• Wind and Structures
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• 제28권6호
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• pp.355-367
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• 2019

Control of horseshoe vortex in the circular cylinder-plate juncture using vortex generator (VG) was studied at $Re_D$(where D is the diameter of the cylinder) = $2.05{\times}10^5$. Impact of a number of parameters e.g., the shape of the VG's, number of VG pairs (n), spacing between the VG and the cylinder leading edge (L), lateral gap between the trailing edges of a VG pair (g), streamwise gap between two VG pairs ($S_{VG}$) and the spacing between the two VG's in parallel arrangement ($Z_{VG}$) etc. were investigated on the horseshoe vortex control. The study is conducted using surface oil flow visualization and surface pressure measurements in low speed wind tunnel. It is observed that all the parameters studied have significant control effect, either by reduction in separation region or by lowering the adverse pressure along the symmetric axis upstream of the juncture.

• Advances in Computational Design
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• 제4권2호
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• pp.141-153
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• 2019

This research is comprised of virtually simulating behavior while experiencing low gravity effects in advance of real world testing in low gravity aboard Zero Gravity Corporation's (Zero-G) research aircraft (727-200F). The experiment simulated a drill rig penetrating a regolith simulant. Regolith is a layer of loose, heterogeneous superficial deposits covering solid rock on surfaces of the Earth' moon, asteroids and Mars. The behavior and propagation of space debris when drilled in low gravity was tested through simulations and visualization in a leading dynamic simulation software as well as discrete element modeling software and in preparation for comparing to real world results from flying the experiment aboard Zero-G. The study of outer space regolith could lead to deeper scientific knowledge of extra-terrestrial surfaces, which could lead us to breakthroughs with respect to space mining or in-situ resource utilization (ISRU). These studies aimed to test and evaluate the drilling process in low to zero gravity environments and to determine static stress analysis on the drill when tested in low gravity environments. These tests and simulations were conducted by a team from Texas A&M University's Department of Construction Science, the United States Air Force Academy's Department of Astronautical Engineering, and Crow Industries

• 한국지반공학회논문집
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• 제35권7호
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• pp.41-50
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• 2019

국내 고준위폐기물처분장 공학적방벽(EBS)의 일부가 되는 완충재로 경주 벤토나이트가 우선적으로 고려되고 있다. 압축벤토나이트는 지하수침투로 인한 팽윤압과 처분용기에서 발산되는 열응력을 경험한다. 따라서 EBS의 성능평가를 위해서 역학적 물성의 산정이 중요하다. 본 논문은 탄성파를 이용하여 경주 압축벤토나이트의 변형특성 측정을 목표로 하였다. 두 개의 $1.59g/cm^3$와 $1.75g/cm^3$의 건조밀도를 가지는 압축벤토나이트 시편을 제작하였고, 자유단-자유단 공진주시험을 수행하여 구속압축파속도와 비구속압축파속도를 측정하였다. 측정된 압축파속도를 이용하여 미소변형에서의 탄성계수($E_{max}$), 구속탄성계수($M_{max}$), 감쇠비($D_{min}$), 포아송비를 측정하였다. 그 결과로 경주 압축벤토나이트의 변형특성을 산정 제시하여 선행연구 결과들과 비교 분석하였다.

• Journal of Microbiology and Biotechnology
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• 제29권5호
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• pp.813-819
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• 2019

Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe respiratory impairment with a reported mortality rate of ~36% in humans. The absence of clinically available MERS-CoV vaccines and treatments to date has resulted in uncontrolled incidence and propagation of the virus. In vaccine design, fusion with the IgG Fc domain is reported to increase the immunogenicity of various vaccine antigens. However, limited reports have documented the potential negative effects of Fc fusion on vaccine antigens. To determine whether Fc fusion affects the immunogenicity of MERS-CoV antigen, we constructed a Fcassociated MERS-CoV spike protein (eS770-Fc, 110 kDa), whereby human IgG4 Fc domain was fused to MERS-CoV spike protein (eS770) via a Gly/Pro linker using baculovirus as the expression system. For comparative analyses, two eS770 proteins lacking the IgG4 Fc domain were generated using the IdeS protease ($eS770-{\Delta}Fc$) or His tag attachment (eS770-His) and the immunogenicity of the above constructs were examined following intramuscular immunization in mice. Contrary to expectations, non-Fc spike proteins ($eS770-{\Delta}Fc$, eS770-His; 90 kDa) showed higher immunogenicity than the Fc fusion protein (eS770-Fc). Moreover, unlike non-Fc spike proteins, eS770-Fc immunization did not elicit neutralizing antibodies against MERS-CoV. The lower immunogenicity of Fc-fused eS770 was related to alterations in the structural conformation of the spike protein. Taken together, our results indicate that IgG Fc fusion reduces the immunogenicity of eS770 by interfering with the proper folding structure.

