• Smart Structures and Systems
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• v.6 no.7
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• pp.767-792
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• 2010

In this paper, the optimal design of vibration control system for smart structures has been investigated semi-analytically via the optimization of geometric parameters like the placements and sizes of piezoelectric sensors and actuators (S/As) bonded on the structures. The criterion based on the maximization of energy dissipation was adopted for the optimization of the control system. Based on the sensing and actuating equations, the total energy stored in the system which is used as the objective function was analytically derived with design variables explicitly presented. Two cases of single and combined vibration modes were addressed for a simply supported beam and a simply supported cylindrical shell. For single vibration mode, the optimal distributions of the piezoelectric S/As could be obtained analytically. However, the Sequential Quadratic Programming (SQP) method has to be employed to solve those which violated the prescribed constraints and to solve the case of combined vibration modes. The results of three examples, which include a simply supported beam, a simply supported cylindrical shell and a simply supported plate, showed good agreement with those obtained by the Genetic Algorithm (GA) method. Moreover, in comparison with the GA method, the proposed method is more effective in obtaining better optimization results and is much more efficient in terms of computation time.

• Structural Engineering and Mechanics
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• v.70 no.3
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• pp.339-350
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• 2019

This research focuses on finite element model updating and damage assessment of structures at element level based on global nondestructive test results. For this purpose, an optimization system is generated to minimize the structural dynamic parameters discrepancies between numerical and experimental models. Objective functions are selected based on the square of Euclidean norm error of vibration frequencies and modal assurance criterion of mode shapes. In order to update the finite element model and detect local damages within the structural members, modern optimization techniques is implemented according to the evolutionary algorithms to meet the global optimized solution. Using a simulated numerical example, application of genetic algorithm (GA), particle swarm (PSO) and artificial bee colony (ABC) algorithms are investigated in FE model updating and damage detection problems to consider their accuracy and convergence characteristics. Then, a hybrid multi stage optimization method is presented merging advantages of PSO and ABC methods in finding damage location and extent. The efficiency of the methods have been examined using two simulated numerical examples, a laboratory dynamic test and a high-rise building field ambient vibration test results. The implemented evolutionary updating methods show successful results in accuracy and speed considering the incomplete and noisy experimental measured data.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2008.03a
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• pp.330-339
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• 2008

Ground-based interceptors(GBI) comprise a major element of the strategic defense against hostile targets like Intercontinental Ballistic Missiles(ICBM) and reentry vehicles(RV) dispersed from them. An optimum design of the subsystems is required to increase the performance and reliability of these GBI. Propulsion subsystem design and optimization is the motivation for this effort. This paper describes an effort in which an entire GBI missile system, including a multi-stage solid rocket booster, is considered simultaneously in a Genetic Algorithm(GA) performance optimization process. Single goal, constrained optimization is performed. For specified payload and miss distance, time of flight, the most important component in the optimization process is the booster, for its takeoff weight, time of flight, or a combination of the two. The GBI is assumed to be a multistage missile that uses target location data provided by two ground based RF radar sensors and two low earth orbit(LEO) IR sensors. 3Dimensional model is developed for a multistage target with a boost phase acceleration profile that depends on total mass, propellant mass and the specific impulse in the gravity field. The monostatic radar cross section (RCS) data of a three stage ICBM is used. For preliminary design, GBI is assumed to have a fixed initial position from the target launch point and zero launch delay. GBI carries the Kill Vehicle(KV) to an optimal position in space to allow it to complete the intercept. The objective is to design and optimize the propulsion system for the GBI that will fulfill mission requirements and objectives. The KV weight and volume requirements are specified in the problem definition before the optimization is computed. We have considered only continuous design variables, while considering discrete variables as input. Though the number of stages should also be one of the design variables, however, in this paper it is fixed as three. The elite solution from GA is passed on to(Sequential Quadratic Programming) SQP as near optimal guess. The SQP then performs local convergence to identify the minimum mass of the GBI. The performance of the three staged GBI is validated using a ballistic missile intercept scenario modeled in Matlab/SIMULINK.

