• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1467-1472
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• 2013

Metabolomics is a field that studies systematic dynamics and secretion of metabolites from cells to understand biological pathways based on metabolite changes. The metabolic profiling of intact human colorectal tissues was performed using high-resolution magic angle spinning (HR-MAS) NMR spectroscopy, which was unnecessary to extract metabolites from tissues. We used two different groups of samples, which were defined as normal and cancer, from 9 patients with colorectal cancer and investigated the samples in NMR experiments with a water suppression pulse sequence. We applied target profiling and multivariative statistical analysis to the analyzed 1D NMR spectra to identify the metabolites and discriminate between normal and cancer tissues. Cancer tissue showed higher levels of arginine, betaine, glutamate, lysine, taurine and lower levels of glutamine, hypoxanthine, isoleucine, lactate, methionine, pyruvate, tyrosine relative to normal tissue. In the OPLS-DA (orthogonal partial least square discriminant analysis), the score plot showed good separation between the normal and cancer groups. These results suggest that metabolic profiling of colorectal cancer could provide new biomarkers.

• Journal of the Korean Society of Food Culture
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• v.37 no.1
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• pp.81-89
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• 2022

This study aimed to evaluate the changes in the content of functional components and antioxidant activity of rice and barley according to the milling process used. A considerable amount of γ-oryzanol was observed in unmilled rice and barley. However, γ-oryzanol was not detected in the rice and barley after the milling process. The highest content of γ-aminobutyric acid (GABA) was observed in the unmilled Keunalbori-1-ho barley. The contents of biotin in all samples also decreased in the milled grains compared to the unmilled grains. The highest content of total polyphenols and flavonoids was observed in the Heuksujeongchal barley, and the highest radical scavenging activity was also found in this grain. The milling process led to a decrease in the content of functional components, including γ-oryzanol, GABA, biotin, polyphenols, and flavonoids in both rice and barley. These results may be useful in the development of processed foods using cereal grains.

• Journal of the Korean Society of Food Culture
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• v.36 no.2
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• pp.226-234
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• 2021

The purpose of this study was to investigate the changes in the content of functional components and the antioxidant activity of cooked rice and porridge composed of selected grains. The results of the study showed that brown rice and oat contained considerable amounts of γ-oryzanol (78.099~238.566 mg/100 g). However, cooked rice showed a decreased content of the same. The highest content of γ-aminobutyric acid (GABA) was observed in brown rice from Samgwang. The contents of biotin in all samples also decreased in cooked rice compared to raw cereal grains. The highest content of total polyphenols and flavonoids were observed in Heukjinmi rice, and the highest radical scavenging activity was also found in this variety. The cooking process led to a decrease in the content of functional components including γ-oryzanol, GABA, biotin, polyphenols, and flavonoids versus the corresponding raw cereal grains. These results may be useful in the development and application of home meal replacements using cereal grains.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.82-86
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• 2004

To cope with the challenge from global market characterized by frequent changes in requirements, manufacturing enterprise should be able to promptly adjust its manufacturing system accordingly. Therefore, it is important to provide manufacturing system designer with an appropriate methodology to (re-)design a manufacturing system subject to requirements change. Axiomatic design theory focuses design activity mainly on functional consideration rather than physical, and has been known as effective especially in the conceptual design phase. This paper introduces an approach to apply the axiomatic design principle to manufacturing system design. It is shown that a new design solution can be reached quickly by finding design parameters for the added or revised functional requirements and thus achieving a set of functional requirements as well as design parameters that satisfy the independence axiom. Some illustrative examples are also given.

• Annals of Clinical Neurophysiology
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• v.10 no.1
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• pp.13-24
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• 2008

Functional neuroimaging, especially positron emission tomography (PET) and functional magnetic resonance imaging (MRI), is the main tool that allows the unveiling of the neurovascular events during a migraine attack. In migraine with aura, functional neuroimaging has contributed greatly to the understanding of the fundamental pathophysiology of the visual aura, whereas in migraine without aura, the PET findings of brainstem activation suggest a pivotal role of brainstem in the generation of migraine headache. In addition, voxel-based morphometry (VBM) method has provided an insight into the morphometric changes of the brain, which might be considered as a consequence of repeated migraine attacks. In this article, I will briefly discuss the main neuroimaging findings pertaining to the pathophysiology of migraine.

