• KSII Transactions on Internet and Information Systems (TIIS)
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• 제14권11호
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• pp.4557-4572
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• 2020

The Alaska competition provides an opportunity to study the practical problems of real-world steganalysis. Participants are required to solve steganalysis involving various embedding schemes, inconsistency JPEG Quality Factor and various processing pipelines. In this paper, we propose a method to ensemble multiple deep learning steganalyzers. We select SRNet and RESDET as our base models. Then we design a three-layers model ensemble network to fuse these base models and output the final prediction. By separating the three colors channels for base model training and feature replacement strategy instead of simply merging features, the performance of the model ensemble is greatly improved. The proposed method won second place in the Alaska 1 competition in the end.

• Journal of Information Processing Systems
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• 제19권1호
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• pp.80-88
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• 2023

RGB-thermal (RGB-T) tracking using unmanned aerial vehicles (UAVs) involves challenges with regards to the similarity of objects, occlusion, fast motion, and motion blur, among other issues. In this study, we propose dynamic tracking aggregation (DTA) as a unified framework to perform object detection and data association. The proposed approach obtains fused features based a transformer model and an L1-norm strategy. To link the current frame with recent information, a dynamically updated embedding called dynamic tracking identification (DTID) is used to model the iterative tracking process. For object association, we designed a long short-term tracking aggregation module for dynamic feature propagation to match spatial and temporal embeddings. DTA achieved a highly competitive performance in an experimental evaluation on public benchmark datasets.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2011년도 춘계학술발표대회
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• pp.1158-1161
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• 2011

고령화 사회로 진입하고 있는 시점에 고령인구에 대한 복지정책 및 사회전반적인 대응 방안이 모색되어져야할 시기이다. 특히, 고령인구 특성상 의료문제를 해결할 수 있는 효과적인 방법들의 연구가 시급하다. 그러한 문제를 해결하는 방안으로 U-헬스분야와 IT 분야 및 건설분야의 융합을 통한 효율적인 헬스케어 서비스 모델 개발이 요구되고 있다. 본 연구에서는 융합모델의 성공적인 결과 도출을 위한 모델의 구성과 추진 전략 등을 제안하였다.

• International Journal of Advanced Culture Technology
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• 제12권2호
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• pp.318-325
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• 2024

The rapid advancement of drone technology has led to the emergence of drone swarms, a game-changing concept in modern warfare. This study explores the military applications, countermeasures, and strategic implications of drone swarms. By examining the current trends in drone swarm development and deployment, this research highlights the potential of this technology to revolutionize the battlefield. The study also investigates the challenges and vulnerabilities associated with drone swarms, emphasizing the need for effective countermeasures. Through an analysis of multi-sensor fusion, directed energy weapons, and artificial intelligence, this research proposes comprehensive strategies to counter the threats posed by drone swarms. Furthermore, the study delves into the ethical and legal issues surrounding the use of autonomous drone swarms, underscoring the necessity for international norms and regulations. The findings of this research contribute to the understanding of the transformative impact of drone swarms on military strategy and national security, while providing valuable insights for policymakers, military strategists, and researchers in the field.

• IMMUNE NETWORK
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• 제11권3호
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• pp.182-189
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• 2011

Background: Cytotoxic T lymphocytes (CTLs) appear to play an important role in the control and prevention of human cytomegalovirus (HCMV) infection. The pp65 antigen is a structural protein, which has been defined as a potential target for effective immunity against HCMV infection. Incorporation of an 11 amino acid region of the HIV TAT protein transduction domain (Tat) into protein facilitates rapid, efficient entry into cells. Methods: To establish a strategy for the generation of HCMV-specific CTLs in vitro, recombinant truncated N- and C-terminal pp65 protein (pp65 N&C) and N- and C-terminal pp65 protein fused with Tat (Tat/pp65 N&C) was produced in E.coli system. Peripheral blood mononuclear cells were stimulated with dendritic cells (DCs) pulsed with pp65 N&C or Tat/pp65 N&C protein and immune responses induced was examined using IFN-${\gamma}$ ELISPOT assay, cytotoxicity assay and tetramer staining. Results: DCs pulsed with Tat/pp65N&C protein could induce higher T-cell responses in vitro compared with pp65N&C. Moreover, the DCs pulsed with Tat/pp65 N&C could stimulate both of $CD8^+$ and $CD4^+$ T-cell responses. The T cells induced by DCs pulsed with Tat/pp65 N&C showed higher cytotoxicity than that of pp65-pulsed DCs against autologous lymphoblastoid B-cell line (LCL) expressing the HCMV-pp65 antigen. Conclusion: Our results suggest that DCs pulsed with Tat/pp65 N&C protein effectively induced pp65-specific CTL in vitro. Tat fusion recombinant protein may be useful for the development of adoptive T-cell immunotherapy and DC-based vaccines.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 1999년도 Proceedings of International Symposium on Remote Sensing
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• pp.158-164
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• 1999

This paper investigated and evaluated the NASA's Shuttle Imaging Radar-C (SIR-C) multiple frequency SAR data for differential backscattering effects of microwave from the surface geological materials overlying the skarn type mineralization. Although an integrated approach in mineral exploration is more cost effective and is well in use, there are still many technical and scientific issues to be further investigated and researched. In this study we have reprocessed several sets of previously surveyed exploration data and experimented with fuzzy logic digital fusion of the preprocessed data with respect to chosen exploration targets. Among the numerous fuzzy logic operators, which are currently available for a data driven integrated exploration strategy, we used varying combinations of fuzzy MIN, fuzzy MAX, and fuzzy SUM operators along with Gamma operator for fusion of exploration data, including the contact metamorphic zone information. The final exploration target tested was a skarn type W-Mo-F mineralization in the study area. The fuzzy logic derived mineral potential anomaly almost exactly matched the differential backscattering anomalies on the C-band and L-band SIR_C data when overlaid on each other. Although this high degree of correlation between these two data sets is remarkable, the differential backscattering anomaly over the skarn type W-Mo-F mineralization in the study area requires further investigation.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2447-2451
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• 2014