• Journal of Pharmaceutical Investigation
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• v.40 no.6
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• pp.363-366
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• 2010

Identification of compounds that function as P-glycoprotein (P-gp) substrates or inhibitors can facilitate the selection and optimization of new drug candidates. The purpose of this study is to optimize the experimental conditions for in vitro P-gp assay using LLC-GA5 cells, which is a well-known transformant cell line derived by transfecting LLC-PK1 with human MDR1. The amount of rhodamine123 transported by the LLC-GA5 and LLC-PK1 cells was evaluated under the following experimental conditions: 3 different types of transport media, colchicine pretreatment or nontreatment of the cells in the culture media, and with and without poly-L-lysine coating of the culture plates. The assay sensitivity was found to considerably differ depending on the diluents used in the transport media. P-gp-mediated transport in LLC-GA5 cells was most clearly characterized in the Hanks' balanced salt solution based transport media. The sensitivity of P-gp-mediated transport was not changed by colchicine pretreatment or poly-L-lysine coating of the culture plates.

• Journal of computational fluids engineering
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• v.19 no.3
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• pp.29-36
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• 2014

In the present study, an aerodynamic design optimization of UAV rotor blades was conducted using a genetic algorithm(GA) coupled with computational fluid dynamics(CFD). To reduce computational cost in making databases, a function approximation was applied using artificial neural networks(ANN) based on a radial basis function network. Three dimensional Reynolds-Averaged Navier-Stokes(RANS) solver was used to solve the flow around UAV rotor blades. Design directions were specified to maximize thrust coefficient maintaining torque coefficient and minimize torque coefficient maintaining thrust coefficient. Design variables such as twist angle, thickness and chord length were adopted to perform a planform optimization. As a result of an optimization regarding to maximizing thrust coefficient, thrust coefficient was increased about 4.5% than base configuration. In case of an optimization minimizing torque coefficient, torque coefficient was decreased about 7.4% comparing with base configuration.

• Proceedings of the KIEE Conference
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• 2005.10b
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• pp.155-157
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• 2005

We propose a new category of hybrid multi-layer neural networks with hetero nodes such as Fuzzy Set based Polynomial Neurons (FSPNs) and Polynomial Neurons (PNs). These networks are based on a genetically optimized multi-layer perceptron. We develop a comprehensive design methodology involving mechanisms of genetic optimization and genetic algorithms, in particular. The augmented genetically optimized HFPNN (namely gHFPNN) results in a structurally optimized structure and comes with a higher level of flexibility in comparison to the one we encounter in the conventional HFPNN. The GA-based design procedure being applied at each layer of HFPNN leads to the selection of preferred nodes (FPNs or PNs) available within the HFPNN. In the sequel, two general optimization mechanisms are explored. First, the structural optimization is realized via GAs whereas the ensuing detailed parametric optimization is carried out in the setting of a standard least square method-based learning. The performance of the gHFPNNs quantified through experimentation where we use a number of modeling benchmarks-synthetic and experimental data already experimented with in fuzzy or neurofuzzy modeling.

• The Korean Journal of Nuclear Medicine Technology
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• v.27 no.2
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• pp.111-127
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• 2023

