• Journal of Society of Preventive Korean Medicine
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• v.21 no.2
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.451-458
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• 2019

Reliability in the course of weapons system development and operation is a key measure of the ability of a system to perform the required functions under specified conditions over a specified period of time, and the mission confidence for the assessment of mission fulfillment is an important indicator of victory or defeat in a battle. Mission reliability indicates the probability that a given task will succeed or fail in an event or environmental situation over a given period of time. The existing mission reliability was calculated after creating a confidence blow map with only physical connections based on the mission. However, as modern weapons systems evolve and advance, the related equipment structure becomes increasingly complex, making it impossible to express mission relevance when mission classification is required based on functional or physical connections. In this study, the mission reliability was calculated for a gun control system, which is part of a ship's combat system, by expressing the association between the physical and functional structures using the design structure matrix technique and the interface matrix technique. We expect the study results to be used as verification data for mission reliability.

• Korean Journal of Agricultural Science
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• v.39 no.3
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• pp.407-412
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• 2012

Soil texture has an important influence on agriculture such as crop selection, movement of nutrient and water, soil electrical conductivity, and crop growth. Conventionally, soil texture has been determined in the laboratory using pipette and hydrometer methods requiring significant amount of time, labor, and cost. Recently, in-situ soil texture classification systems using optical diffuse reflectometry or mechanical resistance have been reported, especially for precision agriculture that needs more data than conventional agriculture. This paper is a part of overall research to develop an in-situ soil texture classification system using image processing. Issues investigated in this study were effects of sensor travel speed and light source and intensity on image quality. When travel speed of image sensor increased from 0 to 10 mm/s, travel distance and number of pixel were increased to 3.30 mm and 9.4, respectively. This travel distances were not negligible even at a speed of 2 mm/s (i.e., 0.66 mm and 1.4), and image degradation was significant. Tests for effects of illumination intensity showed that 7 to 11 Lux seemed a good condition minimizing shade and reflection. When soil water content increased, illumination intensity should be greater to compensate decrease in brightness. Results of the paper would be useful for construction, test, and application of the sensor.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.1315-1318
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• 2003

In this paper, a neural network based approach using a self-organizing feature map is proposed for the segmentation of X ray images. A number of algorithms based on such approaches as histogram analysis, region growing, edge detection and pixel classification have been proposed for segmentation of general images. However, few approaches have been applied to X ray image segmentation because of blur of the X ray image and vagueness of its edge, which are inherent properties of X ray images. To this end, we develop a new model based on the neural network to detect objects in a given X ray image. The new model utilizes Mumford-Shah functional incorporating with a modified adaptive SOFM. Although Mumford-Shah model is an active contour model not based on the gradient of the image for finding edges in image, it has some limitation to accurately represent object images. To avoid this criticism, we utilize an adaptive self organizing feature map developed earlier by the authors.[1] It's learning rule is derived from Mumford-Shah energy function and the boundary of blurred and vague X ray image. The evolution of the neural network is shown to well segment and represent. To demonstrate the performance of the proposed method, segmentation of an industrial part is solved and the experimental results are discussed in detail.

• Journal of Advanced Navigation Technology
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• v.20 no.1
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• pp.1-7
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• 2016

Since 2014, MOLIT (Ministry of Land, Infrastructure, and Transport) is carrying out a KASS project to develop and construct Korean SBAS. KASS can cause damage of human & properties if it has some problem during operation. Therefore, system safety assessment for KASS development is very important. Principal point of system safety assessment is the allocation of DAL(design assurance level) based on the hazard identification and classification. In this parer, the author conducts the allocation of DAL for KASS & its sub-systems based on the international standard(SAE ARP4761), which suggests a best practice of aviation system safety assessment. The result of this paper are the first step of system safety assessment, and can be used for further system safety assessment of KASS project.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.35 no.1
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• pp.57-65
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• 2012

The relationship between product quality/function and customer satisfaction has been considered an important point for the new product development. The seminal paper by Kano was the first to thoroughly address the non-linear relationship between product performance/function and customer satisfaction. In the analysis framework of the original Kano model, five factors are assumed, among which indifference factor occupies 40% in the classification scheme. When we analyze survey response using Kano model, many quality attributes can be resulted in indifference factor. This implies that some attributes which are meaningful tend to be classified as indifferent attributes for the customer satisfaction. In order to tackle this problem, a modified Kano model is proposed by reducing the indifference factor. The modified Kano model can be robust for the survey response. A survey is performed for the quality attributes of the smart phone. The response is analyzed and compared based on the original and modified Kano model. The surveyed quality characteristics of the smart phone are performance related attributes, application programs, functional attributes and subjective emotional quality attributes. Many quality attributes classified as indifference factor in the original model are classified as attractive, must-be, and expected factors, respectively.