Human papillomavirus (HPV) is the primary etiologic agent of cervical cancer. Consideration of safety and non human leukocyte antigen restriction, protein vaccine has become the most likely form of HPV therapeutic vaccine, although none have so far been reported as effective. Since tumor cells consistently express the two proteins E6 and E7, most therapeutic vaccines target one or both of them. In this study, we fabricated DC vaccines by transducing replication-defective recombinant adenoviruses expressing E6/E7 fusion gene of HPV-16, to investigate the lethal effects of specific cytotoxic T lymphocytes (CTL) against CaSki cells in vitro. Mouse immature dendritic cells (DC) were generated from bone marrow, and transfected with pAd-E6/E7 to prepare a DC vaccine and to induce specific CTL. The surface expression of CD40, CD68, MHC II and CD11c was assessed by flow cytometry (FCM), and the lethal effects of CTL against CaSki cells were determined by DAPI, FCM and CCK-8 methods. Immature mouse DC was successfully transfected by pAd-E6/E7 in vitro, and the transfecting efficiency was 40%-50%. A DC vaccine was successfully prepared and was used to induce specific CTL. Experimental results showed that the percentage of apoptosis and killing rate of CaSki cells were significantly increased by coculturing with the specific CTL (p <0.05). These results illustrated that a DC vaccine modified by HPV-16 E6/E7 gene can induce apoptosis of CaSki cells by inducing CTL, which may be used as a new strategy for biological treatment of cervical cancer.

• The Korean Journal of Physiology and Pharmacology
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• 제7권3호
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• pp.163-168
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• 2003

The reactive oxygen species (ROS) are considered to be an important mediator in pancreatic ${\beta}$ cell destruction, thereby triggering the development of insulin-dependent diabetes mellitus. In the present study, HIV-1 Tat-mediated transduction of Cu,Zn-superoxide dismutase (SOD) was investigated to evaluate its protective potential against streptozotocin (STZ)-induced cytotoxicity in insulin-producing MIN6N cells. Tat-SOD fusion protein was successfully delivered into MIN6N cells in a dose-dependent manner and the transduced fusion protein was enzymatically active for 48 h. The STZ induced-cell destruction, superoxide anion radical production, and DNA fragmentation of MIN6N cells were significantly decreased in the cells pretreated with Tat-SOD for 1 h. Furthermore, the transduction of Tat-SOD increased Bcl-2 and heat shock protein 70 (hsp70) expressions in cells exposed to STZ, which might be partly responsible for the effect of Tat-SOD. These results suggest that an increased of free radical scavenging activity by transduction of Tat-SOD enhanced the tolerance of the cell against oxidative stress in STZ-treated MIN6N cells. Therefore, this Tat-SOD transduction technique may provide a new strategy to protect the pancreatic ${\beta}$ cell destruction in ROS-mediated diabetes.

• 영재교육연구
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• 제21권2호
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• pp.357-372
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• 2011

본 연구는 개인의 역량 강화와 국가 경쟁력 제고에 이바지하는 창의인재육성 실현이라는 비전을 추진하기 위해, 한국적 토양과 문화를 고려한 창의인재육성의 방향성을 정립하기 위한 기초연구의 일환으로 진행하였다. 이를 위해 인문사회, 예술, 과학 영역 및 산학연 전문가 6인을 대상으로 3차에 걸친 질적 연구를 진행하였다. 그 결과 한국적 창의인재에 대한 정의와 그 요소, 이를 육성하기 위한 교육적 전략을 '융합'과 '통합'의 키워드에서 찾을 수 있었고, 세부적으로는 평생교육측면에서 창의인재육성을 어떻게 해야 할 것인가에 대해서도 연구할 수 있었다.

• 디지털융복합연구
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• 제18권7호
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• pp.135-148
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• 2020

기술개발에 성공하고도 사업화초기에 자금조달의 어려움으로 사업화에 실패하는 경우가 적지 않게 발생하고 있다. 본 연구의 목적은 주로 이공계 출신의 기술기반 창업자에게 실무적 시사점을 주고자 함이다. 사업화 초기에 각기 다른 유형의 외부자금 조달에 성공한 7개 기업을 선정하여 사례분석을 수행하였다. 그 결과는 다음과 같다. 첫째, 기술의 우수성이 가장 중요하다는 사실을 확인하였다. 둘째, 해당 기술 분야 전공자였거나 관련 분야 근무 경력자였음을 확인하였고, 창업자의 사업의지와 적극적 태도가 더해지면 보다 큰 시너지 효과 창출이 가능하다는 결론을 얻었다. 셋째, 기업 내부역량이 미흡하더라도 정책금융 정보, 금융기관 제공정보 등 외부금융정보를 잘 파악하여 활용하면 자금조달에 성공할 수 있었다. 넷째, 융자와 투자를 모두 받는 연계금융제도의 활용이 필요하다는 점이다. 다섯째, 체계적 IR(Investor Relation)은 계속되어야 한다는 점이다. 정보비대칭을 줄일 수 있는 IR이 계속되는 경우 자금조달에 성공하는 사례가 존재한다는 점 또한 확인할 수 있었다.