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Effect of Manufacturing Method and Acidifier on the Dissolution Rate of Carvedilol from Solid Dispersion Formulations

  • Lim, Dong-Kyun;Bae, Jeong-Woo;Song, Byung-Joo;Jo, Han-Su;Kim, Hyoung-Eun;Lee, Dong-Won;Khang, Gil-Son
    • Journal of Pharmaceutical Investigation
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    • v.41 no.6
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    • pp.363-369
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    • 2011
  • In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

Abnormal Behavior in Color Tracking in the Fringe-Field Switching (FFS) Liquid Crystal Display

  • Jung, Jun-Ho;Ha, Kyung-Su;Chae, Mi-Na;Cho, In-Young;Kim, Woo-Il;Kim, Dae-Hyun;Kim, Sung-Min;Lee, Seung-Hee
    • 한국정보디스플레이학회:학술대회논문집
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    • 2009.10a
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    • pp.616-619
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    • 2009
  • Color tracking behavior of in the fringe-field switching (FFS) mode using a liquid crystal with positive dielectric anisotropy has been studied. In the in-plane switching and vertical alignment devices, color chromaticity at normal direction changes from bluish to yellowish white linearly with increasing grey levels from dark to white state. Interestingly, abnormal behavior in color tracking is observed in FFS devices using a liquid crystal with positive dielectric anisotropy, that is, it changes from bluish to yellowish up to a certain middle grey level but turns over to bluish white with further increasing from a grey level to a fully white state. In this paper, we analyze this abnormal effect from the calculated and experimental results.

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Improved Dissolution Behavior of Aceclofenac Loadings with Kollidon VA 64 Using Spray Drying and Rotary Evaporation Process (분무건조와 용매증발을 이용한 Kollidon VA 64에 포접된 아세클로페낙의 개선된 용출 거동)

  • Yang, Jaewon;Park, Jin Young;Lee, Cheon Jung;Kim, Hye Min;Lee, Hyun Gu;Jang, Na Gum;Ko, Hyun Ah;Cho, Seon Ah;Yang, Dae Hyeok;Khang, Gilson
    • Polymer(Korea)
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    • v.39 no.1
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    • pp.6-12
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    • 2015
  • In order to improve the poor water solubility of aceclofenac, it was loaded into solid Kollidon VA 64 dispersion prepared by spray drying and rotary evaporation methods using different drug and polymer ratios. Morphology and physicochemical behavior of the aceclofenac loaded solid dispersions was analyzed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), and differential scanning calorimetry (DSC). Encapsulation efficiency and dissolution behavior in a simulated intestinal juice of aceclofenac in the solid dispersions was measured using HPLC and the latter was compared with that of the active pharmaceutical ingredient (API) and Airtal$^{(R)}$. It was demonstrated that two methods could significantly improve the dissolution behavior of aceclofenac.