• Title/Summary/Keyword: Functional limitations

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A Study on the Web-based Map Algebraic Processor (웹 기반 지도대수 처리기에 관한 연구)

  • 박기호
    • Spatial Information Research
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    • v.5 no.2
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    • pp.147-160
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    • 1997
  • "The "Map Algebra", beeing recognized as a viable theoretical framework for GIS (Geographica Infonnation System), models map layers as "operands" which are the basic unit of geo-processing, and a variety of GIS commands as "operators." In this paper, we attempt at lifting some limitations of map algebras proposed in GIS literature. First, we model map layer as "function" such that we may employ the notion of meta operator (or, higher-order funtion) available in the functional programming paradigm. This approach provides map algebraic language with "programmability" needed in GIS user language. Second, we extend the semantics of, and improve on the sytactic structure of map algebraic language. Mer the data model and language associated with map algebra are formalized, we proceed to design and implement a prototype of map algebraic processor. The parser of the language in our prototype plays the role of transforming the native and heterogeneous user language of current GISs into a canonical map algebraic language. The prototype, named "MapSee" is a proof-of-concept system for the ideas we propsed in this paper. We believe that the uniform interface based on the map algebraic language will make promising infrastructure to support "Internet GIS." This is because the uniform but powerful interface through the Web clients allow access to both geo-data and geo-processing resources distributed over the network.to both geo-data and geo-processing resources distributed over the network.

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CONSTRUCTION OF RECOMBINANT HSCC-1 ADENOVIRUS VECTOR FOR ORAL CANCER GENE THERAPY (구강암 유전자 치료를 위한 재조합 HSCC-1 아데노바이러스의 개발)

  • Kim, Chang-Hyen;Kim, Jin-Woo;Kim, Myung-Jin;Pyo, Sung-Woon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.27 no.2
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    • pp.103-109
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    • 2005
  • In spite of the ongoing advances, standard therapies for oral cancer still has some limitations in efficacy and in ability to prolong survival rate of advanced disease and result in significant functional defect and severe cosmetic deformity. Currently gene therapy using tumor suppressor gene is considered as a potent candidate for new therapeutic approaches that can improve efficacy and reduce complications. The purpose of this research is to identify the role of adenoviral vector to transfer HCCS-1 tumor suppressor gene in oral cancer cells and to find out whether there is a possibility for it to serve in the field of gene therapy. The human SCC-25 cell line was used for transfection. To determine the efficiency of the adenovirus as a gene delivery vector cell line was transduced with LacZ gene and analysed with X-gal staining. Northern blot was performed to confirm the tranfection with HSCC-1 gene and cell viability was assessed by cell cytotoxicity assay. We had successfully construct the recombinant HSCC-1 adenovirus(Ad5CMV-HCCS-1). DNA extracted from Ad5CMV-HCCS-1 revealed HCCS-1 gene is incorporated. The transduction efficiencies were over than 50% of SCC-25 cells with a MOI of 2 and over 95% with a MOI of 50. Northern blot analysis showed that a single 0.6kb mRNA transcript was expressed in Ad5CMV-HCCS-1 transduced SCC-25 cells. There was no or very low transcription HCCS-1 mRNA in wild and Ad5CMV-LacZ transduced SCC-25 cells. Cells transduced with Ad5CMV-HCCS-1 showed significant growth inhibition. By day 6, Ad5CMV-HCCS-1 treated cell count was decreased to 30% of mock-infected cells, while that of Ad5CMV-LacZ treated cells was 90% of mock-infected cells (p<0.05). Finally, these result suggest that the Ad5CMV-HCCS-1 has potential as a gene therapy tool for oral cancer.

Characteristics of the Tactile Brainwave on the Surface of Interior Finishing Materials - Focusing on the measurement of 'α-wave against β wave' - (실내마감재 표면에 감각하는 촉각적 뇌파특성 - '베타파에 대한 알파파' 측정 중심으로 -)

