18 vector and the nucleotide sequence of the cdd gene was determined. When the putative ribosorne-binding site (Shine-Dalgarno sequence) and initiation codon were predicted to be GAGG at the position 459 and ATG at the position 470, respectively, there was an open reading frame of 885 nucleotides, encoding an 294 amino acid protein. The cdd gene expression in E. coli JF611/pSAMI was amplified about 50 fold compared to that of the wild type. The cdd gene expression was maintained in the stationary phase after rea-ching the peak in the late logarithmic phase.

• 대한의용생체공학회:의공학회지
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• 제37권1호
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• pp.7-14
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• 2016

Radiopharmaceutical agents for positron emission tomography (PET), such as $^{18}F$-FDG and $^{68}Ga$, have been used not only for whole-body PET imaging but also for intraoperative radionuclide-guided surgery due to their quantitative and sensitive imaging characteristics. Current intraoperative probes detect gamma or beta particles, but not both of them. Gamma probes have low sensitivities since a collimator has to be used to reduce backgrounds. Positron probes have a high tumor-to-background ratio, but they have a 1-2 mm depth limitation from the body surface. Most of current intraoperative probes produce only audible sounds proportional to count rates without providing tumor images. This research aims to detect both positrons and annihilation photons from $^{18}F$ using plastic scintillators and a GAGG scintillation crystal attached to silicon photomultiplier (SiPM). The depth-of-interaction (DOI) along the plastic scintillator can be used to obtain the 2-D images of tumors near the body surface. The front and rear part of the intraoperative probe consists of $4{\times}1$ plastic scintillators ($2.9{\times}2.0{\times}12.0mm^3$) for positron detection and a Ce:GAGG scintillation crystal ($12.0{\times}12.0{\times}9.0mm^3$) for annihilation photon detection, respectively. The DOI resolution of $4.4{\pm}1.6mm$ along the plastic scintillator was obtained by using the 3M enhanced specular reflector (ESR) with rectangular holes between the plastic scintillators, which showed the feasibility of a 2-D image pixel size of $2.9{\times}4.4mm^2$ (X-direction ${\times}$ Y-direction).

• 한국방사선학회논문지
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• 제15권4호
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• pp.409-414
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• 2021

감마카메라에서 영상을 획득하기 위해서 직선성 보정을 시행해야 한다. 이를 위해서 섬광체와 감마선이 상호작용한 위치에 대한 정확한 위치 지정을 위해 직선성 맵을 활용하여 디지털 좌표를 획득한다. 본 연구에서는 직선성 맵을 사용하지 않고 순람표와 최대우도함수를 사용하여 왜곡되지 않은 영상을 획득함과 동시에 디지털 좌표를 획득하는 방법을 개발하였다. DETECT2000 시뮬레이션을 통해 소형의 감마카메라를 구성하여 제시된 방법에 대해 검증을 실시하였다. GAGG 섬광체와 SiPM 광센서를 사용하여 감마카메라를 구성하였고, 섬광체의 중심에서 감마선 반응을 일으켜 SiPM에서 획득한 신호의 비율을 사용하여 순람표를 작성하였다. 작성된 순람표와 최대우도함수를 통해 감마선 반응에 의해 획득한 신호의 위치를 디지털 좌표로 획득하여 영상을 구성하였다. 그 결과 일반적으로 획득되는 영상에 비해 직선성이 유지되었으며, 감마선 반응을 발생시킨 위치의 정확도가 우수하였으며, 위치 간 간격이 일정하게 나타났다. 시뮬레이션을 통해 획득한 순람표는 신호의 비율을 사용하여 작성되므로 이를 실험에 직접 활용할 수 있어, 직선성 맵을 작성하지 않고 편리하게 직선성이 보정된 디지털 좌표로 신호의 위치를 획득할 수 있다.