Purpose: Gallium-68 (⁶⁸Ga) is increasingly used in nuclear medicine imaging for various conditions such as lymphoma and neuroendocrine tumors by labeling tracers like Prostate Specific Membrane Antigen (PSMA) and DOTA-TOC. However, compared to Fluorine-18 (¹⁸F) used in conventional nuclear medicine imaging, ⁶⁸Ga has lower spatial resolution and relatively higher Signal to Background Ratio (SBR). Therefore, this study aimed to investigate the optimized parameters and reconstruction methods for PET/CT imaging using the ⁶⁸Ga radiotracer through model-based image evaluation. Materials and Methods: Based on clinical images of ⁶⁸Ga-PSMA PET/CT, a NEMA/IEC 2008 PET phantom model was prepared with a Hot vs Background (H/B) ratio of 10:1. Images were acquired for 9 minutes in list mode using DMIDR (GE, Milwaukee WI, USA). Subsequently, reconstructions were performed for 1 to 8 minutes using OS-EM (Ordered Subset Expectation Maximization) + TOF (Time of Flight) + Sharp IR (VPFX-S), and BSREM (Block Sequential Regularized Expectation Maximization) + TOF + Sharp IR (QCFX-S-400), followed by comparative evaluation. Based on the previous experimental results, images were reconstructed for BSREM + TOF + Sharp IR / 2 minutes (QCFX-S-2min) with varying β-strength values from 100 to 700. The image quality was evaluated using AMIDE (freeware, Ver.1.0.1) and Advanced Workstation (GE, USA). Results: Images reconstructed with QCFX-S-400 showed relatively higher values for SNR (Signal to Noise Ratio), CNR (Contrast to Noise Ratio), count, RC (Recovery Coefficient), and SUV (Standardized Uptake Value) compared to VPFX-S. SNR, CNR, and SUV exhibited the highest values at 2 minutes/bed acquisition time. RC showed the highest values for a 10 mm sphere at 2 minutes/bed acquisition time. For small spheres of 10 mm and 13 mm, an inverse relationship between β-strength increase and count was observed. SNR and CNR peaked at β-strength 400 and then decreased, while SUV and RC exhibited a normal distribution based on sphere size for β-strength values of 400 and above. Conclusion: Based on the experiments, PET/CT imaging using the ⁶⁸Ga radiotracer yielded the most favorable quantitative and qualitative results with a 2 minutes/bed acquisition time and BSREM reconstruction, particularly when applying β-strength 400. The application of BSREM can enhance accurate quantification and image quality in ⁶⁸Ga PET/CT imaging, and an optimization process tailored to each institution's imaging objectives appears necessary.

• Structural Engineering and Mechanics
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• v.11 no.2
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• pp.151-170
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• 2001

With increasing competition, the engineering industry is in need of optimization of designs that would lead to minimum cost or weight. Recent developments in Genetic Algorithms (GAs) makes it possible to model and obtain optimal solutions in structural design that can be put to use in industry. The main objective of this paper is to illustrate typical applications of GAs to practical design of structural systems such as steel trusses, towers, bridges, reinforced concrete frames, bridge decks, shells and layout planning of buildings. Hence, instead of details of GA process, which can be found in the reported literature, attention is focussed on the description of the various applications and the practical aspects that are considered in Genetic Modeling. The paper highlights scope and future directions for wider applications of GA based methodologies for optimal design in practice.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.520-525
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• 2003

The determination of unknown parameters in rotating machinery is a difficult task and optimization techniques represent an alternative technique for parameter identification. The Simulated Annealing(SA) and Genetic Algorithm(GA) are powerful global optimization algorithm. This paper proposes new hybrid algorithm which combined GA with SA and local search algorithm for the purpose of parameter identification. Numerical examples are also presented to verify the efficiency of proposed algorithm. And, this paper presents the general methodology based on hybrid algorithm to identify unknown bearing parameters of flexible rotors using measured unbalance responses. Numerical examples are used to ilustrate the methodology used, which is then validated experimentally.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.8
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• pp.1334-1341
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• 2008

This paper introduces an approach of Hybrid Particle Swarm Optimization(HPSO) for a security-constrained economic dispatch(SCED) with line flow constraints. To reduce a early convergence effect of PSO algorithm, we proposed HPSO algorithm considering a mutation characteristic of Genetic Algorithm(GA). In power system, for considering N-1 line contingency, we have chosen critical line contingency through a process of Screening and Selection based on PI(performance Index). To prove the ability of the proposed HPSO in solving nonlinear optimization problems, SCED problems with nonconvex solution spaces are considered and solved with three different approach(Conventional GA, PSO, HPSO). We have applied to IEEE 118 bus system for verifying a usefulness of the proposed algorithm.