  • Yeo, Mi;Lee, Chang No
    • Korean Institute of Interior Design Journal
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    • v.25 no.2
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    • pp.59-69
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    • 2016
  • This study aimed to understand the importance of applying finishing materials into interior space, and to add meaning to the creation of functional space, associated interior finishing materials with brain science. To achieve this purpose, brainwave(EEG) experiment was conducted. The brainwave appearing when sensing the surface of interior finishing materials with hands was measured. The locations of the electrode were FP1, FP2, F3, F4, C3, C4, P3, P4, O1, O2, F7, F8, T3, T4, T5, T6, CZ, FZ, and PZ and in addition to these, AFZ was added. Eight(8) kinds of finishing materials: metallic material, film paper, lumbar, stone, glass, silk wallpaper, fabric, and paint were used to measure '${\alpha}$-wave against ${\beta}$ wave.' As a result, it was found that the most activated finishing material in term of relaxation was film paper, followed by metallic, glass, paint, fabric, stone, lumbar, and silk wallpaper. To explain in light of this, (1) '${\alpha}$-wave against ${\beta}$ wave' was the most activated at ch1-FP1 and ch2-FP2, and at ch17-AFZ and ch19-FZ, which indicated that metopic-prefrontal lobe showed the highest activation in relaxation. Film paper, among the finishing materials, showed the highest increase in relaxation. (2) In general, '${\alpha}$-wave against ${\beta}$ wave' relaxation was inhibited at ch13-T3 and ch14-T4, and at ch15-T5 and ch16-T6 and the arousal in the temporal lobe was prominent. Silk wallpaper, among the finishing materials, showed the highest arounsal effect. As a result of measuring the superficial touch on the silk wallpaper, which was regarded as the most rough material among the eight finishing materials, the arousal effect of ${\alpha}$-wave against ${\beta}$-wave, among the brainwave characteristics, was found to be the highest. (3) to judge from the scope of this experiment regarding the tactile sensation over the finishing materials, it is considered that the brainwave reaction sometimes appeared contrastive depending on whether the surface was smooth or rough and there also appeared a difference in relaxation and arousal reaction of the brainwave depending on whether the surface was hot or cold, but the sensation on the surface texture was often evaluated differently depending on who you were. For this reason, this study has some limitations.

Quality of Life of Some Obese Patients Wanted to Receive Korean Traditional Medicine (한방 비만클리닉에 내원한 일부 비만 여성의 삶의 질)

  • Cho, Hyeon-Joo;Kwon, Yung-Dal
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.20 no.6
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    • pp.1732-1741
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    • 2006
  • Obesity is chronic disease which influenced on health severly. The causes of obesity have been known as life change, lack of excercise, genetic factor, mental and social economic factors. Especially the obesity of women increased the risk of the diseases such as DM, osteoarthritis, cardiovascular disease, breast cancer and infertility. The limitations of the widely used negative definition of health as the absence of disease and WHO's 1946 definition of health as total social, psychological and physical well-being have long been recognized (WHO 1958). The Quality of Life (QoL) includes functional ability, the degree and quality of social and community interaction, psychological well-being as somatic sensation and life satisfaction. I investigated to compare the differences between obese women (n=63), non-obese women (n=37) in clinic and general women (n=43, control) on baseline characteristics and WHO QoL-BREF. The purpose of this study is to assist the diagnosis and treatment of obesity. WHO QoL-BREF is self administered type which consisted of 26 questions. The prospective question is calculated with 5 scores by Likert's method. The results are as follows : The means of physical, psychological, social, overall and total scores of QoL were significant among BMI group (P<0.05). The score of control group (BMI < 25) was higher than other groups significantly (P<0.05). In multiple regression analysis, the variable of high school/below middle school was significant in environmental and overall domain of QoL scores (P<0.05). The variable of college/below middle school was significant in environmental, overall domain and total score of QoL scores (P<0.05). The variable of above university/below middle school was significant in physical health, environmental, overall domain and total score in QoL scores (P<0.05). The variable of Health perception (moderate/bad) was positively significant in physical health, environmental, overall domain and total score of QoL scores (P<0.05). The variable of Health perception (good/bed) was positively significant in physical health, environmental, social, overall domain and total score of QoL scores (P<0.05). The variable as BMI non-=obese women/control was negatively significant in social domain of QoL scores (P<0.05). Above the results, It suggests that the variable as BMI did't affect on the QoL in patients and control, but the variables as education and health perception affected on the QoL scores. Further study is required to conduct QoL differences between before and after treatment of obese patients.

