• 한국식품영양학회지
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• 제32권1호
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• pp.27-32
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• 2019

The objective of this study was to evaluate novel usability as natural anti-obesity supplement of Selaginella tamariscina extract. The total phenol contents and total flavonoid contents were $60.29{\pm}3.11GAE\;mg/g$ and $14.90{\pm}0.34QE\;mg/g$, respectively. To evaluate anti-obesity activity of Selaginella tamariscina extract, pancreatic lipase inhibition activity as well as its inhibition effect of lipid accumulation in adipocytes were conducted by Oil Red O staining and lipolysis assay. The result of pancreatic lipase inhibition activity of S. tamariscina extract showed a wide range between 40 and 73% dose dependently. While the incubation of 3T3-L1 cells with S. tamariscina extract inhibited differentiation of preadipocytes and reduced lipid accumulation, the level of released free glycerol into culturing medium was increased in multiple concentrations. These results showed that S. tamariscina extract inhibit adipogenesis and pancreatic lipase activity. Thus, S. tamariscina extract can be a candidate for regulating lipid accumulation in obesity.

• 한국전자통신학회논문지
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• 제14권4호
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• pp.755-760
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• 2019

본 논문은 기존 열선조각기, 열선 커팅기, 스핀들을 통합한 멀티 툴 조각기 개발을 통해 복잡한 구조의 형상도 손쉽고 빠르게 제작할 수 있도록 하였다. 또한 G-Code가 단일 툴에만 적용되는 문제점을 해결하고 기존 3D 모델링 툴로써 관리할 수 없는 기계의 세부 동작들을 제어할 수 있도록 소프트웨어를 개발하였다.

• 한국식품영양학회지
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• 제32권4호
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• pp.335-341
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• 2019

Beta-carotene is the most prominent member of the group of carotenoids, natural colorants that occur in the human diet. Beta-carotene is also an effective source of vitamin A in both conventional foods and vitamin supplements, and it's generally safe. In this study, we explored the beta-carotene contents in agricultural products widely and specifically grown in Korea. The beta-carotene contents were ranging from 223 to $27,908{\mu}g/100g$ in leaves, and 0 to $7,588{\mu}g/100g$ in vegetables. In leaves and vegetables, the amount of beta-carotene was the highest in green tea powder ($27,908{\mu}g/100g$), followed by pepper ($7,588{\mu}g/100g$). In fruits, the beta-carotene content was found to range from $0{\mu}g/1,011g$ to maximum of $293.66{\mu}g/100g$(plumcot). However, there beta-carotene was not detected in strawberry. In the case of cereals and specialty crops, the beta-carotene contents were $326{\mu}g/100g$ for non-glutinous rice, $313{\mu}g/100g$ for glutinous rice, $57{\mu}g/100g$ for amaranth and $15{\mu}g/100g$ for pine nut, respectively. However, the beta-carotene content was not detected in other samples. This study revealed the presence of beta-carotene content in agricultural products specifically grown in Korea for nutritional information and food composition database.

• Natural Product Sciences
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• 제25권3호
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• pp.238-243
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• 2019

In this study, the marker compounds of Curcumae Rhizoma (CR) were simultaneously quantified by high-performance liquid chromatography equipped with a photodiode array detector and the anti-inflammatory effects of CR extract and marker compounds in human benign prostatic hyperplasia epithelial-1 (BPH-1) cell lines were investigated. The marker components (4S,5S)-(+)-germacrone-4,5-epoxide, furanodienone, and germacrone, were separated on Gemini $C_{18}$ columns ($250mm{\times}4.6mm$, $5{\mu}m$) at $40^{\circ}C$ by using a gradient of two mobile phases eluting at 1.0 mL/min. Prostaglandin $E_2$ ($PGE_2$) levels in Human BPH-1 cells were determined with an ELISA kit. The coefficients of determination in a calibration curve of each analyte were all 0.9997. The limits of detection and quantification of the three compounds were $0.10-0.32{\mu}g/mL$ and $0.30-0.98{\mu}g/mL$, respectively. The content of three compounds, (4S,5S)-(+)-germacrone-4,5-epoxide, furanodienone, and germacrone, in the CR sample were found to be 5.79 - 5.92 mg/g, 4.72 - 4.86 mg/g, and 1.06 - 1.09 mg/g, respectively. Regarding pharmacological activity against benign prostatic hyperplasia, CR and its components significantly suppressed $PGE_2$ levels of BPH-1 cells. The established analysis method will help to improve quality assessment of CR samples and related products. In addition, CR and its components exhibit antiinflammatory activity in BPH-1 cells, suggesting the inhibitory efficacy of these compounds against the pathogenesis of BPH.

