• Molecules and Cells
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• v.39 no.10
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• pp.722-727
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• 2016

Cardiomyopathy is a major cause of death worldwide. Based on pathohistological abnormalities and clinical manifestation, cardiomyopathies are categorized into several groups: hypertrophic, dilated, restricted, arrhythmogenic right ventricular, and unclassified. Dilated cardiomyopathy, which is characterized by dilation of the left ventricle and systolic dysfunction, is the most severe and prevalent form of cardiomyopathy and usually requires heart transplantation. Its etiology remains unclear. Recent genetic studies of single gene mutations have provided significant insights into the complex processes of cardiac dysfunction. To date, over 40 genes have been demonstrated to contribute to dilated cardiomyopathy. With advances in genetic screening techniques, novel genes associated with this disease are continuously being identified. The respective gene products can be classified into several functional groups such as sarcomere proteins, structural proteins, ion channels, and nuclear envelope proteins. Nuclear envelope proteins are emerging as potential molecular targets in dilated cardiomyopathy. Because they are not directly associated with contractile force generation and transmission, the molecular pathways through which these proteins cause cardiac muscle disorder remain unclear. However, nuclear envelope proteins are involved in many essential cellular processes. Therefore, integrating apparently distinct cellular processes is of great interest in elucidating the etiology of dilated cardiomyopathy. In this mini review, we summarize the genetic factors associated with dilated cardiomyopathy and discuss their cellular functions.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.29 no.4
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• pp.45-52
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• 1997

This study was carried out to investigate the adsorption characteristics of cationic starches onto BKP, BCTMP and talc. Concentration of the unadsorbed cationic starch contained in the supernatant of the pulp or talc slurries was determined using a spectoscopy method and the adsorption isotherm of cationc starch was constructed. When the equilibrium concentration of the cationic starch was low, almost complete adsorption of the starch onto BKP and BCTMP was observed. This indicates that electrostatic attraction is the main driving force for the adsorption of cationc starches onto pulps. BCTMP adsorbed greater amount of cationic starches than BKP since it contained more anionc functional groups on its surface. The adsorption amount of the cationic starch increased as the cationicity of the starches decreased. Surface charge density of the pulp and starch adsorption increased as the pH of the pulp slurry increased. Adsorption amount of the cationic starch onto talc was lower than that onto the pulp due to its low charge density and hydrophobic surface property.

• Journal of Korean Physical Therapy Science
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• v.27 no.2
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• pp.88-95
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• 2020

Background: In the present study to investigate the immediate effects of standing position of the trunk stabilization exercise on Guillain-Barre syndrome patient's balance and gait abilities were examined. Design: Case report and conducted as a single-blind. Methods: Standing position of trunk stabilization exercise was conducted for five Guillain-Barre syndrome patient's who met the selection criteria were recruited. The subjects were conducted conservative exercise and trunk stabilization exercise. Conservative exercise was implemented for thirty min, five times for 8 weeks, and trunk stabilization exercise was implemented for 15 min. The participants' balance was measured via force plate (COP), functional reach test (FRT), timed up and go test (TUG), gait was measured using the 10 m walk test, and 6 minute walk test. Results: After training, the change values of the balance and gait ability in the subjects were significantly greater than pre-test. participants showed significant improvements in COP, FRT, TUG, 10 m walk test and 6 minute walk test pre and post the training (p<0.05). Conclusions: standing position of the trunk stabilization exercise was effective on Guillain-Barre syndrome patient's balance (COP, FRT, TUG) and gait (10 m walk test and 6 minute walk test) abilities were examined.

• The KSFM Journal of Fluid Machinery
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• v.8 no.3 s.30
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• pp.16-25
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• 2005

The purpose of this study is localization of safety relief valves for Nuclear Service. The safety relief valve is the important equipment used to protect the pressure vessel, the steam generator and the other pressure facility from overpressure by discharging the operating medium when the pressure of system is reaching the design pressure of the system. We developed design technology used FEM ' CFM about safety relief valve for Nuclear Service according to ASME (or KEPIC) Code and KHNP's Technical Specification. To prove validity of a design technology, actually, we manufactured and inspected and tested the sample products designed according to a developed technology. The capacity qualification test was achieved according to requirement of ASME(or KEPIC) Code by NBBI and the functional qualification test was achieved according to ASME QME-1 for operating condition in technical specification of KHNP by NLI. Therefore we have to achieve the development of safety relief valves for Nuclear Service with our own technologies.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3385-3390
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• 2010

$Li^+$ ion complex of azacrown ether with restricted motion of freedom and pseudo-bilateral symmetry was studied by infrared spectroscopy, which has shown simplified and broadened vibrational features. The C=O and N-H stretching bands, in particular, shows anomalous broadening nearly ${\sim}50\;cm^{-1}$. The density functional calculation at the level of BP86/6-31+$G^{**}$ shows that $Li^+$ ion is trapped and rather free to move around inside the cavity, as much as about $0.70\;{\AA}$. Through the relocation of $Li^+$ ion inside the cavity, the conformational changes would occur rapidly in its symmetry $C_1\;{\rightleftarrows}\;C_2\;{\rightleftarrows}\;C_1$$. The potential barrier was obtained to be merely ~2.2 kJ/mol for $C_1\;{\rightarrow}\;C_2$. During this conformational alteration, the amide backbone twists concurrently its dihedral angle side to side about up to ${\pm}3$ degree. Selected vibrational modes were interpreted in terms of the force constant variations of local symmetry coordinates between conformations in the framework of $C_1\;{\rightleftarrows}\;C_2\;{\rightleftarrows}\;C_1$.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3103-3108
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• 2010