• Journal of TMJ Balancing Medicine
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• v.5 no.sup
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• pp.19-24
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• 2015

A dizziness case with functional cerebro-spinal therapy (FCST) was reviewed to explore the effect of FCST. The case was managed with Yinyang Balancing Appliance (YBA) and the TMJ Balancing Appliance (TBA), combined with acupuncture, cupping and herbal medicine. Clinical outcome measurement was performed based on subjective measures and clinical observation. The patient showed positive changes starting after the first treatment. Futher clinical and biological research on FCST is expected.

• Journal of the Korean Society of Food Culture
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• v.19 no.4
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• pp.369-377
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• 2004

This study was performed to investigate the change of biologically functional compounds and antioxidant activities in Ecklonia cava with blanching times. As biologically functional compounds, the contents of minerals(K, Ca, Na, Mg, Fe, Cu, Mn and Zn), vitamins($vitamin\;C,\;{\beta}-carotene\;and\;{\alpha}-tocopherol$) and total polyphenol were analyzed. And antioxidant activity was determined through free radicals(DPPH radical, superoxide anion radical, hydroxyl radical and hydrogen peroxide) scavenging activity and linoleic acid peroxidation inhibitory activity. As the blanching time increased, the contents of minerals, vitamin C, ${\beta}-carotene$ and total polyphenol were decreased however ${\alpha}-tocopherol$ was not affected by blanching time, and antioxidant activities were decreased with blanching time.

• PNF and Movement
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• v.6 no.1
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• pp.41-51
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• 2008

Purpose : This paper reviews evidence supporting adaptive plasticity in skeletal muscle fibers induced by various exercise training and neuromuscular activity. Result : Skeletal muscle fiber demonstrates a remarkable adaptability and can adjust its physiologic and contractile makeup in response to alterations in functional demands. This adaptive plasticity results from the ability of muscle fibers to adjust their molecular, functional, and contractile properties in response to altered physiological demands, such as changes in exercise patterns and mechanical loading. The process of activity-dependent plasticity in skeletal muscle involves a multitude of signalling mechanisms initiating replication of specific genetic sequences, enabling subsequent translation of the genetic message and ultimately generating a series of myosin heavy chain isoform. Conclusions : Knowledge of the mechanisms and interaction of activity-dependent adaptive pathways in skeletal muscle is important for our understanding of the synthesis of muscle myosin protein, maintenance of metabolic and functional capacity with physical activity, and therapeutic intervention for functional improvement.

• Applied Microscopy
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• v.46 no.4
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• pp.179-183
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• 2016

Mapping brain structural and functional connections through the whole brain is essential for understanding brain mechanisms and the physiological bases of brain diseases. Although region specific structural or functional deficits cause brain diseases, the changes of interregional connections could also be important factors of brain diseases. This review will introduce common neuroimaging modalities, including structural magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion tensor imaging, and other recent neuroimaging analyses methods, such as voxel-based morphometry, cortical thickness analysis, local gyrification index, and shape analysis for structural imaging. Tract-Based Spatial Statistics, TRActs Constrained by UnderLying Anatomy for diffusion MRI, and independent component analysis for fMRI also will also be introduced.

• Journal of the Korean housing association
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• v.18 no.3
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• pp.19-29
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• 2007

This study is aimed at interpreting into changes and characters of function applied into quantative analysis in ubiquitous house. Digital technology being introduced into architectural fields, It applied expansively from design and construction to user's convenience. The application of digital technology is presented to various change like effectiveness and exactness in design and function of space, which is overlayed digital space to physical space beyond the extent of receiving human needs in physical space. In ubiquitous house, digital technologies are supplied to function coordinated with life, appreciating into positional informations of human and materials, spatial informations. Ubiquitous house is comparably effective into funtional expansion, user's convenience, safty, which, for the future, is going to using on housing of high performance encouraging the application of advanced technology. Therefore this study is classified into human behaviors, functions, performances and characters of digital system in ubiquitous house, which being established into the relation of elements, is interpreted numerically into functional changes and charats being applied to ARM.