• Journal of Acupuncture Research
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• 제36권1호
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• pp.33-37
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• 2019

Background: This study was designed to investigate the potential effects of Galgeungyulpitang for whitening and elasticity treatment by examining its effect on melanoma cells. Methods: The effects of Galgeungyulpitang on B16/F10 melanoma cell viability, production of melanin, tyrosinase and elastase, were investigated. Cell viability was measured by colorimetric assay that assesses cell metabolic activity (MTT assay). Melanin was measured by Hosei's method, tyrosinase was measured by Yogi's method and elastase was measured by James's method. Results: At concentrations higher than $500{\mu}g/mL$ Galgeungyulpitang, cell viability was significantly reduced ($p{\leq}0.05$). At concentrations of $500{\mu}g/mL$ and lower, morphological changes were not observed. The rate of melanin synthesis was significantly reduced to $73.49%{\pm}2.92%$ at a concentration of $500{\mu}g/mL$ Galgeungyulpitang compared with untreated cells (p < 0.05). Extracellular tyrosinase production was not significantly decreased in vitro, however, intracellular tyrosinase production was significantly reduced to $76.06%{\pm}2.17%$ when treated with Galgeungyulpitang at a concentration of $500{\mu}g/mL$ compared with the control (p < 0.05). Elastase Type 1 production was significantly reduced to $74.98%{\pm}3.24%$ and $69.62%{\pm}4.66%$ at concentrations of 250 and $500{\mu}g/mL$ Galgeungyulpitang, respectively (p < 0.05). Elastase Type 4 production was significantly reduced to $72.77%{\pm}3.52%$ at concentrations of 250 and $500{\mu}g/mL$ (p < 0.05). Conclusion: The results in this study showed that Galgeungyulpitang may inhibit melanin and tyrosinase synthesis, and inhibit elastase production, suggesting that Galgeungyulpitang may be potentially beneficial for skin whitening and loss of skin elasticity treatments.

• 전자통신동향분석
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• 제35권6호
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• pp.129-136
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• 2020

Korea launched the world's first commercial 5G services in April 2019. Mobile traffic is expected to increase further with the acceleration of mobile-centric data utilization. It is one of the most important indexes of the growth of the mobile communications market, and it has a close relationship with frequency demand and supply, network management, and information communication policy. To overcome the limitations of an analytical solution due to the high complexity of the real world, this paper estimates the diffusion of 5G users using systemic thinking and the behavior of individual agents. Based on these demand forecasts, contributions to the establishment of strategic policies are suggested. For better understanding, global 5G predictions of subscribers and mobile traffic are also compared.

• 한국인터넷방송통신학회논문지
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• 제19권4호
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• pp.27-33
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• 2019

공급지(s)에서 수요지(t)로 흐르는 복잡한 망에서 망의 최대 흐름을 결정하는 최소절단 면을 찾는 최소절단 문제는 난제로 알려져 있다. 이에 대해 증대경로 알고리즘은 증대경로를 갖는 단일 경로로 분할하여 병목 지점(간선)을 찾는 방식을 채택하고 있으나 최소절단면을 추가적으로 결정해야만 한다. 본 논문에서는 프로스포츠계에서 적용되고 있는 자유계약제 방식을 적용하여, 정점 수 n에 대해 수행 복잡도가 O(n)인 휴리스틱 탐욕 알고리즘을 제안한다. 자유계약 방식은 $v{\in}V{\backslash}\{s,t\}$정점들 중에서 $N_G(S),N_G(T)$정점들을 자유계약 선수라고 가정하고, 이 선수들의 연봉이 보다 상승하는 팀으로 이적하는 방식을 적용하였다. 제안된 알고리즘을 다양한 망 형태에 적용한 결과, 모든 망에서 최소절단 치 뿐 아니라 망에 존재하는 모든 최소절단 들을 찾을 수 있음을 보였다.