• Animal cells and systems
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• v.13 no.2
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• pp.235-245
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• 2009

Embryonic stem (ES) cells have a capability to generate all types of cells. However, the mechanism by which ES cells differentiate into specific cell is still unclear. Using microarray technology, the differentiation process in mouse embryonic stem cells was characterized by temporal gene expression changes of mouse ES cells during differentiation in a monolayer culture. A large number of genes were differentially regulated from 1 day to 14 days, and less number of genes were differentially expressed from 14 days to 28 days. The number of up-regulated genes was linearly increased throughout the 28 days of in vitro differentiation, while the number of down-regulated genes reached the plateau from 14 days to 28 days. Most differentially expressed genes were functionally classified into transcriptional regulation, development, extra cellular matrix (ECM),cytoskeleton organization, cytokines, receptors, RNA processing, DNA replication, chromatin assembly, proliferation and apoptosis related genes. While genes encoding ECM proteins were up-regulated, most of the genes related to proliferation, chromatin assembly, DNA replication, RNA processing, and cytoskeleton organization were down-regulated at 14 days. Genes known to be associated with embryo development or transcriptional regulation were differentially expressed mostly after 14 days of differentiation. These results indicate that the altered expression of ECM genes constitute an early event during the spontaneous differentiation, followed by the inhibition of proliferation and lineage specification. Our study might identify useful time-points for applying selective treatments for directed differentiation of mouse ES cells.

• Journal of Powder Materials
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• v.24 no.6
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• pp.494-507
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• 2017

A three-dimensional physical part can be fabricated from a three-dimensional digital model in a layer-wise manner via additive manufacturing (AM) technology, which is different from the conventional subtractive manufacturing technology. Numerous studies have been conducted to take advantage of the AM opportunities to penetrate bespoke custom product markets, functional engineering part markets, volatile low-volume markets, and spare part markets. Nevertheless, materials issues, machines issues, product issues, and qualification/certification issues still prevent the AM technology from being extensively adopted in industries. The present study briefly reviews the standard classification, technological structures, industrial applications, technological advances, and qualification/certification activities of the AM technology. The economics, productivity, quality, and reliability of the AM technology should be further improved to pass through the technology adoption lifecycle of innovation technology. The AM technology is continuously evolving through the introduction of PM materials, hybridization of AM and conventional manufacturing technologies, adoption of process diagnostics and control systems, and enhanced standardization of the whole lifecycle qualification and certification methodology.

• Journal of Information Technology Services
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• v.18 no.2
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• pp.37-54
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• 2019

The purpose of this study is to present an evaluation model to measure the clarification level of stakeholder requirements of public sector software projects in the Republic of Korea. We tried to grasp the quality of proposal request through evaluation model. It also examines the impact of the level of stakeholder requirements on the level of system requirements. To do this, we analyzed existing research models and related standards related to business requirements and stakeholder requirements, and constructed evaluation models for the system operation concept documents in the ISO/IEC/IEEE 29148. The system operation concept document is a document prepared by organizing the requirements of stakeholders in the organization and sharing the intention of the organization. The evaluation model proposed in this study focuses on evaluating whether the contents related to the system operation concept are faithfully written in the request for proposal. The evaluation items consisted of three items: 'organization status', 'desired changes', and 'operational constraints'. The sample extracted 217 RFPs in the national procurement system. As a result of the analysis, the evaluation model proved to be valid and the internal consistency was maintained. The level of system operation concept was very low, and it was also found to affect the quality of system requirements. It is more important to clearly write stakeholders' requirements than the functional requirements. we propose a news classification methods for sentiment analysis that is effective for bankruptcy prediction model.

• Journal of Korean Society of Environmental Engineers
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• v.35 no.7
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• pp.503-508
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• 2013

The aim of this study was to investigate the microbial communities in animal carcass disposal soils to examine the possible threat of pathogens from leachate. DNA extraction was performed for the soils in three carcass disposal sites located in Gyeonggi-do, Korea, and then 16S rRNA pyrosequencing was conducted to identify the microbial communities. Results indicate that, according to phylum classification, Proteobacteria (100%) was identified in soil A, Actinobacteria (66.4%) > Proteobacteria (31.1%) > Bacteriodetes (2.1%) > Acidobacteria (0.3%) in soil B, and Actinobacteria (63.1%) > Proteobacteria (36.9%) in soil C. According to genus classification, Pseudomonas was dominant in soil A (98%), Arthrobacter in soil B (68%) and C (61%). There were no detections of pathogens such as Salmonella, Campylobacter and Clostridium perfringens. However, high concentration of Ralstonia pickettii causing bacteremia was observed. Although carcass disposal soils examined in this study were not highly contaminated with pathogens, further monitoring is still needed to examine the potential threat of pathogens in leachate derived from carcass disposal sites.