Conducting polymers (CPs) are widely used as matrixes for the entrapment of enzymes in analytical chemistry and biosensing devices. However, enzyme-catalyzed polymerization of CPs is rarely used for immunosensing due to the difficulties involved in the quantitative analysis of colloidal CPs in solution phase. In this study, an enzyme-amplified electrocatalytic immunosensor employing a CP as a redox marker has been developed. A polyanionic polymer matrix, $\alpha$-amino-$\omega$-thiol terminated poly(acrylic acid), was employed for precipitation of CP. The acrylic acid group acts as a polyanionic template. The thiol terminus of the polymer was used to produce self-assembled monolayers (SAMs) on Au electrodes and the amine terminus was employed for immobilization of biomolecules. In an enzymeamplified sandwich type immunosensor, the polyaniline (PANI) produced enzymatically is attracted by the electrostatic force of the matrix polymer. The precipitated PANI was characterized by electrochemical methods.

• Polymer(Korea)
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• v.26 no.6
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• pp.718-727
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• 2002

In this work, an Ar+ beam was irradiated on carbon fiber surfaces to improve the interfacial shear strength (IFSS) of the resulting composites using an ion assisted reaction (IAR) method h single fiber pull-out test was executed to investigate the basic characteristics of the single Carbon fiber/matrix interface. Based on Greszczuk's geometrical model, the debonding force for pull-out of the fiber from the resins was discussed with the applied ion beam energy as a result, it was known that an ion beam treatment produced the functional groups on fiber surface and etching lines along the fiber axis direction, resulting in increasing the adhesion forces between fibers and matrix, which caused the improvement of the IFSS in a composite system. And, it was also found that the maximum IFSS was shown at 0.8 keV ion beam energy in this system.

• Elastomers and Composites
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• v.51 no.4
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• pp.308-316
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• 2016

The rubber materials are widely used in automobile industry due to their capability of a large amount of elastic deformation under a force. Current trend of design process requires prediction of functional properties of parts at early stage. The behavior of rubber material can be modeled using strain energy density function. In this study, five different strain energy density functions - Neo-Hookean model, Reduced Polynomial $2^{nd}$ model, Ogden $3^{rd}$ model, Arruda Boyce model and Van der Waals model - were used to estimate the behavior of carbon black added natural rubber under uniaxial load. Two kinds of tests - uniaxial tension test and biaxial tension test - were performed and used to correlate the coefficients of the strain energy density function. Numerical simulations were carried out using finite element analysis and compared with experimental results. Simulation revealed that Ogden $3^{rd}$ model predicted the behavior of carbon added natural rubber under uniaxial load regardless of experimental data selection for coefficient correlation. However, Reduced Polynomial $2^{nd}$, Ogden $3^{rd}$, and Van der Waals with uniaxial tension test and biaxial tension test data selected for coefficient correlation showed close estimation of behavior of biaxial tension test. Reduced Polynomial $2^{nd}$ model predicted the behavior of biaxial tension test most closely.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.654-654
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• 2013

One of the most important yet unresolved problems in molecular electronics is the controversy over the number and nature of multiple conductance peaks in single-molecule junctions. Currently, there are three competing explanations of this observation: (1) manifestation of different molecule-electrode contact geometries, (2) formation of gauche defects within the molecular core, (3) involvement of different electrode surface orientations [1]. However, the exact origin of multiple conductance peaks is not yet fully understood, which indicates our incomplete understanding of the scientifically as well as techno-logically important organic-metal contacts. To theoretically resolve this problem, we previously applied a multiscale computational approach that combines force fields molecular dynamics (FF MD), density functional theory (DFT), and matrix Green's function (MGF) calculations [2] to a thermally fluctuating haxanedithiol (C6DT) molecule stretched between flat Au(111) electrodes, but could observe only a single conductance peak [3]. In this presentation, using DFT geometry optimizations and MGF calculations, we consider molecular junctions with more realistic molecule-metal contact conformations and Au(111) electrode surface directions. We also conduct DFT-based molecular dynamics for the highly stretched junction models to confirm our conclusion. We conclude that the S-Au coordination number should be the more dominant factor than the electrode surface orientation.

• Journal of Ocean Engineering and Technology
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• v.24 no.3
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• pp.72-78
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• 2010

This paper presents a design approach of driving system for tidal flat vehicle. Firstly, topographic and geological survey of tidal flat zone was accomplished. 'Anac' located in the west-south coast of South Korea was chosen for the survey area. From the survey, the basic design data such as distribution of gullies size and bearing pressure was obtained. To figure out the shape of driving system, numerical simulations were carried out. Through the numerical dynamic simulations using $Recurdyn^{TM}$, the performance of various concepts of driving system was analyzed. From the results, we propose the conceptual design with the functions: a) low contact pressure, b) powerful driving force transmission, c) adaptation to the ground undulation. To satisfy these functional requirements, the driving system adopts rubber tracks, sprockets, tires and suspensions. The static structural analysis of the frame structure was executed as well, from which the detailed design was drawn out. To validate the performance of the designed driving system, the test vehicle which has gasoline engine of 27HP and mechanical transmission was constructed. The driving tests of the vehicle were performed twice at the "Anac" area, and unveiled its capability.