• 한국응용과학기술학회지
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• 제36권1호
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• pp.1-12
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• 2019

돼지감자를 9번 찌고 9번 말려서 차를 제조한 다음 M사의 돼지감자차와 성분 및 기능성을 비교 분석하였다. 개발한 돼지감자차는 칼로리 342.27kcal, 탄수화물 73.87g/100g, 유리당 32.66mg/100g, 회분 6.80g/100g, 단백질 8.21g/100g이었고 무기물 총량은 2,785.67mg/100g, 칼륨 2,563.93mg/g, 칼슘 97.52mg/g, 마그네슘 88.78mg/g 등이었다. 돼지감자차의 유리당 총량은 32.66mg/100g이고 그중 fructose 17.40mg/100g, sucrose 9.03mg/100g, glucose 6.05mg/100g이었다. 돼지감자 차의 포화지방산은 30.34mg/100g, 4 불포화지방산은 69.66mg/100g이었고 그 중 linoleic acid 47.00mg/100g, palmitic acid 25.31mg/100g, linolenic acid 8.61mg/100g이었다. DPPH 라디컬 소거력은 개발한 차 34.2%, 비교용 M사차 5.2%, 지표물질 44.0%였다. ABTS 라디컬 소거력은 개발한 차 93.0%, M사차 61.9%, 지표물질 47.6%였다. SOD 유사활성은 개발한 차 2.7%, M사차 1.6%였다. 플라보노이드 함량은 개발한 차 2.8 fold, M사차 2.0 fold, 지표물질 1.7 fold 였다. 폴리페놀 함량은 개발한 차 38.2 fold, M사차 8.92 fold, 지표물질 14.0 fold였다. ${\alpha}$-Glucosidase 저해율은 개발한 차 9.83%, M사차 8.92%였다. 기호도는 1회 우린 것과 5회 우린 것을 비교하였다. 1회 우린 것을 기준으로 할 때 5회 우린 것의 기호도 중 색은 개발한 차 83.7%, 비교용 차 50.0%, 향기는 개발한 차 78.0%, 비교용 차 42.5%, 맛은 개발한 차 66.7%, 비교용 차 37.5%, 종합적인 기호도는 개발한 차 73.3%, 비교용 차 47.5%로 나타났다. 이같이 비교용 M사차는 우릴수록 추출 성분이 감소하여 5회 후에 종합적인 기호도는 46.3%로 감소한 반면 개발한 차는 감소폭이 적어서 73.3%를 나타냈다. 이같이 개발한 돼지감자차는 비교용 M사차 및 지표물질보다 항산화 작용이 강하고 유효 물질 함량도 더 많고, 기호성도 높으므로 질병 예방 및 개선 효과가 클 것으로 생각한다.

• 한국지반공학회논문집
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• 제35권12호
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• pp.69-89
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• 2019

사질토를 지나 풍화암에 4D 소켓된 매입 PHC말뚝에 대한 매개변수 수치해석 자료를 분석하여 지지력 표해 및 도해(I)이 제안된 바 있다(Choi et al., 2019a). 본 논문에서는 이를 활용하여 직경의 5% 침하량에서 발현되는 동원지지력을 산정할 수 있는 새로운 산정공식을 제안하였다. 제안식은 두 가지이며, 그 중에서 EQ-G1 제안식은 각각의 상대근입길이(L/D)에서 말뚝직경과 ${\bar{N}}$값(보정 N 값)을 고려하여 각 지지력 성분을 평가하며, 검증 결과는 다음과 같다. RQP는 약 71~94%로 나타났으며, 이는 일반 설계에서 사용하고 있는 지지력 산정공식으로 구한 SRF(26~37%)보다 큰 값을 나타냈다. RQP는 적정 설계의 범위로 분포하였는데, 4개 사례에서는 78, 136, 142, 180%로 나타났다. D_E는 β₁에 따라 달라질 수는 있는데, 본 연구에서는 0.85로 가정하였으므로 D_E는 약 85%로 나타났다. 따라서 본 연구에서 제안한 EQ-G1 제안식을 사용하여 PHC말뚝 몸체의 허용압축하중(P_all)까지 활용할 수 있는 적정설계를 수행할 수 있는 것으로 판단된다. 그리고 EQ-G2-3 제안식은 D, ${\bar{N}}$ 및 L/D를 동시에 고려하여 지지력 성분들을 평가할 수 있으며, 매입 PHC말뚝에서 지반의 압축지지력 산정 시 근사해법으로 활용할 수 있다.

• 대한수학회논문집
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• 제34권2호
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• pp.439-449
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• 2019

In 2006, S. Lin and W. Lin introduced the definition of weakly weighted-sharing of meromorphic functions which is between "CM" and "IM". In this paper, using the notion of weakly weighted-sharing, we study the uniqueness of nonconstant homogeneous differential polynomials P[f] and P[g] generated by meromorphic functions f and g, respectively. Our results generalize the results due to S. Lin and W. Lin, and H.-Y. Xu and Y. Hu.