• Nuclear Engineering and Technology
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• 제55권8호
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• pp.2873-2878
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• 2023

The purpose of this study is to perform radiation monitoring by acquiring gamma images and real-time optical images for ^99mTc vial source using charge couple device (CCD) cameras equipped with the proposed compact gamma camera. The compact gamma camera measures 86×65×78.5 mm³ and weighs 934 g. It is equipped with a metal 3D printed diverging collimator manufactured in a 45 field of view (FOV) to detect the location of the source. The circuit's system uses system-on-chip (SoC) and field-programmable-gate-array (FPGA) to establish a good connection between hardware and software. In detection modules, the photodetector (multi-pixel photon counters) is tiled at 8×8 to expand the activation area and improve sensitivity. The gadolinium aluminium gallium garnet (GAGG) measuring 0.5×0.5×3.5 mm³ was arranged in 38×38 arrays. Intrinsic and extrinsic performance tests such as energy spectrum, uniformity, and system sensitivity for other radioisotopes, and sensitivity evaluation at edges within FOV were conducted. The compact gamma camera can be mounted on unmanned equipment such as drones and robots that require miniaturization and light weight, so a wide range of applications in various fields are possible.

• BMB Reports
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• 제44권5호
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• pp.317-322
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• 2011

Hereditary non-polyposis Colorectal Cancer (HNPCC) is an autosomal dominant inheritance syndrome. HNPCC is the most common hereditary variant of colorectal cancer (CRC), which accounts for 2-5% CRCs, mainly due to hMLH1 and hMSH2 mutations that impair DNA repair functions. Our study aimed to identify the patterns of hMSH2 and hMLH1 mutations in Chinese HNPCC patients. Ninety-eight unrelated families from China meeting Amsterdam or Bethesda criteria were included in our study. Germline mutations in MLH1 and MSH2 genes, located in the exons and the splice-site junctions, were screened in the 98 probands by direct sequencing. Eleven mutations were found in ten patients (11%), with six in MLH1 (54.5%) and five in MSH2 (45.5%) genes. One patient had mutations in both MLH1 and MSH2 genes. Three novel mutations in MLH1 gene (c.157_160delGAGG, c.2157dupT and c.-64G>T) were found for the first time, and one suspected hotspot in MSH2 (c.1168C>T) was revealed.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2018-2025
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• 2023

In our previous study, we proposed an integrated PG-PET-based imaging method to increase the prediction accuracy for patient dose distributions. The purpose of the present study is to experimentally validate the feasibility of the PG-PET system. Based on the detector geometry optimized in the previous study, we constructed a dual-head PG-PET system consisting of a 16 × 16 GAGG scintillator and KETEK SiPM arrays, BaSO₄ reflectors, and an 8 × 8 parallel-hole tungsten collimator. The performance of this system as equipped with a proof of principle, we measured the PG and positron emission (PE) distributions from a 3 × 6 × 10 cm³ PMMA phantom for a 45 MeV proton beam. The measured depth was about 17 mm and the expected depth was 16 mm in the computation simulation under the same conditions as the measurements. In the comparison result, we can find a 1 mm difference between computation simulation and measurement. In this study, our results show the feasibility of the PG-PET system for in-vivo range verification. However, further study should be followed with the consideration of the typical measurement conditions in the clinic application.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2158-2165
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• 2023

Marine radioactivity monitoring is critical for taking immediate action in case of unexpected nuclear accidents at nuclear facilities located near coastal areas. Especially when the level of contamination is not predictable, mobile monitoring systems will be useful for wide-area ocean radiation survey and for determination of the level of radioactivity. Here, we used a silicon photomultiplier and a high-efficiency GAGG crystal to fabricate a compact, battery-powered gamma spectroscopy that can be used in an ocean environment. The developed spectroscopy has compact dimensions of 6.5 × 6.5× 8 cm³ and weighs 560 g. We used LoRa, a low-power wireless protocol for communication. Successful data transmission was achieved within 1.4 m water depth. The developed gamma spectroscopy was able to detect radioactivity from a ¹³⁷Cs point source (3.7 kBq) at a distance of 20 cm in water. Moreover, we demonstrated an unmanned radioactivity monitoring system in a real sea by combining unmanned surface vehicle with the developed gamma spectroscopy. A hidden ¹³⁷Cs source (3.07 MBq) was detected by the unmanned system at a distance of 3 m. After successfully testing the developed mobile spectroscopy in an ocean environment, we believe that our proposed system will be an effective solution for mobile real-time marine radioactivity monitoring.