• 대한물리의학회지
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• 제14권4호
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• pp.19-27
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• 2019

PURPOSE: This study examined which stretching exercise had the most positive effect on increasing the range of motion (ROM) of the knee joint in healthy people and whether there was a difference between continuous stretching and intermittent stretching. METHODS: This study included 30 healthy university students from OOO University. The subjects were asked to sit on a mat and perform hamstring-stretching exercise during which the ROM and muscle tone were measured with pre and post-tests. Each subject was assigned randomly to a continuous stretching group (stretching without relaxation time group, n=10, G1) or intermittent stretching group (stretching with 10s relaxing time group, n=10, G2; and stretching with 20s relaxing time group, n=10, G3). The participants conducted hamstring stretching exercises with a sit-and-reach box at three different rest times (0s, 10s, and 20s). Subsequently, they underwent passive knee extension (PKE) tests, in which the ROM of the knee joint was measured with a goniometer, and the muscle tone was evaluated using a MyotonPro. RESULTS: Significant differences in muscle tone, stiffness, and ROM were observed between pre-test and post-test in each groups (p<.05). Although the post hoc tests indicated no significant differences in muscle tone and ROM between the continuous stretching group and intermittent stretching group (p>.05), the rate of change of the ROM showed that the intermittent stretching group developed more effective maintenance of the hamstring flexibility. CONCLUSION: No significant differences in the muscle tone of the hamstring and ROM of the knee joint were observed according to the hamstring stretching exercises with three different rest times. On the other hand, the rate of change of the ROM showed that intermittent stretching maintained the hamstring flexibility more effectively.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제45권6호
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• pp.324-331
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• 2019

Objectives: This study investigated the types and antibiotic sensitivity of bacteria in odontogenic abscesses. Materials and Methods: Pus specimens from 1,772 patients were collected from affected areas during incision and drainage, and bacterial cultures and antibiotic sensitivity tests were performed. The number of antibiotic-resistant bacteria was analyzed relative to the total number of bacteria that were tested for antibiotic susceptibility. Results: Bacterial cultures from 1,772 patients showed a total of 2,489 bacterial species, 2,101 gram-positive and 388 gram-negative. For penicillin G susceptibility tests, 2 out of 31 Staphylococcus aureus strains tested showed sensitivity and 29 showed resistance. For ampicillin susceptibility tests, all 11 S. aureus strains tested showed resistance. In ampicillin susceptibility tests, 46 out of 50 Klebsiella pneumoniae subsp. pneumoniae strains tested showed resistance. Conclusion: When treating odontogenic maxillofacial abscesses, it is appropriate to use antibiotics other than penicillin G and ampicillin as the first-line treatment.

• BMB Reports
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• 제52권10호
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• pp.577-588
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• 2019

DNA methylation at CpG sites is an essential epigenetic mark that regulates gene expression during mammalian development and diseases. Methylome refers to the entire set of methylation modifications present in the whole genome. Over the last several years, an increasing number of reports on brain DNA methylome reported the association between aberrant methylation and the abnormalities in the expression of critical genes known to have critical roles during aging and neurodegenerative diseases. Consequently, the role of methylation in understanding neurodegenerative diseases has been under focus. This review outlines the current knowledge of the human brain DNA methylomes during aging and neurodegenerative diseases. We describe the differentially methylated genes from fetal stage to old age and their biological functions. Additionally, we summarize the key aspects and methylated genes identified from brain methylome studies on neurodegenerative diseases. The brain methylome studies could provide a basis for studying the functional aspects of neurodegenerative diseases.

• Smart Structures and Systems
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• 제24권2호
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• pp.193-207
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• 2019

This study concerns with morphing structures, e.g. as applied in the aerospace industry. A morphing aerofoil structure capable of variable geometry was developed, which was shown to be able to cater for the different aerodynamic requirements at different stages of flight. In this work, the useful and relatively simple method has been applied, which provides a direct method for calculating required morphing shape displacements via finding the most effective bar through calculating bar sensitivity to displacement and calculating set of length actuations for bar assembly to control/adjust shape imperfection of prestressable structural assemblies including complex elements ("macro-elements", e.g., the pantographic element), involving Matrix Condensation. The technique has been verified by experiments on the physical model of an aerofoil shaped morphing pantographic structure. Overall, experimental results agree well with theoretical prediction. Furthermore, the technique of multi-iteration adjustment was presented that effective in eliminating errors that occur in the practical adjustment process itself. It has been demonstrated by the experiments on the physical model of pantographic morphing structure. Finally, the study discusses identification of the most effective bars with the objective of minimal number of actuators or minimum actuation.

• 전자통신동향분석
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• 제34권3호
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• pp.86-92
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• 2019

New products and services, such as 5G and wireless power transmission equipment, have recently brought about changes in the field of electromagnetic technology. There is a need for the evaluation and measurement of the health effects of such technology. To address this need, the development of international standards related to human exposure to electromagnetic waves of these new technologies are currently being discussed. This article briefly introduces the International Standard Organization standards for human exposure to electromagnetic waves, and focuses on the major standard trends for SAR measurement techniques that employ vector probes, wireless power transfer, and 5G base station measurement.

• 한국IT서비스학회지
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• 제18권3호
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• pp.53-74
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• 2019

In this paper, a theoretical measurement model for comparing cultural power of nations as a form of national power is built and applied to the G20 nations. The measurement model is drawn from the literature of the state theories regarding culture, theories of epistemology, and debates about the sources of national power. Taking the multiple indicator approach, indicators reflecting diverse aspects of cultural power are developed are developed. Examined with empirical data, this model is proved as appropriate as a tool for measuring and comparing the cultural power of nations. Diverse aspects of the cultural power of the G20 nations are ranked and interesting points regarding the state and potential of Korean culture and her cultural governance in these respects are elaborated. The overall ranking of the cultural power of Korea is found as the $11^{th}$ while the U.S., U.K. and France respectively as the $1^{st}$, the $2^{nd}$, and the $3^{rd}$. The U.S. is ranked as the 1st in all three aspects of the cultural power of nation: cultural attractiveness, efforts to enhance the national cultural power, and cultural base of a nation. Korea is ranked as $14^{th}$, $11^{th}$, and $6^{th}$ respectively in these three respects of the national cultural power. Based upon typological analysis of the cultural power of Korea, it is found that Korea belongs to Type III. Trying to move eventually toward Type I state via Type II is suggested as a strategy movement for future cultural governance by Korean government and people to enhance her national cultural power.