Application of Nanoparticles Derived from Artemisia princeps for Cosmetic Products (쑥으로부터 유래된 나노입자의 화장품 제품 응용)

  • Jung, So Young;Kang, Hae-Ran;Yoo, Han Jun;Choi, Hyeong;Heo, Hyojin;Cha, Byungsun;Brito, Sofia;Lee, So Min;Yeo, Hye Lim;Kang, Seo Jeong;Lee, Dae Yeop;Kwak, Byeong-Mun;Lee, Mi-Gi;Bin, Bum-Ho
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.47 no.3
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    • pp.265-271
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    • 2021
  • Nanoparticles are substances that are smaller in size and smaller than cells that make up the skin. Therefore, they are very suitable as mediators for transmitting drugs or genes across cell membranes, and also deliver specific ingredients into the skin.In this study, nanoparticles were extracted from mugwort and particles of around 100 nm were obtained through dynamic light scattering (DLS), and the results of concentration-dependent enhancement of cell viability in fibroblasts were obtained through MTT assay. In addition, it was confirmed that the COL1A1 mRNA expression level was increased and the IL-6 mRNA expression level was decreased through the quantitative real-time PCR analysis method. Moreover, as these nanoparticles were confirmed to be stable, they can be applied not only to cell experiments but also to cosmetic formulations. While the demand for plant-derived ingredients continues to increase, excluding chemical ingredients from the recent cosmetics industry trend, there is a limitation in that there are few research results suggesting the application field of plant-derived nanoparticles. Therefore, in order to overcome the limitations of the cosmetic industry at the present time, the results obtained in this study present nanoparticles derived from Artemisia princeps (NDAP) as a highly functional cosmetic material.

Surface and Corrosion Protection Properties of Fluorine Doped PVDF by Plasma Fluorination (플라즈마 불소화에 의해 제조된 불소 도핑 PVDF의 표면 및 부식방지 특성)

  • Kim, Seokjin;Lim, Chaehun;Kim, Daesup;Lee, Young-Seak
    • Applied Chemistry for Engineering
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    • v.32 no.6
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    • pp.653-658
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    • 2021
  • Polyvinylidene fluoride (PVDF) is a promising coating material because of its outstanding processability. The PVDF coating, however, has limitations in anti-corrosion application due to its weak hydrophobicity compared to that of other fluoropolymers. In this study, plasma fluorination was performed using carbon tetrafluoride (CF4) gas to improve anti-corrosion properties of PVDF. The fluorine content and hydrophobicity of PVDF were investigated in different CF4 flow rates, followed by the determination of anti-corrosion properties. The fluorine content on the surface of the PVDF film increased by up to 46.70%, but the surface free energy was independent of CF4 flow rate. Meanwhile, the surface roughness of the PDVF film tended to increase by up to 150% and then decrease with increasing CF4 flow rate. It is considered that the plasma fluorination affects the surface free energy due to the introduction of fluorine functional groups and surface etching. In addition, the degree of corrosion of the PVDF-coated Fe plate was significantly reduced from 49.2% to 19.0% compared to that of the uncoated Fe plate. In particular, the degree of corrosion of the fluorinated PVDF-coated Fe plate was 13.6%, which was 28.4% lower than that of the PVDF-coated Fe plate, showing improved anti-corrosion protection.

Effect on the Improvement of Intestinal Function and Constipation of Products Made from Chinese Gooseberry (Kiwi) (참다래(키위)로 만든 제품의 장 기능 및 변비 개선에 미치는 효과)

  • Cheong, MoonJoo;Kim, Myunghaw
    • The Journal of the Korea Contents Association
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    • v.21 no.7
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    • pp.650-659
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    • 2021
  • In this study, we aimed to investigate the effect of Chinese gooseberry (kiwi)-based products on the improvement of intestinal function and constipation. In this study, 21 participants with no underlying disease and complaining of subjective constipation symptoms were selected. Through a pre-experimental design, the main effects, including the colon stagnation score and colon transit time, were assessed after the consumption of Chinese gooseberry (kiwi)-based products. To evaluate the side effects of this product, a subjective constipation assessment test was performed to analyze the degree of constipation improvement at an individual level. The results for the main effects revealed that the number of constipation groups was statistically significantly decreased, and the colon stagnation score and colon transit time were also reduced. Additionally, the participants' subjective constipation assessment test revealed a significant improvement in both intestinal function and bowel activity before and after the consumption of Chinese gooseberry (kiwi)-based products. Similar to the previously known kelp-, lactobacillus-, and fiber-based products, we showed that Chinese gooseberry (kiwi)-based products exert a significant effect on the improvement of the intestinal function and constipation. Furthermore, the results of this study provide valuable information for the development of healthy food products in the future that can help improve bowel movement. Moreover, Chinese gooseberry (kiwi) used in this study is not a functional food and is easily accessible. However, this study has several limitations as it is based on a pre-experimental design. Therefore, studies on randomized experimental and control groups are needed in the future.

Development of E-PAD based condition evaluation system for facility safety inspection (시설물 안전점검을 위한 E-PAD 기반 상태평가 시스템 개발)

  • Jung, Hae-Yong;Lee, Heung-Su;Yi, Jong-Hwa;Kim, Young-Seok;Park, Chul
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.23 no.4
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    • pp.1-7
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    • 2019
  • As a unify operational processes of the safety inspection for major national facilities, it is expected that the efficiency and professionalism of the project will be enhanced. Also it is being emphasized that the importance of visual inspection that initially find physical and functional defects in facilities. In this study, we developed an E-PAD-based condition evaluation system to check the safety of the facility to overcome the problems and limitations of the existing inspection method. This system consists of introduction, work list, visual inspection, defect table and so on. It is possible to download the inspection drawings at the site and input the damage information to the drawings and check the evaluation grade. In order to verify the E-PAD based condition evaluation system, the inspection data of 10 sample bridges were inputted into the system and the evaluation results were compared. As a result, it was confirmed that the safety grade calculated from the system and the existing safety grade are the same. The feasibility analysis of the AHP method also showed that the function increased by 10%, cost by 36%, and value by 30% compared to the existing method. Therefore, it is expected to contribute to systematic data and information analysis system for improvement of facility management.

Development trends of Solar cell technologies for Small satellite (소형위성용 태양전지 개발 동향 및 발전 방향)

  • Choi, Jun Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.5
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    • pp.310-316
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    • 2021
  • Conventional satellites are generally large satellites that are multi-functional and have high performance. However, small satellites have been gradually drawing attention since the recent development of lightweight and integrated electric, electronic, and optical technologies. As the size and weight of a satellite decrease, the barrier to satellite development is becoming lower due to the cost of manufacture and cheaper launch. However, solar panels are essential for the power supply of satellites but have limitations in miniaturization and weight reduction because they require a large surface area to be efficiently exposed to sunlight. Space solar cells must be manufactured in consideration of various space environments such as spacecraft and environments with solar thermal temperatures. It is necessary to study structural materials for lightweight and high-efficiency solar cells by applying an unfolding mechanism that optimizes the surface-to-volume ratio. Currently, most products are developed and operated as solar cell panels for space applications with a triple-junction structure of InGaP/GaAs/Ge materials for high efficiency. Furthermore, multi-layered junctions have been studied for ultra-high-efficiency solar cells. Flexible thin-film solar cells and organic-inorganic hybrid solar cells are advantageous for material weight reduction and are attracting attention as next-generation solar cells for small satellites.

3D printed interim immediate denture by using the occlusal plane digital transfer method of the POP BOW system in a patient planning to extract upper and lower residual teeth: a case report (상하악 전악 발거 환자에서 POP BOW 시스템의 교합평면 디지털 전이법을 이용한 3D 프린팅 임시 즉시의치의 수복 증례)

  • Park, Do-Hyun;Bae, Eun-Bin;Jung, In-Hwan;Jeong, Chang-Mo;Yun, Mi-Jung;Huh, Jung-Bo;Lee, So-Hyoun
    • Journal of Dental Rehabilitation and Applied Science
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    • v.38 no.3
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    • pp.178-188
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    • 2022
  • Interim immediate denture is fabricated to minimize the period of edentulousness after removal of the patient's remaining teeth and before delivery of final prosthesis. In the case of using the CAD/CAM system, there is an advantage in that the manufacturing process in the clinic and laboratory can be simplified by overcoming some of the limitations of manufacturing interim immediate dentures in the traditional way. However, there are also disadvantages in that errors occur in the process of transmitting information about the patient's intermaxillary relationship to the digital network of the laboratory, resulting in unstable occlusal relationships or non-esthetic prostheses. To overcome this problem, using the simple and accurate POP BOW system's occlusal plane digital transfer method, it was possible to fabricate an esthetic and functional 3D printed interim immediate denture after removal of the remaining upper and lower anterior teeth.